Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00909:Bicra'

27786

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Bicra

Ensembl Gene

ENSMUSG00000070808

Gene Name

BRD4 interacting chromatin remodeling complex associated protein

Synonyms

Gltscr1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.212) question?

Stock #

IGL00909

Quality Score

Status

Chromosome

Chromosomal Location

15704597-15781846 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 15730502 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 5 (D5E)

Ref Sequence

ENSEMBL: ENSMUSP00000148012 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094821] [ENSMUST00000210781]

AlphaFold

F8VPZ9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000094821
AA Change: D5E

PolyPhen 2 Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000092416
Gene: ENSMUSG00000070808
AA Change: D5E

Domain	Start	End	E-Value	Type
low complexity region	86	96	N/A	INTRINSIC
low complexity region	140	155	N/A	INTRINSIC
internal_repeat_1	156	298	1.03e-6	PROSPERO
low complexity region	308	323	N/A	INTRINSIC
low complexity region	427	443	N/A	INTRINSIC
internal_repeat_1	479	614	1.03e-6	PROSPERO
low complexity region	619	638	N/A	INTRINSIC
low complexity region	642	676	N/A	INTRINSIC
low complexity region	719	732	N/A	INTRINSIC
low complexity region	756	782	N/A	INTRINSIC
low complexity region	790	819	N/A	INTRINSIC
low complexity region	827	843	N/A	INTRINSIC
low complexity region	852	906	N/A	INTRINSIC
low complexity region	940	950	N/A	INTRINSIC
low complexity region	987	1006	N/A	INTRINSIC
Pfam:GLTSCR1	1094	1202	4.6e-43	PFAM
low complexity region	1232	1251	N/A	INTRINSIC
low complexity region	1275	1294	N/A	INTRINSIC
low complexity region	1349	1371	N/A	INTRINSIC
low complexity region	1460	1473	N/A	INTRINSIC
low complexity region	1535	1555	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000210781
AA Change: D5E

PolyPhen 2 Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931429L15Rik	T	A	9: 46,220,250 (GRCm39)	D94V	possibly damaging	Het
Adamts20	T	C	15: 94,277,694 (GRCm39)	Y256C	probably damaging	Het
Ajm1	A	G	2: 25,469,419 (GRCm39)	L164P	probably damaging	Het
Ampd1	A	C	3: 102,995,744 (GRCm39)	D218A	probably benign	Het
Arcn1	T	C	9: 44,662,651 (GRCm39)	N332D	probably damaging	Het
Arpp21	T	A	9: 112,005,191 (GRCm39)	I219F	probably damaging	Het
Birc2	A	C	9: 7,833,666 (GRCm39)	W272G	probably damaging	Het
Cd2ap	A	T	17: 43,141,005 (GRCm39)		probably benign	Het
Celsr1	G	A	15: 85,806,436 (GRCm39)	R974W	probably damaging	Het
Col4a2	A	C	8: 11,498,167 (GRCm39)	T1659P	possibly damaging	Het
Coq9	C	T	8: 95,578,530 (GRCm39)	L215F	possibly damaging	Het
Cped1	A	G	6: 22,122,426 (GRCm39)		probably benign	Het
Elapor2	A	T	5: 9,430,282 (GRCm39)	D64V	probably damaging	Het
Gga3	T	A	11: 115,482,567 (GRCm39)	R105W	probably damaging	Het
Hmcn1	C	T	1: 150,514,620 (GRCm39)	R3584Q	probably benign	Het
Hs6st3	T	A	14: 119,376,446 (GRCm39)	L207Q	probably damaging	Het
Ift43	A	G	12: 86,208,807 (GRCm39)	E141G	probably damaging	Het
Mrps31	T	G	8: 22,917,841 (GRCm39)	F287V	probably damaging	Het
Naca	A	G	10: 127,877,551 (GRCm39)		probably benign	Het
Nrf1	C	T	6: 30,098,477 (GRCm39)	T135M	probably damaging	Het
Or5p81	A	G	7: 108,266,907 (GRCm39)	I95V	possibly damaging	Het
Pfas	A	T	11: 68,894,640 (GRCm39)	Y8*	probably null	Het
Ppip5k1	G	A	2: 121,177,839 (GRCm39)	R323W	probably damaging	Het
Rasal1	A	G	5: 120,802,872 (GRCm39)	E376G	probably damaging	Het
Rfc1	A	G	5: 65,437,042 (GRCm39)	L546P	probably benign	Het
Rheb	A	T	5: 25,012,073 (GRCm39)	I129N	probably damaging	Het
Scpep1	A	T	11: 88,843,303 (GRCm39)	F52I	probably damaging	Het
Six2	A	T	17: 85,995,319 (GRCm39)	L21Q	probably damaging	Het
Slit1	G	T	19: 41,590,694 (GRCm39)	T1326K	possibly damaging	Het
Spata2l	T	C	8: 123,960,716 (GRCm39)	D191G	possibly damaging	Het
Susd4	C	A	1: 182,719,552 (GRCm39)	A389D	probably damaging	Het
Tcaf2	A	T	6: 42,601,510 (GRCm39)	F850I	probably damaging	Het
Teddm1b	T	C	1: 153,750,391 (GRCm39)	S67P	probably damaging	Het
Tiparp	T	A	3: 65,439,530 (GRCm39)	V100D	probably damaging	Het
Zdhhc14	A	G	17: 5,803,067 (GRCm39)	H390R	probably benign	Het

