Incidental Mutation 'R3822:Gpr89'
ID 275218
Institutional Source Beutler Lab
Gene Symbol Gpr89
Ensembl Gene ENSMUSG00000028096
Gene Name G protein-coupled receptor 89
Synonyms SH120, 4933412D19Rik
MMRRC Submission 040884-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.383) question?
Stock # R3822 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 96775630-96812662 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 96800260 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 113 (S113P)
Ref Sequence ENSEMBL: ENSMUSP00000029738 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029738] [ENSMUST00000154750]
AlphaFold Q8BS95
Predicted Effect probably benign
Transcript: ENSMUST00000029738
AA Change: S113P

PolyPhen 2 Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000029738
Gene: ENSMUSG00000028096
AA Change: S113P

DomainStartEndE-ValueType
transmembrane domain 4 26 N/A INTRINSIC
transmembrane domain 38 60 N/A INTRINSIC
transmembrane domain 75 97 N/A INTRINSIC
transmembrane domain 110 127 N/A INTRINSIC
Pfam:GPHR_N 140 207 1.1e-31 PFAM
Pfam:ABA_GPCR 276 446 4.9e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139599
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146645
Predicted Effect silent
Transcript: ENSMUST00000154750
SMART Domains Protein: ENSMUSP00000116016
Gene: ENSMUSG00000028096

