Mutagenetix > Incidental Mutations

Incidental Mutation 'R3847:Zmym2'

277448

Institutional Source

Beutler Lab

Gene Symbol

Zmym2

Ensembl Gene

ENSMUSG00000021945

Gene Name

zinc finger, MYM-type 2

Synonyms

RAMP, FIM, MYM, Zfp198, SCLL

MMRRC Submission

040895-MU

Accession Numbers

Is this an essential gene?

Possibly essential (E-score: 0.717) question?

Stock #

R3847 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

56886653-56962701 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 56921499 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000022511 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022511]

Predicted Effect

probably benign
Transcript: ENSMUST00000022511

SMART Domains

Protein: ENSMUSP00000022511
Gene: ENSMUSG00000021945

Domain	Start	End	E-Value	Type
TRASH	330	366	1.55e-5	SMART
TRASH	372	412	7.69e-1	SMART
TRASH	424	459	7.5e1	SMART
TRASH	466	505	6.53e-4	SMART
Pfam:zf-FCS	527	569	1.8e-9	PFAM
TRASH	583	619	4.79e1	SMART
TRASH	638	674	8.49e-3	SMART
TRASH	680	715	7.28e-2	SMART
TRASH	726	761	1.95e-2	SMART
TRASH	767	802	3.89e1	SMART
low complexity region	881	895	N/A	INTRINSIC
low complexity region	904	917	N/A	INTRINSIC
low complexity region	1087	1111	N/A	INTRINSIC
Pfam:DUF3504	1191	1359	7.3e-66	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224922

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.7%
20x: 96.1%

Validation Efficiency

100% (66/66)