Other mutations in Bicra

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01521:Bicra	APN	7	15,723,113 (GRCm39)	missense	probably benign	0.18
IGL01690:Bicra	APN	7	15,721,678 (GRCm39)	missense	probably benign	0.09
IGL01721:Bicra	APN	7	15,722,624 (GRCm39)	missense	probably benign
IGL01994:Bicra	APN	7	15,706,741 (GRCm39)	missense	possibly damaging	0.46
IGL02084:Bicra	APN	7	15,721,663 (GRCm39)	missense	probably benign	0.09
IGL02312:Bicra	APN	7	15,727,066 (GRCm39)	missense	possibly damaging	0.85
IGL02686:Bicra	APN	7	15,721,840 (GRCm39)	missense	probably benign	0.02
IGL02727:Bicra	APN	7	15,713,390 (GRCm39)	missense	possibly damaging	0.95
IGL03031:Bicra	APN	7	15,709,726 (GRCm39)	missense	probably benign	0.16
R0003:Bicra	UTSW	7	15,705,812 (GRCm39)	missense	probably benign
R0025:Bicra	UTSW	7	15,721,436 (GRCm39)	missense	possibly damaging	0.53
R0241:Bicra	UTSW	7	15,709,070 (GRCm39)	missense	probably damaging	1.00
R0241:Bicra	UTSW	7	15,709,070 (GRCm39)	missense	probably damaging	1.00
R0417:Bicra	UTSW	7	15,706,247 (GRCm39)	missense	probably damaging	1.00
R0437:Bicra	UTSW	7	15,722,687 (GRCm39)	missense	possibly damaging	0.73
R0547:Bicra	UTSW	7	15,706,173 (GRCm39)	missense	probably damaging	1.00
R0688:Bicra	UTSW	7	15,723,247 (GRCm39)	missense	probably damaging	1.00
R0855:Bicra	UTSW	7	15,705,929 (GRCm39)	missense	probably damaging	1.00
R1448:Bicra	UTSW	7	15,722,284 (GRCm39)	missense	possibly damaging	0.86
R1637:Bicra	UTSW	7	15,706,614 (GRCm39)	missense	probably benign	0.19
R1899:Bicra	UTSW	7	15,721,676 (GRCm39)	missense	possibly damaging	0.53
R2035:Bicra	UTSW	7	15,730,338 (GRCm39)	missense	possibly damaging	0.53
R2247:Bicra	UTSW	7	15,723,159 (GRCm39)	missense	probably benign	0.33
R2471:Bicra	UTSW	7	15,706,257 (GRCm39)	missense	probably benign	0.04
R2484:Bicra	UTSW	7	15,722,605 (GRCm39)	missense	possibly damaging	0.96
R3437:Bicra	UTSW	7	15,723,223 (GRCm39)	missense	possibly damaging	0.85
R3551:Bicra	UTSW	7	15,713,658 (GRCm39)	missense	probably benign	0.33
R4816:Bicra	UTSW	7	15,722,831 (GRCm39)	missense	possibly damaging	0.53
R4901:Bicra	UTSW	7	15,721,526 (GRCm39)	missense	possibly damaging	0.53
