Incidental Mutation 'R3846:Acad10'
ID 277369
Institutional Source Beutler Lab
Gene Symbol Acad10
Ensembl Gene ENSMUSG00000029456
Gene Name acyl-Coenzyme A dehydrogenase family, member 10
Synonyms 2410021P16Rik
MMRRC Submission 040894-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3846 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 121759089-121798577 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 121772749 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 511 (I511F)
Ref Sequence ENSEMBL: ENSMUSP00000107400 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031412] [ENSMUST00000111770]
AlphaFold Q8K370
Predicted Effect probably benign
Transcript: ENSMUST00000031412
AA Change: I511F

PolyPhen 2 Score 0.194 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000031412
Gene: ENSMUSG00000029456
AA Change: I511F

DomainStartEndE-ValueType
Pfam:HAD_2 45 231 1.6e-14 PFAM
Pfam:Hydrolase 88 225 5e-8 PFAM
Pfam:APH 287 531 1.8e-52 PFAM
Pfam:Acyl-CoA_dh_N 660 787 1.7e-15 PFAM
Pfam:Acyl-CoA_dh_M 791 892 2.7e-20 PFAM
Pfam:Acyl-CoA_dh_1 904 1055 1.1e-35 PFAM
Pfam:Acyl-CoA_dh_2 919 1037 6.4e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111770
AA Change: I511F

PolyPhen 2 Score 0.194 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000107400
Gene: ENSMUSG00000029456
AA Change: I511F

