Incidental Mutation 'R3874:Prl7d1'
ID 276747
Institutional Source Beutler Lab
Gene Symbol Prl7d1
Ensembl Gene ENSMUSG00000021348
Gene Name prolactin family 7, subfamily d, member 1
Synonyms Plfr, PLF-RP, PRP
MMRRC Submission 040792-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3874 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 27892981-27900720 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to G at 27900651 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 1 (M1T)
Ref Sequence ENSEMBL: ENSMUSP00000021776 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021776] [ENSMUST00000224026]
AlphaFold P04769
Predicted Effect probably null
Transcript: ENSMUST00000021776
AA Change: M1T

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000021776
Gene: ENSMUSG00000021348
AA Change: M1T

DomainStartEndE-ValueType
Pfam:Hormone_1 17 240 1.1e-78 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145879
Predicted Effect probably null
Transcript: ENSMUST00000224026
AA Change: M1T

PolyPhen 2 Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130213A22Rik C A 11: 69,012,301 (GRCm39) G26* probably null Het
Abca5 T A 11: 110,201,059 (GRCm39) Y447F probably damaging Het
Acox2 A G 14: 8,248,061 (GRCm38) I407T probably benign Het
Adam8 T C 7: 139,567,520 (GRCm39) N408D probably damaging Het
Adgre1 A T 17: 57,708,925 (GRCm39) T39S probably benign Het
Akap12 G A 10: 4,307,590 (GRCm39) V1467I probably benign Het
Arid1b T A 17: 5,386,790 (GRCm39) probably null Het
Atp2c2 A G 8: 120,462,035 (GRCm39) I303V possibly damaging Het
Bpifc C T 10: 85,827,118 (GRCm39) V144I probably benign Het
Camk4 A G 18: 33,291,907 (GRCm39) E189G possibly damaging Het
Casz1 A G 4: 149,024,046 (GRCm39) probably benign Het
Ccdc134 T C 15: 82,015,643 (GRCm39) V41A possibly damaging Het
Chrd A T 16: 20,557,660 (GRCm39) T753S probably damaging Het
Cracd A G 5: 76,988,739 (GRCm39) D30G probably damaging Het
Cyb561a3 T C 19: 10,562,735 (GRCm39) V125A probably benign Het
D630039A03Rik T A 4: 57,910,606 (GRCm39) T69S probably benign Het
Dchs1 A G 7: 105,410,842 (GRCm39) F1687S probably damaging Het
Dlgap4 T C 2: 156,591,267 (GRCm39) S818P probably benign Het
Dnah2 A G 11: 69,320,174 (GRCm39) I3965T probably damaging Het
Dnai2 G T 11: 114,623,781 (GRCm39) G15W probably damaging Het
Dsg1c A G 18: 20,410,109 (GRCm39) I526V probably benign Het
Far2 G A 6: 148,052,089 (GRCm39) E123K probably benign Het
Gli1 A T 10: 127,166,088 (GRCm39) V1055E probably damaging Het
Hand2 G T 8: 57,775,011 (GRCm39) A24S probably benign Het
Helb T C 10: 119,941,942 (GRCm39) I249V probably benign Het
Hspa4l G A 3: 40,727,074 (GRCm39) V492M probably damaging Het
Hspg2 T C 4: 137,266,660 (GRCm39) I1916T probably damaging Het
Igfals G A 17: 25,100,579 (GRCm39) V557I possibly damaging Het
Itpa T G 2: 130,522,930 (GRCm39) S176A probably damaging Het
Kcnu1 T A 8: 26,375,345 (GRCm39) L353H probably damaging Het
Klhl1 A G 14: 96,755,615 (GRCm39) F47L probably benign Het
Klhl13 T C X: 23,151,415 (GRCm39) D21G probably benign Het
Krt26 T C 11: 99,225,570 (GRCm39) K304E probably damaging Het
Krt9 C T 11: 100,081,675 (GRCm39) V285I probably damaging Het
Mansc1 T C 6: 134,587,146 (GRCm39) R344G possibly damaging Het
Mier2 G T 10: 79,377,631 (GRCm39) P439T possibly damaging Het
Mppe1 T A 18: 67,358,957 (GRCm39) probably null Het
Nedd4l G A 18: 65,300,606 (GRCm39) A243T probably benign Het
Notch4 T A 17: 34,797,043 (GRCm39) C934* probably null Het
Nsmce3 C T 7: 64,521,916 (GRCm39) D251N probably damaging Het
Or10a49 C T 7: 108,468,335 (GRCm39) V9M probably damaging Het
Or12d12 T A 17: 37,610,870 (GRCm39) T148S probably benign Het
Or3a10 A G 11: 73,935,525 (GRCm39) C192R probably damaging Het
Or4f6 T C 2: 111,838,668 (GRCm39) T288A possibly damaging Het
Or5l13 T A 2: 87,779,874 (GRCm39) R234S probably damaging Het
Or8g23 A G 9: 38,971,470 (GRCm39) I164T probably benign Het
