Incidental Mutation 'IGL00951:Tas2r137'
ID27662
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r137
Ensembl Gene ENSMUSG00000052850
Gene Nametaste receptor, type 2, member 137
Synonymsmt2r41
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.073) question?
Stock #IGL00951
Quality Score
Status
Chromosome6
Chromosomal Location40491233-40492305 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 40491979 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 248 (R248*)
Ref Sequence ENSEMBL: ENSMUSP00000063743 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038750] [ENSMUST00000064932]
Predicted Effect probably benign
Transcript: ENSMUST00000038750
SMART Domains Protein: ENSMUSP00000044089
Gene: ENSMUSG00000037140

DomainStartEndE-ValueType
Pfam:TAS2R 1 297 5e-93 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000064932
AA Change: R248*
SMART Domains Protein: ENSMUSP00000063743
Gene: ENSMUSG00000052850
AA Change: R248*

DomainStartEndE-ValueType
Pfam:TAS2R 18 320 2.5e-91 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Armc8 C A 9: 99,505,704 R388L probably benign Het
Bcan T C 3: 87,994,174 E407G probably damaging Het
Brms1l A G 12: 55,866,049 I276V possibly damaging Het
Brpf1 C A 6: 113,322,553 D1182E probably damaging Het
Clpb A G 7: 101,751,260 M268V probably benign Het
Cpne8 A T 15: 90,601,893 probably benign Het
Ddx25 A T 9: 35,552,835 probably null Het
Dgki A G 6: 37,000,159 M672T probably damaging Het
Fhdc1 T C 3: 84,464,313 T112A possibly damaging Het
Galnt7 A T 8: 57,583,824 M177K probably damaging Het
Gucy1a1 T C 3: 82,111,191 D113G probably benign Het
Hp T C 8: 109,577,497 D24G possibly damaging Het
Jak2 A G 19: 29,299,583 R847G probably damaging Het
Lama2 A T 10: 27,030,285 D2391E probably benign Het
Mpzl1 A G 1: 165,605,822 F87L probably damaging Het
Ms4a4d A T 19: 11,554,921 I144F probably benign Het
Olfr152 A T 2: 87,782,539 I2F probably benign Het
Olfr186 G A 16: 59,027,853 T18I probably benign Het
Olfr191 A C 16: 59,086,393 L30R possibly damaging Het
Olfr214 G A 6: 116,557,066 V214I probably benign Het
Olfr818 A G 10: 129,945,712 S2P probably damaging Het
Prr16 A G 18: 51,303,339 R297G probably damaging Het
Ralgps1 A C 2: 33,273,602 L148V probably damaging Het
Rara A G 11: 98,968,166 D150G probably benign Het
Rb1 A T 14: 73,322,072 V64D probably damaging Het
Ros1 A G 10: 52,143,252 Y742H probably damaging Het
Rpl7a A G 2: 26,912,429 D160G possibly damaging Het
Sdccag8 A G 1: 176,878,002 M461V possibly damaging Het
Tagln T A 9: 45,930,872 N141I probably benign Het
Ube2j2 C T 4: 155,946,377 probably benign Het
Ulk1 A G 5: 110,792,404 C384R possibly damaging Het
Ush2a A T 1: 188,263,465 E144D probably benign Het
Vkorc1l1 C T 5: 129,982,267 T144I probably benign Het
Zfp235 T C 7: 24,137,080 F17S probably damaging Het
Other mutations in Tas2r137
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Tas2r137 APN 6 40491340 missense probably benign 0.20
IGL00980:Tas2r137 APN 6 40491418 missense possibly damaging 0.60
IGL02055:Tas2r137 APN 6 40491559 missense probably damaging 1.00
IGL03101:Tas2r137 APN 6 40491830 missense probably benign 0.03
R0149:Tas2r137 UTSW 6 40491298 missense probably benign 0.08
R0361:Tas2r137 UTSW 6 40491298 missense probably benign 0.08
R0755:Tas2r137 UTSW 6 40491410 missense probably damaging 0.99
R2030:Tas2r137 UTSW 6 40492220 missense possibly damaging 0.58
R4885:Tas2r137 UTSW 6 40491400 missense probably damaging 0.98
R5092:Tas2r137 UTSW 6 40491266 missense probably benign
R5182:Tas2r137 UTSW 6 40491932 missense probably benign 0.01
R5952:Tas2r137 UTSW 6 40491542 missense probably benign 0.43
R7494:Tas2r137 UTSW 6 40491320 missense probably damaging 0.99
R7513:Tas2r137 UTSW 6 40492150 missense probably damaging 1.00
R7875:Tas2r137 UTSW 6 40492163 missense probably damaging 1.00
R7958:Tas2r137 UTSW 6 40492163 missense probably damaging 1.00
X0022:Tas2r137 UTSW 6 40491341 missense possibly damaging 0.63
Posted On2013-04-17