Mutagenetix > Incidental Mutation

Incidental Mutation 'R3825:Ncor1'

275353

Institutional Source

Beutler Lab

Gene Symbol

Ncor1

Ensembl Gene

ENSMUSG00000018501

Gene Name

nuclear receptor co-repressor 1

Synonyms

Rxrip13, 5730405M06Rik, A230020K14Rik, N-CoR

MMRRC Submission

040774-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R3825 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

62207132-62348200 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 62264183 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 406 (H406Q)

Ref Sequence

ENSEMBL: ENSMUSP00000125317 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018645] [ENSMUST00000101066] [ENSMUST00000101067] [ENSMUST00000127471] [ENSMUST00000151498] [ENSMUST00000155712]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000018645
AA Change: H816Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000018645
Gene: ENSMUSG00000018501
AA Change: H816Q

Domain	Start	End	E-Value	Type
low complexity region	51	74	N/A	INTRINSIC
Pfam:GPS2_interact	150	239	1.4e-37	PFAM
coiled coil region	302	329	N/A	INTRINSIC
low complexity region	349	366	N/A	INTRINSIC
SANT	437	485	2.76e-7	SMART
coiled coil region	507	544	N/A	INTRINSIC
low complexity region	593	617	N/A	INTRINSIC
SANT	624	672	3.29e-14	SMART
low complexity region	710	731	N/A	INTRINSIC
low complexity region	771	788	N/A	INTRINSIC
low complexity region	888	899	N/A	INTRINSIC
low complexity region	987	995	N/A	INTRINSIC
low complexity region	1002	1013	N/A	INTRINSIC
low complexity region	1036	1049	N/A	INTRINSIC
internal_repeat_2	1061	1298	1.62e-6	PROSPERO
internal_repeat_2	1299	1515	1.62e-6	PROSPERO
low complexity region	1516	1527	N/A	INTRINSIC
coiled coil region	1712	1749	N/A	INTRINSIC
low complexity region	1834	1848	N/A	INTRINSIC
low complexity region	1969	1980	N/A	INTRINSIC
low complexity region	2036	2055	N/A	INTRINSIC
PDB:3N00\|B	2064	2084	4e-7	PDB
low complexity region	2086	2101	N/A	INTRINSIC
low complexity region	2157	2168	N/A	INTRINSIC
PDB:2OVM\|B	2267	2290	2e-8	PDB
low complexity region	2311	2324	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000101066
AA Change: H816Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000098627
Gene: ENSMUSG00000018501
AA Change: H816Q

Domain	Start	End	E-Value	Type
low complexity region	51	74	N/A	INTRINSIC
coiled coil region	176	217	N/A	INTRINSIC
coiled coil region	302	329	N/A	INTRINSIC
low complexity region	349	366	N/A	INTRINSIC
SANT	437	485	2.76e-7	SMART
coiled coil region	507	544	N/A	INTRINSIC
low complexity region	593	617	N/A	INTRINSIC
SANT	624	672	3.29e-14	SMART
low complexity region	710	731	N/A	INTRINSIC
low complexity region	771	788	N/A	INTRINSIC
low complexity region	888	899	N/A	INTRINSIC
low complexity region	987	995	N/A	INTRINSIC
low complexity region	1002	1013	N/A	INTRINSIC
low complexity region	1036	1049	N/A	INTRINSIC
internal_repeat_2	1061	1298	1.62e-6	PROSPERO
internal_repeat_2	1299	1515	1.62e-6	PROSPERO
low complexity region	1516	1527	N/A	INTRINSIC
coiled coil region	1712	1749	N/A	INTRINSIC
low complexity region	1834	1848	N/A	INTRINSIC
low complexity region	1969	1980	N/A	INTRINSIC
low complexity region	2036	2055	N/A	INTRINSIC
PDB:3N00\|B	2064	2084	4e-7	PDB
low complexity region	2086	2101	N/A	INTRINSIC
low complexity region	2157	2168	N/A	INTRINSIC
PDB:2OVM\|B	2267	2290	2e-8	PDB
low complexity region	2311	2324	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000101067
AA Change: H766Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000098628
Gene: ENSMUSG00000018501
AA Change: H766Q

