Mutagenetix > Incidental Mutation

Incidental Mutation 'R3847:Olfr1037'

277410

Institutional Source

Beutler Lab

Gene Symbol

Olfr1037

Ensembl Gene

ENSMUSG00000075205

Gene Name

olfactory receptor 1037

Synonyms

MOR171-52, MOR256-34P, GA_x6K02T2Q125-47560740-47559775

MMRRC Submission

040895-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

R3847 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

86084671-86087385 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 86085407 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 123 (Y123*)

Ref Sequence

ENSEMBL: ENSMUSP00000150319 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099911] [ENSMUST00000213333] [ENSMUST00000216020] [ENSMUST00000216886]

AlphaFold

Q7TR84

Predicted Effect

probably null
Transcript: ENSMUST00000099911
AA Change: Y123*

SMART Domains

Protein: ENSMUSP00000097495
Gene: ENSMUSG00000075205
AA Change: Y123*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.8e-54	PFAM
Pfam:7tm_1	41	290	1.2e-19	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000117964

Predicted Effect

probably null
Transcript: ENSMUST00000213333
AA Change: Y123*

Predicted Effect

probably null
Transcript: ENSMUST00000216020
AA Change: Y123*

Predicted Effect

probably null
Transcript: ENSMUST00000216886
AA Change: Y123*

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.7%
20x: 96.1%

Validation Efficiency

100% (66/66)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930522L14Rik	T	C	5: 109,736,324		probably null	Het
Abcc12	C	T	8: 86,553,391	E338K	probably benign	Het
Abcc5	A	T	16: 20,372,156	S815T	probably benign	Het
Ankrd16	G	A	2: 11,789,808	E335K	probably benign	Het
Atm	A	G	9: 53,503,075	F905S	possibly damaging	Het
Bckdha	C	T	7: 25,631,652	R281H	probably damaging	Het
Blvra	C	T	2: 127,095,191	T188I	probably damaging	Het
Bmp8b	C	A	4: 123,116,168		probably benign	Het
Cacna2d3	A	G	14: 29,347,120		probably null	Het
Cacng8	T	C	7: 3,394,474	S84P	probably damaging	Het
Cad	T	A	5: 31,061,650	V605E	probably damaging	Het
Ccny	A	G	18: 9,449,641	S11P	probably benign	Het
Col3a1	C	A	1: 45,321,990	P112T	unknown	Het
Corin	T	C	5: 72,422,165	E155G	probably benign	Het
Cul9	T	C	17: 46,525,135	Y1195C	probably damaging	Het
Cyp27a1	A	G	1: 74,737,559	E501G	probably damaging	Het
Dennd3	T	A	15: 73,542,732	N457K	possibly damaging	Het
Dnah7a	T	G	1: 53,501,656	I2520L	probably benign	Het
Dst	C	T	1: 34,212,319	S4165F	probably damaging	Het
Fgf14	A	C	14: 123,980,389	I234R	probably benign	Het
Foxp4	A	G	17: 47,875,528	I442T	unknown	Het
Gad2	T	G	2: 22,684,988	D472E	probably benign	Het
Garnl3	G	T	2: 32,992,228	H832N	probably benign	Het
Gm13941	T	C	2: 111,104,853	M11V	unknown	Het
Gnptab	T	A	10: 88,433,577	L714*	probably null	Het
Golgb1	C	A	16: 36,898,733	Q334K	probably benign	Het
Gp9	A	G	6: 87,779,151	I49M	probably benign	Het
Guf1	A	G	5: 69,561,157	N213S	probably damaging	Het
H2-K1	T	G	17: 33,997,329	H281P	probably damaging	Het
Hhip	T	A	8: 79,997,495	M373L	probably benign	Het
Ifi203	C	T	1: 173,933,796	C229Y	possibly damaging	Het
Ighv13-2	A	G	12: 114,357,798	L88S	probably damaging	Het
Kcna3	T	C	3: 107,036,696	Y92H	possibly damaging	Het
Lmo7	A	G	14: 101,922,095		probably null	Het
Lrguk	A	G	6: 34,073,768	D387G	probably damaging	Het
Mki67	A	C	7: 135,696,130	S2392A	probably benign	Het
Mknk2	C	T	10: 80,667,975	W367*	probably null	Het
Mocos	A	G	18: 24,676,662	K441E	probably damaging	Het
Mpnd	T	C	17: 56,011,692	S150P	probably damaging	Het
Naip2	A	T	13: 100,179,432	L280Q	probably damaging	Het
Naip2	G	C	13: 100,179,433	L280V	probably damaging	Het
Neurod4	C	T	10: 130,270,482	V308I	probably benign	Het
Nxf3	C	T	X: 136,073,983	V474I	probably benign	Het
Olfr976	A	T	9: 39,956,581	M118K	probably damaging	Het
Pam	T	A	1: 97,854,756		probably benign	Het
Pde5a	T	C	3: 122,803,160	Y467H	probably damaging	Het
Pibf1	T	A	14: 99,137,121	V332E	possibly damaging	Het
Plxna1	C	A	6: 89,356,519	R376L	probably damaging	Het
Proz	A	G	8: 13,073,533	E268G	probably benign	Het
Rimbp3	A	T	16: 17,210,299	H529L	probably benign	Het
Rnf103	C	G	6: 71,508,875	C163W	probably damaging	Het
Rnf17	T	C	14: 56,512,296	V1433A	probably damaging	Het
Sept11	G	T	5: 93,162,167	M276I	probably damaging	Het
Slc30a4	A	G	2: 122,702,272	V50A	probably damaging	Het
Sorbs1	A	G	19: 40,314,443	V570A	probably damaging	Het
Spout1	T	C	2: 30,177,407		probably null	Het
Syne2	T	C	12: 76,048,622	L5241P	probably damaging	Het
Tas2r110	T	A	6: 132,868,675	I223N	probably damaging	Het
Tead2	T	A	7: 45,232,328		probably null	Het
Thsd1	A	G	8: 22,259,411	H713R	probably damaging	Het
Ttc21b	A	G	2: 66,242,679	L221S	probably damaging	Het
Ugcg	C	T	4: 59,207,798	P46S	probably benign	Het
Vmn2r105	A	G	17: 20,208,690	I708T	possibly damaging	Het
Vmn2r117	G	T	17: 23,460,415	H612N	probably damaging	Het
Wnk1	C	T	6: 119,969,354	G613S	possibly damaging	Het
Zbtb41	T	A	1: 139,423,996	H282Q	probably benign	Het
Zfp335	C	A	2: 164,900,106		probably null	Het
Zmym2	T	A	14: 56,921,499		probably benign	Het

