Incidental Mutation 'IGL00904:Vmn2r74'
ID 27775
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r74
Ensembl Gene ENSMUSG00000090774
Gene Name vomeronasal 2, receptor 74
Synonyms EG546980
Accession Numbers
Essential gene? Probably non essential (E-score: 0.110) question?
Stock # IGL00904
Quality Score
Status
Chromosome 7
Chromosomal Location 85601075-85610690 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 85606788 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 186 (R186H)
Ref Sequence ENSEMBL: ENSMUSP00000126917 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166355]
AlphaFold E9PW21
Predicted Effect probably benign
Transcript: ENSMUST00000166355
AA Change: R186H

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000126917
Gene: ENSMUSG00000090774
AA Change: R186H

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 467 7.3e-28 PFAM
Pfam:NCD3G 510 562 4.7e-20 PFAM
Pfam:7tm_3 592 830 1.3e-52 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aak1 G T 6: 86,923,135 (GRCm39) G236C probably damaging Het
Abi1 C T 2: 22,831,942 (GRCm39) R404Q possibly damaging Het
Atp8b3 C T 10: 80,364,598 (GRCm39) G532R probably damaging Het
Bysl C T 17: 47,912,796 (GRCm39) M331I probably benign Het
Ccdc121rt3 G A 5: 112,502,994 (GRCm39) R237* probably null Het
Cndp1 A G 18: 84,629,790 (GRCm39) S468P probably benign Het
Esd A G 14: 74,987,128 (GRCm39) *266W probably null Het
F5 T C 1: 164,021,578 (GRCm39) V1351A probably benign Het
Fchsd2 A G 7: 100,920,829 (GRCm39) D454G probably benign Het
Fndc1 T A 17: 7,975,195 (GRCm39) M1415L probably benign Het
Ghr T A 15: 3,357,602 (GRCm39) Y222F probably benign Het
Gtf3c2 C T 5: 31,330,202 (GRCm39) S299N probably damaging Het
Ice1 C T 13: 70,750,408 (GRCm39) D93N probably damaging Het
Ints7 T A 1: 191,328,276 (GRCm39) probably null Het
Kif18a A G 2: 109,122,471 (GRCm39) D182G probably damaging Het
Mcm9 A T 10: 53,499,017 (GRCm39) H308Q possibly damaging Het
Mesp2 A G 7: 79,462,401 (GRCm39) D319G probably benign Het
Mrpl55 T A 11: 59,096,499 (GRCm39) S84T probably benign Het
Mybpc3 T C 2: 90,950,374 (GRCm39) V123A probably benign Het
Myom1 T C 17: 71,406,944 (GRCm39) probably benign Het
Nfia C T 4: 97,953,623 (GRCm39) P325S probably damaging Het
Notch4 T C 17: 34,794,535 (GRCm39) probably null Het
Npepps A C 11: 97,149,132 (GRCm39) V130G probably damaging Het
Or7c70 A T 10: 78,683,597 (GRCm39) S51T probably damaging Het
Pja2 G T 17: 64,590,526 (GRCm39) T669K probably damaging Het
Rnf112 G T 11: 61,343,610 (GRCm39) D98E probably damaging Het
Rsl1d1 G A 16: 11,017,558 (GRCm39) T136I probably damaging Het
Samsn1 A T 16: 75,706,008 (GRCm39) probably benign Het
Slc6a9 T C 4: 117,721,814 (GRCm39) L280P probably damaging Het