Domain	Start	End	E-Value	Type
low complexity region	51	74	N/A	INTRINSIC
coiled coil region	176	217	N/A	INTRINSIC
coiled coil region	302	329	N/A	INTRINSIC
low complexity region	349	366	N/A	INTRINSIC
SANT	437	485	2.76e-7	SMART
coiled coil region	507	544	N/A	INTRINSIC
low complexity region	593	617	N/A	INTRINSIC
SANT	624	672	3.29e-14	SMART
low complexity region	716	734	N/A	INTRINSIC
low complexity region	838	849	N/A	INTRINSIC
low complexity region	937	945	N/A	INTRINSIC
low complexity region	952	963	N/A	INTRINSIC
low complexity region	986	999	N/A	INTRINSIC
low complexity region	1448	1459	N/A	INTRINSIC
coiled coil region	1645	1682	N/A	INTRINSIC
low complexity region	1767	1781	N/A	INTRINSIC
low complexity region	1902	1913	N/A	INTRINSIC
low complexity region	1969	1988	N/A	INTRINSIC
PDB:3N00\|B	1997	2017	4e-7	PDB
low complexity region	2019	2034	N/A	INTRINSIC
low complexity region	2089	2100	N/A	INTRINSIC
PDB:2OVM\|B	2199	2222	2e-8	PDB
low complexity region	2243	2256	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000101068

Predicted Effect

probably benign
Transcript: ENSMUST00000127471

SMART Domains

Protein: ENSMUSP00000121806
Gene: ENSMUSG00000018501

Domain	Start	End	E-Value	Type
low complexity region	51	74	N/A	INTRINSIC
coiled coil region	176	217	N/A	INTRINSIC
coiled coil region	302	329	N/A	INTRINSIC
low complexity region	349	366	N/A	INTRINSIC
SANT	437	485	2.76e-7	SMART
coiled coil region	508	545	N/A	INTRINSIC
low complexity region	594	618	N/A	INTRINSIC
SANT	625	673	3.29e-14	SMART
low complexity region	711	732	N/A	INTRINSIC
low complexity region	756	773	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000151498
AA Change: H406Q

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000125317
Gene: ENSMUSG00000018501
AA Change: H406Q

Domain	Start	End	E-Value	Type
SANT	37	85	2.76e-7	SMART
coiled coil region	107	144	N/A	INTRINSIC
low complexity region	193	217	N/A	INTRINSIC
SANT	224	272	3.29e-14	SMART
low complexity region	316	337	N/A	INTRINSIC
low complexity region	361	378	N/A	INTRINSIC
low complexity region	478	489	N/A	INTRINSIC
low complexity region	577	585	N/A	INTRINSIC
low complexity region	592	603	N/A	INTRINSIC
low complexity region	684	697	N/A	INTRINSIC
internal_repeat_2	700	830	5.77e-7	PROSPERO
internal_repeat_2	855	961	5.77e-7	PROSPERO

Predicted Effect

probably benign
Transcript: ENSMUST00000155712
AA Change: H132Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000122654
Gene: ENSMUSG00000018501
AA Change: H132Q

Domain	Start	End	E-Value	Type
low complexity region	26	47	N/A	INTRINSIC
low complexity region	87	104	N/A	INTRINSIC
low complexity region	204	215	N/A	INTRINSIC
low complexity region	303	311	N/A	INTRINSIC
low complexity region	318	329	N/A	INTRINSIC
low complexity region	352	365	N/A	INTRINSIC
low complexity region	785	796	N/A	INTRINSIC
coiled coil region	982	1019	N/A	INTRINSIC
low complexity region	1104	1118	N/A	INTRINSIC
low complexity region	1239	1250	N/A	INTRINSIC
low complexity region	1306	1325	N/A	INTRINSIC
PDB:3N00\|B	1334	1354	3e-7	PDB
low complexity region	1356	1371	N/A	INTRINSIC
low complexity region	1427	1438	N/A	INTRINSIC
PDB:2OVM\|B	1537	1560	2e-8	PDB
low complexity region	1581	1594	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000161288
AA Change: H203Q

SMART Domains

Protein: ENSMUSP00000124045
Gene: ENSMUSG00000018501
AA Change: H203Q

Domain	Start	End	E-Value	Type
SANT	22	70	3.29e-14	SMART
low complexity region	114	135	N/A	INTRINSIC
low complexity region	159	176	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000162077

