Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01100:Gm10801'

278174

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm10801

Ensembl Gene

ENSMUSG00000075015

Gene Name

predicted gene 10801

Synonyms

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.366) question?

Stock #

IGL01100

Quality Score

Status

Chromosome

Chromosomal Location

98492582-98494428 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 98494328 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 135 (Y135F)

Ref Sequence

ENSEMBL: ENSMUSP00000097276 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099683] [ENSMUST00000099684]

AlphaFold

F7C7Q0

Predicted Effect

probably benign
Transcript: ENSMUST00000099683

SMART Domains

Protein: ENSMUSP00000097275
Gene: ENSMUSG00000075014

Domain	Start	End	E-Value	Type
internal_repeat_1	1	41	1.13e-5	PROSPERO
internal_repeat_2	26	49	4.11e-5	PROSPERO
transmembrane domain	78	96	N/A	INTRINSIC
internal_repeat_1	114	174	1.13e-5	PROSPERO
low complexity region	177	188	N/A	INTRINSIC
internal_repeat_2	197	219	4.11e-5	PROSPERO

Predicted Effect

probably benign
Transcript: ENSMUST00000099684
AA Change: Y135F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000097276
Gene: ENSMUSG00000075015
AA Change: Y135F

Domain	Start	End	E-Value	Type
internal_repeat_1	2	73	1.19e-13	PROSPERO
internal_repeat_1	80	167	1.19e-13	PROSPERO

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	G	11: 9,224,673 (GRCm39)		probably null	Het
Abca8a	C	T	11: 109,949,249 (GRCm39)		probably null	Het
Acad11	A	G	9: 103,953,607 (GRCm39)	T32A	probably damaging	Het
Ak7	T	A	12: 105,679,833 (GRCm39)	N122K	probably benign	Het
Arrb1	A	T	7: 99,236,420 (GRCm39)		probably null	Het
Csde1	C	A	3: 102,947,841 (GRCm39)	R132S	possibly damaging	Het
Emilin1	A	G	5: 31,075,748 (GRCm39)	H663R	probably benign	Het
Etaa1	A	G	11: 17,902,576 (GRCm39)		probably null	Het
Fat3	A	T	9: 16,286,524 (GRCm39)	F1000I	probably damaging	Het
Foxj2	T	C	6: 122,805,350 (GRCm39)	L74P	probably damaging	Het
Gas6	C	T	8: 13,525,118 (GRCm39)	V289M	probably benign	Het
Ihh	C	T	1: 74,985,601 (GRCm39)	A295T	probably damaging	Het
Ip6k2	G	T	9: 108,682,943 (GRCm39)	S305I	probably damaging	Het
Kcnk2	A	G	1: 189,072,133 (GRCm39)	V65A	probably damaging	Het
Kif26b	G	A	1: 178,744,809 (GRCm39)	C1635Y	probably benign	Het
Klhdc4	G	A	8: 122,548,582 (GRCm39)	Q44*	probably null	Het
Madd	C	A	2: 90,988,385 (GRCm39)	R1216L	probably damaging	Het
Myo15a	T	A	11: 60,401,984 (GRCm39)	C3076S	probably damaging	Het
Or1l4	A	T	2: 37,091,652 (GRCm39)	H133L	possibly damaging	Het
Or52e18	T	A	7: 104,609,202 (GRCm39)	I246F	probably benign	Het
Polq	C	A	16: 36,881,474 (GRCm39)	P934T	probably benign	Het
Prkaa1	A	T	15: 5,203,799 (GRCm39)	K227M	probably damaging	Het
Psap	G	A	10: 60,135,708 (GRCm39)	G388S	probably benign	Het
Repin1	A	G	6: 48,573,839 (GRCm39)	E200G	probably damaging	Het
Samd9l	C	A	6: 3,375,863 (GRCm39)	S466I	possibly damaging	Het
Slc5a3	A	G	16: 91,876,110 (GRCm39)		probably benign	Het
Smg9	G	A	7: 24,116,376 (GRCm39)	V314M	probably damaging	Het
Tktl1	G	A	X: 73,244,232 (GRCm39)	R352H	probably benign	Het
Ube2z	A	G	11: 95,953,849 (GRCm39)	V123A	probably damaging	Het
Vmn1r176	A	T	7: 23,535,049 (GRCm39)	F35I	probably benign	Het
Zdhhc18	A	T	4: 133,340,269 (GRCm39)	Y293N	probably damaging	Het

