Incidental Mutation 'R3852:Myo10'
| ID |
275990 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo10
|
| Ensembl Gene |
ENSMUSG00000022272 |
| Gene Name |
myosin X |
| Synonyms |
D15Ertd600e, myosin-X |
| MMRRC Submission |
040784-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R3852 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
25622525-25813673 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 25779626 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamic Acid
at position 28
(K28E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000022882
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022882]
[ENSMUST00000110457]
[ENSMUST00000124966]
[ENSMUST00000125667]
[ENSMUST00000131834]
[ENSMUST00000135173]
[ENSMUST00000137601]
[ENSMUST00000151360]
|
| AlphaFold |
F8VQB6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000022882
AA Change: K28E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000022882
Gene: ENSMUSG00000022272
AA Change: K28E
| Domain | Start | End | E-Value | Type |
|---|
|
IQ
|
1 |
17 |
7.83e1 |
SMART |
|
IQ
|
18 |
40 |
1.06e0 |
SMART |
|
IQ
|
41 |
63 |
7.07e-2 |
SMART |
|
PDB:2LW9|B
|
136 |
171 |
7e-13 |
PDB |
|
low complexity region
|
172 |
186 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
235 |
N/A |
INTRINSIC |
|
low complexity region
|
344 |
356 |
N/A |
INTRINSIC |
|
low complexity region
|
401 |
419 |
N/A |
INTRINSIC |
|
PH
|
471 |
570 |
1.39e-21 |
SMART |
|
SCOP:d1faoa_
|
588 |
639 |
3e-6 |
SMART |
|
PH
|
651 |
757 |
6.76e-11 |
SMART |
|
MyTH4
|
805 |
953 |
4.12e-37 |
SMART |
|
B41
|
954 |
1216 |
1.72e-44 |
SMART |
|
Blast:B41
|
1218 |
1303 |
3e-45 |
BLAST |
|
low complexity region
|
1304 |
1316 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000110457
AA Change: K774E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000106087
Gene: ENSMUSG00000022272
AA Change: K774E
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
57 |
740 |
N/A |
SMART |
|
IQ
|
741 |
763 |
1.27e-3 |
SMART |
|
IQ
|
764 |
786 |
1.06e0 |
SMART |
|
IQ
|
787 |
809 |
7.07e-2 |
SMART |
|
Pfam:MYO10_CC
|
881 |
932 |
4.2e-22 |
PFAM |
|
low complexity region
|
959 |
981 |
N/A |
INTRINSIC |
|
low complexity region
|
1090 |
1102 |
N/A |
INTRINSIC |
|
low complexity region
|
1147 |
1165 |
N/A |
INTRINSIC |
|
PH
|
1217 |
1316 |
1.39e-21 |
SMART |
|
PH
|
1397 |
1503 |
6.76e-11 |
SMART |
|
MyTH4
|
1551 |
1699 |
4.12e-37 |
SMART |
|
B41
|
1700 |
1962 |
1.72e-44 |
SMART |
|
low complexity region
|
2050 |
2062 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000124966
AA Change: K28E
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000120817
Gene: ENSMUSG00000022272
AA Change: K28E
| Domain | Start | End | E-Value | Type |
|---|
|
IQ
|
1 |
17 |
7.83e1 |
SMART |
|
IQ
|
18 |
40 |
1.06e0 |
SMART |
|
IQ
|
41 |
63 |
7.07e-2 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000125667
AA Change: K132E
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000120566
Gene: ENSMUSG00000022272
AA Change: K132E
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_head
|
1 |
85 |
5.8e-22 |
PFAM |
|
IQ
|
99 |
121 |
1.27e-3 |
SMART |
|
IQ
|
122 |
144 |
1.06e0 |
SMART |
|
IQ
|
145 |
167 |
7.07e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131834
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000135173
AA Change: K131E
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000118744
Gene: ENSMUSG00000022272
AA Change: K131E
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_head
|
1 |
84 |
1.4e-21 |
PFAM |
|
IQ
|
98 |
120 |
1.27e-3 |
SMART |
|
IQ
|
121 |
143 |
1.06e0 |
SMART |
|
IQ
|
144 |
166 |
7.07e-2 |
SMART |
|
low complexity region
|
168 |
179 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000135981
AA Change: K91E
|
| SMART Domains |
Protein: ENSMUSP00000123057
Gene: ENSMUSG00000022272
AA Change: K91E
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:2DFS|M
|
2 |
38 |
6e-7 |
PDB |
|
Blast:MYSc
|
2 |
42 |
3e-19 |
BLAST |
|
IQ
|
59 |
81 |
1.27e-3 |
SMART |
|
IQ
|
82 |
104 |
1.06e0 |
SMART |
|
IQ
|
105 |
127 |
7.07e-2 |
SMART |
|
Pfam:MYO10_CC
|
199 |
242 |
1.7e-20 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000137601
