Incidental Mutation 'IGL00896:Olfr459'
ID27576
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr459
Ensembl Gene ENSMUSG00000045479
Gene Nameolfactory receptor 459
SynonymsGA_x6K02T2P3E9-5780974-5781915, MOR120-1
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.278) question?
Stock #IGL00896
Quality Score
Status
Chromosome6
Chromosomal Location41768770-41775177 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 41772113 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 62 (L62Q)
Ref Sequence ENSEMBL: ENSMUSP00000149928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050412] [ENSMUST00000214752] [ENSMUST00000214976]
Predicted Effect probably damaging
Transcript: ENSMUST00000050412
AA Change: L62Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000061622
Gene: ENSMUSG00000045479
AA Change: L62Q

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 7.9e-46 PFAM
Pfam:7TM_GPCR_Srsx 34 304 1.7e-6 PFAM
Pfam:7tm_1 40 290 6.2e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203430
AA Change: L62Q
SMART Domains Protein: ENSMUSP00000145036
Gene: ENSMUSG00000045479
AA Change: L62Q

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 7.9e-46 PFAM
Pfam:7TM_GPCR_Srsx 34 304 1.7e-6 PFAM
Pfam:7tm_1 40 290 6.2e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214752
AA Change: L62Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000214976
AA Change: L62Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik A G 3: 37,039,462 T4352A probably benign Het
Adam6a A G 12: 113,545,410 T468A possibly damaging Het
Ankrd35 A G 3: 96,684,276 E626G probably damaging Het
Arhgef4 A G 1: 34,811,696 Y1812C possibly damaging Het
Aurkc T C 7: 7,002,514 Y260H possibly damaging Het
Cpb1 A G 3: 20,252,029 V329A probably benign Het
Cyp2d11 G T 15: 82,391,074 probably benign Het
Dnase1 G A 16: 4,039,212 S28N probably benign Het
Evpl C A 11: 116,222,584 E1427* probably null Het
Gimap6 T C 6: 48,702,460 N214S probably benign Het
Htr1f A T 16: 64,926,106 H274Q probably benign Het
Ipo9 A T 1: 135,400,059 V538E probably damaging Het
Lmf2 T C 15: 89,353,336 K308E probably benign Het
Mog T A 17: 37,017,485 probably null Het
Myo19 T C 11: 84,909,498 V903A probably benign Het
Myt1l A G 12: 29,826,886 T179A unknown Het
Nckap1 C T 2: 80,580,953 V5M possibly damaging Het
Olfr382 T C 11: 73,516,341 N286S probably damaging Het
Olfr630 T C 7: 103,755,006 D193G probably damaging Het
Pcdhb5 T G 18: 37,322,785 probably null Het
Pcm1 C A 8: 41,276,123 Q711K possibly damaging Het
Pde6a A G 18: 61,220,792 D63G possibly damaging Het
Piezo1 T C 8: 122,497,870 M711V possibly damaging Het
Prrxl1 C T 14: 32,605,214 probably benign Het
Rev1 G A 1: 38,098,940 T88I probably damaging Het
Sntg1 A T 1: 8,595,410 probably null Het
Sult2a1 T A 7: 13,832,640 T137S probably benign Het
Txndc15 G A 13: 55,725,675 A283T probably damaging Het
Zswim8 A G 14: 20,716,001 E785G probably damaging Het
Other mutations in Olfr459
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01460:Olfr459 APN 6 41772282 missense probably benign 0.12
IGL02465:Olfr459 APN 6 41771556 missense probably damaging 1.00
R0352:Olfr459 UTSW 6 41772124 missense probably damaging 0.99
R0443:Olfr459 UTSW 6 41771895 missense possibly damaging 0.75
R0480:Olfr459 UTSW 6 41772264 missense probably benign 0.01
R1491:Olfr459 UTSW 6 41771522 missense possibly damaging 0.95
R1495:Olfr459 UTSW 6 41771903 missense probably damaging 1.00
R2103:Olfr459 UTSW 6 41772005 missense probably benign 0.36
R3688:Olfr459 UTSW 6 41772226 nonsense probably null
R3910:Olfr459 UTSW 6 41772149 missense probably benign 0.00
R4709:Olfr459 UTSW 6 41771508 missense probably benign 0.06
R4710:Olfr459 UTSW 6 41771508 missense probably benign 0.06
R4960:Olfr459 UTSW 6 41772069 missense probably damaging 0.97
R5162:Olfr459 UTSW 6 41771772 missense possibly damaging 0.80
R5236:Olfr459 UTSW 6 41772111 missense probably benign 0.00
R5441:Olfr459 UTSW 6 41771848 missense probably benign 0.00
R7171:Olfr459 UTSW 6 41772027 missense probably benign 0.09
R7400:Olfr459 UTSW 6 41771744 missense probably damaging 1.00
R8115:Olfr459 UTSW 6 41771538 missense probably benign 0.00
R8346:Olfr459 UTSW 6 41772123 missense probably damaging 1.00
R8363:Olfr459 UTSW 6 41771750 missense probably benign 0.06
Posted On2013-04-17