Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01295:Malrd1'

278256

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Malrd1

Ensembl Gene

ENSMUSG00000075520

Gene Name

MAM and LDL receptor class A domain containing 1

Synonyms

Diet1, Gm13364, Gm13318

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

IGL01295

Quality Score

Status

Chromosome

Chromosomal Location

15526479-16255555 bp(+) (GRCm38)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

G to A at 16101957 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000116869 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000146205]

AlphaFold

A2AJX4

Predicted Effect

probably null
Transcript: ENSMUST00000146205

SMART Domains

Protein: ENSMUSP00000116869
Gene: ENSMUSG00000075520

Domain	Start	End	E-Value	Type
Pfam:MAM	8	171	1.6e-36	PFAM
LDLa	181	219	6.89e-8	SMART
LDLa	225	262	4.37e-10	SMART
LDLa	264	303	9.55e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	G	T	14: 32,661,936	L691I	possibly damaging	Het
Ano7	A	G	1: 93,380,478	D77G	probably benign	Het
Apol10b	A	T	15: 77,585,596	V127E	probably damaging	Het
Apol11b	G	A	15: 77,638,019	T26M	probably damaging	Het
Atn1	T	C	6: 124,749,276	E80G	probably damaging	Het
Carmil2	T	C	8: 105,695,516	M1139T	probably benign	Het
Cd4	G	A	6: 124,879,378	T50I	probably benign	Het
Celf5	G	T	10: 81,467,080		probably benign	Het
Chd6	G	A	2: 160,988,370		probably benign	Het
Col12a1	A	T	9: 79,643,926	V2136E	probably damaging	Het
Col4a1	G	T	8: 11,236,075		probably benign	Het
Dph1	A	G	11: 75,180,949		probably benign	Het
Dvl2	G	T	11: 70,009,584	V735F	possibly damaging	Het
Eif3b	A	G	5: 140,441,740	I709V	possibly damaging	Het
Elp5	C	T	11: 69,968,470		probably benign	Het
Exd1	A	T	2: 119,530,079		probably benign	Het
Fbxl4	C	A	4: 22,427,348	R530S	probably benign	Het
Fmo4	A	T	1: 162,799,124	D284E	probably damaging	Het
Fn3krp	A	G	11: 121,421,554	Y31C	probably damaging	Het
Galnt14	G	T	17: 73,504,919	Q436K	probably benign	Het
Gm5114	A	T	7: 39,407,817	W793R	probably damaging	Het
Gm9376	T	G	14: 118,267,647	S164A	possibly damaging	Het
Gtf2ird2	G	A	5: 134,192,764	D69N	probably damaging	Het
Hfm1	A	C	5: 106,917,606	M69R	possibly damaging	Het
Ighv9-1	A	C	12: 114,093,999	S94A	probably damaging	Het
Ikzf2	C	T	1: 69,577,987	R67H	probably benign	Het
Ipcef1	A	T	10: 6,900,642	F316L	probably damaging	Het
Kdsr	A	G	1: 106,755,457	V62A	possibly damaging	Het
Kif23	A	T	9: 61,932,129	C279S	possibly damaging	Het
Klf5	C	T	14: 99,301,721	T110I	probably benign	Het
Klhl25	T	A	7: 75,865,872	H175Q	probably benign	Het
Nfatc4	T	C	14: 55,832,505	V710A	probably benign	Het
Olfr1404	A	T	1: 173,215,873	Y74F	probably damaging	Het
Olfr68	C	T	7: 103,778,241	V35I	probably benign	Het
Optn	G	A	2: 5,033,156	T409I	possibly damaging	Het
Pabpc2	T	A	18: 39,774,029	Y116N	probably damaging	Het
Pafah1b1	G	T	11: 74,683,647	R238S	probably damaging	Het
Pdzd9	C	T	7: 120,668,395	G66R	probably damaging	Het
Pih1d1	T	C	7: 45,159,964	L285P	probably damaging	Het
Pirb	G	A	7: 3,717,406	P323S	probably damaging	Het
Pkd1l1	A	G	11: 8,933,685	F396L	possibly damaging	Het
Pla2g4d	G	A	2: 120,281,726	T108M	probably damaging	Het
Plin3	T	C	17: 56,279,814	Y411C	probably damaging	Het
Ppfibp2	T	C	7: 107,747,539		probably benign	Het
Prrc2c	T	C	1: 162,682,492	S995G	probably damaging	Het
Ptf1a	T	C	2: 19,446,618	I253T	probably damaging	Het
Ptprb	A	G	10: 116,362,648	I1684V	probably benign	Het
Ptprk	G	A	10: 28,475,178	V556I	probably benign	Het
Rffl	A	T	11: 82,818,457	C47S	probably damaging	Het
Rnf17	C	T	14: 56,463,064	Q569*	probably null	Het
Shprh	A	G	10: 11,183,868	E1121G	probably damaging	Het
Slc1a5	A	G	7: 16,795,862	D402G	probably damaging	Het
Slc24a3	G	A	2: 145,616,714		probably null	Het
Slc2a13	T	A	15: 91,350,132		probably null	Het
Slc30a8	A	T	15: 52,306,559	N61Y	possibly damaging	Het
Slitrk6	A	T	14: 110,751,436	S280T	possibly damaging	Het
Smad2	G	A	18: 76,302,430	A365T	probably benign	Het
Tcp10b	C	T	17: 13,080,160	P367S	probably damaging	Het
Tdp1	A	G	12: 99,891,670	N163D	probably benign	Het
Thbs1	A	G	2: 118,118,327	D488G	possibly damaging	Het
Trappc12	C	T	12: 28,746,762	S257N	probably damaging	Het
Treml1	T	C	17: 48,365,599		probably benign	Het
Ugt2b36	A	G	5: 87,080,885	V234A	probably damaging	Het
Vmn2r86	T	G	10: 130,453,026	H202P	probably damaging	Het
Vmn2r87	C	A	10: 130,472,009	V787F	probably damaging	Het
Wbp2nl	T	A	15: 82,306,418	M129K	probably damaging	Het
Zdhhc15	T	C	X: 104,544,913		probably null	Het

