Incidental Mutation 'IGL00774:Tmem18'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem18
Ensembl Gene ENSMUSG00000043061
Gene Nametransmembrane protein 18
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.112) question?
Stock #IGL00774
Quality Score
Chromosomal Location30584426-30591215 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 30588721 bp
Amino Acid Change Arginine to Glycine at position 133 (R133G)
Ref Sequence ENSEMBL: ENSMUSP00000050729 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057151]
Predicted Effect unknown
Transcript: ENSMUST00000057151
AA Change: R133G
SMART Domains Protein: ENSMUSP00000050729
Gene: ENSMUSG00000043061
AA Change: R133G

Pfam:TMEM18 14 133 5.7e-49 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218826
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit a male-specific increase in body weight, fat mass and lean mass whether fed standard chow or a high-fat diet, increased suseptibility to diet-induced obesity, increased energy expenditure and increased food intake. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl1 G A 4: 86,388,539 A1397T possibly damaging Het
Aldob A G 4: 49,536,843 S349P probably benign Het
Cd2 A T 3: 101,283,029 probably null Het
Cmtm2a A G 8: 104,292,930 S43P probably damaging Het
Cts6 T C 13: 61,198,339 probably benign Het
Cyp4a10 A T 4: 115,532,538 I447F probably damaging Het
E2f3 A T 13: 29,918,704 D68E probably damaging Het
Ect2 G A 3: 27,098,443 R869W probably damaging Het
Eml1 A G 12: 108,514,515 probably null Het
Fundc1 T A X: 17,558,013 probably null Het
Gabrb1 G T 5: 72,108,446 probably null Het
Lrrk2 T G 15: 91,801,833 probably benign Het
Map3k2 C T 18: 32,228,239 P584L probably benign Het
Mindy2 T C 9: 70,631,033 D340G probably benign Het
Nav3 T C 10: 109,816,263 D877G probably damaging Het
Nol9 T C 4: 152,052,015 S515P probably benign Het
Osgepl1 A G 1: 53,320,246 I305V probably benign Het
Pign A G 1: 105,597,756 V449A probably benign Het
Rad54b G A 4: 11,593,765 R131K probably benign Het
Rgl3 A T 9: 21,987,722 probably benign Het
Scn2a A G 2: 65,735,853 D1407G probably damaging Het
Sf3b3 A T 8: 110,817,638 I790N probably damaging Het
Srebf1 C T 11: 60,205,139 R358Q probably damaging Het
Tnfrsf11b T G 15: 54,254,072 R262S probably benign Het
Tsc1 A T 2: 28,665,011 H171L probably damaging Het
Ubr5 T C 15: 38,006,541 T1157A probably benign Het
Wdcp A G 12: 4,855,303 E608G probably damaging Het
Zbtb40 T G 4: 136,994,524 H848P probably damaging Het
Other mutations in Tmem18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00770:Tmem18 APN 12 30588721 missense unknown
IGL02748:Tmem18 APN 12 30588745 makesense probably null
R1557:Tmem18 UTSW 12 30587199 critical splice acceptor site probably null
R2908:Tmem18 UTSW 12 30587253 nonsense probably null
R7053:Tmem18 UTSW 12 30584507 start codon destroyed probably null 0.85
R7199:Tmem18 UTSW 12 30588655 missense probably benign 0.03
R8322:Tmem18 UTSW 12 30588518 missense probably damaging 1.00
Posted On2015-04-16