Incidental Mutation 'R3824:Vmn2r74'
| ID |
275280 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r74
|
| Ensembl Gene |
ENSMUSG00000090774 |
| Gene Name |
vomeronasal 2, receptor 74 |
| Synonyms |
EG546980 |
| MMRRC Submission |
040885-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.100)
|
| Stock # |
R3824 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85951867-85961482 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 85958258 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Histidine
at position 86
(N86H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126917
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166355]
|
| AlphaFold |
E9PW21 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166355
AA Change: N86H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: N86H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
467 |
7.3e-28 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
4.7e-20 |
PFAM |
|
Pfam:7tm_3
|
592 |
830 |
1.3e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
95% (62/65) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2300002M23Rik |
T |
C |
17: 35,567,611 (GRCm38) |
C20R |
probably benign |
Het |
| 6030468B19Rik |
A |
G |
11: 117,802,913 (GRCm38) |
K69E |
probably damaging |
Het |
| 9430015G10Rik |
T |
A |
4: 156,119,150 (GRCm38) |
|
probably null |
Het |
| A2ml1 |
A |
G |
6: 128,568,763 (GRCm38) |
V467A |
probably damaging |
Het |
| Abcc3 |
T |
C |
11: 94,368,620 (GRCm38) |
|
probably null |
Het |
| Acad10 |
A |
T |
5: 121,622,818 (GRCm38) |
M941K |
probably benign |
Het |
| Agrn |
A |
G |
4: 156,169,302 (GRCm38) |
L1649P |
probably damaging |
Het |
| Arhgap12 |
T |
C |
18: 6,061,930 (GRCm38) |
R402G |
possibly damaging |
Het |
| Atp4b |
T |
C |
8: 13,393,549 (GRCm38) |
Y43C |
probably damaging |
Het |
| Btn2a2 |
T |
A |
13: 23,480,465 (GRCm38) |
T308S |
probably benign |
Het |
| C8b |
G |
T |
4: 104,783,009 (GRCm38) |
A170S |
probably benign |
Het |
| Cabyr |
T |
A |
18: 12,751,690 (GRCm38) |
D411E |
probably benign |
Het |
| Capn3 |
T |
C |
2: 120,484,483 (GRCm38) |
|
probably benign |
Het |
| Cd200r4 |
T |
C |
16: 44,820,950 (GRCm38) |
F19L |
probably benign |
Het |
| Cflar |
T |
A |
1: 58,735,697 (GRCm38) |
Y218N |
probably benign |
Het |
| Col11a2 |
T |
C |
17: 34,054,180 (GRCm38) |
Y630H |
probably damaging |
Het |
| Coq6 |
T |
C |
12: 84,372,415 (GRCm38) |
|
probably benign |
Het |
| Drg2 |
A |
G |
11: 60,459,508 (GRCm38) |
T98A |
possibly damaging |
Het |
| Fam205c |
A |
G |
4: 42,873,492 (GRCm38) |
|
probably null |
Het |
| Fry |
T |
A |
5: 150,496,419 (GRCm38) |
S1015R |
possibly damaging |
Het |
| Gjb4 |
A |
G |
4: 127,351,429 (GRCm38) |
S240P |
probably benign |
Het |
| Glmp |
G |
A |
3: 88,326,411 (GRCm38) |
V107I |
probably damaging |
Het |
| Gls |
A |
C |
1: 52,232,988 (GRCm38) |
M2R |
possibly damaging |
Het |
| Gm13078 |
A |
T |
4: 143,726,685 (GRCm38) |
H121L |
probably benign |
Het |
| Gm5724 |
T |
C |
6: 141,754,374 (GRCm38) |
Q144R |
possibly damaging |
Het |
| Gm906 |
G |
A |
13: 50,245,512 (GRCm38) |
S926F |
possibly damaging |
Het |
| Igfbp4 |
A |
G |
11: 99,048,235 (GRCm38) |
E27G |
probably damaging |
