Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01402:Apol11b'

278347

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Apol11b

Ensembl Gene

ENSMUSG00000091694

Gene Name

apolipoprotein L 11b

Synonyms

A330102K04Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL01402

Quality Score

Status

Chromosome

Chromosomal Location

77518151-77527486 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 77522219 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 26 (T26M)

Ref Sequence

ENSEMBL: ENSMUSP00000137890 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166623] [ENSMUST00000180949] [ENSMUST00000181154] [ENSMUST00000181467]

AlphaFold

E9PUZ0

Predicted Effect

probably damaging
Transcript: ENSMUST00000166623
AA Change: T26M

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000129476
Gene: ENSMUSG00000091694
AA Change: T26M

Domain	Start	End	E-Value	Type
Pfam:ApoL	30	311	8.6e-78	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000180949
AA Change: T26M

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000137890
Gene: ENSMUSG00000091694
AA Change: T26M

Domain	Start	End	E-Value	Type
Pfam:ApoL	29	323	5.1e-76	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000181154
AA Change: T26M

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000137798
Gene: ENSMUSG00000091694
AA Change: T26M

Domain	Start	End	E-Value	Type
Pfam:ApoL	29	76	5.4e-9	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181467

SMART Domains

Protein: ENSMUSP00000138009
Gene: ENSMUSG00000091694

Domain	Start	End	E-Value	Type
Pfam:ApoL	1	144	2.3e-15	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921524L21Rik	T	C	18: 6,638,653 (GRCm39)	S351P	possibly damaging	Het
Abca2	T	C	2: 25,332,015 (GRCm39)	S1376P	probably damaging	Het
Ablim3	A	G	18: 62,004,754 (GRCm39)	Y12H	probably damaging	Het
Akr1b7	A	G	6: 34,398,052 (GRCm39)	R294G	possibly damaging	Het
Aldh3b1	A	C	19: 3,971,205 (GRCm39)	V153G	probably benign	Het
Alk	A	T	17: 72,181,173 (GRCm39)	H1372Q	probably damaging	Het
Ano9	A	C	7: 140,681,955 (GRCm39)	Y731*	probably null	Het
Asl	T	C	5: 130,048,645 (GRCm39)	E43G	probably damaging	Het
Cd4	G	A	6: 124,856,341 (GRCm39)	T50I	probably benign	Het
Cfap43	T	C	19: 47,784,105 (GRCm39)	D476G	probably benign	Het
Cpa1	A	G	6: 30,645,275 (GRCm39)	H417R	possibly damaging	Het
Cpeb3	T	C	19: 37,065,948 (GRCm39)	D407G	probably benign	Het
Dcaf15	A	T	8: 84,825,026 (GRCm39)	C469S	probably damaging	Het
Dpy19l4	C	A	4: 11,273,006 (GRCm39)		probably null	Het
E4f1	A	T	17: 24,663,208 (GRCm39)	L699Q	probably damaging	Het
Eif4g2	A	G	7: 110,676,234 (GRCm39)	F349S	possibly damaging	Het
Ermap	T	C	4: 119,044,355 (GRCm39)	Y147C	probably damaging	Het
Frk	A	C	10: 34,423,381 (GRCm39)	E153A	probably damaging	Het
Fubp3	G	A	2: 31,494,733 (GRCm39)		probably null	Het
Gdi2	A	G	13: 3,614,611 (GRCm39)	T319A	probably benign	Het
Gjc3	A	G	5: 137,956,120 (GRCm39)	F55S	probably damaging	Het
Gm10762	C	T	2: 128,809,005 (GRCm39)		probably benign	Het
Got1	A	G	19: 43,493,048 (GRCm39)	I291T	possibly damaging	Het
Gpr179	C	A	11: 97,229,012 (GRCm39)	G1048*	probably null	Het
Hectd3	G	T	4: 116,853,262 (GRCm39)	R163L	probably damaging	Het
Hectd4	T	C	5: 121,477,480 (GRCm39)		probably benign	Het
Ifnb1	T	C	4: 88,440,480 (GRCm39)	R178G	probably benign	Het
Ino80	T	A	2: 119,287,199 (GRCm39)	D56V	possibly damaging	Het
Kctd1	T	A	18: 15,102,610 (GRCm39)	Q857L	probably damaging	Het
Kdm5a	T	A	6: 120,367,640 (GRCm39)	L445*	probably null	Het
Lins1	G	A	7: 66,363,676 (GRCm39)	V524I	probably damaging	Het
Lrp1	A	T	10: 127,430,901 (GRCm39)	Y383N	probably damaging	Het
Malrd1	G	A	2: 16,106,768 (GRCm39)		probably null	Het
Mgam	A	C	6: 40,621,879 (GRCm39)	K84Q	probably benign	Het
Mlh3	A	T	12: 85,314,703 (GRCm39)	F494L	probably benign	Het
Mpped1	T	C	15: 83,676,414 (GRCm39)	F60S	possibly damaging	Het
Myo1e	A	G	9: 70,245,048 (GRCm39)	Y382C	probably benign	Het
Ncor1	C	A	11: 62,231,300 (GRCm39)	V836F	probably damaging	Het
Nktr	G	A	9: 121,570,218 (GRCm39)		probably null	Het
Or10al4	A	G	17: 38,037,193 (GRCm39)	T93A	probably benign	Het
Or4d5	A	G	9: 40,012,558 (GRCm39)	I76T	probably benign	Het
Or5k8	G	A	16: 58,644,958 (GRCm39)	T38I	probably damaging	Het
Rnf144a	T	A	12: 26,377,300 (GRCm39)	Y93F	probably benign	Het
Rubcn	G	A	16: 32,647,666 (GRCm39)	T636M	probably damaging	Het
Scn5a	A	C	9: 119,315,536 (GRCm39)	L1724R	probably damaging	Het
Sel1l	A	G	12: 91,808,607 (GRCm39)	S45P	possibly damaging	Het
Serpina3k	A	G	12: 104,306,882 (GRCm39)	D38G	probably benign	Het
Sh3bgr	A	C	16: 96,007,690 (GRCm39)	K18N	probably damaging	Het
Slc28a2	T	G	2: 122,282,538 (GRCm39)	I287M	probably damaging	Het
St8sia6	T	C	2: 13,670,318 (GRCm39)	N214S	probably damaging	Het
Syt11	A	G	3: 88,669,523 (GRCm39)	I123T	probably benign	Het
Tcerg1l	A	T	7: 137,861,568 (GRCm39)	I387N	probably damaging	Het
Tfg	C	A	16: 56,514,856 (GRCm39)		probably benign	Het
Tgm4	A	G	9: 122,880,519 (GRCm39)	K307E	possibly damaging	Het
Tmem177	T	C	1: 119,837,791 (GRCm39)	D296G	probably damaging	Het
Tmem270	C	T	5: 134,930,763 (GRCm39)		probably benign	Het
Tnrc6b	G	T	15: 80,764,745 (GRCm39)	G749V	possibly damaging	Het
Trp63	C	A	16: 25,639,135 (GRCm39)		probably benign	Het
Ugt1a8	T	C	1: 88,015,617 (GRCm39)	L10P	probably benign	Het
Vmn2r107	A	T	17: 20,596,009 (GRCm39)	K854M	probably damaging	Het
Vmn2r45	T	C	7: 8,484,467 (GRCm39)	N446S	probably damaging	Het
Vps13c	A	T	9: 67,820,486 (GRCm39)		probably null	Het
Wdr91	G	A	6: 34,865,998 (GRCm39)	P518L	probably benign	Het
Yap1	G	A	9: 7,934,742 (GRCm39)		probably benign	Het
Zfp282	A	C	6: 47,874,770 (GRCm39)	D325A	probably damaging	Het

