Incidental Mutation 'IGL01150:Tedc1'
ID 278219
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tedc1
Ensembl Gene ENSMUSG00000037466
Gene Name tubulin epsilon and delta complex 1
Synonyms 4930427A07Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01150
Quality Score
Status
Chromosome 12
Chromosomal Location 113120041-113129668 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 113126808 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 357 (R357*)
Ref Sequence ENSEMBL: ENSMUSP00000035351 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049271] [ENSMUST00000196755] [ENSMUST00000200522]
AlphaFold Q3UK37
Predicted Effect probably null
Transcript: ENSMUST00000049271
AA Change: R357*
SMART Domains Protein: ENSMUSP00000035351
Gene: ENSMUSG00000037466
AA Change: R357*

DomainStartEndE-ValueType
low complexity region 2 21 N/A INTRINSIC
Pfam:DUF4509 41 221 4.8e-65 PFAM
low complexity region 233 245 N/A INTRINSIC
Pfam:DUF4510 258 418 3.1e-73 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000196755
SMART Domains Protein: ENSMUSP00000143431
Gene: ENSMUSG00000037466

DomainStartEndE-ValueType
low complexity region 1 20 N/A INTRINSIC
Pfam:DUF4509 40 138 4.1e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198072
Predicted Effect probably benign
Transcript: ENSMUST00000200522
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a A G 5: 8,752,550 (GRCm39) D507G possibly damaging Het
Actl6a A G 3: 32,766,313 (GRCm39) I60V probably benign Het
Adra2c T C 5: 35,438,485 (GRCm39) F419S probably damaging Het
Afap1l2 T C 19: 56,918,618 (GRCm39) Y105C probably damaging Het
Arid4b C T 13: 14,369,959 (GRCm39) Q1152* probably null Het
Arsj A G 3: 126,232,433 (GRCm39) D393G probably benign Het
Avp T C 2: 130,422,593 (GRCm39) probably benign Het
Cacna2d3 C T 14: 28,905,598 (GRCm39) V390I possibly damaging Het
Ccdc25 T A 14: 66,097,651 (GRCm39) M195K possibly damaging Het
Cdhr2 T A 13: 54,878,931 (GRCm39) S979T probably benign Het
Cog2 T C 8: 125,269,630 (GRCm39) F390S possibly damaging Het
Dennd5b A G 6: 148,969,583 (GRCm39) V290A probably benign Het
Ebf1 T C 11: 44,759,927 (GRCm39) L188P probably damaging Het
Galt T C 4: 41,757,786 (GRCm39) probably benign Het
Gm12830 C T 4: 114,702,261 (GRCm39) T141I unknown Het
Herc2 T A 7: 55,830,881 (GRCm39) W2965R probably damaging Het
Hrg A G 16: 22,777,909 (GRCm39) probably null Het
Ighv8-5 T C 12: 115,031,194 (GRCm39) Y115C probably damaging Het
Igkv12-89 A G 6: 68,812,127 (GRCm39) V14A probably benign Het
Nav2 A C 7: 49,102,269 (GRCm39) T295P probably benign Het
Niban1 T C 1: 151,593,472 (GRCm39) V719A probably benign Het
Nrg1 G A 8: 32,407,903 (GRCm39) T110I probably damaging Het
Or4c31 T C 2: 88,292,419 (GRCm39) V264A possibly damaging Het
Or51h1 A C 7: 102,308,699 (GRCm39) K224Q probably benign Het
Or7g29 A T 9: 19,286,535 (GRCm39) I214N probably damaging Het
Pclo T C 5: 14,726,926 (GRCm39) probably benign Het
Polg2 T C 11: 106,668,258 (GRCm39) probably null Het
Ptges G T 2: 30,782,720 (GRCm39) R111S probably damaging Het
Rbbp4 T C 4: 129,216,668 (GRCm39) probably benign Het
Rundc3a T C 11: 102,284,602 (GRCm39) V34A probably benign Het
Scn3a C A 2: 65,327,709 (GRCm39) probably null Het
Sec14l3 T C 11: 4,026,238 (GRCm39) probably benign Het
Strip1 C T 3: 107,534,047 (GRCm39) probably null Het
Svep1 T A 4: 58,070,302 (GRCm39) I2495F probably benign Het
Syne1 A G 10: 5,393,154 (GRCm39) S71P probably damaging Het
Tmem161b C T 13: 84,440,526 (GRCm39) R133* probably null Het
Tnnc2 A T 2: 164,619,753 (GRCm39) I71N probably damaging Het
Vps13d T C 4: 144,875,845 (GRCm39) N1554S probably benign Het
Wfdc3 A T 2: 164,574,123 (GRCm39) probably benign Het
Zfp648 A T 1: 154,081,110 (GRCm39) H423L probably damaging Het
Other mutations in Tedc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01066:Tedc1 APN 12 113,126,770 (GRCm39) missense probably damaging 0.97
IGL01074:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01075:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01077:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01084:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01103:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01108:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01137:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01142:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01149:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL01151:Tedc1 APN 12 113,126,808 (GRCm39) nonsense probably null
IGL02646:Tedc1 APN 12 113,120,921 (GRCm39) missense possibly damaging 0.68
IGL02989:Tedc1 APN 12 113,126,941 (GRCm39) missense probably benign 0.09
ANU05:Tedc1 UTSW 12 113,126,808 (GRCm39) nonsense probably null
ANU22:Tedc1 UTSW 12 113,126,808 (GRCm39) nonsense probably null
R1309:Tedc1 UTSW 12 113,125,400 (GRCm39) missense probably benign
R1555:Tedc1 UTSW 12 113,120,117 (GRCm39) unclassified probably benign
R2092:Tedc1 UTSW 12 113,121,340 (GRCm39) missense probably damaging 1.00
R3053:Tedc1 UTSW 12 113,120,087 (GRCm39) unclassified probably benign
R4130:Tedc1 UTSW 12 113,126,828 (GRCm39) missense probably benign 0.01
R5050:Tedc1 UTSW 12 113,120,325 (GRCm39) missense possibly damaging 0.86
R5386:Tedc1 UTSW 12 113,120,302 (GRCm39) missense probably benign 0.03
R6377:Tedc1 UTSW 12 113,124,975 (GRCm39) missense probably damaging 1.00
R6749:Tedc1 UTSW 12 113,121,702 (GRCm39) missense probably damaging 1.00
R6761:Tedc1 UTSW 12 113,125,334 (GRCm39) missense probably damaging 1.00
R8220:Tedc1 UTSW 12 113,120,375 (GRCm39) critical splice donor site probably null
R9240:Tedc1 UTSW 12 113,121,310 (GRCm39) missense probably benign 0.43
Posted On 2015-04-16