Incidental Mutation 'R3874:Vmn2r87'
ID 276738
Institutional Source Beutler Lab
Gene Symbol Vmn2r87
Ensembl Gene ENSMUSG00000091511
Gene Name vomeronasal 2, receptor 87
Synonyms EG625131
MMRRC Submission 040792-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R3874 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 130307690-130333248 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 130315856 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 70 (I70K)
Ref Sequence ENSEMBL: ENSMUSP00000129215 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164227]
AlphaFold E9PZX4
Predicted Effect possibly damaging
Transcript: ENSMUST00000164227
AA Change: I70K

PolyPhen 2 Score 0.622 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000129215
Gene: ENSMUSG00000091511
AA Change: I70K

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 77 422 1.8e-27 PFAM
Pfam:NCD3G 508 562 1.8e-19 PFAM
Pfam:7tm_3 595 829 8.8e-55 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130213A22Rik C A 11: 69,012,301 (GRCm39) G26* probably null Het
Abca5 T A 11: 110,201,059 (GRCm39) Y447F probably damaging Het
Acox2 A G 14: 8,248,061 (GRCm38) I407T probably benign Het
Adam8 T C 7: 139,567,520 (GRCm39) N408D probably damaging Het
Adgre1 A T 17: 57,708,925 (GRCm39) T39S probably benign Het
Akap12 G A 10: 4,307,590 (GRCm39) V1467I probably benign Het
Arid1b T A 17: 5,386,790 (GRCm39) probably null Het
Atp2c2 A G 8: 120,462,035 (GRCm39) I303V possibly damaging Het
Bpifc C T 10: 85,827,118 (GRCm39) V144I probably benign Het
Camk4 A G 18: 33,291,907 (GRCm39) E189G possibly damaging Het
Casz1 A G 4: 149,024,046 (GRCm39) probably benign Het
Ccdc134 T C 15: 82,015,643 (GRCm39) V41A possibly damaging Het
Chrd A T 16: 20,557,660 (GRCm39) T753S probably damaging Het
Cracd A G 5: 76,988,739 (GRCm39) D30G probably damaging Het
Cyb561a3 T C 19: 10,562,735 (GRCm39) V125A probably benign Het
D630039A03Rik T A 4: 57,910,606 (GRCm39) T69S probably benign Het
Dchs1 A G 7: 105,410,842 (GRCm39) F1687S probably damaging Het
Dlgap4 T C 2: 156,591,267 (GRCm39) S818P probably benign Het
Dnah2 A G 11: 69,320,174 (GRCm39) I3965T probably damaging Het
Dnai2 G T 11: 114,623,781 (GRCm39) G15W probably damaging Het
Dsg1c A G 18: 20,410,109 (GRCm39) I526V probably benign Het
Far2 G A 6: 148,052,089 (GRCm39) E123K probably benign Het
Gli1 A T 10: 127,166,088 (GRCm39) V1055E probably damaging Het
Hand2 G T 8: 57,775,011 (GRCm39) A24S probably benign Het
Helb T C 10: 119,941,942 (GRCm39) I249V probably benign Het
Hspa4l G A 3: 40,727,074 (GRCm39) V492M probably damaging Het
Hspg2 T C 4: 137,266,660 (GRCm39) I1916T probably damaging Het
Igfals G A 17: 25,100,579 (GRCm39) V557I possibly damaging Het
Itpa T G 2: 130,522,930 (GRCm39) S176A probably damaging Het
Kcnu1 T A 8: 26,375,345 (GRCm39) L353H probably damaging Het
Klhl1 A G 14: 96,755,615 (GRCm39) F47L probably benign Het
Klhl13 T C X: 23,151,415 (GRCm39) D21G probably benign Het
Krt26 T C 11: 99,225,570 (GRCm39) K304E probably damaging Het
Krt9 C T 11: 100,081,675 (GRCm39) V285I probably damaging Het
Mansc1 T C 6: 134,587,146 (GRCm39) R344G possibly damaging Het
Mier2 G T 10: 79,377,631 (GRCm39) P439T possibly damaging Het
Mppe1 T A 18: 67,358,957 (GRCm39) probably null Het
Nedd4l G A 18: 65,300,606 (GRCm39) A243T probably benign Het
Notch4 T A 17: 34,797,043 (GRCm39) C934* probably null Het
Nsmce3 C T 7: 64,521,916 (GRCm39) D251N probably damaging Het
Or10a49 C T 7: 108,468,335 (GRCm39) V9M probably damaging Het
Or12d12 T A 17: 37,610,870 (GRCm39) T148S probably benign Het
Or3a10 A G 11: 73,935,525 (GRCm39) C192R probably damaging Het