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161116

Predicted Effect

probably benign
Transcript: ENSMUST00000161699

SMART Domains

Protein: ENSMUSP00000124120
Gene: ENSMUSG00000018501

Domain	Start	End	E-Value	Type
coiled coil region	3	40	N/A	INTRINSIC
low complexity region	90	114	N/A	INTRINSIC
SANT	121	169	3.29e-14	SMART
low complexity region	207	225	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162236

SMART Domains

Protein: ENSMUSP00000124698
Gene: ENSMUSG00000018501

Domain	Start	End	E-Value	Type
low complexity region	1	14	N/A	INTRINSIC
low complexity region	41	65	N/A	INTRINSIC
SANT	72	120	3.29e-14	SMART
low complexity region	164	185	N/A	INTRINSIC
low complexity region	225	242	N/A	INTRINSIC

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.6%
20x: 96.0%

Validation Efficiency

98% (63/64)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
PHENOTYPE: Mice homozygous for a targeted mutation in this gene exhibit embryonic lethality with erythrocytic, thymocytic and central nervous system development abnormalities. Mice homozygous for a hypomorphic allele exhibit increased thyroid hormone sensitivity under hypothyroid conditions. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6030468B19Rik	A	G	11: 117,693,739 (GRCm39)	K69E	probably damaging	Het
Abcb5	C	T	12: 118,865,087 (GRCm39)		probably null	Het
Acot1	G	T	12: 84,061,194 (GRCm39)	G167*	probably null	Het
Agbl1	C	T	7: 76,069,715 (GRCm39)	H164Y	probably damaging	Het
Atp4b	T	C	8: 13,443,549 (GRCm39)	Y43C	probably damaging	Het
Bsn	T	C	9: 107,984,055 (GRCm39)	D3333G	unknown	Het
Ccdc27	A	C	4: 154,120,742 (GRCm39)	D351E	unknown	Het
Cd200r4	T	C	16: 44,641,313 (GRCm39)	F19L	probably benign	Het
Dbndd1	T	A	8: 124,236,731 (GRCm39)	I75F	probably damaging	Het
Dennd5b	T	C	6: 148,946,334 (GRCm39)	K426E	probably benign	Het
Drg2	A	G	11: 60,350,334 (GRCm39)	T98A	possibly damaging	Het
Fabp3	C	T	4: 130,206,245 (GRCm39)		probably null	Het
Fmo1	T	C	1: 162,678,916 (GRCm39)		probably benign	Het
Foxn2	A	T	17: 88,791,837 (GRCm39)	I236F	probably damaging	Het
Glmp	G	A	3: 88,233,718 (GRCm39)	V107I	probably damaging	Het
Gpr15	A	G	16: 58,538,723 (GRCm39)	F122S	probably damaging	Het
Gvin-ps3	T	C	7: 105,682,780 (GRCm39)	I158M	possibly damaging	Het
Hmcn1	A	T	1: 150,462,716 (GRCm39)	D5140E	probably benign	Het
Hspa1a	C	T	17: 35,190,703 (GRCm39)	V67M	probably damaging	Het
Igfbp4	A	G	11: 98,939,061 (GRCm39)	E27G	probably damaging	Het
Il7	A	G	3: 7,642,226 (GRCm39)		probably benign	Het
