Incidental Mutation 'R3870:Or2ag2b'
ID 276507
Institutional Source Beutler Lab
Gene Symbol Or2ag2b
Ensembl Gene ENSMUSG00000036744
Gene Name olfactory receptor family 2 subfamily AG member 2B
Synonyms 4933433E02Rik, Olfr701, GA_x6K02T2PBJ9-9195805-9196755, 4932441H21Rik, MOR283-1
MMRRC Submission 040789-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R3870 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 106413336-106419916 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 106418047 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 252 (Y252*)
Ref Sequence ENSEMBL: ENSMUSP00000151783 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075414] [ENSMUST00000080899] [ENSMUST00000166880] [ENSMUST00000217739] [ENSMUST00000219803]
AlphaFold Q9D3U9
Predicted Effect probably null
Transcript: ENSMUST00000075414
AA Change: Y252*
SMART Domains Protein: ENSMUSP00000074868
Gene: ENSMUSG00000036744
AA Change: Y252*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.9e-46 PFAM
Pfam:7tm_1 41 290 2.3e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080899
SMART Domains Protein: ENSMUSP00000079704
Gene: ENSMUSG00000056863

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 2.7e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 300 2.9e-8 PFAM
Pfam:7tm_1 41 290 1.5e-26 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000166880
AA Change: Y252*
SMART Domains Protein: ENSMUSP00000130958
Gene: ENSMUSG00000036744
AA Change: Y252*