Or4f6 T C 2: 111,838,668 (GRCm39) T288A possibly damaging Het
Or5l13 T A 2: 87,779,874 (GRCm39) R234S probably damaging Het
Or8g23 A G 9: 38,971,470 (GRCm39) I164T probably benign Het
Pdzd7 T C 19: 45,034,067 (GRCm39) T6A probably benign Het
Picalm T A 7: 89,838,427 (GRCm39) F493Y probably damaging Het
Prl7d1 A G 13: 27,900,651 (GRCm39) M1T probably null Het
Prl8a1 T C 13: 27,759,441 (GRCm39) K199E possibly damaging Het
Rims1 C T 1: 22,498,740 (GRCm39) R764H probably damaging Het
Rnf17 G T 14: 56,712,870 (GRCm39) R779L possibly damaging Het
Rufy2 T C 10: 62,833,916 (GRCm39) L294P probably damaging Het
Sgsh A G 11: 119,241,773 (GRCm39) L111P probably damaging Het
Slc22a30 G T 19: 8,314,213 (GRCm39) T491K probably benign Het
Slc35b3 T C 13: 39,127,044 (GRCm39) N20D possibly damaging Het
Slc5a4a T C 10: 76,017,489 (GRCm39) F429L probably benign Het
Sulf1 T C 1: 12,887,636 (GRCm39) I270T probably damaging Het
Tmem51 T C 4: 141,759,059 (GRCm39) T230A probably damaging Het
Tnc T A 4: 63,926,947 (GRCm39) I860F probably damaging Het
Trh A T 6: 92,220,679 (GRCm39) V61E possibly damaging Het
Ttn T G 2: 76,584,443 (GRCm39) T22222P probably damaging Het
Uroc1 A T 6: 90,338,494 (GRCm39) K652* probably null Het
Usp34 C T 11: 23,439,033 (GRCm39) P3532S possibly damaging Het
Vmn2r120 A T 17: 57,831,954 (GRCm39) F278L probably benign Het
Vmn2r7 A G 3: 64,627,032 (GRCm39) F86L possibly damaging Het
Vps13a C T 19: 16,722,317 (GRCm39) A332T probably benign Het
Zfp568 T A 7: 29,722,821 (GRCm39) C589S probably damaging Het
Other mutations in Vmn2r87
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01090:Vmn2r87 APN 10 130,333,247 (GRCm39) start codon destroyed probably null 1.00
IGL01295:Vmn2r87 APN 10 130,307,878 (GRCm39) missense probably damaging 1.00
IGL01411:Vmn2r87 APN 10 130,308,429 (GRCm39) missense probably benign 0.03
IGL01680:Vmn2r87 APN 10 130,315,586 (GRCm39) nonsense probably null
IGL01822:Vmn2r87 APN 10 130,307,991 (GRCm39) missense probably damaging 1.00
IGL01835:Vmn2r87 APN 10 130,314,978 (GRCm39) missense probably damaging 1.00
IGL01965:Vmn2r87 APN 10 130,314,924 (GRCm39) missense possibly damaging 0.49
IGL02562:Vmn2r87 APN 10 130,314,513 (GRCm39) missense probably damaging 1.00
IGL02665:Vmn2r87 APN 10 130,333,049 (GRCm39) missense probably benign 0.16
IGL03202:Vmn2r87 APN 10 130,333,091 (GRCm39) missense probably benign
FR4304:Vmn2r87 UTSW 10 130,314,583 (GRCm39) missense probably benign 0.01
FR4340:Vmn2r87 UTSW 10 130,314,583 (GRCm39) missense probably benign 0.01
FR4342:Vmn2r87 UTSW 10 130,314,583 (GRCm39) missense probably benign 0.01
FR4589:Vmn2r87 UTSW 10 130,314,583 (GRCm39) missense probably benign 0.01
LCD18:Vmn2r87 UTSW 10 130,314,583 (GRCm39) missense probably benign 0.01
R0344:Vmn2r87 UTSW 10 130,315,806 (GRCm39) missense probably damaging 1.00
R0374:Vmn2r87 UTSW 10 130,307,848 (GRCm39) missense probably damaging 1.00
R0384:Vmn2r87 UTSW 10 130,307,712 (GRCm39) missense probably benign
R1144:Vmn2r87 UTSW 10 130,312,098 (GRCm39) splice site probably benign
R1172:Vmn2r87 UTSW 10 130,313,453 (GRCm39) missense probably benign 0.03
R1860:Vmn2r87 UTSW 10 130,315,755 (GRCm39) missense probably benign 0.00
R1866:Vmn2r87 UTSW 10 130,308,441 (GRCm39) missense possibly damaging 0.88
R1897:Vmn2r87 UTSW 10 130,307,829 (GRCm39) missense probably damaging 1.00
R2360:Vmn2r87 UTSW 10 130,315,631 (GRCm39) missense probably damaging 0.99
R2909:Vmn2r87 UTSW 10 130,314,865 (GRCm39) missense probably damaging 0.99
R4113:Vmn2r87 UTSW 10 130,315,691 (GRCm39) missense probably benign
