Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00899:Lilra6'

27758

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lilra6

Ensembl Gene

ENSMUSG00000030427

Gene Name

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6

Synonyms

Pira3, 7M1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL00899

Quality Score

Status

Chromosome

Chromosomal Location

3908280-3915503 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 3913057 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 268 (T268S)

Ref Sequence

ENSEMBL: ENSMUSP00000042636 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]

AlphaFold

A0A0B4J1F3

Predicted Effect

probably damaging
Transcript: ENSMUST00000038176
AA Change: T268S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427
AA Change: T268S

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	40	105	3.11e0	SMART
IG	129	315	4.53e-2	SMART
IG_like	237	302	1.54e-1	SMART
IG_like	328	415	1.79e1	SMART
IG_like	429	517	2.66e1	SMART
IG	529	618	8.59e-3	SMART
low complexity region	637	646	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000090689
AA Change: T268S

PolyPhen 2 Score 0.519 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427
AA Change: T268S

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	34	118	7.25e0	SMART
IG_like	129	220	1.62e2	SMART
IG_like	290	377	1.79e1	SMART
IG_like	391	479	2.66e1	SMART
IG	491	580	8.59e-3	SMART
low complexity region	599	608	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131255

Predicted Effect

probably benign
Transcript: ENSMUST00000206077
AA Change: T27S

PolyPhen 2 Score 0.387 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206851

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
AU018091	A	G	7: 3,158,763	I442T	probably benign	Het
Bpifb9a	T	C	2: 154,264,727		probably null	Het
Ccp110	T	A	7: 118,722,684	C521S	probably benign	Het
Chd6	A	G	2: 161,029,298		probably benign	Het
Cndp2	A	T	18: 84,677,376	D133E	probably damaging	Het
Crygs	T	C	16: 22,806,562	E43G	possibly damaging	Het
Ednra	C	T	8: 77,675,071	G197R	probably damaging	Het
Esyt1	A	G	10: 128,517,063	L656P	probably damaging	Het
Ets1	C	T	9: 32,752,808	P118L	probably damaging	Het
Fam98c	A	G	7: 29,152,853		probably benign	Het
Foxi1	G	A	11: 34,205,772	T286I	probably benign	Het
Gimap5	G	A	6: 48,753,173	A226T	possibly damaging	Het
Heatr1	C	T	13: 12,435,176	A2017V	probably benign	Het
Ikbkb	T	C	8: 22,660,447	S740G	possibly damaging	Het
Inppl1	A	T	7: 101,829,158	I617N	probably damaging	Het
Itpkb	T	C	1: 180,332,993	L228P	probably benign	Het
Kcnc4	T	A	3: 107,458,463	D143V	possibly damaging	Het
Krtdap	T	A	7: 30,789,962		probably null	Het
M6pr	A	G	6: 122,315,395	E183G	possibly damaging	Het
Muc5ac	T	A	7: 141,812,703	V2168D	possibly damaging	Het
Nbea	A	G	3: 55,642,845	S2721P	probably benign	Het
Olfr352	A	T	2: 36,870,210	I215L	probably benign	Het
Pqbp1	T	C	X: 7,896,004	N94S	probably benign	Het
Prl3d2	T	C	13: 27,122,349	S20P	probably damaging	Het
Psmb2	T	C	4: 126,707,557	I151T	probably benign	Het
Rapgef6	G	T	11: 54,620,018	E107*	probably null	Het
Slc2a13	T	C	15: 91,497,399	T296A	probably benign	Het
Tcl1b4	A	G	12: 105,204,657	T55A	probably damaging	Het
Tg	T	C	15: 66,674,073		probably null	Het
Trim80	T	G	11: 115,447,665	N440K	probably benign	Het
Ttc13	C	T	8: 124,688,847		probably benign	Het
Ttc38	T	A	15: 85,844,462	I205N	possibly damaging	Het
Ufl1	T	C	4: 25,262,238	D336G	probably damaging	Het
Vmn2r74	A	T	7: 85,957,130	I336K	probably benign	Het
Zbtb26	G	T	2: 37,436,258	Y255*	probably null	Het
Zfp462	T	A	4: 55,007,732	V57E	probably damaging	Het