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 5.8e-31 PFAM
Pfam:7tm_4 139 283 1.8e-44 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209339
Predicted Effect probably null
Transcript: ENSMUST00000217739
AA Change: Y252*
Predicted Effect probably benign
Transcript: ENSMUST00000219803
Meta Mutation Damage Score 0.9707 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency 90% (61/68)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700028J19Rik T A 7: 43,880,828 (GRCm39) probably null Het
Adam22 C A 5: 8,182,418 (GRCm39) C514F probably damaging Het
Akap8 G A 17: 32,536,813 (GRCm39) probably benign Het
Armcx2 A T X: 133,707,048 (GRCm39) V195E probably benign Het
Atg7 T C 6: 114,674,008 (GRCm39) S301P possibly damaging Het
Cc2d2a C A 5: 43,876,033 (GRCm39) Y1003* probably null Het
Ccdc93 A G 1: 121,390,843 (GRCm39) S272G probably benign Het
Ces1d C G 8: 93,901,714 (GRCm39) L418F probably benign Het
Cntnap5a A G 1: 115,987,979 (GRCm39) E170G probably damaging Het
Cplane1 A T 15: 8,247,948 (GRCm39) K1499M probably damaging Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Ehd4 T A 2: 119,967,434 (GRCm39) D120V probably damaging Het
Eif4g3 T A 4: 137,824,211 (GRCm39) V71E probably damaging Het
Exoc5 A G 14: 49,256,853 (GRCm39) probably benign Het
Glud1 T A 14: 34,047,537 (GRCm39) probably benign Het
Gm10985 TTCTCTCTCTCTCTCTCT TTCTCTCTCTCTCTCT 3: 53,752,626 (GRCm39) probably null Het
Gm11555 G T 11: 99,540,816 (GRCm39) C64* probably null Het
Gm5468 A G 15: 25,414,561 (GRCm39) probably benign Het
Gpatch2 T A 1: 187,054,491 (GRCm39) L74Q probably damaging Het
Hnrnpa0 G A 13: 58,275,713 (GRCm39) R139C probably damaging Het
Hrh1 A G 6: 114,457,880 (GRCm39) Y387C probably damaging Het
Ldb3 A T 14: 34,289,440 (GRCm39) D216E probably damaging Het
Lingo1 A T 9: 56,527,009 (GRCm39) S533T probably benign Het
Lmtk2 T G 5: 144,103,245 (GRCm39) probably benign Het
Map1s A G 8: 71,369,745 (GRCm39) E939G possibly damaging Het
Mast1 G A 8: 85,645,360 (GRCm39) T695I probably damaging Het
Mettl21e G A 1: 44,245,524 (GRCm39) R241W probably benign Het
Mfsd4a G A 1: 131,974,091 (GRCm39) T261I probably damaging Het
Mmel1 T C 4: 154,968,095 (GRCm39) S144P probably benign Het
Myo16 A T 8: 10,492,239 (GRCm39) H727L probably benign Het
Ncoa6 T C 2: 155,257,477 (GRCm39) probably null Het
Nipa2 T C 7: 55,582,690 (GRCm39) R352G probably damaging Het
Oaf C T 9: 43,134,055 (GRCm39) R222Q probably benign Het
Pard3 T C 8: 128,136,167 (GRCm39) S847P probably damaging Het
Pgbd1 C T 13: 21,618,540 (GRCm39) R39H possibly damaging Het
Plcb1 A C 2: 135,167,591 (GRCm39) I462L probably damaging Het
Prex2 T C 1: 11,230,416 (GRCm39) V814A possibly damaging Het
Rasal3 G A 17: 32,612,522 (GRCm39) R780W possibly damaging Het
Rubcnl C T 14: 75,278,356 (GRCm39) P380L probably benign Het
Ryk A G 9: 102,768,427 (GRCm39) E359G probably damaging Het
Sall2 C A 14: 52,551,451 (GRCm39) L579F probably damaging Het
Satb2 A G 1: 56,930,379 (GRCm39) S215P probably damaging Het
Scg3 T C 9: 75,582,781 (GRCm39) probably benign Het
Slc35f5 A G 1: 125,490,098 (GRCm39) T65A probably benign Het
Snx33 T C 9: 56,834,024 (GRCm39) N15S probably benign Het
Stat2 T A 10: 128,113,762 (GRCm39) S180R probably benign Het
Stxbp2 A G 8: 3,684,079 (GRCm39) T129A probably damaging Het
Tas1r3 A T 4: 155,945,810 (GRCm39) C529S probably damaging Het
Tlr12 T A 4: 128,510,361 (GRCm39) M630L probably benign Het
Tnfrsf10b T G 14: 70,010,905 (GRCm39) D103E probably benign Het
Togaram1 A C 12: 65,049,419 (GRCm39) E1285D probably benign Het
Tppp A G 13: 74,178,891 (GRCm39) T111A probably benign Het
Trim12c T C 7: 103,997,544 (GRCm39) Q4R probably benign Het
Ttbk2 T G 2: 120,570,500 (GRCm39) S1149R probably damaging Het
Uncx T C 5: 139,533,120 (GRCm39) L395P probably damaging Het
Usp14 A G 18: 10,002,370 (GRCm39) S314P possibly damaging Het
Usp32 A T 11: 84,897,881 (GRCm39) Y1153* probably null Het
Vmn2r6 T C 3: 64,464,042 (GRCm39) E264G probably damaging Het
Vmn2r77 T C 7: 86,461,050 (GRCm39) F792S probably damaging Het
Vps13c A G 9: 67,792,008 (GRCm39) I425V probably benign Het
Vstm4 C T 14: 32,585,712 (GRCm39) A93V probably benign Het
Xrcc6 T A 15: 81,909,885 (GRCm39) S97T probably benign Het
Zscan20 A G 4: 128,480,218 (GRCm39) C758R probably damaging Het
Other mutations in Or2ag2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01476:Or2ag2b APN 7 106,417,827 (GRCm39) missense probably damaging 1.00
IGL01972:Or2ag2b APN 7 106,417,739 (GRCm39) missense probably benign 0.01
IGL02541:Or2ag2b APN 7 106,417,809 (GRCm39) missense probably benign 0.34
R0276:Or2ag2b UTSW 7 106,417,904 (GRCm39) missense probably benign 0.00
R0345:Or2ag2b UTSW 7 106,417,908 (GRCm39) missense probably benign 0.38
R0467:Or2ag2b UTSW 7 106,417,568 (GRCm39) missense possibly damaging 0.49
R1829:Or2ag2b UTSW 7 106,418,214 (GRCm39) missense probably benign
R3116:Or2ag2b UTSW 7 106,417,571 (GRCm39) missense probably damaging 0.98
R5267:Or2ag2b UTSW 7 106,418,015 (GRCm39) missense probably damaging 1.00
R6036:Or2ag2b UTSW 7 106,417,667 (GRCm39) missense probably damaging 1.00
R6036:Or2ag2b UTSW 7 106,417,667 (GRCm39) missense probably damaging 1.00
R7229:Or2ag2b UTSW 7 106,418,202 (GRCm39) missense probably damaging 0.97
R7230:Or2ag2b UTSW 7 106,417,386 (GRCm39) missense possibly damaging 0.78
R7231:Or2ag2b UTSW 7 106,417,650 (GRCm39) missense probably damaging 1.00
R7419:Or2ag2b UTSW 7 106,417,551 (GRCm39) missense possibly damaging 0.89
R7537:Or2ag2b UTSW 7 106,417,581 (GRCm39) missense probably damaging 1.00
R8468:Or2ag2b UTSW 7 106,418,046 (GRCm39) missense possibly damaging 0.66
R9246:Or2ag2b UTSW 7 106,417,938 (GRCm39) missense probably benign 0.00
R9300:Or2ag2b UTSW 7 106,418,111 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AAATTGGCTTGTGCAGACAC -3'
(R):5'- TCATCCTAAACAGTGGCGTG -3'

Sequencing Primer
(F):5'- GACACATCTCAATATGAGCTCATGG -3'
(R):5'- GTGCTGGCAGAATATGTCTCCC -3'
Posted On 2015-04-06