Incidental Mutation 'R3876:Olfr934'
ID 276845
Institutional Source Beutler Lab
Gene Symbol Olfr934
Ensembl Gene ENSMUSG00000057424
Gene Name olfactory receptor 934
Synonyms MOR224-6, GA_x6K02T2PVTD-32678895-32677963
MMRRC Submission 041606-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R3876 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 38981026-38988315 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38982870 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 58 (Y58F)
Ref Sequence ENSEMBL: ENSMUSP00000150864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074211] [ENSMUST00000214324] [ENSMUST00000216238] [ENSMUST00000216823]
AlphaFold Q9EQ87
Predicted Effect probably damaging
Transcript: ENSMUST00000074211
AA Change: Y58F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073835
Gene: ENSMUSG00000057424
AA Change: Y58F

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 1.7e-48 PFAM
Pfam:7TM_GPCR_Srsx 33 222 7.2e-9 PFAM
Pfam:7tm_1 39 286 5.4e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214324
AA Change: Y58F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216238
Predicted Effect probably damaging
Transcript: ENSMUST00000216823
AA Change: Y58F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931414P19Rik G A 14: 54,591,400 R215* probably null Het
Brinp2 C A 1: 158,246,846 L568F probably damaging Het
Brip1 T C 11: 86,152,790 Y316C probably damaging Het
Cdk5rap2 ATGTG ATG 4: 70,289,977 probably null Het
Cfap69 G T 5: 5,584,645 probably benign Het
Chrnb4 T C 9: 55,043,898 E27G probably damaging Het
Clec14a A G 12: 58,268,644 V64A possibly damaging Het
Crygs A G 16: 22,806,512 Y60H probably damaging Het
Dpp10 T A 1: 123,353,487 Q611L probably damaging Het
Entpd1 T C 19: 40,736,820 L450P probably damaging Het
Eogt G A 6: 97,120,190 S317L probably damaging Het
Exosc10 T A 4: 148,572,919 S584T probably benign Het
Fam184a C T 10: 53,699,061 V151I probably damaging Het
Fbxo43 A G 15: 36,152,112 V517A probably damaging Het
Flii T C 11: 60,719,872 T533A possibly damaging Het
Frmpd1 T G 4: 45,284,093 H971Q probably benign Het
Gata3 A T 2: 9,863,143 N333K probably damaging Het
Hectd1 A G 12: 51,768,730 S1525P probably damaging Het
Ibtk A G 9: 85,718,426 I816T probably benign Het
Kirrel C T 3: 87,089,151 M380I probably null Het
Krt34 T C 11: 100,040,965 T143A probably benign Het
Lipn G T 19: 34,069,428 M43I probably benign Het
Lrp1b A G 2: 41,445,194 C779R probably damaging Het
Mios G A 6: 8,233,189 R779Q probably damaging Het
Mme A T 3: 63,362,059 probably benign Het
Ncstn A G 1: 172,070,073 S418P probably benign Het
Olfr1209 T C 2: 88,909,608 T262A possibly damaging Het
Olfr1285 T C 2: 111,408,622 V69A possibly damaging Het
Olfr5 G A 7: 6,481,132 A8V probably benign Het
Olfr800 C T 10: 129,660,274 P156L probably benign Het
Oprk1 T A 1: 5,602,661 C340* probably null Het
Pald1 T A 10: 61,347,487 N323Y probably damaging Het
Pcdhac1 C A 18: 37,091,892 A586E probably damaging Het
Pcnx2 C T 8: 125,888,158 A185T probably benign Het
Pik3r1 G A 13: 101,684,957 H430Y probably benign Het
Polr3b G A 10: 84,720,518 probably null Het
Prl8a6 A T 13: 27,433,032 L225* probably null Het
Psme4 T C 11: 30,856,068 S89P probably damaging Het
Pygl G A 12: 70,201,339 T250I probably damaging Het
Rgs13 T A 1: 144,140,790 K72* probably null Het
Ryr2 T A 13: 11,588,159 I4514F probably damaging Het
Sept3 A T 15: 82,285,801 D32V probably damaging Het
Sfrp2 C T 3: 83,767,028 P163S possibly damaging Het
Spata31 A G 13: 64,920,931 T298A probably benign Het
Stxbp2 T C 8: 3,633,369 probably null Het
Syne1 A T 10: 5,052,345 M282K possibly damaging Het
Timd2 T C 11: 46,671,020 probably null Het
Tlr11 G A 14: 50,363,154 V866I probably benign Het
Trappc10 T C 10: 78,220,186 probably null Het
Zfp512b AG AGG 2: 181,588,763 probably null Het
Other mutations in Olfr934
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02156:Olfr934 APN 9 38982546 missense possibly damaging 0.71
R1061:Olfr934 UTSW 9 38982483 missense probably damaging 1.00
R1604:Olfr934 UTSW 9 38982618 missense probably benign 0.01
R1776:Olfr934 UTSW 9 38982894 missense probably damaging 1.00
R3499:Olfr934 UTSW 9 38982465 missense probably damaging 1.00
R3761:Olfr934 UTSW 9 38982366 missense possibly damaging 0.94
R4191:Olfr934 UTSW 9 38983017 missense probably benign 0.01
R4192:Olfr934 UTSW 9 38983017 missense probably benign 0.01
R4333:Olfr934 UTSW 9 38982588 missense possibly damaging 0.85
R4876:Olfr934 UTSW 9 38982626 nonsense probably null
R5539:Olfr934 UTSW 9 38982277 missense possibly damaging 0.85
R6916:Olfr934 UTSW 9 38982904 missense probably benign 0.14
R7097:Olfr934 UTSW 9 38982618 missense probably benign 0.01
R7338:Olfr934 UTSW 9 38982520 missense probably damaging 0.99
R8116:Olfr934 UTSW 9 38982873 missense probably damaging 1.00
R9350:Olfr934 UTSW 9 38982785 missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- TACCTTAGAGGGAAGCATATGGC -3'
(R):5'- TGTCTTGAAGCTATGCGGAATTTC -3'

Sequencing Primer
(F):5'- CGGTCATAAGCCATCACTGTG -3'
(R):5'- AAGCTATGCGGAATTTCTCAGTTG -3'
Posted On 2015-04-06