MGI Phenotype

FUNCTION: This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transforming growth factor-beta signaling as a Smad binding protein. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit prenatal lethality. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930522L14Rik	T	C	5: 109,736,324		probably null	Het
Abcc12	C	T	8: 86,553,391	E338K	probably benign	Het
Abcc5	A	T	16: 20,372,156	S815T	probably benign	Het
Ankrd16	G	A	2: 11,789,808	E335K	probably benign	Het
Atm	A	G	9: 53,503,075	F905S	possibly damaging	Het
Bckdha	C	T	7: 25,631,652	R281H	probably damaging	Het
Blvra	C	T	2: 127,095,191	T188I	probably damaging	Het
Bmp8b	C	A	4: 123,116,168		probably benign	Het
Cacna2d3	A	G	14: 29,347,120		probably null	Het
Cacng8	T	C	7: 3,394,474	S84P	probably damaging	Het
Cad	T	A	5: 31,061,650	V605E	probably damaging	Het
Ccny	A	G	18: 9,449,641	S11P	probably benign	Het
Col3a1	C	A	1: 45,321,990	P112T	unknown	Het
Corin	T	C	5: 72,422,165	E155G	probably benign	Het
Cul9	T	C	17: 46,525,135	Y1195C	probably damaging	Het
Cyp27a1	A	G	1: 74,737,559	E501G	probably damaging	Het
Dennd3	T	A	15: 73,542,732	N457K	possibly damaging	Het
Dnah7a	T	G	1: 53,501,656	I2520L	probably benign	Het
Dst	C	T	1: 34,212,319	S4165F	probably damaging	Het
Fgf14	A	C	14: 123,980,389	I234R	probably benign	Het
Foxp4	A	G	17: 47,875,528	I442T	unknown	Het
Gad2	T	G	2: 22,684,988	D472E	probably benign	Het
Garnl3	G	T	2: 32,992,228	H832N	probably benign	Het
Gm13941	T	C	2: 111,104,853	M11V	unknown	Het
Gnptab	T	A	10: 88,433,577	L714*	probably null	Het
Golgb1	C	A	16: 36,898,733	Q334K	probably benign	Het
Gp9	A	G	6: 87,779,151	I49M	probably benign	Het
Guf1	A	G	5: 69,561,157	N213S	probably damaging	Het
H2-K1	T	G	17: 33,997,329	H281P	probably damaging	Het
Hhip	T	A	8: 79,997,495	M373L	probably benign	Het
Ifi203	C	T	1: 173,933,796	C229Y	possibly damaging	Het
Ighv13-2	A	G	12: 114,357,798	L88S	probably damaging	Het
Kcna3	T	C	3: 107,036,696	Y92H	possibly damaging	Het
Lmo7	A	G	14: 101,922,095		probably null	Het
Lrguk	A	G	6: 34,073,768	D387G	probably damaging	Het
Mki67	A	C	7: 135,696,130	S2392A	probably benign	Het
Mknk2	C	T	10: 80,667,975	W367*	probably null	Het
Mocos	A	G	18: 24,676,662	K441E	probably damaging	Het
Mpnd	T	C	17: 56,011,692	S150P	probably damaging	Het
Naip2	A	T	13: 100,179,432	L280Q	probably damaging	Het
Naip2	G	C	13: 100,179,433	L280V	probably damaging	Het
Neurod4	C	T	10: 130,270,482	V308I	probably benign	Het
Nxf3	C	T	X: 136,073,983	V474I	probably benign	Het
Olfr1037	A	T	2: 86,085,407	Y123*	probably null	Het
Olfr976	A	T	9: 39,956,581	M118K	probably damaging	Het
Pam	T	A	1: 97,854,756		probably benign	Het
Pde5a	T	C	3: 122,803,160	Y467H	probably damaging	Het
Pibf1	T	A	14: 99,137,121	V332E	possibly damaging	Het
Plxna1	C	A	6: 89,356,519	R376L	probably damaging	Het
Proz	A	G	8: 13,073,533	E268G	probably benign	Het
Rimbp3	A	T	16: 17,210,299	H529L	probably benign	Het
Rnf103	C	G	6: 71,508,875	C163W	probably damaging	Het
Rnf17	T	C	14: 56,512,296	V1433A	probably damaging	Het
Sept11	G	T	5: 93,162,167	M276I	probably damaging	Het
Slc30a4	A	G	2: 122,702,272	V50A	probably damaging	Het
Sorbs1	A	G	19: 40,314,443	V570A	probably damaging	Het
Spout1	T	C	2: 30,177,407		probably null	Het
Syne2	T	C	12: 76,048,622	L5241P	probably damaging	Het
Tas2r110	T	A	6: 132,868,675	I223N	probably damaging	Het
Tead2	T	A	7: 45,232,328		probably null	Het
Thsd1	A	G	8: 22,259,411	H713R	probably damaging	Het
Ttc21b	A	G	2: 66,242,679	L221S	probably damaging	Het
Ugcg	C	T	4: 59,207,798	P46S	probably benign	Het
Vmn2r105	A	G	17: 20,208,690	I708T	possibly damaging	Het
Vmn2r117	G	T	17: 23,460,415	H612N	probably damaging	Het
Wnk1	C	T	6: 119,969,354	G613S	possibly damaging	Het
Zbtb41	T	A	1: 139,423,996	H282Q	probably benign	Het
Zfp335	C	A	2: 164,900,106		probably null	Het

