Mutagenetix > Incidental Mutation

Incidental Mutation 'R3834:Vmn2r104'

275563

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r104

Ensembl Gene

ENSMUSG00000090315

Gene Name

vomeronasal 2, receptor 104

Synonyms

V2r7

MMRRC Submission

040889-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

R3834 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20029425-20048205 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 20029921 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Lysine at position 696 (R696K)

Ref Sequence

ENSEMBL: ENSMUSP00000129895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168050]

AlphaFold

E9Q2J5

Predicted Effect

probably benign
Transcript: ENSMUST00000168050
AA Change: R696K

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: R696K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	85	457	4e-38	PFAM
Pfam:NCD3G	512	565	2.1e-20	PFAM
Pfam:7tm_3	598	833	1.7e-52	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

100% (44/44)

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001C19Rik	AC	A	17: 47,433,423		probably benign	Het
Adh6a	G	A	3: 138,327,514		probably null	Het
Bptf	T	C	11: 107,073,857	T1389A	probably benign	Het
Cfap54	A	G	10: 92,801,123		probably benign	Het
Coq5	G	T	5: 115,284,576	G180W	probably damaging	Het
Cyp2d34	A	G	15: 82,616,746		probably null	Het
Cyp2j13	C	T	4: 96,056,557		probably null	Het
Fam114a1	C	T	5: 65,006,073	T197I	possibly damaging	Het
Fbxo44	A	G	4: 148,156,250	Y227H	probably damaging	Het
Gm5114	T	A	7: 39,408,737	H486L	possibly damaging	Het
Grik4	T	C	9: 42,629,123	R254G	probably benign	Het
Iqcm	T	C	8: 75,577,752	I47T	possibly damaging	Het
Kif20b	A	G	19: 34,935,028	Y278C	probably damaging	Het
Lbhd1	G	A	19: 8,884,057	C43Y	probably benign	Het
Lrfn5	T	A	12: 61,840,030	D201E	probably damaging	Het
Map1a	G	A	2: 121,307,322	G2635D	probably damaging	Het
Ms4a4a	A	T	19: 11,378,855	M35L	probably benign	Het
Muc5b	A	T	7: 141,859,181	I1955F	unknown	Het
Mug2	T	C	6: 122,049,787		probably null	Het
Nav2	T	A	7: 49,545,858	I994N	possibly damaging	Het
Ngly1	T	C	14: 16,290,766		probably benign	Het
Nr1i2	T	C	16: 38,253,929		probably null	Het
Olfr494	A	T	7: 108,368,072	D194V	probably damaging	Het
Olfr561	A	G	7: 102,775,286	Y254C	probably damaging	Het
Olfr651	T	A	7: 104,553,345	V142D	probably benign	Het
Oxct2a	C	T	4: 123,322,473	V372I	probably benign	Het
Pax6	G	A	2: 105,696,450	E234K	probably benign	Het
Pramef17	T	A	4: 143,994,226	K48N	probably benign	Het
Prkdc	A	G	16: 15,791,946	E3138G	probably damaging	Het
Ptprc	T	A	1: 138,083,567	N584I	probably damaging	Het
Ptprt	A	G	2: 161,547,387	V1261A	probably damaging	Het
Rps20	A	T	4: 3,834,610	I84N	probably damaging	Het
Scd3	A	G	19: 44,241,717	Y313C	probably damaging	Het
Sertad2	T	C	11: 20,648,482	I226T	probably benign	Het
Slc15a2	A	T	16: 36,772,128	C191*	probably null	Het
Slco1a1	G	T	6: 141,943,437	Q50K	possibly damaging	Het
Stab2	A	T	10: 86,949,912	I622N	possibly damaging	Het
Tmc4	C	T	7: 3,672,007	V222M	probably benign	Het
Tmem145	T	C	7: 25,311,361	F359L	probably damaging	Het
Tmem238	C	A	7: 4,789,079	R155L	possibly damaging	Het
Vmn1r32	C	A	6: 66,553,663	C43F	probably benign	Het