DomainStartEndE-ValueType
transmembrane domain 4 26 N/A INTRINSIC
transmembrane domain 38 60 N/A INTRINSIC
transmembrane domain 75 97 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199586
Meta Mutation Damage Score 0.0778 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency 100% (34/34)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aarsd1 T A 11: 101,301,971 (GRCm39) I332F probably damaging Het
Acp3 G T 9: 104,201,916 (GRCm39) Q76K probably damaging Het
Anp32e A T 3: 95,842,181 (GRCm39) I100L probably benign Het
Ccdc13 C A 9: 121,660,085 (GRCm39) L76F probably damaging Het
Cd44 T C 2: 102,731,738 (GRCm39) probably null Het
Chka A G 19: 3,932,038 (GRCm39) probably benign Het
Cnot6 A T 11: 49,579,999 (GRCm39) S98T probably benign Het
Cth A G 3: 157,624,136 (GRCm39) F127S probably benign Het
Dnah9 C A 11: 65,741,829 (GRCm39) probably null Het
Dysf T C 6: 84,184,070 (GRCm39) probably benign Het
Flad1 T A 3: 89,318,494 (GRCm39) I20F probably damaging Het
Gm20730 C T 6: 43,058,656 (GRCm39) S52N probably benign Het
Herpud2 G A 9: 25,036,220 (GRCm39) Q147* probably null Het
Hivep1 A T 13: 42,337,787 (GRCm39) H2622L possibly damaging Het
Hlcs T C 16: 94,068,840 (GRCm39) N274D probably benign Het
Ido2 T C 8: 25,023,771 (GRCm39) I356V probably benign Het
Insyn2b T C 11: 34,353,007 (GRCm39) S350P probably benign Het
Itgam A G 7: 127,711,458 (GRCm39) probably null Het
Lama1 C A 17: 68,086,041 (GRCm39) probably null Het
Lrrc4b T A 7: 44,111,982 (GRCm39) V618E probably damaging Het
Man1a2 A G 3: 100,539,913 (GRCm39) I176T possibly damaging Het
Mns1 A G 9: 72,346,730 (GRCm39) E71G probably damaging Het
Ncoa6 T A 2: 155,248,858 (GRCm39) N1482I probably damaging Het
Neto2 C A 8: 86,389,924 (GRCm39) E180* probably null Het
Psmb7 A T 2: 38,503,440 (GRCm39) probably benign Het
Rin2 C T 2: 145,664,550 (GRCm39) T60M probably benign Het
Slc28a3 A G 13: 58,706,092 (GRCm39) V639A probably benign Het
Tenm2 A T 11: 35,915,147 (GRCm39) I2129N probably damaging Het
Topaz1 A G 9: 122,626,848 (GRCm39) D1492G possibly damaging Het
Trank1 G A 9: 111,207,887 (GRCm39) G1711R probably damaging Het
Trpm1 A G 7: 63,867,451 (GRCm39) probably benign Het
Ugt1a6a T A 1: 88,066,251 (GRCm39) V19E probably benign Het
Vmn2r60 A T 7: 41,785,125 (GRCm39) E112D probably damaging Het
Wdr4 T G 17: 31,731,195 (GRCm39) Q55P probably damaging Het
Xpnpep1 G A 19: 52,992,250 (GRCm39) probably benign Het
Zfyve16 A T 13: 92,657,769 (GRCm39) L714Q probably damaging Het
Other mutations in Gpr89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00421:Gpr89 APN 3 96,805,839 (GRCm39) missense probably damaging 1.00
IGL00757:Gpr89 APN 3 96,778,850 (GRCm39) missense probably benign 0.00
IGL01114:Gpr89 APN 3 96,800,865 (GRCm39) missense probably damaging 0.98
IGL02417:Gpr89 APN 3 96,804,741 (GRCm39) nonsense probably null
explorer UTSW 3 96,787,385 (GRCm39) splice site probably null
R0207:Gpr89 UTSW 3 96,778,796 (GRCm39) missense probably damaging 0.99
R0650:Gpr89 UTSW 3 96,804,640 (GRCm39) splice site probably benign
R0704:Gpr89 UTSW 3 96,787,484 (GRCm39) critical splice acceptor site probably null
R1496:Gpr89 UTSW 3 96,812,526 (GRCm39) missense probably benign 0.00
R1869:Gpr89 UTSW 3 96,782,975 (GRCm39) missense probably benign 0.16
R1913:Gpr89 UTSW 3 96,782,949 (GRCm39) missense possibly damaging 0.91
R2264:Gpr89 UTSW 3 96,779,831 (GRCm39) missense probably damaging 0.99
R2276:Gpr89 UTSW 3 96,804,743 (GRCm39) missense probably damaging 1.00
R3922:Gpr89 UTSW 3 96,798,215 (GRCm39) missense probably damaging 1.00
R4984:Gpr89 UTSW 3 96,812,512 (GRCm39) missense probably benign 0.02
R5761:Gpr89 UTSW 3 96,800,196 (GRCm39) missense probably damaging 1.00
R6185:Gpr89 UTSW 3 96,798,149 (GRCm39) missense probably damaging 0.99
R7063:Gpr89 UTSW 3 96,783,014 (GRCm39) missense probably damaging 1.00
R7164:Gpr89 UTSW 3 96,778,714 (GRCm39) missense probably benign 0.04
R7172:Gpr89 UTSW 3 96,787,385 (GRCm39) splice site probably null
R7215:Gpr89 UTSW 3 96,787,404 (GRCm39) missense probably damaging 1.00
R7536:Gpr89 UTSW 3 96,798,209 (GRCm39) missense probably damaging 0.96
R7708:Gpr89 UTSW 3 96,787,941 (GRCm39) missense possibly damaging 0.81
R7849:Gpr89 UTSW 3 96,778,806 (GRCm39) nonsense probably null
R8273:Gpr89 UTSW 3 96,812,505 (GRCm39) missense probably benign
R9643:Gpr89 UTSW 3 96,780,813 (GRCm39) missense probably damaging 0.97
RF019:Gpr89 UTSW 3 96,812,509 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ATTTGGTACCCTCAGAAAGAAGGAAAC -3'
(R):5'- CTGCTTACACATAAGAAAGGTTTCC -3'

Sequencing Primer
(F):5'- CCCTCAGAAAGAAGGAAACATTTTG -3'
(R):5'- CATAAGAAAGGTTTCCTAATGGTGG -3'
Posted On 2015-04-02