Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00563:Tas2r134'

277780

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r134

Ensembl Gene

ENSMUSG00000056115

Gene Name

taste receptor, type 2, member 134

Synonyms

T2R134, Tas2r34

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL00563

Quality Score

Status

Chromosome

Chromosomal Location

51627511-51628408 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 51628088 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 193 (I193T)

Ref Sequence

ENSEMBL: ENSMUSP00000064657 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000070028]

AlphaFold

Q7TQB0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000070028
AA Change: I193T

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000064657
Gene: ENSMUSG00000056115
AA Change: I193T

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	291	1.4e-75	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1500035N22Rik	T	C	5: 24,997,621		probably benign	Het
Atp13a4	T	C	16: 29,403,778		probably benign	Het
AU016765	C	A	17: 64,519,882		noncoding transcript	Het
Clstn2	A	G	9: 97,582,452		probably benign	Het
Crip1	T	A	12: 113,153,612		probably null	Het
Dnah6	T	C	6: 73,195,620	N285S	possibly damaging	Het
Fktn	A	T	4: 53,747,007		probably null	Het
Fndc3a	C	A	14: 72,559,357		probably benign	Het
Focad	T	A	4: 88,348,809	M1019K	unknown	Het
Fuca2	A	T	10: 13,505,907	D188V	probably damaging	Het
Gzmk	C	T	13: 113,173,124	V92I	probably benign	Het
Mprip	C	T	11: 59,752,617	R520W	probably damaging	Het
Mrpl19	A	G	6: 81,965,872	V19A	probably benign	Het
Ndufb3	T	A	1: 58,595,799	H103Q	possibly damaging	Het
Pkd1l3	T	C	8: 109,656,147	V1675A	possibly damaging	Het
Saxo1	C	T	4: 86,445,572	E225K	probably damaging	Het
Sbno1	A	G	5: 124,402,205	S383P	probably damaging	Het
Slc22a29	T	A	19: 8,161,629	T490S	probably benign	Het
Smc6	T	A	12: 11,301,531	S854T	probably benign	Het
Smim23	T	C	11: 32,821,893	T58A	probably benign	Het
Thsd7a	G	T	6: 12,379,659		probably null	Het
Trav13n-4	T	G	14: 53,363,966	V64G	possibly damaging	Het
Trmt10a	G	A	3: 138,147,416	E13K	probably damaging	Het
Txndc11	T	C	16: 11,104,632	S239G	probably damaging	Het
Vmn2r96	T	A	17: 18,583,815	N442K	probably benign	Het
Vps13a	C	T	19: 16,734,714		probably null	Het
Wdr64	A	G	1: 175,698,800	D5G	probably benign	Het

Other mutations in Tas2r134

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00562:Tas2r134	APN	2	51628088	missense	possibly damaging	0.90
IGL01121:Tas2r134	APN	2	51627989	missense	probably damaging	1.00
IGL01122:Tas2r134	APN	2	51627659	missense	probably damaging	1.00
IGL01128:Tas2r134	APN	2	51627659	missense	probably damaging	1.00
IGL01132:Tas2r134	APN	2	51627659	missense	probably damaging	1.00
IGL01312:Tas2r134	APN	2	51628235	missense	probably damaging	1.00
IGL01419:Tas2r134	APN	2	51627747	nonsense	probably null
IGL01774:Tas2r134	APN	2	51628148	missense	probably benign	0.07
IGL02735:Tas2r134	APN	2	51627827	missense	probably damaging	1.00
R0799:Tas2r134	UTSW	2	51628373	missense	probably benign	0.00
R1205:Tas2r134	UTSW	2	51627986	missense	probably benign	0.00
R2267:Tas2r134	UTSW	2	51628237	missense	probably benign	0.01
R3736:Tas2r134	UTSW	2	51627774	missense	probably damaging	1.00
R5254:Tas2r134	UTSW	2	51627547	missense	probably benign	0.39
R5752:Tas2r134	UTSW	2	51627868	missense	probably damaging	1.00
R6162:Tas2r134	UTSW	2	51627559	missense	probably damaging	1.00
R6940:Tas2r134	UTSW	2	51628136	missense	probably benign	0.00
R6954:Tas2r134	UTSW	2	51627770	missense	probably benign	0.00
R6996:Tas2r134	UTSW	2	51627589	missense	probably benign	0.00
R7206:Tas2r134	UTSW	2	51628108	missense	probably benign	0.02
R7303:Tas2r134	UTSW	2	51628133	missense	probably benign	0.01
R7348:Tas2r134	UTSW	2	51628402	missense	possibly damaging	0.92
R7479:Tas2r134	UTSW	2	51627529	missense	not run
R7575:Tas2r134	UTSW	2	51628154	missense	probably damaging	1.00
R7686:Tas2r134	UTSW	2	51628243	missense	possibly damaging	0.54
R8721:Tas2r134	UTSW	2	51627559	missense	probably damaging	1.00
R9384:Tas2r134	UTSW	2	51628022	missense	probably damaging	0.97

Posted On

2015-04-16