Kat6a	G	T	8: 23,352,380 (GRCm39)	V55F	probably damaging	Het
Kynu	A	G	2: 43,571,451 (GRCm39)	T456A	probably benign	Het
Lcorl	A	G	5: 45,932,729 (GRCm39)		probably benign	Het
Lrp5	G	A	19: 3,655,290 (GRCm39)	R1077*	probably null	Het
Mab21l2	T	C	3: 86,454,211 (GRCm39)	E263G	possibly damaging	Het
Macf1	T	A	4: 123,338,744 (GRCm39)	D1436V	probably benign	Het
Map4k2	C	A	19: 6,394,081 (GRCm39)	T252N	probably benign	Het
Mterf2	A	T	10: 84,956,147 (GRCm39)	L159Q	probably damaging	Het
Muc5ac	C	A	7: 141,368,460 (GRCm39)	T3063K	possibly damaging	Het
Myo18a	T	A	11: 77,668,292 (GRCm39)	S51T	possibly damaging	Het
Ncoa3	G	T	2: 165,896,718 (GRCm39)	G503V	possibly damaging	Het
Nectin2	T	C	7: 19,458,510 (GRCm39)	K434E	possibly damaging	Het
Nipal2	A	T	15: 34,578,852 (GRCm39)		probably null	Het
Nub1	G	C	5: 24,912,851 (GRCm39)	S517T	probably benign	Het
Or10a4	T	C	7: 106,696,816 (GRCm39)	L48P	possibly damaging	Het
Or4d10c	A	G	19: 12,065,391 (GRCm39)	V255A	probably damaging	Het
Or8b101	A	T	9: 38,020,134 (GRCm39)	I51F	possibly damaging	Het
Or8c17	T	G	9: 38,179,814 (GRCm39)	S2A	probably benign	Het
Plscr3	G	A	11: 69,740,964 (GRCm39)	V267M	probably benign	Het
Plxnb2	G	T	15: 89,050,602 (GRCm39)	N451K	probably benign	Het
Ppp2r2a	A	G	14: 67,259,892 (GRCm39)	L268P	probably damaging	Het
Ptprb	A	T	10: 116,186,694 (GRCm39)	I1743F	probably benign	Het
Rack1	A	G	11: 48,693,131 (GRCm39)	T105A	probably benign	Het
Rhot1	G	A	11: 80,116,907 (GRCm39)	V94I	probably damaging	Het
Rin2	C	T	2: 145,702,366 (GRCm39)	T354I	probably benign	Het
Smc6	T	A	12: 11,351,517 (GRCm39)		probably benign	Het
Spink8	T	A	9: 109,645,861 (GRCm39)	V11D	probably damaging	Het
Ss18l1	A	T	2: 179,705,103 (GRCm39)	Q365L	unknown	Het
Tbc1d31	T	A	15: 57,779,474 (GRCm39)	H62Q	probably benign	Het
Tbc1d9b	T	C	11: 50,061,954 (GRCm39)	V1171A	possibly damaging	Het
Tln1	G	A	4: 43,536,413 (GRCm39)		probably benign	Het
Tmem220	G	A	11: 66,916,077 (GRCm39)	A25T	possibly damaging	Het
Tmem259	T	C	10: 79,814,282 (GRCm39)	N334S	possibly damaging	Het
Tmod3	A	T	9: 75,414,809 (GRCm39)		probably benign	Het
Tmprss2	A	T	16: 97,398,021 (GRCm39)	Y52N	probably damaging	Het
Tsga10	A	T	1: 37,873,278 (GRCm39)	N200K	possibly damaging	Het
Ube2frt	T	C	12: 36,141,036 (GRCm39)		probably benign	Het
Vmn1r189	T	A	13: 22,286,382 (GRCm39)	T152S	probably benign	Het
Vmn2r76	C	T	7: 85,880,415 (GRCm39)	M90I	probably benign	Het
Zfr	C	T	15: 12,166,277 (GRCm39)	A849V	probably damaging	Het
Znhit6	T	C	3: 145,284,099 (GRCm39)	M95T	probably benign	Het