R4190:Vmn2r87 UTSW 10 130,308,556 (GRCm39) missense probably damaging 1.00
R4197:Vmn2r87 UTSW 10 130,315,779 (GRCm39) missense possibly damaging 0.55
R4201:Vmn2r87 UTSW 10 130,308,448 (GRCm39) missense probably benign 0.03
R4202:Vmn2r87 UTSW 10 130,308,448 (GRCm39) missense probably benign 0.03
R4368:Vmn2r87 UTSW 10 130,315,676 (GRCm39) missense probably benign 0.44
R4485:Vmn2r87 UTSW 10 130,315,678 (GRCm39) nonsense probably null
R4537:Vmn2r87 UTSW 10 130,308,054 (GRCm39) missense probably benign 0.12
R4590:Vmn2r87 UTSW 10 130,315,014 (GRCm39) missense possibly damaging 0.69
R4752:Vmn2r87 UTSW 10 130,314,336 (GRCm39) nonsense probably null
R4873:Vmn2r87 UTSW 10 130,308,367 (GRCm39) missense probably damaging 1.00
R4875:Vmn2r87 UTSW 10 130,308,367 (GRCm39) missense probably damaging 1.00
R4923:Vmn2r87 UTSW 10 130,314,435 (GRCm39) missense probably damaging 0.99
R4970:Vmn2r87 UTSW 10 130,314,422 (GRCm39) missense probably damaging 1.00
R5049:Vmn2r87 UTSW 10 130,308,298 (GRCm39) missense probably damaging 0.96
R5112:Vmn2r87 UTSW 10 130,314,422 (GRCm39) missense probably damaging 1.00
R5187:Vmn2r87 UTSW 10 130,333,208 (GRCm39) missense probably null 0.99
R5618:Vmn2r87 UTSW 10 130,315,817 (GRCm39) missense probably damaging 1.00
R6057:Vmn2r87 UTSW 10 130,308,226 (GRCm39) missense probably benign 0.02
R6220:Vmn2r87 UTSW 10 130,315,807 (GRCm39) missense probably benign 0.01
R6287:Vmn2r87 UTSW 10 130,314,291 (GRCm39) critical splice donor site probably null
R6383:Vmn2r87 UTSW 10 130,314,869 (GRCm39) missense probably damaging 1.00
R6576:Vmn2r87 UTSW 10 130,314,654 (GRCm39) missense probably benign 0.05
R6742:Vmn2r87 UTSW 10 130,308,396 (GRCm39) missense probably damaging 1.00
R7086:Vmn2r87 UTSW 10 130,333,178 (GRCm39) missense probably benign 0.00
R7162:Vmn2r87 UTSW 10 130,313,416 (GRCm39) missense probably benign 0.08
R7419:Vmn2r87 UTSW 10 130,307,992 (GRCm39) missense probably damaging 1.00
R7425:Vmn2r87 UTSW 10 130,314,761 (GRCm39) missense probably damaging 1.00
R7443:Vmn2r87 UTSW 10 130,308,588 (GRCm39) missense probably damaging 1.00
R7571:Vmn2r87 UTSW 10 130,314,940 (GRCm39) missense probably damaging 0.99
R7663:Vmn2r87 UTSW 10 130,308,054 (GRCm39) missense probably damaging 0.97
R7716:Vmn2r87 UTSW 10 130,308,018 (GRCm39) missense probably benign 0.09
R7793:Vmn2r87 UTSW 10 130,313,413 (GRCm39) missense probably benign 0.05
R7806:Vmn2r87 UTSW 10 130,315,679 (GRCm39) missense probably benign
R7841:Vmn2r87 UTSW 10 130,333,095 (GRCm39) missense probably benign 0.31
R8326:Vmn2r87 UTSW 10 130,308,180 (GRCm39) missense possibly damaging 0.67
R8411:Vmn2r87 UTSW 10 130,308,126 (GRCm39) missense probably damaging 0.99
R8445:Vmn2r87 UTSW 10 130,313,335 (GRCm39) missense probably damaging 1.00
R8540:Vmn2r87 UTSW 10 130,314,762 (GRCm39) missense possibly damaging 0.74
R8892:Vmn2r87 UTSW 10 130,308,105 (GRCm39) missense probably damaging 0.99
R9093:Vmn2r87 UTSW 10 130,308,165 (GRCm39) missense probably benign 0.08
R9623:Vmn2r87 UTSW 10 130,315,794 (GRCm39) missense probably damaging 1.00
R9667:Vmn2r87 UTSW 10 130,314,776 (GRCm39) missense probably damaging 1.00
R9797:Vmn2r87 UTSW 10 130,312,064 (GRCm39) missense probably benign 0.44
R9797:Vmn2r87 UTSW 10 130,308,138 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r87 UTSW 10 130,308,183 (GRCm39) missense probably damaging 0.98
Z1176:Vmn2r87 UTSW 10 130,307,713 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- GTCTATGACACATGTATCATCTGC -3'
(R):5'- TAGTGCCCAATGCCTATGAATTC -3'

Sequencing Primer
(F):5'- TGACACATGTATCATCTGCTTTAC -3'
(R):5'- CCCAATGCCTATGAATTCTTAAATTG -3'
Posted On 2015-04-06