Incidental Mutation 'R3838:Nap1l1'
ID 277004
Institutional Source Beutler Lab
Gene Symbol Nap1l1
Ensembl Gene ENSMUSG00000058799
Gene Name nucleosome assembly protein 1-like 1
Synonyms D10Ertd68e
MMRRC Submission 040779-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.333) question?
Stock # R3838 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 111309084-111334011 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 111331183 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151972 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065917] [ENSMUST00000171797] [ENSMUST00000217908] [ENSMUST00000218828] [ENSMUST00000219143] [ENSMUST00000219961]
AlphaFold P28656
Predicted Effect probably null
Transcript: ENSMUST00000065917
SMART Domains Protein: ENSMUSP00000070068
Gene: ENSMUSG00000058799

DomainStartEndE-ValueType
coiled coil region 6 31 N/A INTRINSIC
Pfam:NAP 75 346 1.5e-96 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000171797
SMART Domains Protein: ENSMUSP00000126850
Gene: ENSMUSG00000058799

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
coiled coil region 33 58 N/A INTRINSIC
Pfam:NAP 103 372 9.6e-110 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000217908
Predicted Effect probably null
Transcript: ENSMUST00000218828
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218982
Predicted Effect probably benign
Transcript: ENSMUST00000219143
Predicted Effect probably benign
Transcript: ENSMUST00000219961
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219718
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.8%
  • 20x: 96.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930486L24Rik A G 13: 60,993,041 (GRCm39) Y213H probably damaging Het
Alg8 C T 7: 97,037,752 (GRCm39) H379Y probably damaging Het
Arhgef25 T C 10: 127,025,605 (GRCm39) T12A probably benign Het
Arid4a A G 12: 71,122,559 (GRCm39) E980G possibly damaging Het
Aspm C T 1: 139,405,792 (GRCm39) H1560Y probably benign Het
Atg10 A T 13: 91,085,499 (GRCm39) I150K probably damaging Het
Bud13 A C 9: 46,201,490 (GRCm39) Q387P possibly damaging Het
Champ1 A G 8: 13,929,939 (GRCm39) Y699C probably damaging Het
Clstn1 A G 4: 149,722,790 (GRCm39) E476G probably damaging Het
Col2a1 T C 15: 97,886,857 (GRCm39) D345G unknown Het
Col2a1 A T 15: 97,898,462 (GRCm39) probably benign Het
Col9a2 C G 4: 120,911,455 (GRCm39) R599G probably damaging Het
Dnajb2 G A 1: 75,218,124 (GRCm39) probably null Het
Dock4 G T 12: 40,844,623 (GRCm39) probably null Het
Epx A T 11: 87,765,656 (GRCm39) L101Q probably damaging Het
F13a1 A T 13: 37,231,398 (GRCm39) N21K probably damaging Het
Fam13c C T 10: 70,378,478 (GRCm39) S336L probably damaging Het
Foxj3 T A 4: 119,473,821 (GRCm39) H215Q possibly damaging Het
Gcnt4 A T 13: 97,083,522 (GRCm39) R273* probably null Het
Gpam T C 19: 55,068,890 (GRCm39) N450S probably benign Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Hmcn2 T C 2: 31,303,419 (GRCm39) L3020P probably damaging Het
Hmgcr A G 13: 96,795,597 (GRCm39) I324T probably benign Het
Ighmbp2 T C 19: 3,321,658 (GRCm39) Y367C probably benign Het
Lrrc14b A G 13: 74,511,664 (GRCm39) C139R possibly damaging Het
Lsamp A T 16: 41,954,675 (GRCm39) E174V possibly damaging Het
Mid1ip1 T C X: 10,584,620 (GRCm39) V51A possibly damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Msn C A X: 95,203,805 (GRCm39) Q303K probably damaging Het
Myh7b A G 2: 155,474,909 (GRCm39) K1816E probably damaging Het
Nme2 T A 11: 93,840,803 (GRCm39) E252D probably benign Het
Ntpcr G A 8: 126,464,111 (GRCm39) V79M probably damaging Het
Ogdh C T 11: 6,288,627 (GRCm39) R235* probably null Het
Or10d1 A G 9: 39,484,267 (GRCm39) V96A probably benign Het
Or10w1 A G 19: 13,632,321 (GRCm39) D176G probably benign Het
Or9k2 C A 10: 129,998,275 (GRCm39) E307* probably null Het
P3r3urf A G 4: 116,030,718 (GRCm39) T41A probably benign Het
Pcdh20 T C 14: 88,705,899 (GRCm39) N467S probably benign Het
Pkhd1 G A 1: 20,604,853 (GRCm39) T1154I possibly damaging Het
Polq G T 16: 36,898,711 (GRCm39) R2157I probably damaging Het
