Incidental Mutation 'IGL01298:Vmn2r85'
ID 278259
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r85
Ensembl Gene ENSMUSG00000092048
Gene Name vomeronasal 2, receptor 85
Synonyms EG623734
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # IGL01298
Quality Score
Status
Chromosome 10
Chromosomal Location 130253658-130266615 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 130254690 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 665 (T665A)
Ref Sequence ENSEMBL: ENSMUSP00000128792 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171811]
AlphaFold G3UW56
Predicted Effect probably benign
Transcript: ENSMUST00000171811
AA Change: T665A

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000128792
Gene: ENSMUSG00000092048
AA Change: T665A

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 77 425 9e-26 PFAM
Pfam:NCD3G 508 562 1.1e-18 PFAM
Pfam:7tm_3 595 831 3.7e-54 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adora2a G T 10: 75,169,326 (GRCm39) W263C probably damaging Het
Agtpbp1 G A 13: 59,652,040 (GRCm39) H424Y possibly damaging Het
Angpt2 T G 8: 18,760,544 (GRCm39) N186T probably benign Het
Ank2 A G 3: 126,753,369 (GRCm39) V304A possibly damaging Het
Atg3 T C 16: 44,992,036 (GRCm39) M88T possibly damaging Het
Baz1a G T 12: 55,001,594 (GRCm39) P142Q probably damaging Het
Btbd1 G T 7: 81,444,055 (GRCm39) probably null Het
Cacnb3 T C 15: 98,537,734 (GRCm39) Y70H probably damaging Het
Cd4 G A 6: 124,856,341 (GRCm39) T50I probably benign Het
Cyp7a1 A T 4: 6,275,517 (GRCm39) W19R probably damaging Het
Dock10 T A 1: 80,508,962 (GRCm39) I1610F probably damaging Het
Gm11444 C A 11: 85,738,920 (GRCm39) D58Y unknown Het
Gm7168 A T 17: 14,170,120 (GRCm39) T496S probably benign Het
Gpc5 A G 14: 115,636,600 (GRCm39) S428G probably benign Het
Haus8 T C 8: 71,705,757 (GRCm39) E309G probably damaging Het
Ice1 A G 13: 70,753,023 (GRCm39) L1021P possibly damaging Het
Krtap14 A T 16: 88,622,615 (GRCm39) H121Q probably benign Het
Nwd1 T C 8: 73,388,959 (GRCm39) V170A probably benign Het
Or1j10 T A 2: 36,267,460 (GRCm39) M224K probably benign Het
Or6c3b T C 10: 129,527,898 (GRCm39) Y4C probably damaging Het
Or8g24 G A 9: 38,990,020 (GRCm39) T7I possibly damaging Het
Pfpl T C 19: 12,406,037 (GRCm39) M96T possibly damaging Het
Pramel5 A G 4: 143,997,732 (GRCm39) probably benign Het
Proc T C 18: 32,256,605 (GRCm39) N354S probably benign Het
Prss40 T G 1: 34,599,847 (GRCm39) I47L probably benign Het
Tmprss7 T C 16: 45,484,538 (GRCm39) R541G probably benign Het
Togaram2 T C 17: 72,023,508 (GRCm39) V788A possibly damaging Het
Trbv19 T C 6: 41,155,838 (GRCm39) Y70H probably damaging Het
Ttk C T 9: 83,747,195 (GRCm39) S678L probably benign Het
Other mutations in Vmn2r85
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01160:Vmn2r85 APN 10 130,254,690 (GRCm39) missense probably benign 0.22
IGL01361:Vmn2r85 APN 10 130,254,690 (GRCm39) missense probably benign 0.22
IGL02185:Vmn2r85 APN 10 130,254,561 (GRCm39) missense probably benign 0.13
IGL02505:Vmn2r85 APN 10 130,261,449 (GRCm39) missense probably damaging 1.00
IGL02607:Vmn2r85 APN 10 130,262,290 (GRCm39) missense possibly damaging 0.89
IGL02755:Vmn2r85 APN 10 130,261,381 (GRCm39) missense probably damaging 0.98
IGL03188:Vmn2r85 APN 10 130,254,612 (GRCm39) missense probably benign 0.16
IGL03366:Vmn2r85 APN 10 130,262,328 (GRCm39) missense probably benign 0.00
IGL03397:Vmn2r85 APN 10 130,261,263 (GRCm39) missense probably damaging 1.00
PIT4445001:Vmn2r85 UTSW 10 130,261,572 (GRCm39) missense probably benign 0.00
R0066:Vmn2r85 UTSW 10 130,261,770 (GRCm39) missense probably damaging 1.00
R0128:Vmn2r85 UTSW 10 130,255,054 (GRCm39) splice site probably benign
R0130:Vmn2r85 UTSW 10 130,255,054 (GRCm39) splice site probably benign
R0503:Vmn2r85 UTSW 10 130,258,609 (GRCm39) missense probably damaging 1.00
R0827:Vmn2r85 UTSW 10 130,265,387 (GRCm39) missense possibly damaging 0.89
