Incidental Mutation 'IGL00905:Vmn1r6'
ID27589
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r6
Ensembl Gene ENSMUSG00000115701
Gene Namevomeronasal 1 receptor 6
SynonymsV1rc20
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.125) question?
Stock #IGL00905
Quality Score
Status
Chromosome6
Chromosomal Location56997243-57009825 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 57002804 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Lysine at position 128 (N128K)
Ref Sequence ENSEMBL: ENSMUSP00000154199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079669] [ENSMUST00000226689] [ENSMUST00000227131] [ENSMUST00000227188] [ENSMUST00000227631] [ENSMUST00000227847] [ENSMUST00000228285]
Predicted Effect probably damaging
Transcript: ENSMUST00000079669
AA Change: N150K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000078611
Gene: ENSMUSG00000115701
AA Change: N150K

DomainStartEndE-ValueType
Pfam:V1R 28 293 4.9e-54 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226689
AA Change: N150K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227131
AA Change: N150K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227188
AA Change: N128K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227631
AA Change: N128K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227847
AA Change: N150K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228285
AA Change: N150K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atg16l2 T C 7: 101,300,166 E58G probably damaging Het
D130040H23Rik A T 8: 69,300,770 K16I possibly damaging Het
D630003M21Rik T C 2: 158,213,412 T602A possibly damaging Het
Fam161b C T 12: 84,357,685 V74I probably benign Het
Gm13023 A G 4: 143,795,274 T487A probably benign Het
Grk1 A G 8: 13,416,068 E504G probably benign Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
L3mbtl3 C T 10: 26,313,846 probably null Het
Map1s A G 8: 70,906,029 probably benign Het
Mprip T C 11: 59,772,168 V982A possibly damaging Het
Olfr1107 A G 2: 87,071,219 I305T probably benign Het
Olfr27 T G 9: 39,145,030 F310C probably damaging Het
Phf1 A T 17: 26,936,594 R378W possibly damaging Het
Ptpn3 A T 4: 57,270,050 D37E possibly damaging Het
Rcbtb1 A G 14: 59,228,305 S366G probably benign Het
Scn5a C A 9: 119,536,501 W360L probably damaging Het
Scrib A G 15: 76,064,990 F398S probably damaging Het
Slc25a47 C A 12: 108,855,388 T141K probably benign Het
Slc9a1 T A 4: 133,370,548 M2K probably benign Het
Tango6 G T 8: 106,742,472 probably null Het
Tmem231 A T 8: 111,918,440 probably benign Het
Tnr G A 1: 159,852,182 R242Q probably benign Het
Usp5 G A 6: 124,815,613 P821S probably damaging Het
Utp11 G T 4: 124,683,793 P63Q probably damaging Het
Other mutations in Vmn1r6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01011:Vmn1r6 APN 6 57002544 missense probably benign 0.00
IGL01147:Vmn1r6 APN 6 57002641 missense probably damaging 1.00
IGL01475:Vmn1r6 APN 6 57002911 missense probably damaging 1.00
IGL01638:Vmn1r6 APN 6 57003192 nonsense probably null
IGL01860:Vmn1r6 APN 6 57002689 nonsense probably null
IGL01876:Vmn1r6 APN 6 57002461 missense probably benign 0.12
IGL01988:Vmn1r6 APN 6 57002665 missense probably damaging 0.99
R0531:Vmn1r6 UTSW 6 57002598 missense probably benign 0.00
R1495:Vmn1r6 UTSW 6 57003073 missense possibly damaging 0.58
R1733:Vmn1r6 UTSW 6 57002622 missense probably damaging 1.00
R2037:Vmn1r6 UTSW 6 57003124 missense probably damaging 1.00
R3625:Vmn1r6 UTSW 6 57002935 missense probably damaging 0.96
R4353:Vmn1r6 UTSW 6 57002692 missense possibly damaging 0.63
R4484:Vmn1r6 UTSW 6 57003189 missense probably benign
R4854:Vmn1r6 UTSW 6 57002698 missense probably benign 0.00
R5237:Vmn1r6 UTSW 6 57003194 missense probably damaging 1.00
R5341:Vmn1r6 UTSW 6 57002804 missense probably damaging 1.00
R5611:Vmn1r6 UTSW 6 57002377 missense probably damaging 1.00
R6795:Vmn1r6 UTSW 6 57002437 missense possibly damaging 0.85
Posted On2013-04-17