Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00466:Mroh5'

277521

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mroh5

Ensembl Gene

ENSMUSG00000072487

Gene Name

maestro heat-like repeat family member 5

Synonyms

Gm628, LOC268816

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL00466

Quality Score

Status

Chromosome

Chromosomal Location

73658785-73711520 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to A at 73664638 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000118236 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071419] [ENSMUST00000110021] [ENSMUST00000151999]

AlphaFold

A0A571BEG0

Predicted Effect

probably benign
Transcript: ENSMUST00000071419

SMART Domains

Protein: ENSMUSP00000071366
Gene: ENSMUSG00000072487

Domain	Start	End	E-Value	Type
low complexity region	173	184	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000110021

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136698

Predicted Effect

probably benign
Transcript: ENSMUST00000151999

SMART Domains

Protein: ENSMUSP00000118236
Gene: ENSMUSG00000072487

Domain	Start	End	E-Value	Type
low complexity region	5	16	N/A	INTRINSIC
SCOP:d1gw5a_	294	635	1e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim1	C	T	19: 57,056,618 (GRCm39)	A359T	probably damaging	Het
Atm	A	G	9: 53,410,412 (GRCm39)		probably benign	Het
Ccdc59	G	A	10: 105,683,035 (GRCm39)	S240N	probably benign	Het
Ccdc59	A	T	10: 105,683,034 (GRCm39)	S240C	probably benign	Het
Chrm1	A	T	19: 8,655,438 (GRCm39)	I48F	probably benign	Het
Col28a1	T	C	6: 8,022,081 (GRCm39)		probably benign	Het
Gys2	G	A	6: 142,409,016 (GRCm39)	Q80*	probably null	Het
Hck	A	T	2: 152,978,653 (GRCm39)	T289S	probably benign	Het
Il1rapl2	A	G	X: 137,735,292 (GRCm39)	D403G	probably damaging	Het
Kif16b	A	T	2: 142,689,955 (GRCm39)	L319*	probably null	Het
Kit	T	C	5: 75,771,479 (GRCm39)	I212T	probably benign	Het
Muc6	T	C	7: 141,232,169 (GRCm39)	Y986C	possibly damaging	Het
Nln	A	C	13: 104,172,153 (GRCm39)	V641G	probably damaging	Het
Nyap2	C	A	1: 81,169,695 (GRCm39)	L151I	probably damaging	Het
Plce1	A	G	19: 38,709,473 (GRCm39)	Y1109C	probably damaging	Het
Slc10a4	T	C	5: 73,169,263 (GRCm39)	I296T	probably damaging	Het
Slc35c1	T	A	2: 92,284,703 (GRCm39)	I304F	probably benign	Het
Stxbp2	C	T	8: 3,684,065 (GRCm39)	A124V	probably benign	Het
Stxbp5	A	G	10: 9,675,694 (GRCm39)	Y642H	probably damaging	Het
Tecta	T	C	9: 42,243,844 (GRCm39)	T2003A	probably damaging	Het
Zfp804a	C	A	2: 81,884,219 (GRCm39)	L29I	probably benign	Het

Other mutations in Mroh5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00420:Mroh5	APN	15	73,664,638 (GRCm39)	splice site	probably benign
IGL02937:Mroh5	APN	15	73,661,827 (GRCm39)	missense	probably damaging	1.00
R0102:Mroh5	UTSW	15	73,691,199 (GRCm39)	missense	probably benign	0.07
R0321:Mroh5	UTSW	15	73,661,892 (GRCm39)	missense	probably damaging	1.00
R0433:Mroh5	UTSW	15	73,662,657 (GRCm39)	missense	probably damaging	1.00
R0433:Mroh5	UTSW	15	73,661,877 (GRCm39)	missense	probably benign	0.01
R0707:Mroh5	UTSW	15	73,662,588 (GRCm39)	missense	possibly damaging	0.48
R1666:Mroh5	UTSW	15	73,659,754 (GRCm39)	missense	probably benign	0.43
R1668:Mroh5	UTSW	15	73,659,754 (GRCm39)	missense	probably benign	0.43
R2139:Mroh5	UTSW	15	73,661,940 (GRCm39)	missense	probably damaging	1.00
R2269:Mroh5	UTSW	15	73,664,997 (GRCm39)	missense	probably benign	0.02
R4078:Mroh5	UTSW	15	73,657,889 (GRCm39)	missense	possibly damaging	0.79
R4420:Mroh5	UTSW	15	73,654,923 (GRCm39)	small deletion	probably benign
R4460:Mroh5	UTSW	15	73,663,645 (GRCm39)	missense	probably damaging	0.97
R4585:Mroh5	UTSW	15	73,661,120 (GRCm39)	missense	probably benign	0.38
R5285:Mroh5	UTSW	15	73,654,923 (GRCm39)	small deletion	probably benign
R5287:Mroh5	UTSW	15	73,654,923 (GRCm39)	small deletion	probably benign
R5437:Mroh5	UTSW	15	73,659,818 (GRCm39)	missense	probably benign	0.02
R5760:Mroh5	UTSW	15	73,693,356 (GRCm39)	missense	probably damaging	0.98
R5972:Mroh5	UTSW	15	73,662,568 (GRCm39)	critical splice donor site	probably null
R6192:Mroh5	UTSW	15	73,662,630 (GRCm39)	missense	probably damaging	1.00
R6457:Mroh5	UTSW	15	73,662,691 (GRCm39)	missense	probably damaging	1.00
R6477:Mroh5	UTSW	15	73,662,604 (GRCm39)	missense	probably damaging	1.00
R6776:Mroh5	UTSW	15	73,661,817 (GRCm39)	critical splice donor site	probably null
R6979:Mroh5	UTSW	15	73,664,978 (GRCm39)	missense	probably benign	0.16
R7238:Mroh5	UTSW	15	73,663,278 (GRCm39)	critical splice acceptor site	probably null
R7406:Mroh5	UTSW	15	73,659,583 (GRCm39)	missense	probably benign	0.38
R7853:Mroh5	UTSW	15	73,663,189 (GRCm39)	missense	probably benign	0.00
R7973:Mroh5	UTSW	15	73,664,614 (GRCm39)	nonsense	probably null
R8215:Mroh5	UTSW	15	73,691,139 (GRCm39)	missense	probably damaging	0.96
R8251:Mroh5	UTSW	15	73,655,002 (GRCm39)	missense	probably benign	0.01
R8771:Mroh5	UTSW	15	73,693,203 (GRCm39)	missense	possibly damaging	0.92
R9032:Mroh5	UTSW	15	73,655,302 (GRCm39)	missense	probably benign	0.00
R9070:Mroh5	UTSW	15	73,656,688 (GRCm39)	missense	probably damaging	1.00
R9238:Mroh5	UTSW	15	73,663,586 (GRCm39)	missense	probably benign	0.05
R9321:Mroh5	UTSW	15	73,661,113 (GRCm39)	missense	probably benign	0.00
X0024:Mroh5	UTSW	15	73,659,570 (GRCm39)	missense	probably benign	0.01
Z1088:Mroh5	UTSW	15	73,659,880 (GRCm39)	missense	possibly damaging	0.85

Posted On

2015-04-16