Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01402:Zfp282'

278358

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp282

Ensembl Gene

ENSMUSG00000025821

Gene Name

zinc finger protein 282

Synonyms

HUB1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

IGL01402

Quality Score

Status

Chromosome

Chromosomal Location

47877204-47908485 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 47897836 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Alanine at position 325 (D325A)

Ref Sequence

ENSEMBL: ENSMUSP00000053643 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061890]

AlphaFold

E9PVC2

Predicted Effect

probably damaging
Transcript: ENSMUST00000061890
AA Change: D325A

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000053643
Gene: ENSMUSG00000025821
AA Change: D325A

Domain	Start	End	E-Value	Type
low complexity region	11	20	N/A	INTRINSIC
low complexity region	66	75	N/A	INTRINSIC
Pfam:DUF3669	98	168	1.8e-12	PFAM
KRAB	198	260	1.04e-21	SMART
internal_repeat_1	317	372	1.1e-13	PROSPERO
low complexity region	387	399	N/A	INTRINSIC
low complexity region	403	420	N/A	INTRINSIC
low complexity region	457	499	N/A	INTRINSIC
ZnF_C2H2	514	536	8.94e-3	SMART
ZnF_C2H2	542	564	4.72e-2	SMART
ZnF_C2H2	570	592	1.04e-3	SMART
ZnF_C2H2	598	620	4.24e-4	SMART
ZnF_C2H2	626	648	1.06e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921524L21Rik	T	C	18: 6,638,653	S351P	possibly damaging	Het
Abca2	T	C	2: 25,442,003	S1376P	probably damaging	Het
Ablim3	A	G	18: 61,871,683	Y12H	probably damaging	Het
Akr1b7	A	G	6: 34,421,117	R294G	possibly damaging	Het
Aldh3b1	A	C	19: 3,921,205	V153G	probably benign	Het
Alk	A	T	17: 71,874,178	H1372Q	probably damaging	Het
Ano9	A	C	7: 141,102,042	Y731*	probably null	Het
Apol11b	G	A	15: 77,638,019	T26M	probably damaging	Het
Asl	T	C	5: 130,019,804	E43G	probably damaging	Het
Cd4	G	A	6: 124,879,378	T50I	probably benign	Het
Cfap43	T	C	19: 47,795,666	D476G	probably benign	Het
Cpa1	A	G	6: 30,645,276	H417R	possibly damaging	Het
Cpeb3	T	C	19: 37,088,548	D407G	probably benign	Het
Dcaf15	A	T	8: 84,098,397	C469S	probably damaging	Het
Dpy19l4	C	A	4: 11,273,006		probably null	Het
E4f1	A	T	17: 24,444,234	L699Q	probably damaging	Het
Eif4g2	A	G	7: 111,077,027	F349S	possibly damaging	Het
Ermap	T	C	4: 119,187,158	Y147C	probably damaging	Het
Frk	A	C	10: 34,547,385	E153A	probably damaging	Het
Fubp3	G	A	2: 31,604,721		probably null	Het
Gdi2	A	G	13: 3,564,611	T319A	probably benign	Het
Gjc3	A	G	5: 137,957,858	F55S	probably damaging	Het
Gm10762	C	T	2: 128,967,085		probably benign	Het
Got1	A	G	19: 43,504,609	I291T	possibly damaging	Het
Gpr179	C	A	11: 97,338,186	G1048*	probably null	Het
Hectd3	G	T	4: 116,996,065	R163L	probably damaging	Het
Hectd4	T	C	5: 121,339,417		probably benign	Het
Ifnb1	T	C	4: 88,522,243	R178G	probably benign	Het
Ino80	T	A	2: 119,456,718	D56V	possibly damaging	Het
Kctd1	T	A	18: 14,969,553	Q857L	probably damaging	Het
Kdm5a	T	A	6: 120,390,679	L445*	probably null	Het
Lins1	G	A	7: 66,713,928	V524I	probably damaging	Het
Lrp1	A	T	10: 127,595,032	Y383N	probably damaging	Het
Malrd1	G	A	2: 16,101,957		probably null	Het
Mgam	A	C	6: 40,644,945	K84Q	probably benign	Het
Mlh3	A	T	12: 85,267,929	F494L	probably benign	Het
Mpped1	T	C	15: 83,792,213	F60S	possibly damaging	Het
Myo1e	A	G	9: 70,337,766	Y382C	probably benign	Het
Ncor1	C	A	11: 62,340,474	V836F	probably damaging	Het
Nktr	G	A	9: 121,741,152		probably null	Het
Olfr120	A	G	17: 37,726,302	T93A	probably benign	Het
Olfr175-ps1	G	A	16: 58,824,595	T38I	probably damaging	Het
Olfr984	A	G	9: 40,101,262	I76T	probably benign	Het
Rnf144a	T	A	12: 26,327,301	Y93F	probably benign	Het
Rubcn	G	A	16: 32,827,296	T636M	probably damaging	Het
Scn5a	A	C	9: 119,486,470	L1724R	probably damaging	Het
Sel1l	A	G	12: 91,841,833	S45P	possibly damaging	Het
Serpina3k	A	G	12: 104,340,623	D38G	probably benign	Het
Sh3bgr	A	C	16: 96,206,490	K18N	probably damaging	Het
Slc28a2	T	G	2: 122,452,057	I287M	probably damaging	Het
St8sia6	T	C	2: 13,665,507	N214S	probably damaging	Het
Syt11	A	G	3: 88,762,216	I123T	probably benign	Het
Tcerg1l	A	T	7: 138,259,839	I387N	probably damaging	Het
Tfg	C	A	16: 56,694,493		probably benign	Het
Tgm4	A	G	9: 123,051,454	K307E	possibly damaging	Het
Tmem177	T	C	1: 119,910,061	D296G	probably damaging	Het
Tmem270	C	T	5: 134,901,909		probably benign	Het
Tnrc6b	G	T	15: 80,880,544	G749V	possibly damaging	Het
Trp63	C	A	16: 25,820,385		probably benign	Het
Ugt1a8	T	C	1: 88,087,895	L10P	probably benign	Het
Vmn2r107	A	T	17: 20,375,747	K854M	probably damaging	Het
Vmn2r45	T	C	7: 8,481,468	N446S	probably damaging	Het
Vps13c	A	T	9: 67,913,204		probably null	Het
Wdr91	G	A	6: 34,889,063	P518L	probably benign	Het
Yap1	G	A	9: 7,934,741		probably benign	Het