Other mutations in Zmym2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00516:Zmym2	APN	14	56947937	splice site	probably benign
IGL00587:Zmym2	APN	14	56903360	missense	possibly damaging	0.86
IGL00736:Zmym2	APN	14	56903211	missense	probably benign	0.01
IGL00753:Zmym2	APN	14	56957060	nonsense	probably null
IGL01608:Zmym2	APN	14	56948015	missense	possibly damaging	0.57
IGL01744:Zmym2	APN	14	56946572	missense	probably benign	0.24
IGL02150:Zmym2	APN	14	56911069	splice site	probably benign
IGL02186:Zmym2	APN	14	56943351	missense	probably benign	0.09
IGL02654:Zmym2	APN	14	56911315	missense	probably damaging	1.00
IGL02960:Zmym2	APN	14	56938413	missense	probably benign	0.09
IGL03104:Zmym2	APN	14	56950327	missense	possibly damaging	0.88
IGL03162:Zmym2	APN	14	56914043	missense	probably benign	0.24
IGL03356:Zmym2	APN	14	56957060	nonsense	probably null
IGL03412:Zmym2	APN	14	56959719	nonsense	probably null
R0131:Zmym2	UTSW	14	56943258	missense	probably benign
R0131:Zmym2	UTSW	14	56943258	missense	probably benign
R0132:Zmym2	UTSW	14	56943258	missense	probably benign
R0270:Zmym2	UTSW	14	56949684	splice site	probably null
R0834:Zmym2	UTSW	14	56956963	missense	probably damaging	1.00
R1071:Zmym2	UTSW	14	56959821	missense	possibly damaging	0.93
R1386:Zmym2	UTSW	14	56913091	missense	probably damaging	1.00
R1442:Zmym2	UTSW	14	56943327	missense	probably damaging	0.99
R1472:Zmym2	UTSW	14	56911183	missense	probably benign	0.20
R1595:Zmym2	UTSW	14	56920730	missense	probably benign	0.25
R1598:Zmym2	UTSW	14	56902769	missense	possibly damaging	0.94
R1598:Zmym2	UTSW	14	56914067	missense	probably damaging	1.00
R1916:Zmym2	UTSW	14	56959842	missense	probably damaging	1.00
R2261:Zmym2	UTSW	14	56928262	missense	probably damaging	1.00
R2393:Zmym2	UTSW	14	56920723	missense	probably benign	0.17
R2866:Zmym2	UTSW	14	56928248	missense	probably damaging	1.00
R3727:Zmym2	UTSW	14	56919349	splice site	probably benign
R4043:Zmym2	UTSW	14	56958308	splice site	probably benign
R4074:Zmym2	UTSW	14	56903004	missense	probably damaging	0.99
R4343:Zmym2	UTSW	14	56921562	missense	probably damaging	0.99
R4420:Zmym2	UTSW	14	56956878	missense	probably damaging	0.98
R4645:Zmym2	UTSW	14	56928307	missense	probably damaging	1.00
R5015:Zmym2	UTSW	14	56921594	missense	probably damaging	1.00
R5038:Zmym2	UTSW	14	56956180	missense	possibly damaging	0.86
R5223:Zmym2	UTSW	14	56946514	missense	probably benign
R5364:Zmym2	UTSW	14	56920645	missense	possibly damaging	0.58
R5488:Zmym2	UTSW	14	56956255	missense	possibly damaging	0.56
R5489:Zmym2	UTSW	14	56956255	missense	possibly damaging	0.56
R5818:Zmym2	UTSW	14	56946529	missense	probably benign
R6160:Zmym2	UTSW	14	56950309	missense	probably damaging	1.00
R6437:Zmym2	UTSW	14	56903004	missense	probably damaging	1.00
R7107:Zmym2	UTSW	14	56902712	missense	probably benign	0.01
R7153:Zmym2	UTSW	14	56950202	missense	probably benign	0.16
R7337:Zmym2	UTSW	14	56944100	missense	probably benign	0.04
R7535:Zmym2	UTSW	14	56957079	missense	probably damaging	1.00
R7730:Zmym2	UTSW	14	56956181	missense	possibly damaging	0.95
R7779:Zmym2	UTSW	14	56928283	missense	probably damaging	1.00
R7849:Zmym2	UTSW	14	56946563	missense	probably benign	0.03
R7932:Zmym2	UTSW	14	56946563	missense	probably benign	0.03
Z1176:Zmym2	UTSW	14	56912999	missense	possibly damaging	0.94
Z1177:Zmym2	UTSW	14	56913962	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ATGTTTGTTTTAGGTAATTTGACAGC -3'
(R):5'- TCTCATCAGGCACTCAACAAATTAA -3'

Sequencing Primer
(F):5'- TGGAACTCACTTTGTAGACCACG -3'
(R):5'- GGCACTCAACAAATTAAAAGTAACAG -3'

Posted On

2015-04-06