Het |
| Ints8 |
A |
T |
4: 11,225,621 (GRCm38) |
Y645* |
probably null |
Het |
| Kat6a |
G |
T |
8: 22,862,364 (GRCm38) |
V55F |
probably damaging |
Het |
| Kat8 |
T |
A |
7: 127,924,482 (GRCm38) |
D292E |
possibly damaging |
Het |
| Myo19 |
T |
A |
11: 84,885,679 (GRCm38) |
C54S |
probably damaging |
Het |
| Myo5b |
C |
T |
18: 74,661,655 (GRCm38) |
H532Y |
probably benign |
Het |
| Nckap1 |
T |
C |
2: 80,540,560 (GRCm38) |
K357E |
possibly damaging |
Het |
| Ndufaf1 |
C |
T |
2: 119,660,271 (GRCm38) |
V105M |
probably benign |
Het |
| Olfr1076 |
T |
G |
2: 86,509,023 (GRCm38) |
L188R |
possibly damaging |
Het |
| Olfr1394 |
A |
G |
11: 49,160,793 (GRCm38) |
S260G |
possibly damaging |
Het |
| Olfr888 |
A |
T |
9: 38,108,838 (GRCm38) |
I51F |
possibly damaging |
Het |
| Olfr895 |
T |
G |
9: 38,268,518 (GRCm38) |
S2A |
probably benign |
Het |
| Olfr904 |
T |
A |
9: 38,464,526 (GRCm38) |
C162S |
probably benign |
Het |
| Palld |
T |
C |
8: 61,709,033 (GRCm38) |
D439G |
probably damaging |
Het |
| Pcf11 |
T |
C |
7: 92,659,620 (GRCm38) |
|
probably benign |
Het |
| Pigo |
A |
T |
4: 43,020,909 (GRCm38) |
W678R |
possibly damaging |
Het |
| Pip5kl1 |
A |
T |
2: 32,583,271 (GRCm38) |
|
probably null |
Het |
| Plscr3 |
G |
A |
11: 69,850,138 (GRCm38) |
V267M |
probably benign |
Het |
| Prom2 |
A |
G |
2: 127,535,673 (GRCm38) |
|
probably benign |
Het |
| Ptk7 |
A |
G |
17: 46,565,378 (GRCm38) |
I1049T |
probably damaging |
Het |
| Ptprb |
A |
T |
10: 116,350,789 (GRCm38) |
I1743F |
probably benign |
Het |
| Ptprm |
A |
G |
17: 66,809,575 (GRCm38) |
V894A |
probably benign |
Het |
| Rack1 |
A |
G |
11: 48,802,304 (GRCm38) |
T105A |
probably benign |
Het |
| Rin2 |
C |
T |
2: 145,860,446 (GRCm38) |
T354I |
probably benign |
Het |
| Sdk1 |
A |
G |
5: 141,936,049 (GRCm38) |
T267A |
probably benign |
Het |
| Sorcs3 |
T |
A |
19: 48,722,956 (GRCm38) |
D653E |
probably damaging |
Het |
| St8sia1 |
A |
G |
6: 142,829,025 (GRCm38) |
L276P |
probably damaging |
Het |
| Sync |
T |
C |
4: 129,294,363 (GRCm38) |
V396A |
possibly damaging |
Het |
| Taok3 |
A |
G |
5: 117,255,937 (GRCm38) |
T592A |
probably benign |
Het |
| Tas2r104 |
T |
A |
6: 131,685,039 (GRCm38) |
I236F |
possibly damaging |
Het |
| Tas2r107 |
A |
C |
6: 131,659,330 (GRCm38) |
I252S |
probably benign |
Het |
| Tmem259 |
T |
C |
10: 79,978,448 (GRCm38) |
N334S |
possibly damaging |
Het |
| Tsga10 |
A |
T |
1: 37,834,197 (GRCm38) |
N200K |
possibly damaging |
Het |
| Usp24 |
G |
A |
4: 106,379,066 (GRCm38) |
V984I |
probably benign |
Het |
| Vmn1r189 |
T |
A |
13: 22,102,212 (GRCm38) |
T152S |
probably benign |
Het |
| Vmn1r2 |
A |
T |
4: 3,172,413 (GRCm38) |
T111S |
probably damaging |
Het |
| Zfp12 |
T |
C |
5: 143,240,322 (GRCm38) |
V72A |
probably benign |
Het |
|
| Other mutations in Vmn2r74 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00899:Vmn2r74
|
APN |
7 |
85,957,130 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL00904:Vmn2r74
|
APN |
7 |
85,957,580 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL01285:Vmn2r74
|
APN |
7 |
85,957,484 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
IGL01300:Vmn2r74
|
APN |
7 |
