Incidental Mutation 'IGL00901:Cyp2b9'
ID27766
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp2b9
Ensembl Gene ENSMUSG00000040660
Gene Namecytochrome P450, family 2, subfamily b, polypeptide 9
Synonyms16\alphaoh-a, phenobarbitol inducible, type a, Cyp2b
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.108) question?
Stock #IGL00901
Quality Score
Status
Chromosome7
Chromosomal Location26173411-26210661 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 26198505 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 245 (I245F)
Ref Sequence ENSEMBL: ENSMUSP00000080846 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082214]
Predicted Effect probably damaging
Transcript: ENSMUST00000082214
AA Change: I245F

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000080846
Gene: ENSMUSG00000040660
AA Change: I245F

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:p450 31 488 1.7e-146 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432K21Rik A G 8: 84,166,771 D189G probably damaging Het
Acot6 A G 12: 84,106,476 Y164C probably benign Het
Anpep A G 7: 79,839,423 S334P probably benign Het
Arhgef1 A G 7: 24,912,693 E129G probably damaging Het
Bmt2 G T 6: 13,628,749 H312N probably damaging Het
Ces2g A G 8: 104,965,129 Y272C probably benign Het
Cfap69 T A 5: 5,619,162 probably benign Het
Cftr T C 6: 18,268,430 probably null Het
Clec2g A G 6: 128,948,692 probably benign Het
Fbxo6 T A 4: 148,146,143 I221F probably damaging Het
Fbxw21 A C 9: 109,156,399 C104G probably benign Het
Flna A G X: 74,229,928 S101P probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Ift88 T A 14: 57,444,445 F229I probably damaging Het
Map2k3 T C 11: 60,941,921 S31P probably benign Het
Mia2 A G 12: 59,108,029 D176G probably damaging Het
Olfr102 T G 17: 37,313,707 K226Q possibly damaging Het
Olfr1145 A G 2: 87,810,648 Y276C probably damaging Het
Olfr127 T A 17: 37,904,257 V237D probably damaging Het
Pde7b C T 10: 20,619,129 probably null Het
Polr3b T C 10: 84,631,796 I80T possibly damaging Het
Prpf4b T A 13: 34,894,482 Y692N probably damaging Het
Rabl2 T C 15: 89,590,270 probably benign Het
Rasgrp1 T C 2: 117,285,130 K659R probably damaging Het
Ryr3 A T 2: 112,886,589 S774T probably damaging Het
Sema5b C T 16: 35,651,315 T426M probably damaging Het
Serpinb10 A G 1: 107,540,996 K123R probably benign Het
Slc33a1 T C 3: 63,964,012 D60G probably benign Het
Tnks A T 8: 34,838,395 Y92* probably null Het
Tvp23b T A 11: 62,883,780 probably benign Het
Wnk1 T A 6: 119,960,708 Q1218L probably damaging Het
Other mutations in Cyp2b9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01133:Cyp2b9 APN 7 26210235 missense probably damaging 1.00
IGL01331:Cyp2b9 APN 7 26187715 missense probably damaging 0.99
IGL02281:Cyp2b9 APN 7 26201104 missense probably damaging 0.99
IGL02502:Cyp2b9 APN 7 26187814 critical splice donor site probably null
IGL02713:Cyp2b9 APN 7 26173520 missense probably benign 0.12
IGL03032:Cyp2b9 APN 7 26198600 splice site probably benign
IGL03307:Cyp2b9 APN 7 26199051 missense probably benign 0.00
R0010:Cyp2b9 UTSW 7 26186753 splice site probably benign
R0025:Cyp2b9 UTSW 7 26200813 missense probably benign 0.09
R0040:Cyp2b9 UTSW 7 26173474 missense possibly damaging 0.68
R0184:Cyp2b9 UTSW 7 26187007 nonsense probably null
R0370:Cyp2b9 UTSW 7 26210106 missense probably damaging 1.00
R1595:Cyp2b9 UTSW 7 26200907 missense possibly damaging 0.72
R1751:Cyp2b9 UTSW 7 26186675 missense probably benign 0.05
R1835:Cyp2b9 UTSW 7 26200783 missense probably benign
R1879:Cyp2b9 UTSW 7 26198569 missense probably damaging 0.99
R2256:Cyp2b9 UTSW 7 26173605 critical splice donor site probably null
R2257:Cyp2b9 UTSW 7 26173605 critical splice donor site probably null
R2418:Cyp2b9 UTSW 7 26186707 missense probably benign 0.00
R3420:Cyp2b9 UTSW 7 26210103 missense probably damaging 1.00
R4088:Cyp2b9 UTSW 7 26173456 missense probably damaging 0.99
R4412:Cyp2b9 UTSW 7 26198443 missense probably damaging 1.00
R4495:Cyp2b9 UTSW 7 26200755 missense probably benign 0.00
R4615:Cyp2b9 UTSW 7 26201125 missense probably damaging 1.00
R5375:Cyp2b9 UTSW 7 26187742 missense probably damaging 1.00
R5426:Cyp2b9 UTSW 7 26187655 missense probably benign
R5862:Cyp2b9 UTSW 7 26187807 missense probably benign 0.01
R6237:Cyp2b9 UTSW 7 26173574 missense probably benign 0.02
R6445:Cyp2b9 UTSW 7 26186987 missense probably benign 0.13
R6992:Cyp2b9 UTSW 7 26201139 missense probably benign 0.00
R7515:Cyp2b9 UTSW 7 26199171 missense probably damaging 1.00
R7654:Cyp2b9 UTSW 7 26186942 missense possibly damaging 0.72
R7816:Cyp2b9 UTSW 7 26201092 missense probably benign 0.01
R7850:Cyp2b9 UTSW 7 26186686 nonsense probably null
R7933:Cyp2b9 UTSW 7 26186686 nonsense probably null
Z1177:Cyp2b9 UTSW 7 26201163 missense probably benign 0.31
Posted On2013-04-17