Incidental Mutation 'R3874:Or4f6'
ID 276704
Institutional Source Beutler Lab
Gene Symbol Or4f6
Ensembl Gene ENSMUSG00000108827
Gene Name olfactory receptor family 4 subfamily F member 6
Synonyms Olfr1310, MOR245-3, GA_x6K02T2Q125-73056609-73055671
MMRRC Submission 040792-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.234) question?
Stock # R3874 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 111838591-111839529 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 111838668 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 288 (T288A)
Ref Sequence ENSEMBL: ENSMUSP00000149701 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000207169] [ENSMUST00000213559]
AlphaFold Q8VF85
Predicted Effect possibly damaging
Transcript: ENSMUST00000099602
AA Change: T288A

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000097197
Gene: ENSMUSG00000074949
AA Change: T288A

Pfam:7tm_4 30 305 7.7e-41 PFAM
Pfam:7TM_GPCR_Srsx 35 301 3.3e-8 PFAM
Pfam:7tm_1 41 287 5.9e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000207169
AA Change: T288A

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213559
AA Change: T288A

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
Meta Mutation Damage Score 0.5308 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130213A22Rik C A 11: 69,012,301 (GRCm39) G26* probably null Het
Abca5 T A 11: 110,201,059 (GRCm39) Y447F probably damaging Het
Acox2 A G 14: 8,248,061 (GRCm38) I407T probably benign Het
Adam8 T C 7: 139,567,520 (GRCm39) N408D probably damaging Het
Adgre1 A T 17: 57,708,925 (GRCm39) T39S probably benign Het
Akap12 G A 10: 4,307,590 (GRCm39) V1467I probably benign Het
Arid1b T A 17: 5,386,790 (GRCm39) probably null Het
Atp2c2 A G 8: 120,462,035 (GRCm39) I303V possibly damaging Het
Bpifc C T 10: 85,827,118 (GRCm39) V144I probably benign Het
Camk4 A G 18: 33,291,907 (GRCm39) E189G possibly damaging Het
Casz1 A G 4: 149,024,046 (GRCm39) probably benign Het
Ccdc134 T C 15: 82,015,643 (GRCm39) V41A possibly damaging Het
Chrd A T 16: 20,557,660 (GRCm39) T753S probably damaging Het
Cracd A G 5: 76,988,739 (GRCm39) D30G probably damaging Het
Cyb561a3 T C 19: 10,562,735 (GRCm39) V125A probably benign Het
D630039A03Rik T A 4: 57,910,606 (GRCm39) T69S probably benign Het
Dchs1 A G 7: 105,410,842 (GRCm39) F1687S probably damaging Het
Dlgap4 T C 2: 156,591,267 (GRCm39) S818P probably benign Het
Dnah2 A G 11: 69,320,174 (GRCm39) I3965T probably damaging Het
Dnai2 G T 11: 114,623,781 (GRCm39) G15W probably damaging Het
Dsg1c A G 18: 20,410,109 (GRCm39) I526V probably benign Het
Far2 G A 6: 148,052,089 (GRCm39) E123K probably benign Het
Gli1 A T 10: 127,166,088 (GRCm39) V1055E probably damaging Het
Hand2 G T 8: 57,775,011 (GRCm39) A24S probably benign Het
Helb T C 10: 119,941,942 (GRCm39) I249V probably benign Het
Hspa4l G A 3: 40,727,074 (GRCm39) V492M probably damaging Het
Hspg2 T C 4: 137,266,660 (GRCm39) I1916T probably damaging Het
Igfals G A 17: 25,100,579 (GRCm39) V557I possibly damaging Het
Itpa T G 2: 130,522,930 (GRCm39) S176A probably damaging Het
Kcnu1 T A 8: 26,375,345 (GRCm39) L353H probably damaging Het
Klhl1 A G 14: 96,755,615 (GRCm39) F47L probably benign Het
Klhl13 T C X: 23,151,415 (GRCm39) D21G probably benign Het
Krt26 T C 11: 99,225,570 (GRCm39) K304E probably damaging Het
Krt9 C T 11: 100,081,675 (GRCm39) V285I probably damaging Het
Mansc1 T C 6: 134,587,146 (GRCm39) R344G possibly damaging Het
Mier2 G T 10: 79,377,631 (GRCm39) P439T possibly damaging Het
Mppe1 T A 18: 67,358,957 (GRCm39) probably null Het