85,957,206 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01410:Vmn2r74
|
APN |
7 |
85,961,292 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
IGL01827:Vmn2r74
|
APN |
7 |
85,957,592 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02094:Vmn2r74
|
APN |
7 |
85,961,461 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02252:Vmn2r74
|
APN |
7 |
85,957,323 (GRCm38) |
missense |
probably benign |
0.41 |
|
IGL02349:Vmn2r74
|
APN |
7 |
85,952,516 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02438:Vmn2r74
|
APN |
7 |
85,952,616 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02554:Vmn2r74
|
APN |
7 |
85,957,373 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03036:Vmn2r74
|
APN |
7 |
85,952,692 (GRCm38) |
nonsense |
probably null |
|
|
IGL03370:Vmn2r74
|
APN |
7 |
85,958,057 (GRCm38) |
missense |
probably benign |
|
|
R0115:Vmn2r74
|
UTSW |
7 |
85,957,356 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0333:Vmn2r74
|
UTSW |
7 |
85,952,283 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0415:Vmn2r74
|
UTSW |
7 |
85,961,410 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0571:Vmn2r74
|
UTSW |
7 |
85,952,421 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0626:Vmn2r74
|
UTSW |
7 |
85,961,309 (GRCm38) |
nonsense |
probably null |
|
|
R0659:Vmn2r74
|
UTSW |
7 |
85,955,914 (GRCm38) |
splice site |
probably benign |
|
|
R1202:Vmn2r74
|
UTSW |
7 |
85,961,337 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R1473:Vmn2r74
|
UTSW |
7 |
85,961,410 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1908:Vmn2r74
|
UTSW |
7 |
85,952,442 (GRCm38) |
missense |
probably benign |
|
|
R2079:Vmn2r74
|
UTSW |
7 |
85,957,175 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2368:Vmn2r74
|
UTSW |
7 |
85,961,314 (GRCm38) |
missense |
probably benign |
0.39 |
|
R3782:Vmn2r74
|
UTSW |
7 |
85,956,114 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3977:Vmn2r74
|
UTSW |
7 |
85,958,137 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4182:Vmn2r74
|
UTSW |
7 |
85,957,187 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R4289:Vmn2r74
|
UTSW |
7 |
85,957,354 (GRCm38) |
missense |
probably benign |
|
|
R4294:Vmn2r74
|
UTSW |
7 |
85,957,416 (GRCm38) |
missense |
probably benign |
0.14 |
|
R4645:Vmn2r74
|
UTSW |
7 |
85,957,109 (GRCm38) |
missense |
probably benign |
|
|
R4646:Vmn2r74
|
UTSW |
7 |
85,957,574 (GRCm38) |
missense |
probably benign |
0.42 |
|
R4655:Vmn2r74
|
UTSW |
7 |
85,961,347 (GRCm38) |
missense |
probably benign |
|
|
R4901:Vmn2r74
|
UTSW |
7 |
85,955,991 (GRCm38) |
nonsense |
probably null |
|
|
R5532:Vmn2r74
|
UTSW |
7 |
85,951,989 (GRCm38) |
missense |
probably benign |
0.32 |
|
R5642:Vmn2r74
|
UTSW |
7 |
85,957,380 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5913:Vmn2r74
|
UTSW |
7 |
85,951,890 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,951,890 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6035:Vmn2r74
|
UTSW |
7 |
85,951,890 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6039:Vmn2r74
|
UTSW |
7 |
85,958,318 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R6039:Vmn2r74
|
UTSW |
7 |
