Incidental Mutation 'IGL01128:Tas2r134'
| ID |
278188 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r134
|
| Ensembl Gene |
ENSMUSG00000056115 |
| Gene Name |
taste receptor, type 2, member 134 |
| Synonyms |
Tas2r34, T2R134 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.056)
|
| Stock # |
IGL01128
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
51517523-51518419 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 51517671 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Phenylalanine
at position 50
(C50F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000064657
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000070028]
|
| AlphaFold |
Q7TQB0 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000070028
AA Change: C50F
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000064657
Gene: ENSMUSG00000056115
AA Change: C50F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
291 |
1.4e-75 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110038F14Rik |
G |
A |
15: 76,834,475 (GRCm39) |
V124I |
probably damaging |
Het |
| Adgrf5 |
G |
T |
17: 43,733,400 (GRCm39) |
D75Y |
possibly damaging |
Het |
| Aen |
G |
A |
7: 78,557,050 (GRCm39) |
M299I |
probably damaging |
Het |
| Ahi1 |
A |
G |
10: 20,950,332 (GRCm39) |
T128A |
probably benign |
Het |
| Bves |
T |
A |
10: 45,229,944 (GRCm39) |
F249L |
probably damaging |
Het |
| Capns1 |
T |
C |
7: 29,889,558 (GRCm39) |
I214V |
probably benign |
Het |
| Cgnl1 |
G |
T |
9: 71,631,843 (GRCm39) |
Q503K |
possibly damaging |
Het |
| Ep300 |
A |
G |
15: 81,514,207 (GRCm39) |
|
probably benign |
Het |
| Fam117b |
T |
A |
1: 60,008,177 (GRCm39) |
F337Y |
probably damaging |
Het |
| Fam178b |
A |
T |
1: 36,683,435 (GRCm39) |
V95E |
probably damaging |
Het |
| Gak |
T |
A |
5: 108,740,236 (GRCm39) |
M560L |
probably damaging |
Het |
| Gna11 |
C |
A |
10: 81,366,718 (GRCm39) |
A331S |
probably damaging |
Het |
| Gtf3c3 |
A |
C |
1: 54,468,035 (GRCm39) |
F201V |
possibly damaging |
Het |
| Kat6b |
G |
A |
14: 21,710,928 (GRCm39) |
R734H |
probably benign |
Het |
| Lag3 |
T |
C |
6: 124,886,380 (GRCm39) |
D191G |
probably damaging |
Het |
| Mttp |
T |
A |
3: 137,839,758 (GRCm39) |
|
probably null |
Het |
| Nlgn3 |
A |
T |
X: 100,363,698 (GRCm39) |
T790S |
probably benign |
Het |
| Or11g27 |
A |
G |
14: 50,771,406 (GRCm39) |
D179G |
probably damaging |
Het |
| Or5b123 |
G |
A |
19: 13,597,110 (GRCm39) |
E195K |
probably damaging |
Het |
| Pkd2l2 |
T |
A |
18: 34,550,068 (GRCm39) |
Y238N |
probably damaging |
Het |
| Plg |
A |
T |
17: 12,615,586 (GRCm39) |
|
probably benign |
Het |
| Ptprm |
A |
T |
17: 67,349,096 (GRCm39) |
C376S |
probably damaging |
Het |
| Rexo1 |
T |
C |
10: 80,385,573 (GRCm39) |
D495G |
probably benign |
Het |
| Rims1 |
A |
T |
1: 22,573,256 (GRCm39) |
V315D |
probably damaging |
Het |
| Ros1 |
G |
A |
10: 52,018,424 (GRCm39) |
Q745* |
probably null |
Het |
| Satb1 |
A |
G |
17: 52,112,317 (GRCm39) |
V99A |
probably damaging |
Het |
| Sema3e |
C |
T |
5: 14,282,129 (GRCm39) |
P422S |
probably damaging |
Het |
| Stkld1 |
G |
T |
2: 26,841,483 (GRCm39) |
W476L |
probably benign |
Het |
| Syna |
T |
C |
5: 134,588,334 (GRCm39) |
D205G |
probably damaging |
Het |
| Togaram1 |
A |
G |
12: 65,027,650 (GRCm39) |
T880A |
probably benign |
Het |
| Uckl1 |
T |
C |
2: 181,212,130 (GRCm39) |
E363G |
probably damaging |
Het |
| Yeats2 |
T |
A |
16: 19,980,718 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Tas2r134 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00562:Tas2r134
|
APN |
2 |
51,518,100 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL00563:Tas2r134
|
APN |
2 |
51,518,100 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01121:Tas2r134
|
APN |
2 |
51,518,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01122:Tas2r134
|
APN |
2 |
51,517,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01132:Tas2r134
|
APN |
2 |
51,517,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01312:Tas2r134
|
APN |
2 |
51,518,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01419:Tas2r134
|
APN |
2 |
51,517,759 (GRCm39) |
nonsense |
probably null |
|
|
IGL01774:Tas2r134
|
APN |
2 |
51,518,160 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02735:Tas2r134
|
APN |
2 |
51,517,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0799:Tas2r134
|
UTSW |
2 |
51,518,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1205:Tas2r134
|
UTSW |
2 |
51,517,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2267:Tas2r134
|
UTSW |
2 |
51,518,249 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3736:Tas2r134
|
UTSW |
2 |
51,517,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Tas2r134
|
UTSW |
2 |
51,517,559 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5752:Tas2r134
|
UTSW |
2 |
51,517,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6162:Tas2r134
|
UTSW |
2 |
51,517,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6940:Tas2r134
|
UTSW |
2 |
51,518,148 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6954:Tas2r134
|
UTSW |
2 |
51,517,782 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6996:Tas2r134
|
UTSW |
2 |
51,517,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7206:Tas2r134
|
UTSW |
2 |
51,518,120 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7303:Tas2r134
|
UTSW |
2 |
51,518,145 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7348:Tas2r134
|
UTSW |
2 |
51,518,414 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7479:Tas2r134
|
UTSW |
2 |
51,517,541 (GRCm39) |
missense |
not run |
|
|
R7575:Tas2r134
|
UTSW |
2 |
51,518,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7686:Tas2r134
|
UTSW |
2 |
51,518,255 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8721:Tas2r134
|
UTSW |
2 |
51,517,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9384:Tas2r134
|
UTSW |
2 |
51,518,034 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9622:Tas2r134
|
UTSW |
2 |
51,518,358 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Posted On |
2015-04-16 |
Incidental Mutation