Incidental Mutation 'IGL00907:Olfr477'
ID27782
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr477
Ensembl Gene ENSMUSG00000096151
Gene Nameolfactory receptor 477
SynonymsGA_x6K02T2PBJ9-10319672-10320604, MOR204-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.168) question?
Stock #IGL00907
Quality Score
Status
Chromosome7
Chromosomal Location107986693-107992723 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 107990890 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Valine at position 175 (D175V)
Ref Sequence ENSEMBL: ENSMUSP00000091654 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091605] [ENSMUST00000214677]
Predicted Effect probably damaging
Transcript: ENSMUST00000091605
AA Change: D175V

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000091654
Gene: ENSMUSG00000096151
AA Change: D175V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8e-52 PFAM
Pfam:7tm_1 41 290 1.9e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214677
AA Change: D175V

PolyPhen 2 Score 0.558 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Armt1 A G 10: 4,454,051 F379V possibly damaging Het
Atp8b1 T C 18: 64,561,705 D502G possibly damaging Het
Brwd3 A G X: 108,784,246 probably benign Het
Ccdc171 T A 4: 83,864,249 H1259Q probably damaging Het
Chd7 T C 4: 8,840,435 I1401T probably damaging Het
Csf1 T C 3: 107,750,346 N76S probably damaging Het
Dld A G 12: 31,332,330 probably benign Het
Eif5 T A 12: 111,540,555 I141N probably damaging Het
Etl4 G A 2: 20,766,478 G674D possibly damaging Het
Fam234a G A 17: 26,213,526 R550W probably damaging Het
Hipk2 A G 6: 38,818,273 S347P probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Hsd17b2 A T 8: 117,734,694 I157L probably benign Het
Ibtk A G 9: 85,690,331 S1269P possibly damaging Het
Igsf3 T C 3: 101,427,448 probably benign Het
Kin G A 2: 10,080,704 R25H probably damaging Het
Kin T C 2: 10,080,706 W26R probably damaging Het
Kir3dl1 G A X: 136,525,162 C95Y probably damaging Het
Lamc2 A G 1: 153,144,651 V383A probably benign Het
Mael A G 1: 166,204,849 Y314H probably damaging Het
Npat T C 9: 53,563,290 V794A possibly damaging Het
Nr4a2 T A 2: 57,109,217 I340F probably damaging Het
Olfr1195 A G 2: 88,683,294 V146A probably benign Het
Olfr836 T A 9: 19,121,232 D89E possibly damaging Het
Pdcd11 T C 19: 47,107,564 V641A probably benign Het
Phf24 C T 4: 42,938,667 T264I probably benign Het
Sars2 G T 7: 28,753,423 probably benign Het
Scn1a A C 2: 66,327,797 S411A probably damaging Het
Srsf5 T C 12: 80,947,834 V112A probably damaging Het
Susd2 T C 10: 75,640,931 N206S probably benign Het
Thrap3 C T 4: 126,165,578 G892S probably benign Het
Ttc32 T A 12: 9,034,953 Y58N probably damaging Het
Other mutations in Olfr477
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01078:Olfr477 APN 7 107990943 missense probably benign 0.02
IGL01141:Olfr477 APN 7 107990551 missense probably damaging 1.00
IGL02613:Olfr477 APN 7 107991174 nonsense probably null
R0625:Olfr477 UTSW 7 107991189 missense probably damaging 1.00
R0791:Olfr477 UTSW 7 107990533 missense probably benign 0.27
R1254:Olfr477 UTSW 7 107990440 missense probably benign 0.01
R1456:Olfr477 UTSW 7 107990398 missense probably benign 0.06
R1522:Olfr477 UTSW 7 107990533 missense probably benign 0.27
R1541:Olfr477 UTSW 7 107990841 missense probably benign 0.10
R2889:Olfr477 UTSW 7 107990577 missense probably benign 0.06
R5653:Olfr477 UTSW 7 107990385 missense probably benign 0.38
R6146:Olfr477 UTSW 7 107990413 missense probably damaging 1.00
R6190:Olfr477 UTSW 7 107991100 missense probably damaging 1.00
R7103:Olfr477 UTSW 7 107990598 missense possibly damaging 0.92
R7191:Olfr477 UTSW 7 107990646 missense possibly damaging 0.88
R7553:Olfr477 UTSW 7 107990475 missense probably benign 0.03
R7681:Olfr477 UTSW 7 107991148 missense possibly damaging 0.80
Z1088:Olfr477 UTSW 7 107990731 missense probably benign 0.42
Z1177:Olfr477 UTSW 7 107991094 missense probably damaging 1.00
Posted On2013-04-17