Mutagenetix > Incidental Mutation

Incidental Mutation 'R3874:Vmn2r120'

276760

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r120

Ensembl Gene

ENSMUSG00000090655

Gene Name

vomeronasal 2, receptor 120

Synonyms

EG224916

MMRRC Submission

040792-MU

Accession Numbers

Genbank: NM_001104591; MGI: 3644483

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

R3874 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

57508783-57545314 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 57524954 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 278 (F278L)

Ref Sequence

ENSEMBL: ENSMUSP00000129296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165781]

AlphaFold

A0A3Q4EG79

Predicted Effect

probably benign
Transcript: ENSMUST00000165781
AA Change: F278L

PolyPhen 2 Score 0.400 (Sensitivity: 0.89; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: F278L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	80	474	5.9e-42	PFAM
Pfam:NCD3G	517	570	7.5e-22	PFAM
Pfam:7tm_3	598	836	1.3e-54	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.5%
20x: 95.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9130213A22Rik	C	A	11: 69,121,475	G26*	probably null	Het
Abca5	T	A	11: 110,310,233	Y447F	probably damaging	Het
Acox2	A	G	14: 8,248,061	I407T	probably benign	Het
Adam8	T	C	7: 139,987,607	N408D	probably damaging	Het
Adgre1	A	T	17: 57,401,925	T39S	probably benign	Het
Akap12	G	A	10: 4,357,590	V1467I	probably benign	Het
Arid1b	T	A	17: 5,336,515		probably null	Het
Atp2c2	A	G	8: 119,735,296	I303V	possibly damaging	Het
Bpifc	C	T	10: 85,991,254	V144I	probably benign	Het
C530008M17Rik	A	G	5: 76,840,892	D30G	probably damaging	Het
Camk4	A	G	18: 33,158,854	E189G	possibly damaging	Het
Casz1	A	G	4: 148,939,589		probably benign	Het
Ccdc134	T	C	15: 82,131,442	V41A	possibly damaging	Het
Chrd	A	T	16: 20,738,910	T753S	probably damaging	Het
Cyb561a3	T	C	19: 10,585,371	V125A	probably benign	Het
D630039A03Rik	T	A	4: 57,910,606	T69S	probably benign	Het
Dchs1	A	G	7: 105,761,635	F1687S	probably damaging	Het
Dlgap4	T	C	2: 156,749,347	S818P	probably benign	Het
Dnah2	A	G	11: 69,429,348	I3965T	probably damaging	Het
Dnaic2	G	T	11: 114,732,955	G15W	probably damaging	Het
Dsg1c	A	G	18: 20,277,052	I526V	probably benign	Het
Far2	G	A	6: 148,150,591	E123K	probably benign	Het
Gli1	A	T	10: 127,330,219	V1055E	probably damaging	Het
Hand2	G	T	8: 57,321,976	A24S	probably benign	Het
Helb	T	C	10: 120,106,037	I249V	probably benign	Het
Hspa4l	G	A	3: 40,772,642	V492M	probably damaging	Het
Hspg2	T	C	4: 137,539,349	I1916T	probably damaging	Het
Igfals	G	A	17: 24,881,605	V557I	possibly damaging	Het
Itpa	T	G	2: 130,681,010	S176A	probably damaging	Het
Kcnu1	T	A	8: 25,885,317	L353H	probably damaging	Het
Klhl1	A	G	14: 96,518,179	F47L	probably benign	Het
Klhl13	T	C	X: 23,285,176	D21G	probably benign	Het
Krt26	T	C	11: 99,334,744	K304E	probably damaging	Het
Krt9	C	T	11: 100,190,849	V285I	probably damaging	Het
Mansc1	T	C	6: 134,610,183	R344G	possibly damaging	Het
Mier2	G	T	10: 79,541,797	P439T	possibly damaging	Het
Mppe1	T	A	18: 67,225,886		probably null	Het
Nedd4l	G	A	18: 65,167,535	A243T	probably benign	Het
Notch4	T	A	17: 34,578,069	C934*	probably null	Het
Nsmce3	C	T	7: 64,872,168	D251N	probably damaging	Het
Olfr101	T	A	17: 37,299,979	T148S	probably benign	Het
Olfr1156	T	A	2: 87,949,530	R234S	probably damaging	Het
Olfr1310	T	C	2: 112,008,323	T288A	possibly damaging	Het
Olfr139	A	G	11: 74,044,699	C192R	probably damaging	Het
Olfr517	C	T	7: 108,869,128	V9M	probably damaging	Het
Olfr937	A	G	9: 39,060,174	I164T	probably benign	Het
Pdzd7	T	C	19: 45,045,628	T6A	probably benign	Het
Picalm	T	A	7: 90,189,219	F493Y	probably damaging	Het
Prl7d1	A	G	13: 27,716,668	M1T	probably null	Het
Prl8a1	T	C	13: 27,575,458	K199E	possibly damaging	Het
Rims1	C	T	1: 22,428,489	R764H	probably damaging	Het
Rnf17	G	T	14: 56,475,413	R779L	possibly damaging	Het
Rufy2	T	C	10: 62,998,137	L294P	probably damaging	Het
Sgsh	A	G	11: 119,350,947	L111P	probably damaging	Het
Slc22a30	G	T	19: 8,336,849	T491K	probably benign	Het
Slc35b3	T	C	13: 38,943,068	N20D	possibly damaging	Het
Slc5a4a	T	C	10: 76,181,655	F429L	probably benign	Het
Sulf1	T	C	1: 12,817,412	I270T	probably damaging	Het
Tmem51	T	C	4: 142,031,748	T230A	probably damaging	Het
Tnc	T	A	4: 64,008,710	I860F	probably damaging	Het
Trh	A	T	6: 92,243,698	V61E	possibly damaging	Het
Ttn	T	G	2: 76,754,099	T22222P	probably damaging	Het
Uroc1	A	T	6: 90,361,512	K652*	probably null	Het
Usp34	C	T	11: 23,489,033	P3532S	possibly damaging	Het
Vmn2r7	A	G	3: 64,719,611	F86L	possibly damaging	Het
Vmn2r87	A	T	10: 130,479,987	I70K	possibly damaging	Het
Vps13a	C	T	19: 16,744,953	A332T	probably benign	Het
Zfp568	T	A	7: 30,023,396	C589S	probably damaging	Het