Nedd4l G A 18: 65,300,606 (GRCm39) A243T probably benign Het
Notch4 T A 17: 34,797,043 (GRCm39) C934* probably null Het
Nsmce3 C T 7: 64,521,916 (GRCm39) D251N probably damaging Het
Or10a49 C T 7: 108,468,335 (GRCm39) V9M probably damaging Het
Or12d12 T A 17: 37,610,870 (GRCm39) T148S probably benign Het
Or3a10 A G 11: 73,935,525 (GRCm39) C192R probably damaging Het
Or5l13 T A 2: 87,779,874 (GRCm39) R234S probably damaging Het
Or8g23 A G 9: 38,971,470 (GRCm39) I164T probably benign Het
Pdzd7 T C 19: 45,034,067 (GRCm39) T6A probably benign Het
Picalm T A 7: 89,838,427 (GRCm39) F493Y probably damaging Het
Prl7d1 A G 13: 27,900,651 (GRCm39) M1T probably null Het
Prl8a1 T C 13: 27,759,441 (GRCm39) K199E possibly damaging Het
Rims1 C T 1: 22,498,740 (GRCm39) R764H probably damaging Het
Rnf17 G T 14: 56,712,870 (GRCm39) R779L possibly damaging Het
Rufy2 T C 10: 62,833,916 (GRCm39) L294P probably damaging Het
Sgsh A G 11: 119,241,773 (GRCm39) L111P probably damaging Het
Slc22a30 G T 19: 8,314,213 (GRCm39) T491K probably benign Het
Slc35b3 T C 13: 39,127,044 (GRCm39) N20D possibly damaging Het
Slc5a4a T C 10: 76,017,489 (GRCm39) F429L probably benign Het
Sulf1 T C 1: 12,887,636 (GRCm39) I270T probably damaging Het
Tmem51 T C 4: 141,759,059 (GRCm39) T230A probably damaging Het
Tnc T A 4: 63,926,947 (GRCm39) I860F probably damaging Het
Trh A T 6: 92,220,679 (GRCm39) V61E possibly damaging Het
Ttn T G 2: 76,584,443 (GRCm39) T22222P probably damaging Het
Uroc1 A T 6: 90,338,494 (GRCm39) K652* probably null Het
Usp34 C T 11: 23,439,033 (GRCm39) P3532S possibly damaging Het
Vmn2r120 A T 17: 57,831,954 (GRCm39) F278L probably benign Het
Vmn2r7 A G 3: 64,627,032 (GRCm39) F86L possibly damaging Het
Vmn2r87 A T 10: 130,315,856 (GRCm39) I70K possibly damaging Het
Vps13a C T 19: 16,722,317 (GRCm39) A332T probably benign Het
Zfp568 T A 7: 29,722,821 (GRCm39) C589S probably damaging Het
Other mutations in Or4f6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01947:Or4f6 APN 2 111,839,361 (GRCm39) missense possibly damaging 0.86
IGL02700:Or4f6 APN 2 111,839,036 (GRCm39) missense probably benign 0.04
IGL03008:Or4f6 APN 2 111,838,868 (GRCm39) missense possibly damaging 0.95
IGL03121:Or4f6 APN 2 111,838,953 (GRCm39) missense probably benign 0.02
R0025:Or4f6 UTSW 2 111,839,365 (GRCm39) missense probably damaging 0.98
R1624:Or4f6 UTSW 2 111,838,877 (GRCm39) missense probably damaging 1.00
R1851:Or4f6 UTSW 2 111,839,036 (GRCm39) missense probably benign 0.04
R3872:Or4f6 UTSW 2 111,838,668 (GRCm39) missense possibly damaging 0.95
R3873:Or4f6 UTSW 2 111,838,668 (GRCm39) missense possibly damaging 0.95
R4651:Or4f6 UTSW 2 111,838,595 (GRCm39) missense probably damaging 1.00
R4652:Or4f6 UTSW 2 111,838,595 (GRCm39) missense probably damaging 1.00
R4834:Or4f6 UTSW 2 111,839,276 (GRCm39) missense probably damaging 1.00
R5076:Or4f6 UTSW 2 111,838,937 (GRCm39) missense probably damaging 0.99
R7262:Or4f6 UTSW 2 111,838,902 (GRCm39) missense probably damaging 1.00
R7339:Or4f6 UTSW 2 111,838,820 (GRCm39) missense probably damaging 1.00
R7657:Or4f6 UTSW 2 111,839,093 (GRCm39) missense probably benign 0.02
R7798:Or4f6 UTSW 2 111,838,617 (GRCm39) missense probably benign
R7875:Or4f6 UTSW 2 111,839,192 (GRCm39) missense probably benign 0.32
R8869:Or4f6 UTSW 2 111,838,596 (GRCm39) missense possibly damaging 0.88
R9689:Or4f6 UTSW 2 111,839,124 (GRCm39) missense probably benign 0.29
X0027:Or4f6 UTSW 2 111,839,169 (GRCm39) missense probably damaging 1.00
Z1176:Or4f6 UTSW 2 111,838,802 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-04-06