Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00904:Vmn2r74'

27775

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r74

Ensembl Gene

ENSMUSG00000090774

Gene Name

vomeronasal 2, receptor 74

Synonyms

EG546980

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.107) question?

Stock #

IGL00904

Quality Score

Status

Chromosome

Chromosomal Location

85951867-85961482 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 85957580 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Histidine at position 186 (R186H)

Ref Sequence

ENSEMBL: ENSMUSP00000126917 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166355]

Predicted Effect

probably benign
Transcript: ENSMUST00000166355
AA Change: R186H

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: R186H

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	467	7.3e-28	PFAM
Pfam:NCD3G	510	562	4.7e-20	PFAM
Pfam:7tm_3	592	830	1.3e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aak1	G	T	6: 86,946,153	G236C	probably damaging	Het
Abi1	C	T	2: 22,941,930	R404Q	possibly damaging	Het
Atp8b3	C	T	10: 80,528,764	G532R	probably damaging	Het
Bysl	C	T	17: 47,601,871	M331I	probably benign	Het
Cndp1	A	G	18: 84,611,665	S468P	probably benign	Het
Esd	A	G	14: 74,749,688	*266W	probably null	Het
F5	T	C	1: 164,194,009	V1351A	probably benign	Het
Fchsd2	A	G	7: 101,271,622	D454G	probably benign	Het
Fndc1	T	A	17: 7,756,363	M1415L	probably benign	Het
Ghr	T	A	15: 3,328,120	Y222F	probably benign	Het
Gm6583	G	A	5: 112,355,128	R237*	probably null	Het
Gtf3c2	C	T	5: 31,172,858	S299N	probably damaging	Het
Ice1	C	T	13: 70,602,289	D93N	probably damaging	Het
Ints7	T	A	1: 191,596,164		probably null	Het
Kif18a	A	G	2: 109,292,126	D182G	probably damaging	Het
Mcm9	A	T	10: 53,622,921	H308Q	possibly damaging	Het
Mesp2	A	G	7: 79,812,653	D319G	probably benign	Het
Mrpl55	T	A	11: 59,205,673	S84T	probably benign	Het
Mybpc3	T	C	2: 91,120,029	V123A	probably benign	Het
Myom1	T	C	17: 71,099,949		probably benign	Het
Nfia	C	T	4: 98,065,386	P325S	probably damaging	Het
Notch4	T	C	17: 34,575,561		probably null	Het
Npepps	A	C	11: 97,258,306	V130G	probably damaging	Het
Olfr1356	A	T	10: 78,847,763	S51T	probably damaging	Het
Pja2	G	T	17: 64,283,531	T669K	probably damaging	Het
Rnf112	G	T	11: 61,452,784	D98E	probably damaging	Het
Rsl1d1	G	A	16: 11,199,694	T136I	probably damaging	Het
Samsn1	A	T	16: 75,909,120		probably benign	Het
Slc6a9	T	C	4: 117,864,617	L280P	probably damaging	Het
Svep1	T	C	4: 58,097,398	N1382D	probably benign	Het
Vmn2r100	T	G	17: 19,526,000	C474G	probably damaging	Het
Wdr7	T	C	18: 63,796,231	I1046T	probably benign	Het