Other mutations in Vmn2r120

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01335:Vmn2r120	APN	17	57525732	missense	possibly damaging	0.86
IGL01346:Vmn2r120	APN	17	57545232	missense	probably benign	0.11
IGL01996:Vmn2r120	APN	17	57525222	missense	possibly damaging	0.92
IGL02503:Vmn2r120	APN	17	57509385	missense	probably benign	0.40
IGL02582:Vmn2r120	APN	17	57524724	missense	probably damaging	0.99
IGL02747:Vmn2r120	APN	17	57524719	missense	probably benign	0.19
IGL02896:Vmn2r120	APN	17	57509008	missense	probably damaging	1.00
IGL03139:Vmn2r120	APN	17	57524742	missense	probably benign	0.39
IGL03342:Vmn2r120	APN	17	57509372	missense	probably benign	0.03
A4554:Vmn2r120	UTSW	17	57525715	missense	probably benign	0.01
R0207:Vmn2r120	UTSW	17	57525052	missense	probably benign	0.17
R0472:Vmn2r120	UTSW	17	57524518	missense	probably benign	0.03
R0517:Vmn2r120	UTSW	17	57508949	missense	probably damaging	1.00
R1109:Vmn2r120	UTSW	17	57525829	missense	probably benign	0.09
R1316:Vmn2r120	UTSW	17	57525939	missense	probably benign	0.28
R1543:Vmn2r120	UTSW	17	57522374	missense	probably benign	0.09
R1795:Vmn2r120	UTSW	17	57525038	missense	probably benign	0.35
R1850:Vmn2r120	UTSW	17	57525826	missense	probably benign	0.19
R1920:Vmn2r120	UTSW	17	57524839	missense	probably benign	0.01
R1921:Vmn2r120	UTSW	17	57524839	missense	probably benign	0.01
R1922:Vmn2r120	UTSW	17	57524839	missense	probably benign	0.01
R2063:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2064:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2065:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2067:Vmn2r120	UTSW	17	57524553	missense	possibly damaging	0.88
R2286:Vmn2r120	UTSW	17	57508958	missense	probably damaging	1.00
R2291:Vmn2r120	UTSW	17	57509479	missense	probably damaging	1.00
R3416:Vmn2r120	UTSW	17	57509241	missense	possibly damaging	0.89
R4023:Vmn2r120	UTSW	17	57536718	missense	possibly damaging	0.92
R4024:Vmn2r120	UTSW	17	57536718	missense	possibly damaging	0.92
R4348:Vmn2r120	UTSW	17	57522466	missense	possibly damaging	0.47
R4409:Vmn2r120	UTSW	17	57509477	missense	probably damaging	1.00
R4610:Vmn2r120	UTSW	17	57509120	missense	probably damaging	1.00
R4771:Vmn2r120	UTSW	17	57524887	missense	probably damaging	1.00
R4786:Vmn2r120	UTSW	17	57522048	missense	probably benign	0.14
R4927:Vmn2r120	UTSW	17	57509125	missense	probably damaging	1.00