Other mutations in Zfp282

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00732:Zfp282	APN	6	47880390	missense	probably damaging	1.00
IGL00755:Zfp282	APN	6	47880390	missense	probably damaging	1.00
IGL01404:Zfp282	APN	6	47897836	missense	probably damaging	0.99
IGL01484:Zfp282	APN	6	47890120	missense	possibly damaging	0.76
IGL01560:Zfp282	APN	6	47880277	missense	probably damaging	1.00
IGL02949:Zfp282	APN	6	47897914	missense	probably damaging	1.00
FR4304:Zfp282	UTSW	6	47904797	small insertion	probably benign
FR4589:Zfp282	UTSW	6	47904791	small insertion	probably benign
FR4737:Zfp282	UTSW	6	47904790	small insertion	probably benign
FR4737:Zfp282	UTSW	6	47904799	small insertion	probably benign
FR4976:Zfp282	UTSW	6	47904790	small insertion	probably benign
R0020:Zfp282	UTSW	6	47880009	missense	probably damaging	1.00
R0020:Zfp282	UTSW	6	47880009	missense	probably damaging	1.00
R0118:Zfp282	UTSW	6	47892932	missense	probably benign	0.34
R0415:Zfp282	UTSW	6	47897881	missense	probably damaging	0.99
R0415:Zfp282	UTSW	6	47905053	missense	possibly damaging	0.88
R0607:Zfp282	UTSW	6	47880369	missense	probably damaging	1.00
R0710:Zfp282	UTSW	6	47880384	missense	probably damaging	1.00
R0946:Zfp282	UTSW	6	47880009	missense	probably damaging	1.00
R1054:Zfp282	UTSW	6	47904599	missense	probably benign	0.00
R1401:Zfp282	UTSW	6	47890174	nonsense	probably null
R1572:Zfp282	UTSW	6	47892867	missense	probably damaging	1.00
R2016:Zfp282	UTSW	6	47897787	splice site	probably null
R2971:Zfp282	UTSW	6	47897932	splice site	probably null
R4064:Zfp282	UTSW	6	47880094	missense	probably damaging	0.99
R4478:Zfp282	UTSW	6	47890696	nonsense	probably null
R4530:Zfp282	UTSW	6	47890633	missense	probably benign	0.00
R4532:Zfp282	UTSW	6	47890633	missense	probably benign	0.00
R5068:Zfp282	UTSW	6	47877703	missense	probably benign	0.01
R5261:Zfp282	UTSW	6	47897890	missense	probably damaging	0.99
R5326:Zfp282	UTSW	6	47905327	missense	probably benign
R5551:Zfp282	UTSW	6	47890645	missense	possibly damaging	0.59
R6046:Zfp282	UTSW	6	47880168	missense	probably damaging	1.00
R6408:Zfp282	UTSW	6	47880385	missense	probably damaging	1.00
R7535:Zfp282	UTSW	6	47904944	missense	probably benign	0.03
R8098:Zfp282	UTSW	6	47890718	missense	probably benign	0.00
R8158:Zfp282	UTSW	6	47890692	missense	possibly damaging	0.61
R8304:Zfp282	UTSW	6	47904788	small deletion	probably benign
R8385:Zfp282	UTSW	6	47905089	missense	possibly damaging	0.88
R8543:Zfp282	UTSW	6	47904627	missense	probably benign	0.40
R8817:Zfp282	UTSW	6	47904826	missense	probably benign	0.00
S24628:Zfp282	UTSW	6	47897881	missense	probably damaging	0.99
S24628:Zfp282	UTSW	6	47905053	missense	possibly damaging	0.88
Z1177:Zfp282	UTSW	6	47890637	missense	probably benign	0.00

Posted On

2015-04-16