Incidental Mutation 'R3840:Slc22a13'
ID 277118
Institutional Source Beutler Lab
Gene Symbol Slc22a13
Ensembl Gene ENSMUSG00000074028
Gene Name solute carrier family 22 (organic cation transporter), member 13
Synonyms OCTL3, OCTL1, ORCTL3
MMRRC Submission 040780-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R3840 (G1)
Quality Score 206
Status Not validated
Chromosome 9
Chromosomal Location 119022040-119038164 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 119037855 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 91 (D91G)
Ref Sequence ENSEMBL: ENSMUSP00000081855 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084797] [ENSMUST00000170400]
AlphaFold Q6A4L0
Predicted Effect probably benign
Transcript: ENSMUST00000084797
AA Change: D91G

PolyPhen 2 Score 0.176 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000081855
Gene: ENSMUSG00000074028
AA Change: D91G

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
Pfam:Sugar_tr 104 514 2.2e-41 PFAM
Pfam:MFS_1 133 468 2.6e-26 PFAM
Pfam:MFS_1 355 537 2.1e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000170400
SMART Domains Protein: ENSMUSP00000131982
Gene: ENSMUSG00000070280

DomainStartEndE-ValueType
transmembrane domain 68 90 N/A INTRINSIC
Pfam:Sugar_tr 150 555 1.2e-28 PFAM
Pfam:MFS_1 178 514 7.6e-28 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik A T 18: 6,620,104 (GRCm39) K11N probably benign Het
Abcc8 A G 7: 45,757,524 (GRCm39) I1375T possibly damaging Het
Ate1 A T 7: 130,117,867 (GRCm39) D39E probably damaging Het
BC035947 G T 1: 78,474,482 (GRCm39) N683K probably benign Het
Cdca2 A T 14: 67,917,720 (GRCm39) Y559* probably null Het
Cmya5 A G 13: 93,231,140 (GRCm39) V1316A probably damaging Het
Cntnap5b C T 1: 100,311,202 (GRCm39) T936I possibly damaging Het
Col6a5 T C 9: 105,805,810 (GRCm39) N1032S unknown Het
Cracd A T 5: 77,006,858 (GRCm39) Q1073L unknown Het
Epc2 A G 2: 49,378,750 (GRCm39) K68R probably damaging Het
Erbb3 A T 10: 128,406,193 (GRCm39) F1075I probably benign Het
F11r G T 1: 171,288,457 (GRCm39) R100L probably damaging Het
Fam171b C A 2: 83,710,406 (GRCm39) Q693K possibly damaging Het
Fam83c C T 2: 155,676,668 (GRCm39) R34H probably benign Het
Fmn2 GAAGA GAAGAAAGA 1: 174,409,599 (GRCm39) probably null Het
Gask1b T A 3: 79,815,897 (GRCm39) D302E probably benign Het
Ggt1 T A 10: 75,417,219 (GRCm39) Y5* probably null Het
Hsph1 T A 5: 149,544,180 (GRCm39) probably null Het
Jhy T A 9: 40,856,142 (GRCm39) E115V probably benign Het
Kcnu1 G T 8: 26,375,380 (GRCm39) V365L possibly damaging Het
Lrrc4c A G 2: 97,460,537 (GRCm39) T388A probably damaging Het
Mastl T C 2: 23,030,563 (GRCm39) D202G probably damaging Het
Medag T A 5: 149,350,888 (GRCm39) I121N probably damaging Het
Mideas T C 12: 84,218,383 (GRCm39) R526G probably damaging Het
Mocos C T 18: 24,809,681 (GRCm39) A428V probably damaging Het
Mok C T 12: 110,781,591 (GRCm39) V59M probably benign Het
Neb C A 2: 52,097,672 (GRCm39) probably null Het
Nr2c2 C T 6: 92,140,119 (GRCm39) R464W probably damaging Het
Or10al7 A G 17: 38,366,239 (GRCm39) S73P probably damaging Het
Or52s1 G A 7: 102,861,900 (GRCm39) G267R probably damaging Het
Otud1 G T 2: 19,663,554 (GRCm39) E228* probably null Het
Pcdhga11 A T 18: 37,890,602 (GRCm39) N537Y probably damaging Het
Pkd1l1 T C 11: 8,839,050 (GRCm39) Y878C probably damaging Het
Podxl C T 6: 31,500,016 (GRCm39) V485I probably damaging Het
Psmd12 T C 11: 107,376,398 (GRCm39) I44T probably benign Het
Rap1gap T C 4: 137,444,758 (GRCm39) F182S probably damaging Het
Slc4a11 A G 2: 130,529,974 (GRCm39) F268S probably damaging Het
Snap91 C T 9: 86,721,618 (GRCm39) V74M probably damaging Het
Tmem87b T A 2: 128,668,304 (GRCm39) L150* probably null Het
Tmprss7 T A 16: 45,481,195 (GRCm39) R664* probably null Het
Tnfrsf11b T A 15: 54,115,478 (GRCm39) H373L probably damaging Het
Tnfrsf23 A G 7: 143,235,266 (GRCm39) S33P probably benign Het
Tro A G X: 149,429,198 (GRCm39) probably benign Het
Tulp1 A G 17: 28,572,689 (GRCm39) V489A probably damaging Het
Wac C A 18: 7,918,535 (GRCm39) P416H probably damaging Het
Zap70 T A 1: 36,817,498 (GRCm39) I247N probably damaging Het
Zfp617 G A 8: 72,685,961 (GRCm39) G97E probably damaging Het
Other mutations in Slc22a13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02828:Slc22a13 APN 9 119,024,773 (GRCm39) missense probably benign 0.25
IGL02871:Slc22a13 APN 9 119,025,077 (GRCm39) missense probably benign 0.01
R0764:Slc22a13 UTSW 9 119,037,746 (GRCm39) splice site probably null
R1469:Slc22a13 UTSW 9 119,022,361 (GRCm39) missense possibly damaging 0.67
R1469:Slc22a13 UTSW 9 119,022,361 (GRCm39) missense possibly damaging 0.67
R1545:Slc22a13 UTSW 9 119,038,113 (GRCm39) missense probably benign 0.00
R2154:Slc22a13 UTSW 9 119,037,753 (GRCm39) missense probably benign 0.00
R2321:Slc22a13 UTSW 9 119,024,694 (GRCm39) missense possibly damaging 0.61
R3808:Slc22a13 UTSW 9 119,025,143 (GRCm39) missense probably benign
R4736:Slc22a13 UTSW 9 119,022,698 (GRCm39) missense probably damaging 1.00
R6286:Slc22a13 UTSW 9 119,037,778 (GRCm39) nonsense probably null
R6899:Slc22a13 UTSW 9 119,025,473 (GRCm39) missense probably damaging 1.00
R7579:Slc22a13 UTSW 9 119,024,226 (GRCm39) missense possibly damaging 0.62
R8755:Slc22a13 UTSW 9 119,038,126 (GRCm39) start codon destroyed probably damaging 0.98
Z1177:Slc22a13 UTSW 9 119,022,370 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGCATACAGGCAACAGGTAGC -3'
(R):5'- GGCATTCCCAATTTCCTGGC -3'

Sequencing Primer
(F):5'- TACAGGCAACAGGTAGCTATATAC -3'
(R):5'- GCTGCATTCTTCATATTTGGCCAAG -3'
Posted On 2015-04-06