|Institutional Source||Beutler Lab|
|Gene Name||glutamate receptor, ionotropic, kainate 3|
|Essential gene?||Possibly non essential (E-score: 0.280)|
|Stock #||R3842 (G1)|
|Chromosomal Location||125490700-125714173 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 125693954 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000030676 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000030676]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||100% (37/37)|
FUNCTION: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Transcript variants encoding different isoforms have been described for this gene, however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit significantly reduced short- and long-term synaptic potentiation. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Grik3||
(F):5'- AAAGCTGAATACGCACGGC -3'
(R):5'- ACAGCACCGTACTCTATTTTGG -3'
(F):5'- GTCTTGAGGTAGATCCAAGAATTTGC -3'
(R):5'- GTCTGCTTGGCCAGGTCATC -3'