Other mutations in Lilra6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00508:Lilra6	APN	7	3911554	missense	probably benign	0.04
IGL00569:Lilra6	APN	7	3914589	missense	probably damaging	0.99
IGL00955:Lilra6	APN	7	3911404	splice site	probably benign
IGL01585:Lilra6	APN	7	3914499	missense	probably benign	0.01
IGL02195:Lilra6	APN	7	3914550	missense	probably benign	0.00
IGL02586:Lilra6	APN	7	3908820	missense	probably benign	0.36
IGL02719:Lilra6	APN	7	3912992	missense	possibly damaging	0.96
IGL03166:Lilra6	APN	7	3912627	missense	possibly damaging	0.69
IGL03329:Lilra6	APN	7	3914648	splice site	probably benign
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0423:Lilra6	UTSW	7	3914775	splice site	probably benign
R0483:Lilra6	UTSW	7	3913139	missense	probably benign	0.02
R0511:Lilra6	UTSW	7	3912785	missense	possibly damaging	0.77
R1472:Lilra6	UTSW	7	3912719	missense	probably damaging	1.00
R1560:Lilra6	UTSW	7	3911408	critical splice donor site	probably null
R1584:Lilra6	UTSW	7	3912662	missense	probably damaging	1.00
R1781:Lilra6	UTSW	7	3915067	missense	probably benign	0.28
R2411:Lilra6	UTSW	7	3911454	missense	probably damaging	1.00
R2420:Lilra6	UTSW	7	3914858	missense	probably damaging	1.00
R4021:Lilra6	UTSW	7	3911418	missense	probably benign	0.20
R4074:Lilra6	UTSW	7	3914890	missense	probably benign	0.23
R4284:Lilra6	UTSW	7	3908804	missense	possibly damaging	0.76
R4508:Lilra6	UTSW	7	3912029	nonsense	probably null
R4894:Lilra6	UTSW	7	3912531	missense	probably benign	0.01
R4977:Lilra6	UTSW	7	3914383	missense	probably benign	0.01
R5048:Lilra6	UTSW	7	3915441	critical splice donor site	probably null
R5164:Lilra6	UTSW	7	3914881	missense	probably damaging	1.00
R5185:Lilra6	UTSW	7	3914636	missense	probably benign	0.00
R5527:Lilra6	UTSW	7	3914587	start gained	probably benign
R6281:Lilra6	UTSW	7	3911973	missense	probably damaging	1.00
R6480:Lilra6	UTSW	7	3912933	missense	probably damaging	1.00
R6512:Lilra6	UTSW	7	3914388	missense	probably benign	0.06
R6565:Lilra6	UTSW	7	3915020	missense	probably benign
R7017:Lilra6	UTSW	7	3908708	missense	possibly damaging	0.93
R7095:Lilra6	UTSW	7	3913197	missense	probably damaging	1.00
R7747:Lilra6	UTSW	7	3912996	missense	probably benign	0.16
R8056:Lilra6	UTSW	7	3912552	missense	probably damaging	1.00
R8280:Lilra6	UTSW	7	3913047	missense	probably benign	0.01
R9197:Lilra6	UTSW	7	3912717	missense	possibly damaging	0.94
R9354:Lilra6	UTSW	7	3911629	missense	probably damaging	1.00
R9379:Lilra6	UTSW	7	3913167	missense	probably damaging	1.00
R9406:Lilra6	UTSW	7	3914854	missense	probably benign
R9462:Lilra6	UTSW	7	3911995	missense	probably damaging	0.97
R9649:Lilra6	UTSW	7	3914522	missense	possibly damaging	0.47
Z1176:Lilra6	UTSW	7	3915074	critical splice acceptor site	probably null
Z1177:Lilra6	UTSW	7	3912581	missense	possibly damaging	0.48

Posted On

2013-04-17