85,958,318 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R6170:Vmn2r74
|
UTSW |
7 |
85,957,140 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6232:Vmn2r74
|
UTSW |
7 |
85,958,290 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R6238:Vmn2r74
|
UTSW |
7 |
85,952,072 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6255:Vmn2r74
|
UTSW |
7 |
85,952,451 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6468:Vmn2r74
|
UTSW |
7 |
85,961,391 (GRCm38) |
missense |
probably benign |
0.34 |
|
R6732:Vmn2r74
|
UTSW |
7 |
85,957,550 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6816:Vmn2r74
|
UTSW |
7 |
85,961,413 (GRCm38) |
nonsense |
probably null |
|
|
R6836:Vmn2r74
|
UTSW |
7 |
85,957,422 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6995:Vmn2r74
|
UTSW |
7 |
85,957,652 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R6995:Vmn2r74
|
UTSW |
7 |
85,952,735 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7186:Vmn2r74
|
UTSW |
7 |
85,951,942 (GRCm38) |
nonsense |
probably null |
|
|
R7246:Vmn2r74
|
UTSW |
7 |
85,955,965 (GRCm38) |
missense |
probably benign |
|
|
R7374:Vmn2r74
|
UTSW |
7 |
85,957,422 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7505:Vmn2r74
|
UTSW |
7 |
85,957,071 (GRCm38) |
nonsense |
probably null |
|
|
R7525:Vmn2r74
|
UTSW |
7 |
85,961,302 (GRCm38) |
missense |
probably benign |
|
|
R7569:Vmn2r74
|
UTSW |
7 |
85,952,336 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r74
|
UTSW |
7 |
85,957,538 (GRCm38) |
missense |
probably benign |
0.11 |
|
R7956:Vmn2r74
|
UTSW |
7 |
85,955,958 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8119:Vmn2r74
|
UTSW |
7 |
85,961,482 (GRCm38) |
start codon destroyed |
probably null |
0.08 |
|
R8131:Vmn2r74
|
UTSW |
7 |
85,952,735 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8147:Vmn2r74
|
UTSW |
7 |
85,956,019 (GRCm38) |
nonsense |
probably null |
|
|
R8181:Vmn2r74
|
UTSW |
7 |
85,956,116 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8184:Vmn2r74
|
UTSW |
7 |
85,952,246 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8375:Vmn2r74
|
UTSW |
7 |
85,952,706 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R8948:Vmn2r74
|
UTSW |
7 |
85,957,361 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8950:Vmn2r74
|
UTSW |
7 |
85,957,361 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9033:Vmn2r74
|
UTSW |
7 |
85,957,206 (GRCm38) |
missense |
probably benign |
|
|
R9342:Vmn2r74
|
UTSW |
7 |
85,957,416 (GRCm38) |
missense |
probably benign |
0.14 |
|
R9578:Vmn2r74
|
UTSW |
7 |
85,956,893 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9607:Vmn2r74
|
UTSW |
7 |
85,961,411 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9776:Vmn2r74
|
UTSW |
7 |
85,956,004 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
Z1176:Vmn2r74
|
UTSW |
7 |
85,955,627 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z31818:Vmn2r74
|
UTSW |
7 |
85,955,521 (GRCm38) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATGAACAGGTATGGCCCAATG -3'
(R):5'- CCGTTTTCTGTCAGTTAAAACCAG -3'
Sequencing Primer
(F):5'- CTTGAAGATACTGCCCATAACGGTG -3'
(R):5'- CTGTCAGTTAAAACCAGTATGCAAC -3'
|
| Posted On |
2015-04-02 |
Incidental Mutation