R5285:Vmn2r120	UTSW	17	57536703	missense	probably damaging	1.00
R5566:Vmn2r120	UTSW	17	57545290	missense	possibly damaging	0.95
R5578:Vmn2r120	UTSW	17	57522514	missense	probably benign	0.01
R5643:Vmn2r120	UTSW	17	57524977	missense	probably benign	0.01
R5644:Vmn2r120	UTSW	17	57524977	missense	probably benign	0.01
R5781:Vmn2r120	UTSW	17	57524938	missense	probably benign	0.00
R6084:Vmn2r120	UTSW	17	57525721	missense	probably benign	0.15
R6120:Vmn2r120	UTSW	17	57525973	missense	probably benign	0.02
R6160:Vmn2r120	UTSW	17	57509418	missense	probably benign	0.03
R6248:Vmn2r120	UTSW	17	57545287	missense	probably benign	0.03
R6256:Vmn2r120	UTSW	17	57524700	nonsense	probably null
R6730:Vmn2r120	UTSW	17	57525012	missense	probably benign	0.03
R6821:Vmn2r120	UTSW	17	57536659	missense	probably benign	0.00
R6868:Vmn2r120	UTSW	17	57545218	missense	probably benign	0.00
R6880:Vmn2r120	UTSW	17	57509187	missense	probably damaging	1.00
R6986:Vmn2r120	UTSW	17	57509340	missense	probably damaging	1.00
R7276:Vmn2r120	UTSW	17	57524881	missense	probably benign	0.11
R7373:Vmn2r120	UTSW	17	57509406	missense	probably benign	0.35
R7653:Vmn2r120	UTSW	17	57509258	missense	possibly damaging	0.93
R7667:Vmn2r120	UTSW	17	57536657	missense	probably benign	0.04
R7775:Vmn2r120	UTSW	17	57525942	missense	probably damaging	1.00
R7778:Vmn2r120	UTSW	17	57525942	missense	probably damaging	1.00
R7797:Vmn2r120	UTSW	17	57508874	missense	probably damaging	1.00
R7824:Vmn2r120	UTSW	17	57525942	missense	probably damaging	1.00
R7902:Vmn2r120	UTSW	17	57509244	missense	possibly damaging	0.87
R7922:Vmn2r120	UTSW	17	57524683	missense	probably damaging	0.99
R8508:Vmn2r120	UTSW	17	57525843	missense	probably benign	0.03
R8847:Vmn2r120	UTSW	17	57509217	missense	probably benign	0.01
R8882:Vmn2r120	UTSW	17	57545229	missense	probably benign	0.01
R9134:Vmn2r120	UTSW	17	57525093	missense	probably damaging	1.00
R9161:Vmn2r120	UTSW	17	57524864	missense
R9336:Vmn2r120	UTSW	17	57525201	missense	possibly damaging	0.91
RF005:Vmn2r120	UTSW	17	57521991	missense	possibly damaging	0.65
Z1177:Vmn2r120	UTSW	17	57509245	missense	probably benign	0.00
Z1188:Vmn2r120	UTSW	17	57522436	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACCCGTGAAAATGGACAATTC -3'
(R):5'- TCATTTTAGCTGGACCTGGG -3'

Sequencing Primer
(F):5'- CCGTGAAAATGGACAATTCAAATAC -3'
(R):5'- GTGGGGCTGATCATCACAG -3'

Posted On

2015-04-06