Other mutations in Malrd1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Malrd1	APN	2	16142186	splice site	probably benign
IGL01296:Malrd1	APN	2	16101957	critical splice donor site	probably null
IGL01399:Malrd1	APN	2	16101957	critical splice donor site	probably null
IGL01400:Malrd1	APN	2	16101957	critical splice donor site	probably null
IGL01401:Malrd1	APN	2	16101957	critical splice donor site	probably null
IGL01402:Malrd1	APN	2	16101957	critical splice donor site	probably null
IGL01405:Malrd1	APN	2	16101957	critical splice donor site	probably null
IGL01406:Malrd1	APN	2	16101957	critical splice donor site	probably null
IGL02105:Malrd1	APN	2	16127863	missense	unknown
IGL02581:Malrd1	APN	2	16142312	nonsense	probably null
IGL03015:Malrd1	APN	2	16042271	missense	unknown
IGL03038:Malrd1	APN	2	16127967	missense	unknown
R1353:Malrd1	UTSW	2	16127968	missense	unknown
R1385:Malrd1	UTSW	2	16042228	missense	unknown
R2242:Malrd1	UTSW	2	16101944	missense	unknown
R2888:Malrd1	UTSW	2	16074757	missense	unknown
R4398:Malrd1	UTSW	2	16150783	missense	unknown
R4982:Malrd1	UTSW	2	16042129	missense	probably benign	0.29
R5148:Malrd1	UTSW	2	16142226	missense	unknown
R5195:Malrd1	UTSW	2	16150810	missense	unknown
R5828:Malrd1	UTSW	2	15526653	missense	probably benign	0.00
R5892:Malrd1	UTSW	2	15614267	missense	probably benign	0.03
R6034:Malrd1	UTSW	2	15845326	missense	possibly damaging	0.78
R6034:Malrd1	UTSW	2	15845326	missense	possibly damaging	0.78
R6195:Malrd1	UTSW	2	15695326	missense	probably damaging	1.00
R6318:Malrd1	UTSW	2	16042267	missense	unknown
R6438:Malrd1	UTSW	2	15614206	missense
R6457:Malrd1	UTSW	2	15526597	start gained	probably benign
R6457:Malrd1	UTSW	2	15667929	missense	probably benign	0.41
R6499:Malrd1	UTSW	2	15931689	missense	probably benign	0.03
R6575:Malrd1	UTSW	2	15842628	missense	probably benign	0.00
R6792:Malrd1	UTSW	2	16150756	missense	unknown
R6796:Malrd1	UTSW	2	15869784	missense	unknown
R6930:Malrd1	UTSW	2	15797667	missense	unknown
R6959:Malrd1	UTSW	2	16218009	missense	probably damaging	0.97
R6993:Malrd1	UTSW	2	16150791	missense	unknown
R7102:Malrd1	UTSW	2	16142303	missense	unknown
R7112:Malrd1	UTSW	2	15925176	missense	unknown
R7248:Malrd1	UTSW	2	16101911	missense	unknown