R1432:Vmn2r85 UTSW 10 130,261,155 (GRCm39) missense possibly damaging 0.74
R1521:Vmn2r85 UTSW 10 130,261,788 (GRCm39) missense probably damaging 0.99
R2029:Vmn2r85 UTSW 10 130,261,443 (GRCm39) nonsense probably null
R2034:Vmn2r85 UTSW 10 130,262,242 (GRCm39) splice site probably benign
R2852:Vmn2r85 UTSW 10 130,255,035 (GRCm39) missense probably benign 0.03
R2853:Vmn2r85 UTSW 10 130,255,035 (GRCm39) missense probably benign 0.03
R3084:Vmn2r85 UTSW 10 130,261,081 (GRCm39) missense probably benign 0.00
R3085:Vmn2r85 UTSW 10 130,261,081 (GRCm39) missense probably benign 0.00
R3430:Vmn2r85 UTSW 10 130,254,758 (GRCm39) missense probably damaging 0.97
R3694:Vmn2r85 UTSW 10 130,254,171 (GRCm39) missense probably damaging 0.99
R3932:Vmn2r85 UTSW 10 130,254,336 (GRCm39) missense probably damaging 1.00
R4207:Vmn2r85 UTSW 10 130,254,574 (GRCm39) missense probably damaging 1.00
R4628:Vmn2r85 UTSW 10 130,261,235 (GRCm39) missense probably benign 0.00
R4814:Vmn2r85 UTSW 10 130,254,567 (GRCm39) missense probably benign 0.12
R4948:Vmn2r85 UTSW 10 130,254,990 (GRCm39) missense probably damaging 1.00
R4951:Vmn2r85 UTSW 10 130,261,113 (GRCm39) missense probably damaging 1.00
R4959:Vmn2r85 UTSW 10 130,257,302 (GRCm39) missense probably damaging 1.00
R5336:Vmn2r85 UTSW 10 130,258,574 (GRCm39) missense possibly damaging 0.63
R5643:Vmn2r85 UTSW 10 130,262,343 (GRCm39) missense probably damaging 1.00
R6061:Vmn2r85 UTSW 10 130,261,531 (GRCm39) missense probably benign 0.09
R6115:Vmn2r85 UTSW 10 130,258,672 (GRCm39) missense probably damaging 1.00
R6190:Vmn2r85 UTSW 10 130,261,330 (GRCm39) missense possibly damaging 0.88
R6518:Vmn2r85 UTSW 10 130,265,281 (GRCm39) missense probably benign 0.00
R6533:Vmn2r85 UTSW 10 130,262,529 (GRCm39) missense probably benign 0.00
R6610:Vmn2r85 UTSW 10 130,261,838 (GRCm39) missense probably damaging 0.97
R6809:Vmn2r85 UTSW 10 130,261,795 (GRCm39) missense probably benign
R6962:Vmn2r85 UTSW 10 130,261,452 (GRCm39) missense probably damaging 0.99
R7075:Vmn2r85 UTSW 10 130,258,557 (GRCm39) missense probably benign 0.06
R7104:Vmn2r85 UTSW 10 130,262,376 (GRCm39) missense probably benign
R7424:Vmn2r85 UTSW 10 130,254,849 (GRCm39) missense probably damaging 1.00
R7516:Vmn2r85 UTSW 10 130,254,852 (GRCm39) missense probably damaging 1.00
R7537:Vmn2r85 UTSW 10 130,258,735 (GRCm39) missense probably benign 0.01
R7768:Vmn2r85 UTSW 10 130,254,562 (GRCm39) missense probably damaging 1.00
R7810:Vmn2r85 UTSW 10 130,261,081 (GRCm39) missense probably benign 0.00
R8078:Vmn2r85 UTSW 10 130,265,364 (GRCm39) nonsense probably null
R8115:Vmn2r85 UTSW 10 130,261,820 (GRCm39) missense probably benign 0.06
R8262:Vmn2r85 UTSW 10 130,254,738 (GRCm39) missense probably damaging 0.98
R8395:Vmn2r85 UTSW 10 130,261,797 (GRCm39) missense probably damaging 0.99
R8409:Vmn2r85 UTSW 10 130,261,257 (GRCm39) missense probably benign 0.16
R8547:Vmn2r85 UTSW 10 130,261,311 (GRCm39) missense probably damaging 1.00
R8875:Vmn2r85 UTSW 10 130,254,171 (GRCm39) missense probably damaging 0.99
R9035:Vmn2r85 UTSW 10 130,261,479 (GRCm39) missense probably benign
R9040:Vmn2r85 UTSW 10 130,254,311 (GRCm39) missense probably damaging 1.00
R9115:Vmn2r85 UTSW 10 130,254,153 (GRCm39) missense probably benign 0.00
R9182:Vmn2r85 UTSW 10 130,265,350 (GRCm39) missense probably benign 0.00
R9245:Vmn2r85 UTSW 10 130,261,534 (GRCm39) missense probably damaging 1.00
R9245:Vmn2r85 UTSW 10 130,255,033 (GRCm39) missense possibly damaging 0.92
R9405:Vmn2r85 UTSW 10 130,261,215 (GRCm39) missense probably damaging 0.99
R9502:Vmn2r85 UTSW 10 130,261,387 (GRCm39) missense probably damaging 0.99
R9520:Vmn2r85 UTSW 10 130,254,993 (GRCm39) missense probably benign
R9653:Vmn2r85 UTSW 10 130,261,694 (GRCm39) missense probably damaging 0.99
Z1176:Vmn2r85 UTSW 10 130,261,713 (GRCm39) missense probably damaging 0.99
Z1177:Vmn2r85 UTSW 10 130,254,776 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16