Other mutations in Ncor1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01067:Ncor1	APN	11	62,283,354 (GRCm39)	missense	probably damaging	1.00
IGL01343:Ncor1	APN	11	62,216,312 (GRCm39)	critical splice donor site	probably null
IGL01392:Ncor1	APN	11	62,231,420 (GRCm39)	missense	probably damaging	0.99
IGL01402:Ncor1	APN	11	62,231,300 (GRCm39)	missense	probably damaging	1.00
IGL01714:Ncor1	APN	11	62,225,410 (GRCm39)	missense	possibly damaging	0.58
IGL01772:Ncor1	APN	11	62,240,173 (GRCm39)	intron	probably benign
IGL01889:Ncor1	APN	11	62,225,427 (GRCm39)	missense	possibly damaging	0.69
IGL02058:Ncor1	APN	11	62,235,463 (GRCm39)	missense	probably damaging	1.00
IGL02065:Ncor1	APN	11	62,310,435 (GRCm39)	missense	possibly damaging	0.95
IGL02073:Ncor1	APN	11	62,249,743 (GRCm39)	missense	probably damaging	0.99
IGL02176:Ncor1	APN	11	62,220,485 (GRCm39)	unclassified	probably benign
IGL02288:Ncor1	APN	11	62,240,229 (GRCm39)	missense	probably benign	0.01
IGL02348:Ncor1	APN	11	62,224,485 (GRCm39)	splice site	probably benign
IGL02608:Ncor1	APN	11	62,264,040 (GRCm39)	missense	probably benign	0.07
laggard	UTSW	11	62,260,130 (GRCm39)	missense	probably damaging	1.00
Shortstep	UTSW	11	62,225,367 (GRCm39)	missense	probably damaging	1.00
LCD18:Ncor1	UTSW	11	62,419,782 (GRCm38)	critical splice acceptor site	probably benign
PIT4382001:Ncor1	UTSW	11	62,235,489 (GRCm39)	missense	probably damaging	0.96
PIT4576001:Ncor1	UTSW	11	62,224,543 (GRCm39)	missense	probably damaging	0.99
R0026:Ncor1	UTSW	11	62,329,255 (GRCm39)	missense	probably damaging	1.00
R0038:Ncor1	UTSW	11	62,283,377 (GRCm39)	missense	probably damaging	0.99
R0038:Ncor1	UTSW	11	62,283,377 (GRCm39)	missense	probably damaging	0.99
R0103:Ncor1	UTSW	11	62,233,871 (GRCm39)	missense	possibly damaging	0.85
R0103:Ncor1	UTSW	11	62,233,871 (GRCm39)	missense	possibly damaging	0.85
R0144:Ncor1	UTSW	11	62,283,421 (GRCm39)	missense	probably damaging	1.00
R0427:Ncor1	UTSW	11	62,301,746 (GRCm39)	missense	probably damaging	1.00
R0501:Ncor1	UTSW	11	62,264,148 (GRCm39)	missense	possibly damaging	0.73
R0544:Ncor1	UTSW	11	62,224,603 (GRCm39)	missense	probably damaging	1.00
R0544:Ncor1	UTSW	11	62,224,602 (GRCm39)	missense	probably damaging	1.00
R0563:Ncor1	UTSW	11	62,234,056 (GRCm39)	missense	probably damaging	0.97
R1074:Ncor1	UTSW	11	62,283,377 (GRCm39)	missense	probably damaging	0.99
R1266:Ncor1	UTSW	11	62,224,866 (GRCm39)	missense	probably damaging	0.98
R1444:Ncor1	UTSW	11	62,294,632 (GRCm39)	missense	probably damaging	1.00
R1452:Ncor1	UTSW	11	62,225,457 (GRCm39)	missense	probably damaging	1.00
R1534:Ncor1	UTSW	11	62,269,330 (GRCm39)	missense	possibly damaging	0.92
R1710:Ncor1	UTSW	11	62,313,831 (GRCm39)	missense	probably damaging	1.00
R1762:Ncor1	UTSW	11	62,275,610 (GRCm39)	missense	possibly damaging	0.82
R1771:Ncor1	UTSW	11	62,217,938 (GRCm39)	missense	probably damaging	1.00
R1864:Ncor1	UTSW	11	62,272,245 (GRCm39)	missense	probably damaging	1.00
R1902:Ncor1	UTSW	11	62,228,984 (GRCm39)	missense	probably damaging	1.00