AA Change: K741E
PolyPhen 2
Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000118280
Gene: ENSMUSG00000022272
AA Change: K741E
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
24 |
707 |
N/A |
SMART |
|
IQ
|
708 |
730 |
1.27e-3 |
SMART |
|
IQ
|
731 |
753 |
1.06e0 |
SMART |
|
IQ
|
754 |
776 |
7.07e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145587
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151360
|
| SMART Domains |
Protein: ENSMUSP00000119367
Gene: ENSMUSG00000022272
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_head
|
1 |
51 |
7.1e-16 |
PFAM |
|
| Meta Mutation Damage Score |
0.4216 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.7%
|
| Validation Efficiency |
96% (45/47) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mutations are semi-lethal with over half of homozygous embryos exhibiting exencephaly. Surviving mutants show decreased body weight, white spotting, syndactyly, persistence of hyaloid vascular system and other eye defects. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 44 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcf3 |
T |
C |
16: 20,560,439 (GRCm38) |
V685A |
probably damaging |
Het |
| Abhd4 |
T |
C |
14: 54,265,367 (GRCm38) |
Y44H |
probably damaging |
Het |
| AI429214 |
A |
G |
8: 36,994,442 (GRCm38) |
D248G |
probably damaging |
Het |
| AY358078 |
A |
G |
14: 51,805,553 (GRCm38) |
T233A |
unknown |
Het |
| Calcr |
T |
C |
6: 3,693,735 (GRCm38) |
Y353C |
probably damaging |
Het |
| Ccdc34 |
A |
G |
2: 110,032,428 (GRCm38) |
K193E |
possibly damaging |
Het |
| Dhcr24 |
A |
G |
4: 106,573,873 (GRCm38) |
E253G |
probably benign |
Het |
| Dnah6 |
A |
G |
6: 73,127,927 (GRCm38) |
V1841A |
possibly damaging |
Het |
| Dpp10 |
A |
T |
1: 123,485,924 (GRCm38) |
Y186* |
probably null |
Het |
| Dpysl4 |
C |
T |
7: 139,100,935 (GRCm38) |
T575M |
probably damaging |
Het |
| Dusp7 |
T |
A |
9: 106,373,893 (GRCm38) |
S406T |
probably benign |
Het |
| Gga3 |
T |
A |
11: 115,587,542 (GRCm38) |
T475S |
probably benign |
Het |
| Gm10271 |
T |
A |
10: 116,956,874 (GRCm38) |
K36* |
probably null |
Het |
| Gm572 |
G |
A |
4: 148,668,872 (GRCm38) |
E325K |
possibly damaging |
Het |
| Golga2 |
A |
G |
2: 32,305,611 (GRCm38) |
E806G |
probably benign |
Het |
| Igf1 |
A |
T |
10: 87,915,319 (GRCm38) |
K126* |
probably null |
Het |
| Itpkc |
A |
T |
7: 27,227,612 (GRCm38) |
N292K |
probably benign |
Het |
| Klhl1 |
A |
T |
14: 96,280,205 (GRCm38) |
M345K |
probably benign |
Het |
| Lrp2 |
A |
G |
2: 69,537,565 (GRCm38) |
V201A |
probably damaging |
Het |
| Lrrc8a |
C |
T |
2: 30,261,960 (GRCm38) |
T757M |
probably benign |
Het |
| Mios |
T |
A |
6: 8,216,453 (GRCm38) |
I459K |
probably benign |
Het |
| Mrps11 |
T |
C |
7: 78,790,645 (GRCm38) |
I94T |
probably damaging |
Het |
| Ms4a4c |
T |
A |
19: 11,416,395 (GRCm38) |
S68T |
probably benign |
Het |
| Mstn |
C |
T |
1: 53,061,971 (GRCm38) |
T69I |
possibly damaging |
Het |
| Nol6 |
A |
G |
4: 41,117,452 (GRCm38) |
S914P |
probably damaging |
Het |
| Ntn1 |
C |
G |
11: 68,385,793 (GRCm38) |
D110H |
probably damaging |
Het |
| Olfr547 |
C |
A |
7: 102,535,280 (GRCm38) |
H178N |
probably benign |
Het |
| Olfr585 |
T |
C |
7: 103,098,184 (GRCm38) |
S148P |
probably damaging |
Het |
| Pcdh17 |
C |
T |
14: 84,447,259 (GRCm38) |
Q389* |
probably null |
Het |
| Pik3r2 |
G |
A |
8: 70,770,421 (GRCm38) |
R452C |
probably benign |
Het |
| Prr14l |
T |
C |
5: 32,830,345 (GRCm38) |
E602G |
probably damaging |
Het |
| Rusc2 |
C |
A |
4: 43,416,424 (GRCm38) |
Q577K |
probably benign |
Het |
| Sacm1l |
T |
A |
9: 123,587,576 (GRCm38) |
M534K |
probably damaging |
Het |
| Shroom3 |
G |
T |
5: 92,943,086 (GRCm38) |
V1151F |
probably damaging |
Het |
| Slco4a1 |
C |
T |
2: 180,464,091 (GRCm38) |
T22M |
probably benign |
Het |
| Svs1 |
C |
T |
6: 48,987,994 (GRCm38) |
P312L |
possibly damaging |
Het |
| Tas2r104 |
A |
T |
6: 131,684,925 (GRCm38) |
C274S |
probably benign |
Het |
| Tnrc6c |
C |
T |
11: 117,723,529 (GRCm38) |
R838W |
probably damaging |
Het |
| Trim43c |
T |
A |
9: 88,840,401 (GRCm38) |
H33Q |
probably damaging |
Het |
| Ttc17 |
A |
T |
