Incidental Mutation 'IGL00937:Olfr555'
ID27835
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr555
Ensembl Gene ENSMUSG00000073970
Gene Nameolfactory receptor 555
SynonymsMOR10-1, GA_x6K02T2PBJ9-5375442-5376389
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.168) question?
Stock #IGL00937
Quality Score
Status
Chromosome7
Chromosomal Location102658823-102659770 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 102659348 bp
ZygosityHeterozygous
Amino Acid Change Serine to Threonine at position 176 (S176T)
Ref Sequence ENSEMBL: ENSMUSP00000095823 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098220]
Predicted Effect probably damaging
Transcript: ENSMUST00000098220
AA Change: S176T

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000095823
Gene: ENSMUSG00000073970
AA Change: S176T

DomainStartEndE-ValueType
Pfam:7tm_4 32 311 2.5e-126 PFAM
Pfam:7TM_GPCR_Srsx 36 308 1.7e-7 PFAM
Pfam:7tm_1 42 293 1.2e-19 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cc2d2a A T 5: 43,688,122 probably null Het
Cd34 A G 1: 194,960,114 E381G probably damaging Het
Chka A G 19: 3,892,189 E381G probably benign Het
Dennd1b T A 1: 139,170,239 C673S probably benign Het
E130308A19Rik G A 4: 59,690,846 A227T probably benign Het
F13b T A 1: 139,517,360 probably benign Het
Hipk3 T C 2: 104,433,172 N933D possibly damaging Het
Mmp27 T C 9: 7,578,899 probably benign Het
Nod1 C T 6: 54,937,364 V815I probably benign Het
Olfr411 C T 11: 74,347,429 V52I probably benign Het
Olfr448 T A 6: 42,896,634 F61Y probably damaging Het
Olfr552 T A 7: 102,604,357 M1K probably null Het
Olfr613 C A 7: 103,551,857 A24E probably damaging Het
Olfr697 T A 7: 106,741,157 Y259F probably damaging Het
Pms1 T A 1: 53,275,251 E45V possibly damaging Het
Prkcsh T C 9: 22,006,565 S126P possibly damaging Het
Pros1 A T 16: 62,910,045 L299F probably damaging Het
Scrn1 A G 6: 54,520,733 I291T probably benign Het
Slc15a2 A T 16: 36,751,880 Y676* probably null Het
Tenm2 A C 11: 36,024,623 V2028G probably damaging Het
Trpa1 T C 1: 14,880,277 probably benign Het
Other mutations in Olfr555
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01150:Olfr555 APN 7 102659492 missense probably benign 0.00
IGL02610:Olfr555 APN 7 102659567 missense probably benign 0.41
IGL02679:Olfr555 APN 7 102659177 missense possibly damaging 0.55
R0332:Olfr555 UTSW 7 102659465 missense probably damaging 0.99
R1493:Olfr555 UTSW 7 102659013 missense probably damaging 1.00
R1631:Olfr555 UTSW 7 102659201 missense probably damaging 1.00
R1682:Olfr555 UTSW 7 102659697 missense probably damaging 0.96
R3026:Olfr555 UTSW 7 102659129 missense possibly damaging 0.90
R3103:Olfr555 UTSW 7 102659481 missense probably benign 0.00
R4592:Olfr555 UTSW 7 102659478 missense probably damaging 0.99
R4782:Olfr555 UTSW 7 102658834 missense possibly damaging 0.63
R6282:Olfr555 UTSW 7 102659647 missense probably benign 0.00
R7571:Olfr555 UTSW 7 102659051 missense probably damaging 1.00
R8001:Olfr555 UTSW 7 102659034 missense probably damaging 1.00
Posted On2013-04-17