Incidental Mutation 'IGL01122:Tas2r134'
| ID |
278184 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r134
|
| Ensembl Gene |
ENSMUSG00000056115 |
| Gene Name |
taste receptor, type 2, member 134 |
| Synonyms |
Tas2r34, T2R134 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.056)
|
| Stock # |
IGL01122
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
51517523-51518419 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 51517671 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Phenylalanine
at position 50
(C50F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000064657
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000070028]
|
| AlphaFold |
Q7TQB0 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000070028
AA Change: C50F
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000064657
Gene: ENSMUSG00000056115
AA Change: C50F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
291 |
1.4e-75 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arhgap6 |
A |
T |
X: 168,029,666 (GRCm39) |
K142N |
possibly damaging |
Het |
| Atp13a1 |
T |
A |
8: 70,251,555 (GRCm39) |
L540Q |
probably damaging |
Het |
| Cacna1a |
T |
C |
8: 85,341,422 (GRCm39) |
|
probably null |
Het |
| Cops6 |
A |
G |
5: 138,160,635 (GRCm39) |
K129E |
probably benign |
Het |
| Cracd |
T |
C |
5: 77,018,522 (GRCm39) |
*1289Q |
probably null |
Het |
| Cyp11a1 |
T |
C |
9: 57,923,589 (GRCm39) |
I98T |
probably damaging |
Het |
| Cyp2c65 |
A |
G |
19: 39,060,621 (GRCm39) |
|
probably null |
Het |
| Dapl1 |
A |
T |
2: 59,324,839 (GRCm39) |
K30I |
probably damaging |
Het |
| Dlg2 |
A |
G |
7: 92,091,816 (GRCm39) |
M894V |
possibly damaging |
Het |
| Eme2 |
C |
T |
17: 25,112,320 (GRCm39) |
A202T |
possibly damaging |
Het |
| Fbxw22 |
A |
T |
9: 109,215,739 (GRCm39) |
S170T |
probably damaging |
Het |
| Havcr2 |
A |
G |
11: 46,347,254 (GRCm39) |
Y77C |
probably damaging |
Het |
| Ivd |
T |
A |
2: 118,707,361 (GRCm39) |
|
probably benign |
Het |
| Map3k9 |
T |
C |
12: 81,778,900 (GRCm39) |
D471G |
possibly damaging |
Het |
| Med12 |
T |
C |
X: 100,325,149 (GRCm39) |
|
probably benign |
Het |
| Megf6 |
C |
T |
4: 154,338,264 (GRCm39) |
R445W |
probably damaging |
Het |
| Mptx1 |
A |
G |
1: 174,159,964 (GRCm39) |
Y90C |
probably damaging |
Het |
| Nek1 |
G |
A |
8: 61,574,000 (GRCm39) |
V1083I |
possibly damaging |
Het |
| Nepn |
T |
A |
10: 52,267,911 (GRCm39) |
I59N |
probably damaging |
Het |
| Or4a72 |
A |
G |
2: 89,405,767 (GRCm39) |
I101T |
possibly damaging |
Het |
| Pbdc1 |
T |
C |
X: 104,126,297 (GRCm39) |
|
probably benign |
Het |
| Phlpp1 |
G |
T |
1: 106,101,166 (GRCm39) |
R478L |
possibly damaging |
Het |
| Ppp2r3c |
C |
T |
12: 55,344,587 (GRCm39) |
G127D |
probably benign |
Het |
| Ppp2r3d |
A |
G |
9: 101,088,844 (GRCm39) |
L493P |
probably benign |
Het |
| Pramel24 |
A |
G |
4: 143,454,971 (GRCm39) |
D423G |
probably benign |
Het |
| Psap |
T |
C |
10: 60,135,253 (GRCm39) |
V303A |
probably benign |
Het |
| Rdh13 |
T |
C |
7: 4,445,694 (GRCm39) |
K60R |
probably benign |
Het |
| Scaf4 |
A |
G |
16: 90,045,518 (GRCm39) |
S528P |
unknown |
Het |
| Sfmbt1 |
A |
G |
14: 30,532,268 (GRCm39) |
I543V |
probably damaging |
Het |
| Speg |
T |
C |
1: 75,386,679 (GRCm39) |
L1271P |
probably damaging |
Het |
| Stard9 |
C |
A |
2: 120,528,960 (GRCm39) |
T1739K |
possibly damaging |
Het |
| Tmprss11b |
G |
T |
5: 86,811,376 (GRCm39) |
T186K |
probably benign |
Het |
| U2surp |
G |
T |
9: 95,372,287 (GRCm39) |
Q291K |
probably benign |
Het |
| Ulk4 |
A |
G |
9: 120,997,358 (GRCm39) |
I738T |
possibly damaging |
Het |
| Urb1 |
A |
T |
16: 90,601,346 (GRCm39) |
S142T |
possibly damaging |
Het |
| Vmn2r112 |
T |
A |
17: 22,821,988 (GRCm39) |
I222N |
probably benign |
Het |
| Zmym4 |
T |
C |
4: 126,758,045 (GRCm39) |
N1503S |
probably damaging |
Het |
|
| Other mutations in Tas2r134 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00562:Tas2r134
|
APN |
2 |
51,518,100 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL00563:Tas2r134
|
APN |
2 |
51,518,100 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01121:Tas2r134
|
APN |
2 |
51,518,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01128:Tas2r134
|
APN |
2 |
51,517,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01132:Tas2r134
|
APN |
2 |
51,517,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01312:Tas2r134
|
APN |
2 |
51,518,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01419:Tas2r134
|
APN |
2 |
51,517,759 (GRCm39) |
nonsense |
probably null |
|
|
IGL01774:Tas2r134
|
APN |
2 |
51,518,160 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02735:Tas2r134
|
APN |
2 |
51,517,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0799:Tas2r134
|
UTSW |
2 |
51,518,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1205:Tas2r134
|
UTSW |
2 |
51,517,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2267:Tas2r134
|
UTSW |
2 |
51,518,249 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3736:Tas2r134
|
UTSW |
2 |
51,517,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Tas2r134
|
UTSW |
2 |
51,517,559 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5752:Tas2r134
|
UTSW |
2 |
51,517,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6162:Tas2r134
|
UTSW |
2 |
51,517,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6940:Tas2r134
|
UTSW |
2 |
51,518,148 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6954:Tas2r134
|
UTSW |
2 |
51,517,782 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6996:Tas2r134
|
UTSW |
2 |
51,517,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7206:Tas2r134
|
UTSW |
2 |
51,518,120 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7303:Tas2r134
|
UTSW |
2 |
51,518,145 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7348:Tas2r134
|
UTSW |
2 |
51,518,414 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7479:Tas2r134
|
UTSW |
2 |
51,517,541 (GRCm39) |
missense |
not run |
|
|
R7575:Tas2r134
|
UTSW |
2 |
51,518,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7686:Tas2r134
|
UTSW |
2 |
51,518,255 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8721:Tas2r134
|
UTSW |
2 |
51,517,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9384:Tas2r134
|
UTSW |
2 |
51,518,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9622:Tas2r134
|
UTSW |
2 |
51,518,358 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Posted On |
2015-04-16 |
Incidental Mutation