Incidental Mutation 'IGL01322:Klra1'
ID 278279
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klra1
Ensembl Gene ENSMUSG00000079853
Gene Name killer cell lectin-like receptor, subfamily A, member 1
Synonyms Ly49A, Ly49o<129>
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # IGL01322
Quality Score
Status
Chromosome 6
Chromosomal Location 130340881-130363837 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 130341224 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 250 (I250F)
Ref Sequence ENSEMBL: ENSMUSP00000032288 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032288]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000032288
AA Change: I250F

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000032288
Gene: ENSMUSG00000079853
AA Change: I250F

DomainStartEndE-ValueType
Blast:CLECT 73 118 9e-8 BLAST
CLECT 139 254 4.02e-15 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127570
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T A 7: 120,038,422 (GRCm39) L368Q probably damaging Het
Abca2 T A 2: 25,336,794 (GRCm39) probably null Het
Ano7 T A 1: 93,323,230 (GRCm39) V497D probably benign Het
B4gat1 T C 19: 5,090,037 (GRCm39) Y345H probably damaging Het
Bckdha T A 7: 25,358,132 (GRCm39) R12W possibly damaging Het
Bcl7c T A 7: 127,306,608 (GRCm39) N93Y probably damaging Het
Cc2d2a C A 5: 43,846,345 (GRCm39) T368K probably benign Het
Chek1 G A 9: 36,629,717 (GRCm39) Q210* probably null Het
Chrdl2 A G 7: 99,666,248 (GRCm39) Y56C probably damaging Het
Cspg4 T A 9: 56,805,872 (GRCm39) F2228I probably damaging Het
Dnah7a T C 1: 53,473,205 (GRCm39) M3474V probably benign Het
Dph7 T C 2: 24,855,629 (GRCm39) S143P possibly damaging Het
Ehbp1 T A 11: 22,039,636 (GRCm39) K821N probably damaging Het
Eomes T C 9: 118,313,898 (GRCm39) S648P probably benign Het
Fam20a A G 11: 109,573,738 (GRCm39) V215A probably damaging Het
Fer1l4 T A 2: 155,862,259 (GRCm39) probably null Het
Frem2 A G 3: 53,448,459 (GRCm39) V2319A probably benign Het
Gtf3c4 T C 2: 28,723,584 (GRCm39) D575G probably benign Het
Ifit1bl2 A G 19: 34,596,404 (GRCm39) V404A probably benign Het
Kcnf1 T C 12: 17,225,349 (GRCm39) M291V probably benign Het
Klra4 T A 6: 130,038,985 (GRCm39) T136S probably benign Het
Mcrs1 A T 15: 99,141,266 (GRCm39) I399N probably damaging Het
Neo1 T C 9: 58,814,368 (GRCm39) E866G possibly damaging Het
Notch3 T C 17: 32,363,445 (GRCm39) D1206G probably damaging Het
Or10ab4 A G 7: 107,654,188 (GRCm39) probably benign Het
Or14c43 T A 7: 86,115,480 (GRCm39) I287N probably damaging Het
Or4z4 A C 19: 12,076,769 (GRCm39) V78G probably benign Het
Or5ae1 T A 7: 84,565,590 (GRCm39) V201E probably damaging Het
Or5b95 A C 19: 12,658,113 (GRCm39) I214L probably benign Het
Or6c210 A G 10: 129,495,995 (GRCm39) T107A probably benign Het
Pnkd A G 1: 74,390,716 (GRCm39) N336D probably damaging Het
Prag1 T C 8: 36,571,088 (GRCm39) V557A probably benign Het
Ptgfr A C 3: 151,541,323 (GRCm39) S62A probably benign Het
Smc2 A G 4: 52,450,842 (GRCm39) Y220C probably damaging Het
Sufu G A 19: 46,439,382 (GRCm39) E246K probably damaging Het
Sult2a1 T A 7: 13,566,604 (GRCm39) R124* probably null Het
Sult4a1 T A 15: 83,970,817 (GRCm39) Y196F possibly damaging Het
Trim15 G A 17: 37,175,975 (GRCm39) R191W probably damaging Het
Ttn A G 2: 76,773,319 (GRCm39) V2361A possibly damaging Het
Usp16 T C 16: 87,263,164 (GRCm39) V122A possibly damaging Het
Vmn1r122 T A 7: 20,868,036 (GRCm39) K6N probably benign Het
Vmn1r34 G A 6: 66,613,899 (GRCm39) Q280* probably null Het
Vmn2r45 T A 7: 8,484,332 (GRCm39) H491L possibly damaging Het
Wdpcp T C 11: 21,661,949 (GRCm39) L407P probably damaging Het
Zfp157 T C 5: 138,445,840 (GRCm39) I65T probably benign Het
Other mutations in Klra1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01132:Klra1 APN 6 130,341,237 (GRCm39) nonsense probably null
IGL01320:Klra1 APN 6 130,341,224 (GRCm39) missense probably benign 0.02
IGL02149:Klra1 APN 6 130,352,293 (GRCm39) missense probably damaging 1.00
IGL02666:Klra1 APN 6 130,341,278 (GRCm39) missense probably damaging 1.00
IGL02895:Klra1 APN 6 130,352,203 (GRCm39) missense possibly damaging 0.51
R0004:Klra1 UTSW 6 130,349,836 (GRCm39) missense probably damaging 1.00
R0408:Klra1 UTSW 6 130,354,737 (GRCm39) missense probably benign 0.13
R0442:Klra1 UTSW 6 130,349,835 (GRCm39) missense probably damaging 1.00
R0498:Klra1 UTSW 6 130,349,782 (GRCm39) critical splice donor site probably null
R0765:Klra1 UTSW 6 130,356,055 (GRCm39) splice site probably benign
R1761:Klra1 UTSW 6 130,349,836 (GRCm39) missense probably damaging 1.00
R1922:Klra1 UTSW 6 130,349,828 (GRCm39) missense probably benign 0.01
R1987:Klra1 UTSW 6 130,354,742 (GRCm39) missense probably benign
R2882:Klra1 UTSW 6 130,354,826 (GRCm39) splice site probably null
R5054:Klra1 UTSW 6 130,352,247 (GRCm39) missense probably damaging 0.99
R5190:Klra1 UTSW 6 130,352,241 (GRCm39) missense probably damaging 1.00
R5572:Klra1 UTSW 6 130,349,802 (GRCm39) missense possibly damaging 0.73
R5825:Klra1 UTSW 6 130,357,592 (GRCm39) missense probably damaging 1.00
R6784:Klra1 UTSW 6 130,349,817 (GRCm39) missense probably benign 0.00
R8957:Klra1 UTSW 6 130,357,609 (GRCm39) missense possibly damaging 0.89
R9154:Klra1 UTSW 6 130,357,607 (GRCm39) missense
Z1176:Klra1 UTSW 6 130,349,814 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16