R1906:Ncor1	UTSW	11	62,240,211 (GRCm39)	missense	possibly damaging	0.81
R2009:Ncor1	UTSW	11	62,216,427 (GRCm39)	missense	probably benign	0.43
R3708:Ncor1	UTSW	11	62,235,513 (GRCm39)	missense	probably damaging	1.00
R3923:Ncor1	UTSW	11	62,216,442 (GRCm39)	missense	probably damaging	1.00
R3966:Ncor1	UTSW	11	62,235,583 (GRCm39)	missense	probably damaging	1.00
R4049:Ncor1	UTSW	11	62,220,494 (GRCm39)	splice site	probably null
R4350:Ncor1	UTSW	11	62,301,644 (GRCm39)	critical splice donor site	probably null
R4351:Ncor1	UTSW	11	62,301,644 (GRCm39)	critical splice donor site	probably null
R4359:Ncor1	UTSW	11	62,249,736 (GRCm39)	missense	probably damaging	1.00
R4712:Ncor1	UTSW	11	62,235,660 (GRCm39)	missense	probably damaging	1.00
R4723:Ncor1	UTSW	11	62,269,438 (GRCm39)	missense	probably benign	0.26
R4863:Ncor1	UTSW	11	62,283,464 (GRCm39)	missense	possibly damaging	0.92
R4875:Ncor1	UTSW	11	62,324,437 (GRCm39)	small deletion	probably benign
R4956:Ncor1	UTSW	11	62,231,431 (GRCm39)	missense	probably damaging	1.00
R4993:Ncor1	UTSW	11	62,234,167 (GRCm39)	missense	probably damaging	1.00
R5079:Ncor1	UTSW	11	62,236,063 (GRCm39)	missense	possibly damaging	0.92
R5144:Ncor1	UTSW	11	62,240,290 (GRCm39)	missense	probably damaging	1.00
R5223:Ncor1	UTSW	11	62,229,826 (GRCm39)	missense	probably damaging	1.00
R5243:Ncor1	UTSW	11	62,229,788 (GRCm39)	missense	probably damaging	1.00
R5271:Ncor1	UTSW	11	62,231,371 (GRCm39)	missense	probably damaging	1.00
R5285:Ncor1	UTSW	11	62,283,475 (GRCm39)	missense	probably damaging	1.00
R5533:Ncor1	UTSW	11	62,233,837 (GRCm39)	missense	probably benign	0.00
R5580:Ncor1	UTSW	11	62,280,604 (GRCm39)	nonsense	probably null
R5593:Ncor1	UTSW	11	62,260,130 (GRCm39)	missense	probably damaging	1.00
R5609:Ncor1	UTSW	11	62,249,679 (GRCm39)	splice site	probably null
R5632:Ncor1	UTSW	11	62,229,060 (GRCm39)	missense	possibly damaging	0.85
R5830:Ncor1	UTSW	11	62,235,589 (GRCm39)	missense	possibly damaging	0.71
R5896:Ncor1	UTSW	11	62,274,016 (GRCm39)	missense	probably damaging	1.00
R5973:Ncor1	UTSW	11	62,240,136 (GRCm39)	splice site	probably null
R6013:Ncor1	UTSW	11	62,211,903 (GRCm39)	missense	probably benign
R6019:Ncor1	UTSW	11	62,263,987 (GRCm39)	missense	probably benign	0.00
R6032:Ncor1	UTSW	11	62,264,147 (GRCm39)	missense	possibly damaging	0.54
R6032:Ncor1	UTSW	11	62,264,147 (GRCm39)	missense	possibly damaging	0.54
R6075:Ncor1	UTSW	11	62,208,675 (GRCm39)	missense	probably damaging	1.00
R6091:Ncor1	UTSW	11	62,310,443 (GRCm39)	missense	probably damaging	0.98
R6248:Ncor1	UTSW	11	62,257,808 (GRCm39)	missense	probably damaging	1.00
R6281:Ncor1	UTSW	11	62,264,371 (GRCm39)	missense	possibly damaging	0.71
R6351:Ncor1	UTSW	11	62,264,124 (GRCm39)	missense	probably benign	0.30
R6469:Ncor1	UTSW	11	62,234,128 (GRCm39)	missense	probably damaging	1.00
R6502:Ncor1	UTSW	11	62,272,240 (GRCm39)	nonsense	probably null
R6614:Ncor1	UTSW	11	62,221,645 (GRCm39)	missense	probably benign	0.01
R6650:Ncor1	UTSW	11	62,225,367 (GRCm39)	missense	probably damaging	1.00
R6765:Ncor1	UTSW	11	62,264,272 (GRCm39)	missense	probably benign	0.01