Pdzd7 T C 19: 45,034,067 (GRCm39) T6A probably benign Het
Picalm T A 7: 89,838,427 (GRCm39) F493Y probably damaging Het
Prl8a1 T C 13: 27,759,441 (GRCm39) K199E possibly damaging Het
Rims1 C T 1: 22,498,740 (GRCm39) R764H probably damaging Het
Rnf17 G T 14: 56,712,870 (GRCm39) R779L possibly damaging Het
Rufy2 T C 10: 62,833,916 (GRCm39) L294P probably damaging Het
Sgsh A G 11: 119,241,773 (GRCm39) L111P probably damaging Het
Slc22a30 G T 19: 8,314,213 (GRCm39) T491K probably benign Het
Slc35b3 T C 13: 39,127,044 (GRCm39) N20D possibly damaging Het
Slc5a4a T C 10: 76,017,489 (GRCm39) F429L probably benign Het
Sulf1 T C 1: 12,887,636 (GRCm39) I270T probably damaging Het
Tmem51 T C 4: 141,759,059 (GRCm39) T230A probably damaging Het
Tnc T A 4: 63,926,947 (GRCm39) I860F probably damaging Het
Trh A T 6: 92,220,679 (GRCm39) V61E possibly damaging Het
Ttn T G 2: 76,584,443 (GRCm39) T22222P probably damaging Het
Uroc1 A T 6: 90,338,494 (GRCm39) K652* probably null Het
Usp34 C T 11: 23,439,033 (GRCm39) P3532S possibly damaging Het
Vmn2r120 A T 17: 57,831,954 (GRCm39) F278L probably benign Het
Vmn2r7 A G 3: 64,627,032 (GRCm39) F86L possibly damaging Het
Vmn2r87 A T 10: 130,315,856 (GRCm39) I70K possibly damaging Het
Vps13a C T 19: 16,722,317 (GRCm39) A332T probably benign Het
Zfp568 T A 7: 29,722,821 (GRCm39) C589S probably damaging Het
Other mutations in Prl7d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01390:Prl7d1 APN 13 27,894,149 (GRCm39) missense possibly damaging 0.91
IGL01735:Prl7d1 APN 13 27,898,372 (GRCm39) missense possibly damaging 0.83
IGL02139:Prl7d1 APN 13 27,896,066 (GRCm39) missense probably damaging 1.00
PIT4305001:Prl7d1 UTSW 13 27,898,320 (GRCm39) missense possibly damaging 0.90
PIT4531001:Prl7d1 UTSW 13 27,894,161 (GRCm39) missense probably damaging 1.00
R0555:Prl7d1 UTSW 13 27,896,038 (GRCm39) missense probably benign 0.13
R0625:Prl7d1 UTSW 13 27,894,123 (GRCm39) missense probably benign 0.10
R0631:Prl7d1 UTSW 13 27,894,165 (GRCm39) missense probably benign 0.32
R0837:Prl7d1 UTSW 13 27,898,321 (GRCm39) missense probably benign 0.06
R1403:Prl7d1 UTSW 13 27,893,180 (GRCm39) missense possibly damaging 0.89
R1403:Prl7d1 UTSW 13 27,893,180 (GRCm39) missense possibly damaging 0.89
R1459:Prl7d1 UTSW 13 27,893,240 (GRCm39) missense possibly damaging 0.81
R1643:Prl7d1 UTSW 13 27,896,114 (GRCm39) missense possibly damaging 0.53
R1691:Prl7d1 UTSW 13 27,893,365 (GRCm39) missense probably damaging 0.97
R2016:Prl7d1 UTSW 13 27,894,156 (GRCm39) missense probably damaging 1.00
R3873:Prl7d1 UTSW 13 27,900,651 (GRCm39) start codon destroyed probably null 0.92
R5251:Prl7d1 UTSW 13 27,893,227 (GRCm39) missense probably benign 0.33
R5275:Prl7d1 UTSW 13 27,893,230 (GRCm39) missense probably damaging 0.99
R5295:Prl7d1 UTSW 13 27,893,230 (GRCm39) missense probably damaging 0.99
R5398:Prl7d1 UTSW 13 27,894,057 (GRCm39) missense probably damaging 1.00
R6798:Prl7d1 UTSW 13 27,893,380 (GRCm39) critical splice acceptor site probably null
R6818:Prl7d1 UTSW 13 27,898,454 (GRCm39) missense probably benign 0.07
R6825:Prl7d1 UTSW 13 27,894,125 (GRCm39) missense probably benign 0.01
R7478:Prl7d1 UTSW 13 27,894,168 (GRCm39) nonsense probably null
R7795:Prl7d1 UTSW 13 27,893,263 (GRCm39) missense probably damaging 1.00
R7995:Prl7d1 UTSW 13 27,894,054 (GRCm39) missense probably benign
R8193:Prl7d1 UTSW 13 27,893,230 (GRCm39) missense
R9313:Prl7d1 UTSW 13 27,893,182 (GRCm39) missense probably benign
R9424:Prl7d1 UTSW 13 27,894,185 (GRCm39) missense probably benign 0.00
R9430:Prl7d1 UTSW 13 27,898,360 (GRCm39) missense possibly damaging 0.80
R9733:Prl7d1 UTSW 13 27,898,339 (GRCm39) missense probably benign 0.00
R9758:Prl7d1 UTSW 13 27,893,260 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- GAAAGGTTTTCTCAGATCCACTGG -3'
(R):5'- GTTCATGGTATCTAGGCTACTTAACCC -3'

Sequencing Primer
(F):5'- TCAGATCCACTGGGCTCTAC -3'
(R):5'- GTATCTAGGCTACTTAACCCTGAGG -3'
Posted On 2015-04-06