Incidental Mutation 'R3822:Cnot6'
ID 275236
Institutional Source Beutler Lab
Gene Symbol Cnot6
Ensembl Gene ENSMUSG00000020362
Gene Name CCR4-NOT transcription complex, subunit 6
Synonyms A230103N10Rik
MMRRC Submission 040884-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.301) question?
Stock # R3822 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 49562330-49603550 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 49579999 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 98 (S98T)
Ref Sequence ENSEMBL: ENSMUSP00000121239 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020624] [ENSMUST00000145353]
AlphaFold Q8K3P5
Predicted Effect probably benign
Transcript: ENSMUST00000020624
AA Change: S98T

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000020624
Gene: ENSMUSG00000020362
AA Change: S98T

DomainStartEndE-ValueType
LRR 50 72 1.41e0 SMART
LRR_TYP 73 95 2.71e-2 SMART
LRR_TYP 96 119 1.67e-2 SMART
Pfam:Exo_endo_phos 187 526 1.9e-23 PFAM
low complexity region 529 542 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000109183
Predicted Effect probably benign
Transcript: ENSMUST00000145353
AA Change: S98T

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000121239
Gene: ENSMUSG00000020362
AA Change: S98T

DomainStartEndE-ValueType
LRR 50 72 1.41e0 SMART
LRR_TYP 73 95 2.71e-2 SMART
LRR_TYP 96 119 1.67e-2 SMART
Pfam:Exo_endo_phos 192 531 1.9e-23 PFAM
low complexity region 534 547 N/A INTRINSIC
Meta Mutation Damage Score 0.0611 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency 100% (34/34)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aarsd1 T A 11: 101,301,971 (GRCm39) I332F probably damaging Het
Acp3 G T 9: 104,201,916 (GRCm39) Q76K probably damaging Het
Anp32e A T 3: 95,842,181 (GRCm39) I100L probably benign Het
Ccdc13 C A 9: 121,660,085 (GRCm39) L76F probably damaging Het
Cd44 T C 2: 102,731,738 (GRCm39) probably null Het
Chka A G 19: 3,932,038 (GRCm39) probably benign Het
Cth A G 3: 157,624,136 (GRCm39) F127S probably benign Het
Dnah9 C A 11: 65,741,829 (GRCm39) probably null Het
Dysf T C 6: 84,184,070 (GRCm39) probably benign Het
Flad1 T A 3: 89,318,494 (GRCm39) I20F probably damaging Het
Gm20730 C T 6: 43,058,656 (GRCm39) S52N probably benign Het
Gpr89 A G 3: 96,800,260 (GRCm39) S113P probably benign Het
Herpud2 G A 9: 25,036,220 (GRCm39) Q147* probably null Het
Hivep1 A T 13: 42,337,787 (GRCm39) H2622L possibly damaging Het
Hlcs T C 16: 94,068,840 (GRCm39) N274D probably benign Het
Ido2 T C 8: 25,023,771 (GRCm39) I356V probably benign Het
Insyn2b T C 11: 34,353,007 (GRCm39) S350P probably benign Het
Itgam A G 7: 127,711,458 (GRCm39) probably null Het
Lama1 C A 17: 68,086,041 (GRCm39) probably null Het
Lrrc4b T A 7: 44,111,982 (GRCm39) V618E probably damaging Het
Man1a2 A G 3: 100,539,913 (GRCm39) I176T possibly damaging Het
Mns1 A G 9: 72,346,730 (GRCm39) E71G probably damaging Het
Ncoa6 T A 2: 155,248,858 (GRCm39) N1482I probably damaging Het
Neto2 C A 8: 86,389,924 (GRCm39) E180* probably null Het
Psmb7 A T 2: 38,503,440 (GRCm39) probably benign Het
Rin2 C T 2: 145,664,550 (GRCm39) T60M probably benign Het
Slc28a3 A G 13: 58,706,092 (GRCm39) V639A probably benign Het
Tenm2 A T 11: 35,915,147 (GRCm39) I2129N probably damaging Het
Topaz1 A G 9: 122,626,848 (GRCm39) D1492G possibly damaging Het
Trank1 G A 9: 111,207,887 (GRCm39) G1711R probably damaging Het
Trpm1 A G 7: 63,867,451 (GRCm39) probably benign Het
Ugt1a6a T A 1: 88,066,251 (GRCm39) V19E probably benign Het
Vmn2r60 A T 7: 41,785,125 (GRCm39) E112D probably damaging Het
Wdr4 T G 17: 31,731,195 (GRCm39) Q55P probably damaging Het
Xpnpep1 G A 19: 52,992,250 (GRCm39) probably benign Het
Zfyve16 A T 13: 92,657,769 (GRCm39) L714Q probably damaging Het
Other mutations in Cnot6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00546:Cnot6 APN 11 49,576,093 (GRCm39) missense probably benign 0.01
IGL00969:Cnot6 APN 11 49,575,947 (GRCm39) missense probably benign
IGL01655:Cnot6 APN 11 49,568,131 (GRCm39) missense probably damaging 1.00
IGL02074:Cnot6 APN 11 49,580,070 (GRCm39) missense probably benign 0.00
IGL02670:Cnot6 APN 11 49,575,941 (GRCm39) nonsense probably null
R0326:Cnot6 UTSW 11 49,568,263 (GRCm39) missense probably damaging 1.00
R0625:Cnot6 UTSW 11 49,573,998 (GRCm39) missense probably damaging 1.00
R1079:Cnot6 UTSW 11 49,575,930 (GRCm39) missense probably benign 0.01
R3820:Cnot6 UTSW 11 49,579,999 (GRCm39) missense probably benign 0.04
R3821:Cnot6 UTSW 11 49,579,999 (GRCm39) missense probably benign 0.04
R4202:Cnot6 UTSW 11 49,593,463 (GRCm39) missense probably damaging 1.00
R4515:Cnot6 UTSW 11 49,593,363 (GRCm39) splice site probably null
R6010:Cnot6 UTSW 11 49,574,066 (GRCm39) nonsense probably null
R6193:Cnot6 UTSW 11 49,570,850 (GRCm39) missense probably benign 0.06
R7149:Cnot6 UTSW 11 49,570,970 (GRCm39) missense probably benign
R7501:Cnot6 UTSW 11 49,576,159 (GRCm39) missense probably benign 0.01
R7556:Cnot6 UTSW 11 49,566,144 (GRCm39) missense probably benign 0.15
R8263:Cnot6 UTSW 11 49,573,002 (GRCm39) missense probably damaging 0.99
R8398:Cnot6 UTSW 11 49,593,445 (GRCm39) missense probably damaging 1.00
R8497:Cnot6 UTSW 11 49,566,191 (GRCm39) missense possibly damaging 0.46
R8519:Cnot6 UTSW 11 49,575,941 (GRCm39) missense probably benign
R9683:Cnot6 UTSW 11 49,580,164 (GRCm39) missense possibly damaging 0.93
RF003:Cnot6 UTSW 11 49,593,440 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ATCTCTGGACAGTCAATTCTTACC -3'
(R):5'- ATTTTGGCAGCCGCTCTATC -3'

Sequencing Primer
(F):5'- AAAGCCATGCCTCCTTTC -3'
(R):5'- GGCAGCCGCTCTATCTAACC -3'
Posted On 2015-04-02