Incidental Mutation 'R3838:Or10d1'
ID 276996
Institutional Source Beutler Lab
Gene Symbol Or10d1
Ensembl Gene ENSMUSG00000059366
Gene Name olfactory receptor family 10 subfamily D member 1
Synonyms MOR224-3, GA_x6K02T2PVTD-33270211-33269276, Olfr959
MMRRC Submission 040779-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R3838 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 39483618-39484553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39484267 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 96 (V96A)
Ref Sequence ENSEMBL: ENSMUSP00000150349 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079178] [ENSMUST00000215194] [ENSMUST00000216298]
AlphaFold Q9EQ86
Predicted Effect probably benign
Transcript: ENSMUST00000079178
AA Change: V96A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000078176
Gene: ENSMUSG00000059366
AA Change: V96A

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 4.3e-49 PFAM
Pfam:7TM_GPCR_Srsx 33 251 1.2e-7 PFAM
Pfam:7tm_1 39 286 2.7e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215194
AA Change: V96A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216298
AA Change: V96A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.8%
  • 20x: 96.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930486L24Rik A G 13: 60,993,041 (GRCm39) Y213H probably damaging Het
Alg8 C T 7: 97,037,752 (GRCm39) H379Y probably damaging Het
Arhgef25 T C 10: 127,025,605 (GRCm39) T12A probably benign Het
Arid4a A G 12: 71,122,559 (GRCm39) E980G possibly damaging Het
Aspm C T 1: 139,405,792 (GRCm39) H1560Y probably benign Het
Atg10 A T 13: 91,085,499 (GRCm39) I150K probably damaging Het
Bud13 A C 9: 46,201,490 (GRCm39) Q387P possibly damaging Het
Champ1 A G 8: 13,929,939 (GRCm39) Y699C probably damaging Het
Clstn1 A G 4: 149,722,790 (GRCm39) E476G probably damaging Het
Col2a1 T C 15: 97,886,857 (GRCm39) D345G unknown Het
Col2a1 A T 15: 97,898,462 (GRCm39) probably benign Het
Col9a2 C G 4: 120,911,455 (GRCm39) R599G probably damaging Het
Dnajb2 G A 1: 75,218,124 (GRCm39) probably null Het
Dock4 G T 12: 40,844,623 (GRCm39) probably null Het
Epx A T 11: 87,765,656 (GRCm39) L101Q probably damaging Het
F13a1 A T 13: 37,231,398 (GRCm39) N21K probably damaging Het
Fam13c C T 10: 70,378,478 (GRCm39) S336L probably damaging Het
Foxj3 T A 4: 119,473,821 (GRCm39) H215Q possibly damaging Het
Gcnt4 A T 13: 97,083,522 (GRCm39) R273* probably null Het
Gpam T C 19: 55,068,890 (GRCm39) N450S probably benign Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Hmcn2 T C 2: 31,303,419 (GRCm39) L3020P probably damaging Het
Hmgcr A G 13: 96,795,597 (GRCm39) I324T probably benign Het
Ighmbp2 T C 19: 3,321,658 (GRCm39) Y367C probably benign Het
Lrrc14b A G 13: 74,511,664 (GRCm39) C139R possibly damaging Het
Lsamp A T 16: 41,954,675 (GRCm39) E174V possibly damaging Het
Mid1ip1 T C X: 10,584,620 (GRCm39) V51A possibly damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Msn C A X: 95,203,805 (GRCm39) Q303K probably damaging Het
Myh7b A G 2: 155,474,909 (GRCm39) K1816E probably damaging Het
Nap1l1 T A 10: 111,331,183 (GRCm39) probably null Het
