Incidental Mutation 'IGL00951:Tas2r140'
ID 27662
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r140
Ensembl Gene ENSMUSG00000071147
Gene Name taste receptor, type 2, member 140
Synonyms TRB5, mt2r64, Tas2r40, Tas2r13, mTRB3, TRB3, T2R40
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL00951
Quality Score
Status
Chromosome 6
Chromosomal Location 133031818-133032756 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 40468913 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 248 (R248*)
Ref Sequence ENSEMBL: ENSMUSP00000063743 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038750] [ENSMUST00000064932]
AlphaFold Q7TQA4
Predicted Effect probably benign
Transcript: ENSMUST00000038750
SMART Domains Protein: ENSMUSP00000044089
Gene: ENSMUSG00000037140

DomainStartEndE-ValueType
Pfam:TAS2R 1 297 5e-93 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000064932
AA Change: R248*
SMART Domains Protein: ENSMUSP00000063743
Gene: ENSMUSG00000052850
AA Change: R248*

DomainStartEndE-ValueType
Pfam:TAS2R 18 320 2.5e-91 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Armc8 C A 9: 99,387,757 (GRCm39) R388L probably benign Het
Bcan T C 3: 87,901,481 (GRCm39) E407G probably damaging Het
Brms1l A G 12: 55,912,834 (GRCm39) I276V possibly damaging Het
Brpf1 C A 6: 113,299,514 (GRCm39) D1182E probably damaging Het
Clpb A G 7: 101,400,467 (GRCm39) M268V probably benign Het
Cpne8 A T 15: 90,486,096 (GRCm39) probably benign Het
Ddx25 A T 9: 35,464,131 (GRCm39) probably null Het
Dgki A G 6: 36,977,094 (GRCm39) M672T probably damaging Het
Fhdc1 T C 3: 84,371,620 (GRCm39) T112A possibly damaging Het
Galnt7 A T 8: 58,036,858 (GRCm39) M177K probably damaging Het
Gucy1a1 T C 3: 82,018,498 (GRCm39) D113G probably benign Het
Hp T C 8: 110,304,129 (GRCm39) D24G possibly damaging Het
Jak2 A G 19: 29,276,983 (GRCm39) R847G probably damaging Het
Lama2 A T 10: 26,906,281 (GRCm39) D2391E probably benign Het
Mpzl1 A G 1: 165,433,391 (GRCm39) F87L probably damaging Het
Ms4a4d A T 19: 11,532,285 (GRCm39) I144F probably benign Het
Or5h18 G A 16: 58,848,216 (GRCm39) T18I probably benign Het
Or5h23 A C 16: 58,906,756 (GRCm39) L30R possibly damaging Het
Or5i1 A T 2: 87,612,883 (GRCm39) I2F probably benign Het
Or6c219 A G 10: 129,781,581 (GRCm39) S2P probably damaging Het
Or6d14 G A 6: 116,534,027 (GRCm39) V214I probably benign Het
Prr16 A G 18: 51,436,411 (GRCm39) R297G probably damaging Het
Ralgps1 A C 2: 33,163,614 (GRCm39) L148V probably damaging Het
Rara A G 11: 98,858,992 (GRCm39) D150G probably benign Het
Rb1 A T 14: 73,559,512 (GRCm39) V64D probably damaging Het
Ros1 A G 10: 52,019,348 (GRCm39) Y742H probably damaging Het
Rpl7a A G 2: 26,802,441 (GRCm39) D160G possibly damaging Het
Sdccag8 A G 1: 176,705,568 (GRCm39) M461V possibly damaging Het
Tagln T A 9: 45,842,170 (GRCm39) N141I probably benign Het
Ube2j2 C T 4: 156,030,834 (GRCm39) probably benign Het
Ulk1 A G 5: 110,940,270 (GRCm39) C384R possibly damaging Het
Ush2a A T 1: 187,995,662 (GRCm39) E144D probably benign Het
Vkorc1l1 C T 5: 130,011,108 (GRCm39) T144I probably benign Het
Zfp235 T C 7: 23,836,505 (GRCm39) F17S probably damaging Het
Other mutations in Tas2r140
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Tas2r140 APN 6 40,468,274 (GRCm39) missense probably benign 0.20