Reep6 C A 10: 80,171,723 (GRCm39) A533E probably damaging Het
Senp2 T C 16: 21,828,485 (GRCm39) S32P probably damaging Het
Septin11 T A 5: 93,296,258 (GRCm39) I52N probably damaging Het
Shld2 T C 14: 33,967,325 (GRCm39) D77G probably benign Het
Slc17a4 C T 13: 24,085,752 (GRCm39) R387H probably benign Het
Spdye4b C T 5: 143,178,084 (GRCm39) T11I probably benign Het
Srrt C T 5: 137,300,387 (GRCm39) probably null Het
Sspo T A 6: 48,457,754 (GRCm39) C3085S probably damaging Het
Stim1 C T 7: 102,060,503 (GRCm39) T182I possibly damaging Het
Thbs2 C A 17: 14,908,113 (GRCm39) V217L probably benign Het
Thpo G A 16: 20,547,498 (GRCm39) R38C probably damaging Het
Tmem210 A G 2: 25,178,444 (GRCm39) E35G possibly damaging Het
Trim12c T A 7: 103,990,075 (GRCm39) probably benign Het
Tvp23b A G 11: 62,774,455 (GRCm39) H33R possibly damaging Het
Usp14 A G 18: 10,024,532 (GRCm39) probably null Het
Vmn2r73 A G 7: 85,507,258 (GRCm39) W685R probably benign Het
Zfp618 G A 4: 63,051,801 (GRCm39) A861T probably benign Het
Zfp715 A G 7: 42,949,180 (GRCm39) V260A probably benign Het
Other mutations in Nap1l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01154:Nap1l1 APN 10 111,322,536 (GRCm39) missense probably damaging 0.98
IGL01453:Nap1l1 APN 10 111,328,839 (GRCm39) missense probably benign 0.09
IGL01734:Nap1l1 APN 10 111,328,760 (GRCm39) missense probably benign 0.26
IGL01843:Nap1l1 APN 10 111,328,772 (GRCm39) missense possibly damaging 0.93
PIT1430001:Nap1l1 UTSW 10 111,322,597 (GRCm39) missense probably damaging 1.00
PIT4131001:Nap1l1 UTSW 10 111,322,583 (GRCm39) missense probably null
R0020:Nap1l1 UTSW 10 111,326,884 (GRCm39) missense probably benign 0.01
R0020:Nap1l1 UTSW 10 111,326,884 (GRCm39) missense probably benign 0.01
R0131:Nap1l1 UTSW 10 111,321,370 (GRCm39) missense probably benign 0.17
R0131:Nap1l1 UTSW 10 111,321,370 (GRCm39) missense probably benign 0.17
R0132:Nap1l1 UTSW 10 111,321,370 (GRCm39) missense probably benign 0.17
R0601:Nap1l1 UTSW 10 111,326,224 (GRCm39) splice site probably benign
R1576:Nap1l1 UTSW 10 111,330,681 (GRCm39) missense probably damaging 1.00
R1619:Nap1l1 UTSW 10 111,329,240 (GRCm39) missense possibly damaging 0.77
R1969:Nap1l1 UTSW 10 111,326,914 (GRCm39) missense probably benign 0.03
R2071:Nap1l1 UTSW 10 111,328,761 (GRCm39) missense possibly damaging 0.46
R2383:Nap1l1 UTSW 10 111,329,272 (GRCm39) missense probably damaging 1.00
R3836:Nap1l1 UTSW 10 111,331,183 (GRCm39) splice site probably null
R3837:Nap1l1 UTSW 10 111,331,183 (GRCm39) splice site probably null
R3839:Nap1l1 UTSW 10 111,331,183 (GRCm39) splice site probably null
R4084:Nap1l1 UTSW 10 111,325,938 (GRCm39) missense possibly damaging 0.92
R4609:Nap1l1 UTSW 10 111,328,741 (GRCm39) nonsense probably null
R4985:Nap1l1 UTSW 10 111,325,944 (GRCm39) missense probably benign 0.01
R5906:Nap1l1 UTSW 10 111,326,891 (GRCm39) nonsense probably null
R5982:Nap1l1 UTSW 10 111,331,229 (GRCm39) missense possibly damaging 0.71
R6522:Nap1l1 UTSW 10 111,330,084 (GRCm39) missense probably damaging 0.99
R6868:Nap1l1 UTSW 10 111,330,669 (GRCm39) missense probably damaging 1.00
R7134:Nap1l1 UTSW 10 111,330,655 (GRCm39) critical splice acceptor site probably null
R7202:Nap1l1 UTSW 10 111,326,964 (GRCm39) missense probably damaging 1.00
R7789:Nap1l1 UTSW 10 111,326,317 (GRCm39) missense probably benign 0.01
R7950:Nap1l1 UTSW 10 111,328,769 (GRCm39) missense probably damaging 1.00
R8404:Nap1l1 UTSW 10 111,317,162 (GRCm39) start codon destroyed probably null 0.53
R8502:Nap1l1 UTSW 10 111,317,162 (GRCm39) start codon destroyed probably null 0.53
R8933:Nap1l1 UTSW 10 111,328,710 (GRCm39) missense probably benign 0.04
R9680:Nap1l1 UTSW 10 111,330,657 (GRCm39) missense probably damaging 0.99
R9772:Nap1l1 UTSW 10 111,325,911 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACGTTGGCTGCAGTAAATCTTTTC -3'
(R):5'- CCTTTGTGTGGAAAACAATCTAAGC -3'

Sequencing Primer
(F):5'- AAAGCTGTCTGGATGTCTCAAG -3'
(R):5'- TGTGTGGAAAACAATCTAAGCAACAG -3'
Posted On 2015-04-06