Nme2 T A 11: 93,840,803 (GRCm39) E252D probably benign Het
Ntpcr G A 8: 126,464,111 (GRCm39) V79M probably damaging Het
Ogdh C T 11: 6,288,627 (GRCm39) R235* probably null Het
Or10w1 A G 19: 13,632,321 (GRCm39) D176G probably benign Het
Or9k2 C A 10: 129,998,275 (GRCm39) E307* probably null Het
P3r3urf A G 4: 116,030,718 (GRCm39) T41A probably benign Het
Pcdh20 T C 14: 88,705,899 (GRCm39) N467S probably benign Het
Pkhd1 G A 1: 20,604,853 (GRCm39) T1154I possibly damaging Het
Polq G T 16: 36,898,711 (GRCm39) R2157I probably damaging Het
Reep6 C A 10: 80,171,723 (GRCm39) A533E probably damaging Het
Senp2 T C 16: 21,828,485 (GRCm39) S32P probably damaging Het
Septin11 T A 5: 93,296,258 (GRCm39) I52N probably damaging Het
Shld2 T C 14: 33,967,325 (GRCm39) D77G probably benign Het
Slc17a4 C T 13: 24,085,752 (GRCm39) R387H probably benign Het
Spdye4b C T 5: 143,178,084 (GRCm39) T11I probably benign Het
Srrt C T 5: 137,300,387 (GRCm39) probably null Het
Sspo T A 6: 48,457,754 (GRCm39) C3085S probably damaging Het
Stim1 C T 7: 102,060,503 (GRCm39) T182I possibly damaging Het
Thbs2 C A 17: 14,908,113 (GRCm39) V217L probably benign Het
Thpo G A 16: 20,547,498 (GRCm39) R38C probably damaging Het
Tmem210 A G 2: 25,178,444 (GRCm39) E35G possibly damaging Het
Trim12c T A 7: 103,990,075 (GRCm39) probably benign Het
Tvp23b A G 11: 62,774,455 (GRCm39) H33R possibly damaging Het
Usp14 A G 18: 10,024,532 (GRCm39) probably null Het
Vmn2r73 A G 7: 85,507,258 (GRCm39) W685R probably benign Het
Zfp618 G A 4: 63,051,801 (GRCm39) A861T probably benign Het
Zfp715 A G 7: 42,949,180 (GRCm39) V260A probably benign Het
Other mutations in Or10d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02825:Or10d1 APN 9 39,483,877 (GRCm39) missense probably damaging 0.97
R0122:Or10d1 UTSW 9 39,484,020 (GRCm39) missense probably damaging 1.00
R0483:Or10d1 UTSW 9 39,484,139 (GRCm39) missense probably damaging 1.00
R1843:Or10d1 UTSW 9 39,484,031 (GRCm39) missense possibly damaging 0.74
R2038:Or10d1 UTSW 9 39,484,283 (GRCm39) missense probably damaging 1.00
R4801:Or10d1 UTSW 9 39,484,154 (GRCm39) missense probably benign 0.00
R4802:Or10d1 UTSW 9 39,484,154 (GRCm39) missense probably benign 0.00
R4839:Or10d1 UTSW 9 39,484,441 (GRCm39) missense probably benign
R4967:Or10d1 UTSW 9 39,484,054 (GRCm39) missense probably damaging 1.00
R6128:Or10d1 UTSW 9 39,484,549 (GRCm39) missense probably benign 0.00
R6196:Or10d1 UTSW 9 39,483,776 (GRCm39) missense possibly damaging 0.75
R6551:Or10d1 UTSW 9 39,483,856 (GRCm39) missense probably benign 0.00
R7757:Or10d1 UTSW 9 39,483,761 (GRCm39) missense probably benign 0.02
R7892:Or10d1 UTSW 9 39,483,845 (GRCm39) missense possibly damaging 0.96
R8674:Or10d1 UTSW 9 39,484,249 (GRCm39) missense probably damaging 1.00
R8693:Or10d1 UTSW 9 39,483,800 (GRCm39) missense probably damaging 1.00
R8958:Or10d1 UTSW 9 39,484,091 (GRCm39) missense probably benign 0.00
R9101:Or10d1 UTSW 9 39,483,805 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GAAAAGTAGCCTGAATGCAGCC -3'
(R):5'- GGAAACTATGCTCTTTGTCCTG -3'

Sequencing Primer
(F):5'- AGTAGCGTAATGGGTAGC -3'
(R):5'- CTACATCTTCACTCTGATGGGAAAC -3'
Posted On 2015-04-06