Other mutations in Vmn2r104

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn2r104	APN	17	20038239	missense	probably damaging	0.98
IGL01098:Vmn2r104	APN	17	20048096	missense	probably benign	0.27
IGL01333:Vmn2r104	APN	17	20042793	missense	probably benign	0.17
IGL01527:Vmn2r104	APN	17	20042896	missense	possibly damaging	0.82
IGL01773:Vmn2r104	APN	17	20040668	missense	probably benign	0.10
IGL01939:Vmn2r104	APN	17	20029925	missense	probably damaging	0.99
IGL02121:Vmn2r104	APN	17	20041794	nonsense	probably null
IGL02305:Vmn2r104	APN	17	20042856	missense	probably benign	0.09
IGL02374:Vmn2r104	APN	17	20042786	missense	probably benign	0.34
IGL03260:Vmn2r104	APN	17	20042821	missense	probably benign	0.05
IGL03366:Vmn2r104	APN	17	20029604	missense	probably damaging	1.00
R0091:Vmn2r104	UTSW	17	20041813	missense	possibly damaging	0.79
R0125:Vmn2r104	UTSW	17	20029807	missense	probably damaging	0.98
R0257:Vmn2r104	UTSW	17	20029627	missense	probably damaging	1.00
R0381:Vmn2r104	UTSW	17	20048002	nonsense	probably null
R0709:Vmn2r104	UTSW	17	20042904	missense	probably damaging	1.00
R0786:Vmn2r104	UTSW	17	20042725	missense	probably benign
R1575:Vmn2r104	UTSW	17	20042215	missense	probably damaging	1.00
R1827:Vmn2r104	UTSW	17	20042235	missense	probably damaging	0.97
R1932:Vmn2r104	UTSW	17	20040769	missense	probably damaging	1.00
R1956:Vmn2r104	UTSW	17	20042051	missense	probably damaging	0.98
R2203:Vmn2r104	UTSW	17	20029821	missense	probably benign	0.05
R2205:Vmn2r104	UTSW	17	20029821	missense	probably benign	0.05
R2859:Vmn2r104	UTSW	17	20048193	missense	possibly damaging	0.82
R3701:Vmn2r104	UTSW	17	20029556	missense	probably damaging	1.00
R4151:Vmn2r104	UTSW	17	20029885	missense	probably damaging	1.00
R4470:Vmn2r104	UTSW	17	20042241	missense	probably damaging	1.00
R4625:Vmn2r104	UTSW	17	20048181	missense	probably benign	0.00
R4754:Vmn2r104	UTSW	17	20040768	nonsense	probably null
R4911:Vmn2r104	UTSW	17	20030026	missense	probably benign	0.00
R5270:Vmn2r104	UTSW	17	20038266	missense	probably damaging	1.00
R5279:Vmn2r104	UTSW	17	20041884	missense	probably benign	0.07
R5311:Vmn2r104	UTSW	17	20029901	missense	probably damaging	1.00
R5370:Vmn2r104	UTSW	17	20030188	missense	probably damaging	0.97
R5461:Vmn2r104	UTSW	17	20030081	missense	probably damaging	1.00
R5683:Vmn2r104	UTSW	17	20040719	nonsense	probably null
R5795:Vmn2r104	UTSW	17	20030110	missense	probably benign	0.02
R5795:Vmn2r104	UTSW	17	20030282	missense	possibly damaging	0.89
R5970:Vmn2r104	UTSW	17	20029471	missense	probably benign	0.01
R5983:Vmn2r104	UTSW	17	20041708	missense	probably damaging	1.00
R5992:Vmn2r104	UTSW	17	20029485	missense	probably damaging	1.00
R6066:Vmn2r104	UTSW	17	20038311	missense	possibly damaging	0.69
R6156:Vmn2r104	UTSW	17	20041647	missense	probably damaging	1.00
R6182:Vmn2r104	UTSW	17	20030245	missense	probably benign	0.16
R6245:Vmn2r104	UTSW	17	20041567	missense	possibly damaging	0.69
R6333:Vmn2r104	UTSW	17	20029586	missense	probably benign	0.30
R6573:Vmn2r104	UTSW	17	20042225	missense	probably damaging	1.00
R7101:Vmn2r104	UTSW	17	20030096	missense	possibly damaging	0.65
R7123:Vmn2r104	UTSW	17	20040826	missense	probably benign	0.12
R7485:Vmn2r104	UTSW	17	20029475	missense	probably benign	0.01
R7514:Vmn2r104	UTSW	17	20029529	missense	probably damaging	1.00
R7634:Vmn2r104	UTSW	17	20041709	missense	possibly damaging	0.48
R7958:Vmn2r104	UTSW	17	20042726	missense	probably benign
R8031:Vmn2r104	UTSW	17	20042786	missense	probably benign	0.34
R8094:Vmn2r104	UTSW	17	20030221	missense	possibly damaging	0.77
R8191:Vmn2r104	UTSW	17	20030203	missense	possibly damaging	0.89
R8308:Vmn2r104	UTSW	17	20040778	missense	possibly damaging	0.55
R8691:Vmn2r104	UTSW	17	20041848	missense	probably damaging	0.98
R8795:Vmn2r104	UTSW	17	20042726	missense	probably benign
R8900:Vmn2r104	UTSW	17	20041662	missense	probably damaging	0.99
R8913:Vmn2r104	UTSW	17	20029706	missense	probably damaging	1.00
R9180:Vmn2r104	UTSW	17	20042825	missense	probably benign	0.00
R9199:Vmn2r104	UTSW	17	20041835	missense	probably damaging	0.99
R9282:Vmn2r104	UTSW	17	20040836	missense	probably damaging	1.00
R9303:Vmn2r104	UTSW	17	20048177	missense	possibly damaging	0.90
R9305:Vmn2r104	UTSW	17	20048177	missense	possibly damaging	0.90
R9322:Vmn2r104	UTSW	17	20042825	missense	probably benign	0.00
R9325:Vmn2r104	UTSW	17	20048171	missense	possibly damaging	0.95
R9414:Vmn2r104	UTSW	17	20029988	missense	probably damaging	0.99
R9785:Vmn2r104	UTSW	17	20048147	missense	probably benign
RF007:Vmn2r104	UTSW	17	20048040	missense	probably benign	0.36
Z1177:Vmn2r104	UTSW	17	20029789	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCCCAGGACTGAATGGAAGG -3'
(R):5'- CAAGGCCAATAATCGGACTCTAAG -3'

Sequencing Primer
(F):5'- GCAACAGCTGAGCCCTTGTTG -3'
(R):5'- ATCGGACTCTAAGTTACATTTTGCTC -3'

Posted On

2015-04-06