|Institutional Source||Beutler Lab|
|Gene Name||A kinase (PRKA) anchor protein 8|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R3870 (G1)|
|Chromosomal Location||32303676-32321153 bp(-) (GRCm38)|
|Type of Mutation||unclassified|
|DNA Base Change (assembly)||G to A at 32317839 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000051389 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000002699] [ENSMUST00000050214]|
|Coding Region Coverage||
|Validation Efficiency||90% (61/68)|
FUNCTION: This gene encodes a member of the A-kinase anchoring protein (AKAP) family. These proteins are characterized by their ability to bind to the R subunit of protein kinase A (PKA) and anchor the protein at different subcellular locations. This protein has been shown to regulate apoptosis and to be involved in palatogenesis. Knockdown of this gene has been associated with altered histone modifications and reduced expression of developmental genes in mouse embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
PHENOTYPE: Mice homozygous for a gene trap insertion are viable and overtly normal. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Akap8||
(F):5'- AGTTCAAACTCCCCTTCAGG -3'
(R):5'- TTTCATGGGAGAAGTCAGGCC -3'
(F):5'- AGGTCAGCCTAGCTCTGATAC -3'
(R):5'- CCTGCCTGGGAGAGAAATATTATTG -3'