Svep1 T C 4: 58,097,398 (GRCm39) N1382D probably benign Het
Vmn2r100 T G 17: 19,746,262 (GRCm39) C474G probably damaging Het
Wdr7 T C 18: 63,929,302 (GRCm39) I1046T probably benign Het
Other mutations in Vmn2r74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00899:Vmn2r74 APN 7 85,606,338 (GRCm39) missense probably benign 0.03
IGL01285:Vmn2r74 APN 7 85,606,692 (GRCm39) missense possibly damaging 0.54
IGL01300:Vmn2r74 APN 7 85,606,414 (GRCm39) missense probably benign 0.00
IGL01410:Vmn2r74 APN 7 85,610,500 (GRCm39) missense possibly damaging 0.83
IGL01827:Vmn2r74 APN 7 85,606,800 (GRCm39) missense probably benign 0.00
IGL02094:Vmn2r74 APN 7 85,610,669 (GRCm39) missense probably benign 0.01
IGL02252:Vmn2r74 APN 7 85,606,531 (GRCm39) missense probably benign 0.41
IGL02349:Vmn2r74 APN 7 85,601,724 (GRCm39) missense probably damaging 0.99
IGL02438:Vmn2r74 APN 7 85,601,824 (GRCm39) missense probably damaging 0.98
IGL02554:Vmn2r74 APN 7 85,606,581 (GRCm39) missense probably benign 0.00
IGL03036:Vmn2r74 APN 7 85,601,900 (GRCm39) nonsense probably null
IGL03370:Vmn2r74 APN 7 85,607,265 (GRCm39) missense probably benign
R0115:Vmn2r74 UTSW 7 85,606,564 (GRCm39) missense probably benign 0.00
R0333:Vmn2r74 UTSW 7 85,601,491 (GRCm39) missense probably benign 0.06
R0415:Vmn2r74 UTSW 7 85,610,618 (GRCm39) missense probably damaging 1.00
R0571:Vmn2r74 UTSW 7 85,601,629 (GRCm39) missense probably damaging 1.00
R0626:Vmn2r74 UTSW 7 85,610,517 (GRCm39) nonsense probably null
R0659:Vmn2r74 UTSW 7 85,605,122 (GRCm39) splice site probably benign
R1202:Vmn2r74 UTSW 7 85,610,545 (GRCm39) missense possibly damaging 0.83
R1473:Vmn2r74 UTSW 7 85,610,618 (GRCm39) missense probably damaging 1.00
R1908:Vmn2r74 UTSW 7 85,601,650 (GRCm39) missense probably benign
R2079:Vmn2r74 UTSW 7 85,606,383 (GRCm39) missense probably benign 0.00
R2368:Vmn2r74 UTSW 7 85,610,522 (GRCm39) missense probably benign 0.39
R3782:Vmn2r74 UTSW 7 85,605,322 (GRCm39) missense probably benign 0.01
R3824:Vmn2r74 UTSW 7 85,607,466 (GRCm39) missense probably damaging 1.00
R3977:Vmn2r74 UTSW 7 85,607,345 (GRCm39) missense probably benign 0.01
R4182:Vmn2r74 UTSW 7 85,606,395 (GRCm39) missense possibly damaging 0.87
R4289:Vmn2r74 UTSW 7 85,606,562 (GRCm39) missense probably benign
R4294:Vmn2r74 UTSW 7 85,606,624 (GRCm39) missense probably benign 0.14
R4645:Vmn2r74 UTSW 7 85,606,317 (GRCm39) missense probably benign
R4646:Vmn2r74 UTSW 7 85,606,782 (GRCm39) missense probably benign 0.42
R4655:Vmn2r74 UTSW 7 85,610,555 (GRCm39) missense probably benign
R4901:Vmn2r74 UTSW 7 85,605,199 (GRCm39) nonsense probably null
R5532:Vmn2r74 UTSW 7 85,601,197 (GRCm39) missense probably benign 0.32
R5642:Vmn2r74 UTSW 7 85,606,588 (GRCm39) missense probably benign 0.00
