Incidental Mutation 'IGL00899:Lilra6'
ID 27758
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lilra6
Ensembl Gene ENSMUSG00000030427
Gene Name leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
Synonyms Pira3, 7M1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock # IGL00899
Quality Score
Status
Chromosome 7
Chromosomal Location 3908280-3915503 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 3913057 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 268 (T268S)
Ref Sequence ENSEMBL: ENSMUSP00000042636 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]
AlphaFold A0A0B4J1F3
Predicted Effect probably damaging
Transcript: ENSMUST00000038176
AA Change: T268S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427
AA Change: T268S

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
IG_like 40 105 3.11e0 SMART
IG 129 315 4.53e-2 SMART
IG_like 237 302 1.54e-1 SMART
IG_like 328 415 1.79e1 SMART
IG_like 429 517 2.66e1 SMART
IG 529 618 8.59e-3 SMART
low complexity region 637 646 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000090689
AA Change: T268S

PolyPhen 2 Score 0.519 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427
AA Change: T268S

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
IG_like 34 118 7.25e0 SMART
IG_like 129 220 1.62e2 SMART
IG_like 290 377 1.79e1 SMART
IG_like 391 479 2.66e1 SMART
IG 491 580 8.59e-3 SMART
low complexity region 599 608 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131255
Predicted Effect probably benign
Transcript: ENSMUST00000206077
AA Change: T27S

PolyPhen 2 Score 0.387 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206851
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AU018091 A G 7: 3,158,763 I442T probably benign Het
Bpifb9a T C 2: 154,264,727 probably null Het
Ccp110 T A 7: 118,722,684 C521S probably benign Het
Chd6 A G 2: 161,029,298 probably benign Het
Cndp2 A T 18: 84,677,376 D133E probably damaging Het
Crygs T C 16: 22,806,562 E43G possibly damaging Het
Ednra C T 8: 77,675,071 G197R probably damaging Het
Esyt1 A G 10: 128,517,063 L656P probably damaging Het
Ets1 C T 9: 32,752,808 P118L probably damaging Het
Fam98c A G 7: 29,152,853 probably benign Het
Foxi1 G A 11: 34,205,772 T286I probably benign Het
Gimap5 G A 6: 48,753,173 A226T possibly damaging Het
Heatr1 C T 13: 12,435,176 A2017V probably benign Het
Ikbkb T C 8: 22,660,447 S740G possibly damaging Het
Inppl1 A T 7: 101,829,158 I617N probably damaging Het
Itpkb T C 1: 180,332,993 L228P probably benign Het
Kcnc4 T A 3: 107,458,463 D143V possibly damaging Het
Krtdap T A 7: 30,789,962 probably null Het
M6pr A G 6: 122,315,395 E183G possibly damaging Het
Muc5ac T A 7: 141,812,703 V2168D possibly damaging Het
Nbea A G 3: 55,642,845 S2721P probably benign Het
Olfr352 A T 2: 36,870,210 I215L probably benign Het
Pqbp1 T C X: 7,896,004 N94S probably benign Het
Prl3d2 T C 13: 27,122,349 S20P probably damaging Het
Psmb2 T C 4: 126,707,557 I151T probably benign Het
Rapgef6 G T 11: 54,620,018 E107* probably null Het
Slc2a13 T C 15: 91,497,399 T296A probably benign Het
Tcl1b4 A G 12: 105,204,657 T55A probably damaging Het
Tg T C 15: 66,674,073 probably null Het
Trim80 T G 11: 115,447,665 N440K probably benign Het
Ttc13 C T 8: 124,688,847 probably benign Het
Ttc38 T A 15: 85,844,462 I205N possibly damaging Het
Ufl1 T C 4: 25,262,238 D336G probably damaging Het
Vmn2r74 A T 7: 85,957,130 I336K probably benign Het
Zbtb26 G T 2: 37,436,258 Y255* probably null Het
Zfp462 T A 4: 55,007,732 V57E probably damaging Het
Other mutations in Lilra6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00508:Lilra6 APN 7 3911554 missense probably benign 0.04
IGL00569:Lilra6 APN 7 3914589 missense probably damaging 0.99
IGL00955:Lilra6 APN 7 3911404 splice site probably benign
IGL01585:Lilra6 APN 7 3914499 missense probably benign 0.01
IGL02195:Lilra6 APN 7 3914550 missense probably benign 0.00
IGL02586:Lilra6 APN 7 3908820 missense probably benign 0.36
IGL02719:Lilra6 APN 7 3912992 missense possibly damaging 0.96
IGL03166:Lilra6 APN 7 3912627 missense possibly damaging 0.69
IGL03329:Lilra6 APN 7 3914648 splice site probably benign
R0233:Lilra6 UTSW 7 3914936 missense possibly damaging 0.69
R0233:Lilra6 UTSW 7 3914936 missense possibly damaging 0.69
R0423:Lilra6 UTSW 7 3914775 splice site probably benign
R0483:Lilra6 UTSW 7 3913139 missense probably benign 0.02
R0511:Lilra6 UTSW 7 3912785 missense possibly damaging 0.77
R1472:Lilra6 UTSW 7 3912719 missense probably damaging 1.00
R1560:Lilra6 UTSW 7 3911408 critical splice donor site probably null
R1584:Lilra6 UTSW 7 3912662 missense probably damaging 1.00
R1781:Lilra6 UTSW 7 3915067 missense probably benign 0.28
R2411:Lilra6 UTSW 7 3911454 missense probably damaging 1.00
R2420:Lilra6 UTSW 7 3914858 missense probably damaging 1.00
R4021:Lilra6 UTSW 7 3911418 missense probably benign 0.20
R4074:Lilra6 UTSW 7 3914890 missense probably benign 0.23
R4284:Lilra6 UTSW 7 3908804 missense possibly damaging 0.76
R4508:Lilra6 UTSW 7 3912029 nonsense probably null
R4894:Lilra6 UTSW 7 3912531 missense probably benign 0.01
R4977:Lilra6 UTSW 7 3914383 missense probably benign 0.01
R5048:Lilra6 UTSW 7 3915441 critical splice donor site probably null
R5164:Lilra6 UTSW 7 3914881 missense probably damaging 1.00
R5185:Lilra6 UTSW 7 3914636 missense probably benign 0.00
R5527:Lilra6 UTSW 7 3914587 start gained probably benign
R6281:Lilra6 UTSW 7 3911973 missense probably damaging 1.00
R6480:Lilra6 UTSW 7 3912933 missense probably damaging 1.00
R6512:Lilra6 UTSW 7 3914388 missense probably benign 0.06
R6565:Lilra6 UTSW 7 3915020 missense probably benign
R7017:Lilra6 UTSW 7 3908708 missense possibly damaging 0.93
R7095:Lilra6 UTSW 7 3913197 missense probably damaging 1.00
R7747:Lilra6 UTSW 7 3912996 missense probably benign 0.16
R8056:Lilra6 UTSW 7 3912552 missense probably damaging 1.00
R8280:Lilra6 UTSW 7 3913047 missense probably benign 0.01
R9197:Lilra6 UTSW 7 3912717 missense possibly damaging 0.94
R9354:Lilra6 UTSW 7 3911629 missense probably damaging 1.00
R9379:Lilra6 UTSW 7 3913167 missense probably damaging 1.00
R9406:Lilra6 UTSW 7 3914854 missense probably benign
Z1176:Lilra6 UTSW 7 3915074 critical splice acceptor site probably null
Z1177:Lilra6 UTSW 7 3912581 missense possibly damaging 0.48
Posted On 2013-04-17