Other mutations in Apol11b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01294:Apol11b	APN	15	77,522,219 (GRCm39)	missense	probably damaging	0.99
IGL01295:Apol11b	APN	15	77,522,219 (GRCm39)	missense	probably damaging	0.99
IGL01398:Apol11b	APN	15	77,522,219 (GRCm39)	missense	probably damaging	0.99
IGL01399:Apol11b	APN	15	77,522,219 (GRCm39)	missense	probably damaging	0.99
IGL01400:Apol11b	APN	15	77,522,219 (GRCm39)	missense	probably damaging	0.99
R1815:Apol11b	UTSW	15	77,519,772 (GRCm39)	missense	probably damaging	1.00
R2327:Apol11b	UTSW	15	77,522,153 (GRCm39)	missense	probably damaging	0.97
R3917:Apol11b	UTSW	15	77,519,504 (GRCm39)	missense	probably benign	0.03
R4424:Apol11b	UTSW	15	77,522,133 (GRCm39)	critical splice donor site	probably null
R4766:Apol11b	UTSW	15	77,519,133 (GRCm39)	missense	probably benign	0.00
R4804:Apol11b	UTSW	15	77,519,466 (GRCm39)	missense	probably damaging	1.00
R5440:Apol11b	UTSW	15	77,519,793 (GRCm39)	nonsense	probably null
R5600:Apol11b	UTSW	15	77,519,288 (GRCm39)	missense	probably damaging	0.97
R5866:Apol11b	UTSW	15	77,524,747 (GRCm39)	missense	probably null	0.97
R5997:Apol11b	UTSW	15	77,519,697 (GRCm39)	missense	probably benign	0.01
R6213:Apol11b	UTSW	15	77,522,200 (GRCm39)	missense	possibly damaging	0.82
R6249:Apol11b	UTSW	15	77,519,537 (GRCm39)	missense	probably benign	0.00
R6364:Apol11b	UTSW	15	77,522,258 (GRCm39)	missense	possibly damaging	0.46
R6984:Apol11b	UTSW	15	77,519,546 (GRCm39)	missense	probably benign	0.01
R8064:Apol11b	UTSW	15	77,519,417 (GRCm39)	missense	not run
R9081:Apol11b	UTSW	15	77,524,771 (GRCm39)	missense	possibly damaging	0.91
R9082:Apol11b	UTSW	15	77,524,771 (GRCm39)	missense	possibly damaging	0.91
R9105:Apol11b	UTSW	15	77,524,771 (GRCm39)	missense	possibly damaging	0.91
R9569:Apol11b	UTSW	15	77,524,771 (GRCm39)	missense	possibly damaging	0.91
R9570:Apol11b	UTSW	15	77,524,771 (GRCm39)	missense	possibly damaging	0.91
R9571:Apol11b	UTSW	15	77,524,771 (GRCm39)	missense	possibly damaging	0.91
R9573:Apol11b	UTSW	15	77,524,771 (GRCm39)	missense	possibly damaging	0.91
R9790:Apol11b	UTSW	15	77,519,475 (GRCm39)	missense	probably benign	0.17
R9791:Apol11b	UTSW	15	77,519,475 (GRCm39)	missense	probably benign	0.17
Z1088:Apol11b	UTSW	15	77,522,207 (GRCm39)	missense	probably benign	0.17
Z1176:Apol11b	UTSW	15	77,522,207 (GRCm39)	missense	probably benign	0.17
Z1177:Apol11b	UTSW	15	77,522,207 (GRCm39)	missense	probably benign	0.17

Posted On

2015-04-16