Other mutations in Gm10801

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01154:Gm10801	APN	2	98,494,328 (GRCm39)	missense	probably benign
Haplo	UTSW	2	98,494,252 (GRCm39)	splice site	probably benign
Ladder	UTSW	2	98,494,246 (GRCm39)	splice site	probably null
PIT4131001:Gm10801	UTSW	2	98,492,648 (GRCm39)	missense	probably benign
PIT4142001:Gm10801	UTSW	2	98,492,648 (GRCm39)	missense	probably benign
R0026:Gm10801	UTSW	2	98,494,254 (GRCm39)	splice site	probably benign
R0063:Gm10801	UTSW	2	98,494,185 (GRCm39)	missense	probably benign	0.30
R0334:Gm10801	UTSW	2	98,494,352 (GRCm39)	missense	possibly damaging	0.66
R0335:Gm10801	UTSW	2	98,494,352 (GRCm39)	missense	possibly damaging	0.66
R1172:Gm10801	UTSW	2	98,494,252 (GRCm39)	splice site	probably benign
R1321:Gm10801	UTSW	2	98,494,252 (GRCm39)	splice site	probably benign
R1871:Gm10801	UTSW	2	98,494,185 (GRCm39)	missense	probably benign	0.30
R1924:Gm10801	UTSW	2	98,494,197 (GRCm39)	missense	probably damaging	1.00
R2163:Gm10801	UTSW	2	98,494,352 (GRCm39)	missense	possibly damaging	0.66
R2306:Gm10801	UTSW	2	98,494,352 (GRCm39)	missense	possibly damaging	0.66
R2379:Gm10801	UTSW	2	98,494,185 (GRCm39)	missense	probably benign	0.30
R3078:Gm10801	UTSW	2	98,494,197 (GRCm39)	missense	probably damaging	1.00
R3605:Gm10801	UTSW	2	98,494,352 (GRCm39)	missense	possibly damaging	0.66
R3892:Gm10801	UTSW	2	98,494,246 (GRCm39)	splice site	probably null
R3930:Gm10801	UTSW	2	98,494,361 (GRCm39)	missense	possibly damaging	0.48
R4638:Gm10801	UTSW	2	98,494,352 (GRCm39)	missense	possibly damaging	0.66
R4709:Gm10801	UTSW	2	98,494,246 (GRCm39)	splice site	probably null
R5390:Gm10801	UTSW	2	98,494,151 (GRCm39)	small insertion	probably benign
R5405:Gm10801	UTSW	2	98,494,151 (GRCm39)	small insertion	probably benign
R5535:Gm10801	UTSW	2	98,492,844 (GRCm39)	frame shift	probably null
R5653:Gm10801	UTSW	2	98,494,396 (GRCm39)	missense	probably damaging	1.00
R5747:Gm10801	UTSW	2	98,494,352 (GRCm39)	missense	possibly damaging	0.66
R5987:Gm10801	UTSW	2	98,494,152 (GRCm39)	nonsense	probably null
R6086:Gm10801	UTSW	2	98,494,148 (GRCm39)	nonsense	probably null
R6090:Gm10801	UTSW	2	98,494,151 (GRCm39)	small insertion	probably benign
R6093:Gm10801	UTSW	2	98,494,152 (GRCm39)	nonsense	probably null
R6112:Gm10801	UTSW	2	98,494,409 (GRCm39)	missense	probably benign	0.00
R6184:Gm10801	UTSW	2	98,494,151 (GRCm39)	small insertion	probably benign
R6352:Gm10801	UTSW	2	98,494,151 (GRCm39)	small insertion	probably benign
R6357:Gm10801	UTSW	2	98,494,152 (GRCm39)	frame shift	probably null
R6395:Gm10801	UTSW	2	98,494,152 (GRCm39)	small insertion	probably benign
R6514:Gm10801	UTSW	2	98,494,214 (GRCm39)	missense	probably benign	0.19
R6547:Gm10801	UTSW	2	98,494,148 (GRCm39)	nonsense	probably null
R6560:Gm10801	UTSW	2	98,494,152 (GRCm39)	nonsense	probably null
R6640:Gm10801	UTSW	2	98,494,152 (GRCm39)	nonsense	probably null
R6675:Gm10801	UTSW	2	98,494,151 (GRCm39)	small insertion	probably benign
R6679:Gm10801	UTSW	2	98,494,151 (GRCm39)	small insertion	probably benign
R6684:Gm10801	UTSW	2	98,494,152 (GRCm39)	nonsense	probably null
R6758:Gm10801	UTSW	2	98,494,152 (GRCm39)	nonsense	probably null
R6786:Gm10801	UTSW	2	98,494,148 (GRCm39)	nonsense	probably null
R6886:Gm10801	UTSW	2	98,494,151 (GRCm39)	small insertion	probably benign
R7783:Gm10801	UTSW	2	98,494,152 (GRCm39)	nonsense	probably null
R8032:Gm10801	UTSW	2	98,494,152 (GRCm39)	nonsense	probably null
R8684:Gm10801	UTSW	2	98,492,669 (GRCm39)	frame shift	probably null
R8831:Gm10801	UTSW	2	98,494,334 (GRCm39)	missense	probably damaging	0.96
R8843:Gm10801	UTSW	2	98,494,151 (GRCm39)	small insertion	probably benign
R8946:Gm10801	UTSW	2	98,492,669 (GRCm39)	frame shift	probably null
R9135:Gm10801	UTSW	2	98,494,152 (GRCm39)	nonsense	probably null
R9136:Gm10801	UTSW	2	98,494,152 (GRCm39)	nonsense	probably null
R9423:Gm10801	UTSW	2	98,494,148 (GRCm39)	nonsense	probably null
R9773:Gm10801	UTSW	2	98,494,345 (GRCm39)	missense	probably benign

Posted On

2015-04-16