R6852:Ncor1	UTSW	11	62,234,071 (GRCm39)	missense	probably damaging	0.97
R6909:Ncor1	UTSW	11	62,220,312 (GRCm39)	missense	probably damaging	1.00
R6965:Ncor1	UTSW	11	62,244,059 (GRCm39)	critical splice donor site	probably null
R7054:Ncor1	UTSW	11	62,275,619 (GRCm39)	missense	probably null
R7248:Ncor1	UTSW	11	62,275,598 (GRCm39)	missense	possibly damaging	0.89
R7352:Ncor1	UTSW	11	62,224,737 (GRCm39)	missense	probably damaging	0.99
R7396:Ncor1	UTSW	11	62,234,044 (GRCm39)	missense	probably damaging	0.99
R7434:Ncor1	UTSW	11	62,274,025 (GRCm39)	missense	probably damaging	0.99
R7552:Ncor1	UTSW	11	62,264,250 (GRCm39)	missense	possibly damaging	0.53
R7565:Ncor1	UTSW	11	62,292,091 (GRCm39)	missense	probably damaging	1.00
R7575:Ncor1	UTSW	11	62,274,082 (GRCm39)	missense	probably benign	0.21
R7622:Ncor1	UTSW	11	62,208,794 (GRCm39)	missense	probably benign	0.00
R7664:Ncor1	UTSW	11	62,289,154 (GRCm39)	missense	probably damaging	1.00
R7814:Ncor1	UTSW	11	62,224,752 (GRCm39)	missense	probably damaging	0.99
R7963:Ncor1	UTSW	11	62,225,359 (GRCm39)	missense	probably benign	0.28
R7990:Ncor1	UTSW	11	62,240,321 (GRCm39)	critical splice acceptor site	probably null
R8302:Ncor1	UTSW	11	62,224,681 (GRCm39)	missense	probably benign	0.00
R8334:Ncor1	UTSW	11	62,274,070 (GRCm39)	missense	probably damaging	0.99
R8512:Ncor1	UTSW	11	62,324,437 (GRCm39)	small deletion	probably benign
R8728:Ncor1	UTSW	11	62,221,685 (GRCm39)	missense	probably benign	0.04
R8777:Ncor1	UTSW	11	62,324,494 (GRCm39)	missense	probably damaging	1.00
R8777:Ncor1	UTSW	11	62,324,492 (GRCm39)	missense	probably benign	0.03
R8777-TAIL:Ncor1	UTSW	11	62,324,494 (GRCm39)	missense	probably damaging	1.00
R8777-TAIL:Ncor1	UTSW	11	62,324,492 (GRCm39)	missense	probably benign	0.03
R8821:Ncor1	UTSW	11	62,260,234 (GRCm39)	missense	probably benign	0.07
R8831:Ncor1	UTSW	11	62,260,234 (GRCm39)	missense	probably benign	0.07
R8988:Ncor1	UTSW	11	62,233,871 (GRCm39)	nonsense	probably null
R9111:Ncor1	UTSW	11	62,280,585 (GRCm39)	missense	possibly damaging	0.95
R9147:Ncor1	UTSW	11	62,224,672 (GRCm39)	missense	probably damaging	1.00
R9391:Ncor1	UTSW	11	62,216,376 (GRCm39)	nonsense	probably null
R9467:Ncor1	UTSW	11	62,324,448 (GRCm39)	small insertion	probably benign
R9467:Ncor1	UTSW	11	62,324,437 (GRCm39)	small insertion	probably benign
R9510:Ncor1	UTSW	11	62,324,442 (GRCm39)	small insertion	probably benign
R9511:Ncor1	UTSW	11	62,324,449 (GRCm39)	small insertion	probably benign
R9560:Ncor1	UTSW	11	62,263,948 (GRCm39)	missense	possibly damaging	0.96
R9687:Ncor1	UTSW	11	62,260,193 (GRCm39)	missense	possibly damaging	0.93
X0065:Ncor1	UTSW	11	62,249,817 (GRCm39)	missense	probably benign	0.23
X0065:Ncor1	UTSW	11	62,245,395 (GRCm39)	critical splice donor site	probably null
Z1176:Ncor1	UTSW	11	62,329,342 (GRCm39)	critical splice acceptor site	probably null

Predicted Primers

PCR Primer
(F):5'- GATCTGTTCAGCCACTACCAC -3'
(R):5'- GTCCAGTGAAGACAGCAGTG -3'

Sequencing Primer
(F):5'- AGCCACTACCACGTCTTCATC -3'
(R):5'- ATGCTGCTTCTCGAGGAAAC -3'

Posted On

2015-04-02