Other mutations in Olfr1037

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01390:Olfr1037	APN	2	86085640	missense	probably benign	0.05
IGL02534:Olfr1037	APN	2	86085369	missense	probably damaging	1.00
IGL03204:Olfr1037	APN	2	86085671	nonsense	probably null
R0054:Olfr1037	UTSW	2	86085361	missense	probably benign	0.38
R0054:Olfr1037	UTSW	2	86085361	missense	probably benign	0.38
R0131:Olfr1037	UTSW	2	86085500	missense	probably damaging	1.00
R0131:Olfr1037	UTSW	2	86085500	missense	probably damaging	1.00
R0666:Olfr1037	UTSW	2	86085213	missense	probably benign	0.03
R0732:Olfr1037	UTSW	2	86085584	missense	probably benign	0.00
R1167:Olfr1037	UTSW	2	86085291	missense	probably benign	0.16
R1899:Olfr1037	UTSW	2	86085720	missense	probably benign
R3082:Olfr1037	UTSW	2	86085709	missense	probably benign
R3848:Olfr1037	UTSW	2	86085407	nonsense	probably null
R4079:Olfr1037	UTSW	2	86085312	missense	possibly damaging	0.67
R4193:Olfr1037	UTSW	2	86085700	missense	probably benign	0.01
R4832:Olfr1037	UTSW	2	86084846	missense	probably benign	0.00
R5244:Olfr1037	UTSW	2	86084956	missense	probably damaging	1.00
R5643:Olfr1037	UTSW	2	86085159	missense	probably damaging	0.98
R5644:Olfr1037	UTSW	2	86085159	missense	probably damaging	0.98
R5974:Olfr1037	UTSW	2	86084881	missense	probably benign
R6136:Olfr1037	UTSW	2	86084901	missense	probably damaging	1.00
R6189:Olfr1037	UTSW	2	86084913	missense	possibly damaging	0.53
R6483:Olfr1037	UTSW	2	86085440	missense	probably benign	0.00
R6569:Olfr1037	UTSW	2	86085505	missense	possibly damaging	0.87
R6724:Olfr1037	UTSW	2	86085357	missense	possibly damaging	0.81
R6867:Olfr1037	UTSW	2	86085738	missense	possibly damaging	0.59
R7081:Olfr1037	UTSW	2	86085595	missense	probably damaging	1.00
R7207:Olfr1037	UTSW	2	86084815	missense	possibly damaging	0.93
R7436:Olfr1037	UTSW	2	86084907	missense	probably damaging	1.00
R8699:Olfr1037	UTSW	2	86085174	missense	probably damaging	0.98
R9347:Olfr1037	UTSW	2	86085567	missense	possibly damaging	0.78
R9798:Olfr1037	UTSW	2	86085262	missense	probably damaging	0.99
X0062:Olfr1037	UTSW	2	86085114	missense	probably damaging	1.00
Z1088:Olfr1037	UTSW	2	86084982	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- AAATCTCCTTGAGGCTGGTG -3'
(R):5'- TAATCTGGCCTTTGTAGACCTTTG -3'

Sequencing Primer
(F):5'- CTGGTGTCTGAGCAGGCAAG -3'
(R):5'- AGACCTTTGCTATTCCTCTTCGGTAG -3'

Posted On

2015-04-06