Incidental Mutation 'R3826:Zfp37'
ID 275391
Institutional Source Beutler Lab
Gene Symbol Zfp37
Ensembl Gene ENSMUSG00000028389
Gene Name zinc finger protein 37
Synonyms Zfp-37, Tzn
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.373) question?
Stock # R3826 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 62107774-62127634 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 62110800 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 88 (N88S)
Ref Sequence ENSEMBL: ENSMUSP00000152400 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068822] [ENSMUST00000129511] [ENSMUST00000220873] [ENSMUST00000221329] [ENSMUST00000222050] [ENSMUST00000222748]
AlphaFold P17141
Predicted Effect probably benign
Transcript: ENSMUST00000068822
AA Change: N129S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000070463
Gene: ENSMUSG00000028389
AA Change: N129S

DomainStartEndE-ValueType
KRAB 13 62 5.89e-12 SMART
low complexity region 113 122 N/A INTRINSIC
ZnF_C2H2 255 277 2.75e-3 SMART
ZnF_C2H2 283 305 3.95e-4 SMART
ZnF_C2H2 311 333 2.2e-2 SMART
ZnF_C2H2 339 361 8.02e-5 SMART
ZnF_C2H2 367 389 1.13e-4 SMART
ZnF_C2H2 395 417 9.88e-5 SMART
ZnF_C2H2 423 445 2.61e-4 SMART
ZnF_C2H2 451 473 6.08e-5 SMART
ZnF_C2H2 479 501 5.99e-4 SMART
ZnF_C2H2 507 529 5.99e-4 SMART
ZnF_C2H2 535 557 1.03e-2 SMART
ZnF_C2H2 563 585 9.88e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129511
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148664
Predicted Effect probably benign
Transcript: ENSMUST00000220873
AA Change: N88S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000221329
AA Change: N126S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000222050
AA Change: N125S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000222748
AA Change: N88S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.7%
  • 20x: 96.3%
Validation Efficiency 100% (56/56)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Allele List at MGI

All alleles(4) : Gene trapped(4)

Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm1 T A 3: 59,843,896 (GRCm39) S197T possibly damaging Het
Actl6b T C 5: 137,565,535 (GRCm39) L377P probably damaging Het
Apc C A 18: 34,412,388 (GRCm39) Q236K possibly damaging Het
Atn1 G A 6: 124,723,182 (GRCm39) probably benign Het
Ccr3 A G 9: 123,829,714 (GRCm39) T350A possibly damaging Het
Cdc42bpg T C 19: 6,367,675 (GRCm39) V1015A probably damaging Het
Chd2 A G 7: 73,141,163 (GRCm39) Y577H possibly damaging Het
Col1a2 A G 6: 4,516,960 (GRCm39) probably benign Het
Col4a1 C A 8: 11,259,650 (GRCm39) G1341V probably damaging Het
Commd9 C A 2: 101,727,486 (GRCm39) N93K probably benign Het
Cplane2 C T 4: 140,945,900 (GRCm39) R148C probably damaging Het
Cx3cl1 A T 8: 95,503,934 (GRCm39) probably benign Het
Dhx37 T C 5: 125,508,677 (GRCm39) K86R probably benign Het
Dlec1 T C 9: 118,972,129 (GRCm39) probably benign Het
Dnah17 G A 11: 117,931,984 (GRCm39) probably benign Het
Fam234a T C 17: 26,437,163 (GRCm39) E172G probably benign Het
Ffar2 A T 7: 30,519,510 (GRCm39) I10N possibly damaging Het
Gas2 T C 7: 51,586,367 (GRCm39) probably null Het
Gpat4 G A 8: 23,670,171 (GRCm39) P286L probably damaging Het
Grpel1 T A 5: 36,626,827 (GRCm39) N36K probably benign Het
Hgfac C A 5: 35,205,506 (GRCm39) D595E probably damaging Het
Kcnj10 A T 1: 172,197,616 (GRCm39) S377C probably damaging Het
Kcnq2 C T 2: 180,746,693 (GRCm39) V369I possibly damaging Het
Kcnt1 T C 2: 25,805,880 (GRCm39) probably null Het
Lpcat1 T C 13: 73,637,212 (GRCm39) I114T possibly damaging Het
Mast4 G T 13: 102,875,319 (GRCm39) H1350N probably damaging Het
Mcts1 T C X: 37,691,445 (GRCm39) probably benign Het
Muc21 A G 17: 35,932,504 (GRCm39) probably benign Het
Myg1 G C 15: 102,246,171 (GRCm39) G349R probably damaging Het
Ncor2 T C 5: 125,195,756 (GRCm39) probably benign Het
Or1o4 T A 17: 37,591,140 (GRCm39) Y57F probably damaging Het
Or5t17 T A 2: 86,832,388 (GRCm39) I25K probably damaging Het
Or9g4b C T 2: 85,616,559 (GRCm39) R235* probably null Het
Panx2 A G 15: 88,952,664 (GRCm39) D377G probably damaging Het
Pcdhb10 C A 18: 37,545,470 (GRCm39) T182N probably damaging Het
Pdha2 G T 3: 140,916,889 (GRCm39) F206L possibly damaging Het
Pgd T C 4: 149,250,461 (GRCm39) probably benign Het
Pgs1 C T 11: 117,910,584 (GRCm39) probably null Het
Rere T C 4: 150,554,785 (GRCm39) V161A probably benign Het
Rgs12 G A 5: 35,123,359 (GRCm39) V381M possibly damaging Het
Rrm2 G T 12: 24,758,598 (GRCm39) A47S probably benign Het
Rsph6a T C 7: 18,791,539 (GRCm39) L236P probably damaging Het
Rtkn2 A T 10: 67,833,456 (GRCm39) probably null Het
Rubcnl C T 14: 75,269,665 (GRCm39) L108F possibly damaging Het
Sap18b T C 8: 96,552,185 (GRCm39) F65S probably damaging Het
Scap A G 9: 110,210,365 (GRCm39) M925V probably benign Het
Slc7a8 A G 14: 54,975,029 (GRCm39) I200T probably damaging Het
Srrm3 A G 5: 135,886,068 (GRCm39) D336G probably damaging Het
Stk11 T C 10: 79,963,782 (GRCm39) probably null Het
Tiam2 C G 17: 3,557,976 (GRCm39) probably benign Het
Tmem59l A G 8: 70,939,951 (GRCm39) L6S unknown Het
Trio T A 15: 27,833,156 (GRCm39) K75N probably damaging Het
Tspan18 T C 2: 93,050,453 (GRCm39) I57V probably benign Het
Ube3b C A 5: 114,538,012 (GRCm39) Q368K probably damaging Het
Zfhx4 A T 3: 5,466,269 (GRCm39) K2142N probably damaging Het
Zswim8 C T 14: 20,761,157 (GRCm39) R142* probably null Het
Other mutations in Zfp37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02742:Zfp37 APN 4 62,110,548 (GRCm39) missense possibly damaging 0.69
B6584:Zfp37 UTSW 4 62,109,615 (GRCm39) missense probably damaging 1.00
R0383:Zfp37 UTSW 4 62,110,122 (GRCm39) start codon destroyed probably null 0.61
R0457:Zfp37 UTSW 4 62,109,902 (GRCm39) nonsense probably null
R1258:Zfp37 UTSW 4 62,110,054 (GRCm39) missense probably damaging 1.00
R2072:Zfp37 UTSW 4 62,109,945 (GRCm39) missense probably damaging 1.00
R2073:Zfp37 UTSW 4 62,109,945 (GRCm39) missense probably damaging 1.00
R2261:Zfp37 UTSW 4 62,109,873 (GRCm39) missense probably damaging 1.00
R2262:Zfp37 UTSW 4 62,109,873 (GRCm39) missense probably damaging 1.00
R2507:Zfp37 UTSW 4 62,109,493 (GRCm39) missense probably damaging 1.00
R2897:Zfp37 UTSW 4 62,110,014 (GRCm39) missense probably damaging 1.00
R2898:Zfp37 UTSW 4 62,110,014 (GRCm39) missense probably damaging 1.00
R3879:Zfp37 UTSW 4 62,109,572 (GRCm39) nonsense probably null
R4034:Zfp37 UTSW 4 62,109,933 (GRCm39) missense probably damaging 1.00
R4491:Zfp37 UTSW 4 62,110,365 (GRCm39) missense probably benign 0.07
R4823:Zfp37 UTSW 4 62,109,740 (GRCm39) missense probably benign 0.18
R5186:Zfp37 UTSW 4 62,109,493 (GRCm39) missense probably damaging 1.00
R5650:Zfp37 UTSW 4 62,110,002 (GRCm39) missense probably damaging 1.00
R5886:Zfp37 UTSW 4 62,109,471 (GRCm39) missense probably damaging 1.00
R5925:Zfp37 UTSW 4 62,109,450 (GRCm39) missense possibly damaging 0.47
R7050:Zfp37 UTSW 4 62,109,908 (GRCm39) missense possibly damaging 0.72
R7553:Zfp37 UTSW 4 62,110,236 (GRCm39) missense probably damaging 1.00
R7583:Zfp37 UTSW 4 62,110,253 (GRCm39) start gained probably benign
R7646:Zfp37 UTSW 4 62,109,532 (GRCm39) missense probably damaging 0.99
R8061:Zfp37 UTSW 4 62,109,665 (GRCm39) nonsense probably null
R8076:Zfp37 UTSW 4 62,109,553 (GRCm39) missense possibly damaging 0.67
R8477:Zfp37 UTSW 4 62,110,240 (GRCm39) missense probably damaging 1.00
R8756:Zfp37 UTSW 4 62,110,371 (GRCm39) missense possibly damaging 0.94
R9000:Zfp37 UTSW 4 62,126,651 (GRCm39) missense unknown
R9362:Zfp37 UTSW 4 62,110,299 (GRCm39) missense probably benign 0.11
R9400:Zfp37 UTSW 4 62,109,904 (GRCm39) missense probably damaging 1.00
R9745:Zfp37 UTSW 4 62,110,644 (GRCm39) missense possibly damaging 0.58
X0026:Zfp37 UTSW 4 62,123,326 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTATGGGATGCACTATGACGGC -3'
(R):5'- TTGAGTGGGAGTGCAGAAACTC -3'

Sequencing Primer
(F):5'- GGATGCACTATGACGGCATACTTTC -3'
(R):5'- GTGCAGAAACTCACAAGAATGTCTC -3'
Posted On 2015-04-02