R7249:Malrd1	UTSW	2	15623340	missense	probably damaging	0.97
R7334:Malrd1	UTSW	2	16006718	missense	probably damaging	0.99
R7394:Malrd1	UTSW	2	15695199	missense	unknown
R7399:Malrd1	UTSW	2	15610090	missense
R7476:Malrd1	UTSW	2	16142304	missense	unknown
R7582:Malrd1	UTSW	2	15695270	missense	unknown
R7604:Malrd1	UTSW	2	15925192	missense	unknown
R7662:Malrd1	UTSW	2	15871454	missense	unknown
R7681:Malrd1	UTSW	2	16218102	missense	unknown
R7740:Malrd1	UTSW	2	15614215	missense	not run
R7747:Malrd1	UTSW	2	16074835	missense	unknown
R7754:Malrd1	UTSW	2	15797799	splice site	probably null
R7950:Malrd1	UTSW	2	16128068	missense	unknown
R8194:Malrd1	UTSW	2	15925120	missense	unknown
R8260:Malrd1	UTSW	2	15614206	missense
R8314:Malrd1	UTSW	2	15752832	missense	unknown
R8342:Malrd1	UTSW	2	15633224	missense	unknown
R8386:Malrd1	UTSW	2	15696844	missense	unknown
R8492:Malrd1	UTSW	2	15610123	missense
R8728:Malrd1	UTSW	2	15696942	nonsense	probably null
R8756:Malrd1	UTSW	2	15752895	critical splice donor site	probably null
R8869:Malrd1	UTSW	2	15565557	critical splice donor site	probably null
R8888:Malrd1	UTSW	2	15845227	missense	unknown
R8895:Malrd1	UTSW	2	15845227	missense	unknown
R8902:Malrd1	UTSW	2	16255334	nonsense	probably null
R8954:Malrd1	UTSW	2	15551367	missense
R8960:Malrd1	UTSW	2	15565430	nonsense	probably null
R9005:Malrd1	UTSW	2	15845329	missense	unknown
R9135:Malrd1	UTSW	2	15797705	missense	unknown
R9267:Malrd1	UTSW	2	16255266	missense	unknown
R9330:Malrd1	UTSW	2	16255278	missense	unknown
R9359:Malrd1	UTSW	2	15614177	missense
R9383:Malrd1	UTSW	2	15695201	missense	unknown
R9389:Malrd1	UTSW	2	15703156	missense	unknown
R9403:Malrd1	UTSW	2	15614177	missense
R9454:Malrd1	UTSW	2	15752849	missense	unknown
R9454:Malrd1	UTSW	2	15797726	nonsense	probably null
R9520:Malrd1	UTSW	2	16074820	missense	unknown
R9544:Malrd1	UTSW	2	15635998	missense	unknown
R9609:Malrd1	UTSW	2	15695270	missense	unknown
R9667:Malrd1	UTSW	2	15565215	critical splice acceptor site	probably null
R9721:Malrd1	UTSW	2	15696827	missense	unknown
R9787:Malrd1	UTSW	2	15620590	missense	unknown
R9800:Malrd1	UTSW	2	15842594	missense	unknown
Z1176:Malrd1	UTSW	2	16217845	missense	unknown
Z1191:Malrd1	UTSW	2	16042226	missense	unknown

Posted On

2015-04-16