DomainStartEndE-ValueType
Pfam:HAD_2 45 231 2.3e-14 PFAM
Pfam:APH 287 523 3.2e-50 PFAM
Pfam:EcKinase 390 504 5.2e-8 PFAM
Pfam:Acyl-CoA_dh_N 660 787 3.4e-14 PFAM
Pfam:Acyl-CoA_dh_M 791 845 2.7e-13 PFAM
Pfam:Acyl-CoA_dh_1 904 1055 9.4e-36 PFAM
Pfam:Acyl-CoA_dh_2 919 1037 1.6e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133775
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137789
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143187
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 97% (38/39)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930568D16Rik A G 2: 35,244,570 (GRCm39) Y261H probably damaging Het
Adgb G A 10: 10,258,465 (GRCm39) probably benign Het
Adgrg3 T C 8: 95,767,049 (GRCm39) V468A probably benign Het
Ano4 A T 10: 88,831,114 (GRCm39) I468N possibly damaging Het
Apool A T X: 111,274,155 (GRCm39) probably benign Het
Arhgap32 T C 9: 32,101,320 (GRCm39) V295A probably benign Het
Ccser2 A G 14: 36,662,245 (GRCm39) V313A probably benign Het
Ctnnd1 T C 2: 84,447,271 (GRCm39) I325V probably benign Het
Cubn T C 2: 13,287,819 (GRCm39) D3420G probably damaging Het
Dnah12 A G 14: 26,431,366 (GRCm39) T395A probably benign Het
Dock2 T G 11: 34,623,198 (GRCm39) H65P possibly damaging Het
Fsip2 A T 2: 82,816,759 (GRCm39) Q4164L possibly damaging Het
Gapvd1 A T 2: 34,619,084 (GRCm39) Y96* probably null Het
Gja3 T A 14: 57,273,161 (GRCm39) K404* probably null Het
Hdac1-ps A G 17: 78,800,401 (GRCm39) K464R possibly damaging Het
Hmcn2 A G 2: 31,320,362 (GRCm39) I3948V possibly damaging Het
Hr C T 14: 70,808,893 (GRCm39) R1090W probably damaging Het
Hrnr A G 3: 93,239,464 (GRCm39) H3234R unknown Het
Ifi207 T A 1: 173,562,869 (GRCm39) E92D probably benign Het
Iqgap2 G A 13: 95,810,186 (GRCm39) probably benign Het
Itgax G T 7: 127,732,939 (GRCm39) V273F probably damaging Het
Lamc3 A G 2: 31,814,604 (GRCm39) M1043V probably benign Het
Lgmn T C 12: 102,370,588 (GRCm39) N114S possibly damaging Het
Mov10l1 A G 15: 88,896,345 (GRCm39) N678D possibly damaging Het
Nlrp9c A G 7: 26,081,701 (GRCm39) probably null Het
Notch4 A G 17: 34,797,071 (GRCm39) T940A probably damaging Het
Nudt15 T A 14: 73,760,911 (GRCm39) Q60L probably benign Het
Or10ag56 T C 2: 87,139,526 (GRCm39) V151A probably benign Het
Or52e7 T C 7: 104,684,896 (GRCm39) C164R probably benign Het
Phip G A 9: 82,758,179 (GRCm39) R1505* probably null Het
Ptger2 T G 14: 45,226,784 (GRCm39) S121R probably damaging Het
Scyl2 A T 10: 89,476,403 (GRCm39) F907L probably damaging Het
Silc1 T A 12: 27,210,301 (GRCm39) noncoding transcript Het
Trpc4 C A 3: 54,225,433 (GRCm39) F843L probably benign Het
Tysnd1 C T 10: 61,531,867 (GRCm39) S173L possibly damaging Het
Vmn2r124 T A 17: 18,293,953 (GRCm39) V680D possibly damaging Het
Vmn2r91 G A 17: 18,327,860 (GRCm39) V485I probably benign Het
Other mutations in Acad10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02379:Acad10 APN 5 121,760,106 (GRCm39) missense probably damaging 1.00
IGL02469:Acad10 APN 5 121,783,522 (GRCm39) missense probably damaging 1.00
IGL02526:Acad10 APN 5 121,784,923 (GRCm39) missense probably damaging 0.99
IGL02623:Acad10 APN 5 121,767,993 (GRCm39) missense possibly damaging 0.94
IGL02643:Acad10 APN 5 121,769,633 (GRCm39) missense probably benign
IGL02685:Acad10 APN 5 121,770,672 (GRCm39) missense probably benign
IGL03139:Acad10 APN 5 121,764,145 (GRCm39) missense probably benign
IGL03267:Acad10 APN 5 121,775,412 (GRCm39) missense probably benign 0.34
P0026:Acad10 UTSW 5 121,775,415 (GRCm39) missense probably damaging 1.00
R0099:Acad10 UTSW 5 121,759,353 (GRCm39) missense probably damaging 1.00
R0453:Acad10 UTSW 5 121,765,445 (GRCm39) nonsense probably null
R1051:Acad10 UTSW 5 121,764,143 (GRCm39) missense probably damaging 0.97
R1052:Acad10 UTSW 5 121,787,604 (GRCm39) missense possibly damaging 0.65
R1116:Acad10 UTSW 5 121,768,814 (GRCm39) missense probably damaging 1.00
R1548:Acad10 UTSW 5 121,764,104 (GRCm39) splice site probably benign
R1548:Acad10 UTSW 5 121,764,103 (GRCm39) splice site probably benign
R1571:Acad10 UTSW 5 121,759,411 (GRCm39) missense probably damaging 0.99
R1592:Acad10 UTSW 5 121,783,444 (GRCm39) missense probably damaging 0.99
R1741:Acad10 UTSW 5 121,785,899 (GRCm39) missense probably damaging 1.00
R1789:Acad10 UTSW 5 121,769,456 (GRCm39) missense possibly damaging 0.67
R1974:Acad10 UTSW 5 121,764,248 (GRCm39) missense possibly damaging 0.95
R2007:Acad10 UTSW 5 121,772,814 (GRCm39) missense probably damaging 1.00
R2085:Acad10 UTSW 5 121,787,523 (GRCm39) missense possibly damaging 0.79
R2351:Acad10 UTSW 5 121,767,990 (GRCm39) missense probably benign 0.23
R2511:Acad10 UTSW 5 121,769,630 (GRCm39) missense probably benign 0.02
R2570:Acad10 UTSW 5 121,768,267 (GRCm39) missense probably damaging 1.00
R3824:Acad10 UTSW 5 121,760,881 (GRCm39) missense probably benign
R4106:Acad10 UTSW 5 121,769,527 (GRCm39) missense probably damaging 0.98
R4107:Acad10 UTSW 5 121,769,527 (GRCm39) missense probably damaging 0.98
R4108:Acad10 UTSW 5 121,769,527 (GRCm39) missense probably damaging 0.98
R5569:Acad10 UTSW 5 121,764,143 (GRCm39) missense probably damaging 0.97
R5704:Acad10 UTSW 5 121,769,606 (GRCm39) missense probably benign 0.03
R5845:Acad10 UTSW 5 121,764,146 (GRCm39) missense probably benign
R5990:Acad10 UTSW 5 121,783,468 (GRCm39) missense probably damaging 1.00
R6019:Acad10 UTSW 5 121,772,864 (GRCm39) missense possibly damaging 0.88
R6145:Acad10 UTSW 5 121,760,096 (GRCm39) missense probably damaging 0.97
R6384:Acad10 UTSW 5 121,790,066 (GRCm39) missense probably benign 0.43
R6491:Acad10 UTSW 5 121,768,220 (GRCm39) missense probably damaging 1.00
R6608:Acad10 UTSW 5 121,770,555 (GRCm39) missense probably benign 0.02
R6941:Acad10 UTSW 5 121,787,420 (GRCm39) missense probably damaging 1.00
R7221:Acad10 UTSW 5 121,768,273 (GRCm39) missense probably damaging 1.00
R7283:Acad10 UTSW 5 121,787,538 (GRCm39) missense possibly damaging 0.79
R7355:Acad10 UTSW 5 121,768,780 (GRCm39) nonsense probably null
R7483:Acad10 UTSW 5 121,794,075 (GRCm39) critical splice donor site probably null
R7553:Acad10 UTSW 5 121,777,318 (GRCm39) missense probably damaging 1.00
R7721:Acad10 UTSW 5 121,784,929 (GRCm39) splice site probably null
R8075:Acad10 UTSW 5 121,790,148 (GRCm39) missense probably benign 0.00
R8400:Acad10 UTSW 5 121,764,268 (GRCm39) missense possibly damaging 0.82
R9171:Acad10 UTSW 5 121,767,981 (GRCm39) missense probably benign 0.14
X0061:Acad10 UTSW 5 121,760,876 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAGAGTGTCAGCTGGCATGC -3'
(R):5'- GGCAAATATTGTCTCCAGCTGTC -3'

Sequencing Primer
(F):5'- TGTCAGCTGGCATGCAGGAG -3'
(R):5'- AGCTGTCTCCATTCATTCTGTGG -3'
Posted On 2015-04-06