R5913:Vmn2r74 UTSW 7 85,601,098 (GRCm39) missense probably damaging 0.98
R6035:Vmn2r74 UTSW 7 85,601,098 (GRCm39) missense probably damaging 0.98
R6035:Vmn2r74 UTSW 7 85,601,098 (GRCm39) missense probably damaging 0.98
R6039:Vmn2r74 UTSW 7 85,607,526 (GRCm39) critical splice acceptor site probably null
R6039:Vmn2r74 UTSW 7 85,607,526 (GRCm39) critical splice acceptor site probably null
R6170:Vmn2r74 UTSW 7 85,606,348 (GRCm39) missense probably benign 0.03
R6232:Vmn2r74 UTSW 7 85,607,498 (GRCm39) missense possibly damaging 0.82
R6238:Vmn2r74 UTSW 7 85,601,280 (GRCm39) missense probably damaging 1.00
R6255:Vmn2r74 UTSW 7 85,601,659 (GRCm39) missense possibly damaging 0.90
R6468:Vmn2r74 UTSW 7 85,610,599 (GRCm39) missense probably benign 0.34
R6732:Vmn2r74 UTSW 7 85,606,758 (GRCm39) missense probably damaging 1.00
R6816:Vmn2r74 UTSW 7 85,610,621 (GRCm39) nonsense probably null
R6836:Vmn2r74 UTSW 7 85,606,630 (GRCm39) missense probably benign 0.00
R6995:Vmn2r74 UTSW 7 85,606,860 (GRCm39) critical splice acceptor site probably null
R6995:Vmn2r74 UTSW 7 85,601,943 (GRCm39) missense probably benign 0.01
R7186:Vmn2r74 UTSW 7 85,601,150 (GRCm39) nonsense probably null
R7246:Vmn2r74 UTSW 7 85,605,173 (GRCm39) missense probably benign
R7374:Vmn2r74 UTSW 7 85,606,630 (GRCm39) missense probably benign 0.02
R7505:Vmn2r74 UTSW 7 85,606,279 (GRCm39) nonsense probably null
R7525:Vmn2r74 UTSW 7 85,610,510 (GRCm39) missense probably benign
R7569:Vmn2r74 UTSW 7 85,601,544 (GRCm39) missense probably damaging 0.99
R7644:Vmn2r74 UTSW 7 85,606,746 (GRCm39) missense probably benign 0.11
R7956:Vmn2r74 UTSW 7 85,605,166 (GRCm39) missense probably benign 0.09
R8119:Vmn2r74 UTSW 7 85,610,690 (GRCm39) start codon destroyed probably null 0.08
R8131:Vmn2r74 UTSW 7 85,601,943 (GRCm39) missense probably benign 0.01
R8147:Vmn2r74 UTSW 7 85,605,227 (GRCm39) nonsense probably null
R8181:Vmn2r74 UTSW 7 85,605,324 (GRCm39) missense probably damaging 1.00
R8184:Vmn2r74 UTSW 7 85,601,454 (GRCm39) missense probably benign 0.00
R8375:Vmn2r74 UTSW 7 85,601,914 (GRCm39) missense possibly damaging 0.64
R8948:Vmn2r74 UTSW 7 85,606,569 (GRCm39) missense probably damaging 1.00
R8950:Vmn2r74 UTSW 7 85,606,569 (GRCm39) missense probably damaging 1.00
R9033:Vmn2r74 UTSW 7 85,606,414 (GRCm39) missense probably benign
R9342:Vmn2r74 UTSW 7 85,606,624 (GRCm39) missense probably benign 0.14
R9578:Vmn2r74 UTSW 7 85,606,101 (GRCm39) missense probably benign 0.01
R9607:Vmn2r74 UTSW 7 85,610,619 (GRCm39) missense probably benign 0.02
R9776:Vmn2r74 UTSW 7 85,605,212 (GRCm39) missense possibly damaging 0.70
Z1176:Vmn2r74 UTSW 7 85,604,835 (GRCm39) missense probably damaging 1.00
Z31818:Vmn2r74 UTSW 7 85,604,729 (GRCm39) splice site probably null
Posted On 2013-04-17