Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01128:Tas2r134'

278188

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r134

Ensembl Gene

ENSMUSG00000056115

Gene Name

taste receptor, type 2, member 134

Synonyms

T2R134, Tas2r34

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01128

Quality Score

Status

Chromosome

Chromosomal Location

51627511-51628408 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 51627659 bp

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Phenylalanine at position 50 (C50F)

Ref Sequence

ENSEMBL: ENSMUSP00000064657 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000070028]

Predicted Effect

probably damaging
Transcript: ENSMUST00000070028
AA Change: C50F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000064657
Gene: ENSMUSG00000056115
AA Change: C50F

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	291	1.4e-75	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,950,275	V124I	probably damaging	Het
Adgrf5	G	T	17: 43,422,509	D75Y	possibly damaging	Het
Aen	G	A	7: 78,907,302	M299I	probably damaging	Het
Ahi1	A	G	10: 21,074,433	T128A	probably benign	Het
Bves	T	A	10: 45,353,848	F249L	probably damaging	Het
Capns1	T	C	7: 30,190,133	I214V	probably benign	Het
Cgnl1	G	T	9: 71,724,561	Q503K	possibly damaging	Het
Ep300	A	G	15: 81,630,006		probably benign	Het
Fam117b	T	A	1: 59,969,018	F337Y	probably damaging	Het
Fam178b	A	T	1: 36,644,354	V95E	probably damaging	Het
Gak	T	A	5: 108,592,370	M560L	probably damaging	Het
Gna11	C	A	10: 81,530,884	A331S	probably damaging	Het
Gtf3c3	A	C	1: 54,428,876	F201V	possibly damaging	Het
Kat6b	G	A	14: 21,660,860	R734H	probably benign	Het
Lag3	T	C	6: 124,909,417	D191G	probably damaging	Het
Mttp	T	A	3: 138,133,997		probably null	Het
Nlgn3	A	T	X: 101,320,092	T790S	probably benign	Het
Olfr1487	G	A	19: 13,619,746	E195K	probably damaging	Het
Olfr743	A	G	14: 50,533,949	D179G	probably damaging	Het
Pkd2l2	T	A	18: 34,417,015	Y238N	probably damaging	Het
Plg	A	T	17: 12,396,699		probably benign	Het
Ptprm	A	T	17: 67,042,101	C376S	probably damaging	Het
Rexo1	T	C	10: 80,549,739	D495G	probably benign	Het
Rims1	A	T	1: 22,534,175	V315D	probably damaging	Het
Ros1	G	A	10: 52,142,328	Q745*	probably null	Het
Satb1	A	G	17: 51,805,289	V99A	probably damaging	Het
Sema3e	C	T	5: 14,232,115	P422S	probably damaging	Het
Stkld1	G	T	2: 26,951,471	W476L	probably benign	Het
Syna	T	C	5: 134,559,480	D205G	probably damaging	Het
Togaram1	A	G	12: 64,980,876	T880A	probably benign	Het
Uckl1	T	C	2: 181,570,337	E363G	probably damaging	Het
Yeats2	T	A	16: 20,161,968		probably benign	Het

Other mutations in Tas2r134

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00562:Tas2r134	APN	2	51628088	missense	possibly damaging	0.90
IGL00563:Tas2r134	APN	2	51628088	missense	possibly damaging	0.90
IGL01121:Tas2r134	APN	2	51627989	missense	probably damaging	1.00
IGL01122:Tas2r134	APN	2	51627659	missense	probably damaging	1.00
IGL01132:Tas2r134	APN	2	51627659	missense	probably damaging	1.00
IGL01312:Tas2r134	APN	2	51628235	missense	probably damaging	1.00
IGL01419:Tas2r134	APN	2	51627747	nonsense	probably null
IGL01774:Tas2r134	APN	2	51628148	missense	probably benign	0.07
IGL02735:Tas2r134	APN	2	51627827	missense	probably damaging	1.00
R0799:Tas2r134	UTSW	2	51628373	missense	probably benign	0.00
R1205:Tas2r134	UTSW	2	51627986	missense	probably benign	0.00
R2267:Tas2r134	UTSW	2	51628237	missense	probably benign	0.01
R3736:Tas2r134	UTSW	2	51627774	missense	probably damaging	1.00
R5254:Tas2r134	UTSW	2	51627547	missense	probably benign	0.39
R5752:Tas2r134	UTSW	2	51627868	missense	probably damaging	1.00
R6162:Tas2r134	UTSW	2	51627559	missense	probably damaging	1.00
R6940:Tas2r134	UTSW	2	51628136	missense	probably benign	0.00
R6954:Tas2r134	UTSW	2	51627770	missense	probably benign	0.00
R6996:Tas2r134	UTSW	2	51627589	missense	probably benign	0.00
R7206:Tas2r134	UTSW	2	51628108	missense	probably benign	0.02
R7303:Tas2r134	UTSW	2	51628133	missense	probably benign	0.01
R7348:Tas2r134	UTSW	2	51628402	missense	possibly damaging	0.92
R7479:Tas2r134	UTSW	2	51627529	missense	not run
R7575:Tas2r134	UTSW	2	51628154	missense	probably damaging	1.00
R7686:Tas2r134	UTSW	2	51628243	missense	possibly damaging	0.54

Posted On

2015-04-16