IGL00980:Tas2r140 APN 6 40,468,352 (GRCm39) missense possibly damaging 0.60
IGL02055:Tas2r140 APN 6 40,468,493 (GRCm39) missense probably damaging 1.00
IGL03101:Tas2r140 APN 6 40,468,764 (GRCm39) missense probably benign 0.03
R0149:Tas2r140 UTSW 6 40,468,232 (GRCm39) missense probably benign 0.08
R0244:Tas2r140 UTSW 6 133,032,290 (GRCm39) missense possibly damaging 0.46
R0361:Tas2r140 UTSW 6 40,468,232 (GRCm39) missense probably benign 0.08
R0666:Tas2r140 UTSW 6 133,032,405 (GRCm39) missense probably benign 0.22
R0755:Tas2r140 UTSW 6 40,468,344 (GRCm39) missense probably damaging 0.99
R1174:Tas2r140 UTSW 6 133,031,834 (GRCm39) missense probably benign 0.27
R1237:Tas2r140 UTSW 6 133,032,171 (GRCm39) missense probably benign 0.04
R1553:Tas2r140 UTSW 6 133,032,471 (GRCm39) missense probably damaging 0.99
R2030:Tas2r140 UTSW 6 133,032,213 (GRCm39) missense probably benign 0.23
R2030:Tas2r140 UTSW 6 40,469,154 (GRCm39) missense possibly damaging 0.58
R3123:Tas2r140 UTSW 6 133,032,204 (GRCm39) missense probably benign 0.05
R3124:Tas2r140 UTSW 6 133,032,204 (GRCm39) missense probably benign 0.05
R4233:Tas2r140 UTSW 6 133,031,915 (GRCm39) missense probably damaging 1.00
R4234:Tas2r140 UTSW 6 133,031,915 (GRCm39) missense probably damaging 1.00
R4236:Tas2r140 UTSW 6 133,031,915 (GRCm39) missense probably damaging 1.00
R4525:Tas2r140 UTSW 6 133,032,207 (GRCm39) missense possibly damaging 0.66
R4803:Tas2r140 UTSW 6 133,032,743 (GRCm39) missense possibly damaging 0.77
R4840:Tas2r140 UTSW 6 133,032,528 (GRCm39) missense probably benign 0.01
R4885:Tas2r140 UTSW 6 40,468,334 (GRCm39) missense probably damaging 0.98
R5092:Tas2r140 UTSW 6 40,468,200 (GRCm39) missense probably benign
R5182:Tas2r140 UTSW 6 40,468,866 (GRCm39) missense probably benign 0.01
R5317:Tas2r140 UTSW 6 133,032,543 (GRCm39) missense probably benign 0.06
R5937:Tas2r140 UTSW 6 133,032,236 (GRCm39) missense probably benign 0.01
R5952:Tas2r140 UTSW 6 40,468,476 (GRCm39) missense probably benign 0.43
R6142:Tas2r140 UTSW 6 133,032,698 (GRCm39) missense probably damaging 1.00
R7127:Tas2r140 UTSW 6 133,031,922 (GRCm39) missense possibly damaging 0.62
R7143:Tas2r140 UTSW 6 133,032,482 (GRCm39) missense probably benign 0.00
R7178:Tas2r140 UTSW 6 133,032,623 (GRCm39) missense probably damaging 1.00
R7494:Tas2r140 UTSW 6 40,468,254 (GRCm39) missense probably damaging 0.99
R7513:Tas2r140 UTSW 6 40,469,084 (GRCm39) missense probably damaging 1.00
R7875:Tas2r140 UTSW 6 40,469,097 (GRCm39) missense probably damaging 1.00
R7979:Tas2r140 UTSW 6 40,468,601 (GRCm39) missense probably damaging 1.00
R8804:Tas2r140 UTSW 6 133,032,326 (GRCm39) missense probably damaging 0.98
R9029:Tas2r140 UTSW 6 133,032,181 (GRCm39) missense possibly damaging 0.69
R9055:Tas2r140 UTSW 6 133,032,380 (GRCm39) missense possibly damaging 0.77
R9257:Tas2r140 UTSW 6 40,468,592 (GRCm39) missense probably damaging 0.98
R9385:Tas2r140 UTSW 6 133,032,241 (GRCm39) missense probably benign 0.03
R9530:Tas2r140 UTSW 6 133,032,494 (GRCm39) missense probably benign 0.00
R9760:Tas2r140 UTSW 6 40,469,036 (GRCm39) missense probably benign 0.41
X0022:Tas2r140 UTSW 6 40,468,275 (GRCm39) missense possibly damaging 0.63
Posted On 2013-04-17