Other mutations in Vmn2r74

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00899:Vmn2r74	APN	7	85957130	missense	probably benign	0.03
IGL01285:Vmn2r74	APN	7	85957484	missense	possibly damaging	0.54
IGL01300:Vmn2r74	APN	7	85957206	missense	probably benign	0.00
IGL01410:Vmn2r74	APN	7	85961292	missense	possibly damaging	0.83
IGL01827:Vmn2r74	APN	7	85957592	missense	probably benign	0.00
IGL02094:Vmn2r74	APN	7	85961461	missense	probably benign	0.01
IGL02252:Vmn2r74	APN	7	85957323	missense	probably benign	0.41
IGL02349:Vmn2r74	APN	7	85952516	missense	probably damaging	0.99
IGL02438:Vmn2r74	APN	7	85952616	missense	probably damaging	0.98
IGL02554:Vmn2r74	APN	7	85957373	missense	probably benign	0.00
IGL03036:Vmn2r74	APN	7	85952692	nonsense	probably null
IGL03370:Vmn2r74	APN	7	85958057	missense	probably benign
R0115:Vmn2r74	UTSW	7	85957356	missense	probably benign	0.00
R0333:Vmn2r74	UTSW	7	85952283	missense	probably benign	0.06
R0415:Vmn2r74	UTSW	7	85961410	missense	probably damaging	1.00
R0571:Vmn2r74	UTSW	7	85952421	missense	probably damaging	1.00
R0626:Vmn2r74	UTSW	7	85961309	nonsense	probably null
R0659:Vmn2r74	UTSW	7	85955914	splice site	probably benign
R1202:Vmn2r74	UTSW	7	85961337	missense	possibly damaging	0.83
R1473:Vmn2r74	UTSW	7	85961410	missense	probably damaging	1.00
R1908:Vmn2r74	UTSW	7	85952442	missense	probably benign
R2079:Vmn2r74	UTSW	7	85957175	missense	probably benign	0.00
R2368:Vmn2r74	UTSW	7	85961314	missense	probably benign	0.39
R3782:Vmn2r74	UTSW	7	85956114	missense	probably benign	0.01
R3824:Vmn2r74	UTSW	7	85958258	missense	probably damaging	1.00
R3977:Vmn2r74	UTSW	7	85958137	missense	probably benign	0.01
R4182:Vmn2r74	UTSW	7	85957187	missense	possibly damaging	0.87
R4289:Vmn2r74	UTSW	7	85957354	missense	probably benign
R4294:Vmn2r74	UTSW	7	85957416	missense	probably benign	0.14
R4645:Vmn2r74	UTSW	7	85957109	missense	probably benign
R4646:Vmn2r74	UTSW	7	85957574	missense	probably benign	0.42
R4655:Vmn2r74	UTSW	7	85961347	missense	probably benign
R4901:Vmn2r74	UTSW	7	85955991	nonsense	probably null
R5532:Vmn2r74	UTSW	7	85951989	missense	probably benign	0.32
R5642:Vmn2r74	UTSW	7	85957380	missense	probably benign	0.00
R5913:Vmn2r74	UTSW	7	85951890	missense	probably damaging	0.98
R6035:Vmn2r74	UTSW	7	85951890	missense	probably damaging	0.98
R6035:Vmn2r74	UTSW	7	85951890	missense	probably damaging	0.98
R6039:Vmn2r74	UTSW	7	85958318	critical splice acceptor site	probably null
R6039:Vmn2r74	UTSW	7	85958318	critical splice acceptor site	probably null
R6170:Vmn2r74	UTSW	7	85957140	missense	probably benign	0.03
R6232:Vmn2r74	UTSW	7	85958290	missense	possibly damaging	0.82
R6238:Vmn2r74	UTSW	7	85952072	missense	probably damaging	1.00
R6255:Vmn2r74	UTSW	7	85952451	missense	possibly damaging	0.90
R6468:Vmn2r74	UTSW	7	85961391	missense	probably benign	0.34
R6732:Vmn2r74	UTSW	7	85957550	missense	probably damaging	1.00
R6816:Vmn2r74	UTSW	7	85961413	nonsense	probably null
R6836:Vmn2r74	UTSW	7	85957422	missense	probably benign	0.00
R6995:Vmn2r74	UTSW	7	85952735	missense	probably benign	0.01
R6995:Vmn2r74	UTSW	7	85957652	critical splice acceptor site	probably null
R7186:Vmn2r74	UTSW	7	85951942	nonsense	probably null
R7246:Vmn2r74	UTSW	7	85955965	missense	probably benign
R7374:Vmn2r74	UTSW	7	85957422	missense	probably benign	0.02
R7505:Vmn2r74	UTSW	7	85957071	nonsense	probably null
R7525:Vmn2r74	UTSW	7	85961302	missense	probably benign
R7569:Vmn2r74	UTSW	7	85952336	missense	probably damaging	0.99
R7644:Vmn2r74	UTSW	7	85957538	missense	probably benign	0.11
R7956:Vmn2r74	UTSW	7	85955958	missense	probably benign	0.09
R8119:Vmn2r74	UTSW	7	85961482	start codon destroyed	probably null	0.08
R8131:Vmn2r74	UTSW	7	85952735	missense	probably benign	0.01
R8147:Vmn2r74	UTSW	7	85956019	nonsense	probably null
R8181:Vmn2r74	UTSW	7	85956116	missense	probably damaging	1.00
R8184:Vmn2r74	UTSW	7	85952246	missense	probably benign	0.00
R8375:Vmn2r74	UTSW	7	85952706	missense	possibly damaging	0.64
Z1176:Vmn2r74	UTSW	7	85955627	missense	probably damaging	1.00
Z31818:Vmn2r74	UTSW	7	85955521	splice site	probably null

Posted On

2013-04-17