R5035:Bicra	UTSW	7	15,713,349 (GRCm39)	missense	possibly damaging	0.90
R5078:Bicra	UTSW	7	15,709,382 (GRCm39)	missense	probably damaging	1.00
R5094:Bicra	UTSW	7	15,709,296 (GRCm39)	missense	probably damaging	1.00
R5195:Bicra	UTSW	7	15,713,878 (GRCm39)	missense	possibly damaging	0.93
R5496:Bicra	UTSW	7	15,721,766 (GRCm39)	missense	probably benign	0.33
R5780:Bicra	UTSW	7	15,713,679 (GRCm39)	missense	possibly damaging	0.96
R6541:Bicra	UTSW	7	15,713,054 (GRCm39)	missense	probably benign	0.00
R6560:Bicra	UTSW	7	15,723,119 (GRCm39)	missense	possibly damaging	0.53
R6575:Bicra	UTSW	7	15,713,056 (GRCm39)	missense	probably benign	0.25
R6854:Bicra	UTSW	7	15,722,687 (GRCm39)	missense	probably benign	0.18
R6967:Bicra	UTSW	7	15,706,130 (GRCm39)	missense	probably damaging	0.97
R7283:Bicra	UTSW	7	15,706,425 (GRCm39)	missense	probably damaging	1.00
R7454:Bicra	UTSW	7	15,706,059 (GRCm39)	missense	probably benign	0.30
R7462:Bicra	UTSW	7	15,713,060 (GRCm39)	missense	possibly damaging	0.84
R7488:Bicra	UTSW	7	15,723,367 (GRCm39)	critical splice acceptor site	probably null
R7506:Bicra	UTSW	7	15,722,138 (GRCm39)	missense	possibly damaging	0.96
R7534:Bicra	UTSW	7	15,705,860 (GRCm39)	missense	probably damaging	0.98
R7915:Bicra	UTSW	7	15,722,447 (GRCm39)	missense	probably benign
R8063:Bicra	UTSW	7	15,712,969 (GRCm39)	missense	probably benign
R8147:Bicra	UTSW	7	15,722,395 (GRCm39)	missense	possibly damaging	0.93
R8699:Bicra	UTSW	7	15,723,113 (GRCm39)	missense	probably benign	0.18
R8784:Bicra	UTSW	7	15,705,875 (GRCm39)	missense	probably damaging	1.00
R8859:Bicra	UTSW	7	15,721,737 (GRCm39)	missense	possibly damaging	0.73
R8971:Bicra	UTSW	7	15,721,481 (GRCm39)	missense	probably benign	0.08
R9487:Bicra	UTSW	7	15,705,717 (GRCm39)	missense	probably damaging	0.99
R9614:Bicra	UTSW	7	15,705,880 (GRCm39)	missense	probably damaging	1.00
R9721:Bicra	UTSW	7	15,713,101 (GRCm39)	missense	probably damaging	1.00
R9777:Bicra	UTSW	7	15,705,987 (GRCm39)	missense	probably benign	0.09
X0064:Bicra	UTSW	7	15,709,700 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-04-17