2: 94,369,413 (GRCm38) |
I411K |
possibly damaging |
Het |
| Ttn |
A |
C |
2: 76,955,024 (GRCm38) |
V669G |
possibly damaging |
Het |
| Ttn |
G |
T |
2: 76,751,334 (GRCm38) |
L23072I |
possibly damaging |
Het |
| Vmn1r60 |
A |
T |
7: 5,545,027 (GRCm38) |
F25I |
possibly damaging |
Het |
| Vmn2r9 |
A |
G |
5: 108,848,131 (GRCm38) |
I217T |
probably damaging |
Het |
|
| Other mutations in Myo10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Myo10
|
APN |
15 |
25,776,380 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01068:Myo10
|
APN |
15 |
25,739,309 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL01352:Myo10
|
APN |
15 |
25,701,697 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01388:Myo10
|
APN |
15 |
25,736,617 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
IGL01460:Myo10
|
APN |
15 |
25,714,108 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01553:Myo10
|
APN |
15 |
25,776,329 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01732:Myo10
|
APN |
15 |
25,732,063 (GRCm38) |
missense |
probably benign |
0.10 |
|
IGL01992:Myo10
|
APN |
15 |
25,799,548 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02000:Myo10
|
APN |
15 |
25,808,066 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02045:Myo10
|
APN |
15 |
25,726,488 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02307:Myo10
|
APN |
15 |
25,776,315 (GRCm38) |
splice site |
probably benign |
|
|
IGL02511:Myo10
|
APN |
15 |
25,723,889 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL03240:Myo10
|
APN |
15 |
25,701,602 (GRCm38) |
missense |
probably damaging |
1.00 |
|
least
|
UTSW |
15 |
25,726,475 (GRCm38) |
nonsense |
probably null |
|
|
R0037:Myo10
|
UTSW |
15 |
25,666,532 (GRCm38) |
intron |
probably benign |
|
|
R0153:Myo10
|
UTSW |
15 |
25,781,238 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R0282:Myo10
|
UTSW |
15 |
25,793,167 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0360:Myo10
|
UTSW |
15 |
25,804,368 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0585:Myo10
|
UTSW |
15 |
25,736,455 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0617:Myo10
|
UTSW |
15 |
25,738,005 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0729:Myo10
|
UTSW |
15 |
25,722,157 (GRCm38) |
splice site |
probably benign |
|
|
R0771:Myo10
|
UTSW |
15 |
25,778,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0960:Myo10
|
UTSW |
15 |
25,801,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1562:Myo10
|
UTSW |
15 |
25,780,411 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R1651:Myo10
|
UTSW |
15 |
25,742,369 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1789:Myo10
|
UTSW |
15 |
25,726,525 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1816:Myo10
|
UTSW |
15 |
25,800,200 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1835:Myo10
|
UTSW |
15 |
25,805,587 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R1908:Myo10
|
UTSW |
15 |
25,801,222 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2082:Myo10
|
UTSW |
15 |
25,785,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2101:Myo10
|
UTSW |
15 |
25,722,259 (GRCm38) |
missense |
probably benign |
0.26 |
|
R2129:Myo10
|
UTSW |
15 |
25,781,799 (GRCm38) |
missense |
probably benign |
0.09 |
|
R2141:Myo10
|
UTSW |
15 |
25,714,108 (GRCm38) |
missense |
probably benign |
|
|
R2142:Myo10
|
UTSW |
15 |
25,714,108 (GRCm38) |
missense |
probably benign |
|
|
R2920:Myo10
|
UTSW |
15 |
25,801,140 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2938:Myo10
|
UTSW |
15 |
25,795,717 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3723:Myo10
|
UTSW |
15 |
25,803,288 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4162:Myo10
|
UTSW |
15 |
25,726,415 (GRCm38) |
splice site |
probably null |
|
|
R4163:Myo10
|
UTSW |
15 |
25,726,415 (GRCm38) |
splice site |
probably null |
|
|
R4164:Myo10
|
UTSW |
15 |
25,726,415 (GRCm38) |
splice site |
probably null |
|
|
R4177:Myo10
|
UTSW |
15 |
25,734,051 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R4409:Myo10
|
UTSW |
15 |
25,807,869 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4667:Myo10
|
UTSW |
15 |
