Incidental Mutation 'IGL01355:Olfr165'
ID 278305
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr165
Ensembl Gene ENSMUSG00000050158
Gene Name olfactory receptor 165
Synonyms MOR279-1, GA_x54KRFPKG5P-15855164-15854223
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # IGL01355
Quality Score
Status
Chromosome 16
Chromosomal Location 19406244-19423134 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 19407583 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 145 (M145I)
Ref Sequence ENSEMBL: ENSMUSP00000146100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052516] [ENSMUST00000206110] [ENSMUST00000206410]
AlphaFold Q8VFA2
Predicted Effect probably benign
Transcript: ENSMUST00000052516
AA Change: M144I

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000062079
Gene: ENSMUSG00000050158
AA Change: M144I

DomainStartEndE-ValueType
Pfam:7tm_4 29 309 5.6e-48 PFAM
Pfam:7TM_GPCR_Srsx 36 306 6e-10 PFAM
Pfam:7tm_1 42 291 4e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000103984
Predicted Effect probably benign
Transcript: ENSMUST00000206110
AA Change: M144I

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000206410
AA Change: M145I

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ajap1 C T 4: 153,386,481 V290I probably damaging Het
Ankrd12 A G 17: 65,970,340 probably benign Het
Anxa4 A T 6: 86,752,205 I140N probably damaging Het
Asap2 A G 12: 21,218,086 probably benign Het
Cd36 C T 5: 17,813,074 V214I possibly damaging Het
Col24a1 T C 3: 145,314,876 L336S probably benign Het
Dcc C T 18: 71,809,114 V311I probably benign Het
Gpr146 A T 5: 139,378,904 probably benign Het
Irf1 T C 11: 53,774,361 V188A probably benign Het
Limk1 G A 5: 134,657,900 probably benign Het
Mcidas T C 13: 112,999,069 F342S probably damaging Het
Mctp1 A G 13: 76,384,955 T141A probably benign Het
Mnd1 C A 3: 84,116,477 A101S probably benign Het
Nsun7 T C 5: 66,294,868 S466P probably damaging Het
Olfr1279 T A 2: 111,307,093 I296K probably benign Het
Olfr617 A G 7: 103,584,373 E117G probably damaging Het
Pik3c2g G T 6: 139,852,857 G371V probably damaging Het
Sdad1 A G 5: 92,302,679 V199A probably damaging Het
Spg11 C T 2: 122,113,156 V172I probably benign Het
Tas2r108 A G 6: 40,493,751 T54A possibly damaging Het
Tmem121b A G 6: 120,492,466 L430P probably damaging Het
Traf3ip1 A G 1: 91,518,297 D384G probably damaging Het
Trank1 A G 9: 111,365,520 T871A possibly damaging Het
Vegfa T C 17: 46,025,421 M258V possibly damaging Het
Zbtb49 A G 5: 38,210,616 probably null Het
Other mutations in Olfr165
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01353:Olfr165 APN 16 19407583 missense probably benign 0.03
IGL01363:Olfr165 APN 16 19407583 missense probably benign 0.03
IGL01467:Olfr165 APN 16 19407789 missense probably benign 0.24
IGL02267:Olfr165 APN 16 19407164 missense possibly damaging 0.80
R1194:Olfr165 UTSW 16 19407180 missense possibly damaging 0.75
R1624:Olfr165 UTSW 16 19407704 missense probably benign 0.06
R2248:Olfr165 UTSW 16 19407194 missense probably damaging 0.98
R4865:Olfr165 UTSW 16 19407301 missense probably damaging 0.98
R4988:Olfr165 UTSW 16 19407110 missense probably benign 0.00
R5384:Olfr165 UTSW 16 19407797 missense probably damaging 1.00
R5858:Olfr165 UTSW 16 19407225 missense possibly damaging 0.91
R5997:Olfr165 UTSW 16 19407944 missense probably benign 0.10
R6301:Olfr165 UTSW 16 19407417 missense possibly damaging 0.96
R6570:Olfr165 UTSW 16 19407318 missense probably benign 0.00
R6703:Olfr165 UTSW 16 19407372 missense probably benign 0.03
R6953:Olfr165 UTSW 16 19407528 missense probably benign 0.04
R7424:Olfr165 UTSW 16 19407194 missense probably damaging 0.98
R7975:Olfr165 UTSW 16 19407551 missense probably damaging 1.00
R8312:Olfr165 UTSW 16 19407237 missense probably benign 0.11
R8880:Olfr165 UTSW 16 19407646 nonsense probably null
R9008:Olfr165 UTSW 16 19407423 missense probably benign 0.00
R9394:Olfr165 UTSW 16 19407269 missense probably benign
R9698:Olfr165 UTSW 16 19407592 nonsense probably null
Z1176:Olfr165 UTSW 16 19407735 missense probably benign
Posted On 2015-04-16