25,793,153 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4905:Myo10
|
UTSW |
15 |
25,800,212 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4933:Myo10
|
UTSW |
15 |
25,781,118 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4968:Myo10
|
UTSW |
15 |
25,808,184 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5081:Myo10
|
UTSW |
15 |
25,785,940 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5123:Myo10
|
UTSW |
15 |
25,726,483 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5310:Myo10
|
UTSW |
15 |
25,778,078 (GRCm38) |
splice site |
probably null |
|
|
R6073:Myo10
|
UTSW |
15 |
25,736,642 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6117:Myo10
|
UTSW |
15 |
25,805,659 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6185:Myo10
|
UTSW |
15 |
25,726,510 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6749:Myo10
|
UTSW |
15 |
25,714,110 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6819:Myo10
|
UTSW |
15 |
25,781,410 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R6875:Myo10
|
UTSW |
15 |
25,805,659 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6908:Myo10
|
UTSW |
15 |
25,804,383 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6963:Myo10
|
UTSW |
15 |
25,734,063 (GRCm38) |
missense |
probably benign |
0.31 |
|
R7144:Myo10
|
UTSW |
15 |
25,723,925 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7266:Myo10
|
UTSW |
15 |
25,782,981 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7380:Myo10
|
UTSW |
15 |
25,779,620 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7460:Myo10
|
UTSW |
15 |
25,807,827 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7614:Myo10
|
UTSW |
15 |
25,701,623 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7618:Myo10
|
UTSW |
15 |
25,726,475 (GRCm38) |
nonsense |
probably null |
|
|
R7717:Myo10
|
UTSW |
15 |
25,731,970 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7811:Myo10
|
UTSW |
15 |
25,804,524 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7830:Myo10
|
UTSW |
15 |
25,737,971 (GRCm38) |
nonsense |
probably null |
|
|
R7862:Myo10
|
UTSW |
15 |
25,666,436 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8232:Myo10
|
UTSW |
15 |
25,804,314 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R8264:Myo10
|
UTSW |
15 |
25,800,109 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8377:Myo10
|
UTSW |
15 |
25,804,395 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8385:Myo10
|
UTSW |
15 |
25,804,398 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8426:Myo10
|
UTSW |
15 |
25,799,490 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8439:Myo10
|
UTSW |
15 |
25,725,072 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8696:Myo10
|
UTSW |
15 |
25,799,486 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8775:Myo10
|
UTSW |
15 |
25,800,059 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8775-TAIL:Myo10
|
UTSW |
15 |
25,800,059 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8970:Myo10
|
UTSW |
15 |
25,803,381 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R9024:Myo10
|
UTSW |
15 |
25,793,209 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R9196:Myo10
|
UTSW |
15 |
25,805,630 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9224:Myo10
|
UTSW |
15 |
25,807,995 (GRCm38) |
missense |
probably benign |
0.33 |
|
R9308:Myo10
|
UTSW |
15 |
25,781,776 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9358:Myo10
|
UTSW |
15 |
25,781,434 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R9606:Myo10
|
UTSW |
15 |
25,776,315 (GRCm38) |
frame shift |
probably null |
|
|
R9722:Myo10
|
UTSW |
15 |
25,801,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF013:Myo10
|
UTSW |
15 |
25,799,479 (GRCm38) |
missense |
probably damaging |
0.99 |
|
Z1177:Myo10
|
UTSW |
15 |
25,799,554 (GRCm38) |
critical splice donor site |
probably null |
|
|
Z1177:Myo10
|
UTSW |
15 |
25,781,401 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCATAATAAGAGACCGGGTCCAAG -3'
(R):5'- TTCTGTTTCAGCCGGCAGAG -3'
Sequencing Primer
(F):5'- AGACCGGGTCCAAGTCTGG -3'
(R):5'- GGCAGAGCACATACCTTTCCTC -3'
|
| Posted On |
2015-04-06 |
Incidental Mutation