Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00937:Or2ag15'

27836

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2ag15

Ensembl Gene

ENSMUSG00000051591

Gene Name

olfactory receptor family 2 subfamily AG member 15

Synonyms

GA_x6K02T2PBJ9-9119301-9118348, Olfr697, MOR283-5

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

IGL00937

Quality Score

Status

Chromosome

Chromosomal Location

106340112-106341163 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 106340364 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 259 (Y259F)

Ref Sequence

ENSEMBL: ENSMUSP00000152039 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050541] [ENSMUST00000217734]

AlphaFold

Q8VFM4

Predicted Effect

probably damaging
Transcript: ENSMUST00000050541
AA Change: Y259F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000055207
Gene: ENSMUSG00000051591
AA Change: Y259F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.2e-46	PFAM
Pfam:7TM_GPCR_Srsx	35	305	4.7e-7	PFAM
Pfam:7tm_1	41	290	8.7e-26	PFAM
Pfam:7TM_GPCR_Srx	69	306	4.3e-6	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000217734
AA Change: Y259F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cc2d2a	A	T	5: 43,845,464 (GRCm39)		probably null	Het
Cd34	A	G	1: 194,642,422 (GRCm39)	E381G	probably damaging	Het
Chka	A	G	19: 3,942,189 (GRCm39)	E381G	probably benign	Het
Dennd1b	T	A	1: 139,097,977 (GRCm39)	C673S	probably benign	Het
E130308A19Rik	G	A	4: 59,690,846 (GRCm39)	A227T	probably benign	Het
F13b	T	A	1: 139,445,098 (GRCm39)		probably benign	Het
Hipk3	T	C	2: 104,263,517 (GRCm39)	N933D	possibly damaging	Het
Mmp27	T	C	9: 7,578,900 (GRCm39)		probably benign	Het
Nod1	C	T	6: 54,914,349 (GRCm39)	V815I	probably benign	Het
Or2a5	T	A	6: 42,873,568 (GRCm39)	F61Y	probably damaging	Het
Or3a1d	C	T	11: 74,238,255 (GRCm39)	V52I	probably benign	Het
Or51ab3	C	A	7: 103,201,064 (GRCm39)	A24E	probably damaging	Het
Or51h1	T	A	7: 102,308,555 (GRCm39)	S176T	probably damaging	Het
Or52k2	T	A	7: 102,253,564 (GRCm39)	M1K	probably null	Het
Pms1	T	A	1: 53,314,410 (GRCm39)	E45V	possibly damaging	Het
Prkcsh	T	C	9: 21,917,861 (GRCm39)	S126P	possibly damaging	Het
Pros1	A	T	16: 62,730,408 (GRCm39)	L299F	probably damaging	Het
Scrn1	A	G	6: 54,497,718 (GRCm39)	I291T	probably benign	Het
Slc15a2	A	T	16: 36,572,242 (GRCm39)	Y676*	probably null	Het
Tenm2	A	C	11: 35,915,450 (GRCm39)	V2028G	probably damaging	Het
Trpa1	T	C	1: 14,950,501 (GRCm39)		probably benign	Het

Other mutations in Or2ag15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Or2ag15	APN	7	106,340,908 (GRCm39)	missense	probably benign	0.20
IGL01368:Or2ag15	APN	7	106,340,829 (GRCm39)	missense	probably benign	0.19
IGL01410:Or2ag15	APN	7	106,340,706 (GRCm39)	missense	probably benign	0.19
IGL01415:Or2ag15	APN	7	106,340,706 (GRCm39)	missense	probably benign	0.19
IGL01962:Or2ag15	APN	7	106,340,991 (GRCm39)	missense	probably benign	0.12
IGL02654:Or2ag15	APN	7	106,340,555 (GRCm39)	nonsense	probably null
IGL02903:Or2ag15	APN	7	106,340,917 (GRCm39)	missense	probably damaging	1.00
IGL03347:Or2ag15	APN	7	106,340,177 (GRCm39)	utr 3 prime	probably benign
IGL03391:Or2ag15	APN	7	106,340,962 (GRCm39)	missense	probably damaging	1.00
R0139:Or2ag15	UTSW	7	106,340,832 (GRCm39)	missense	probably benign	0.05
R0142:Or2ag15	UTSW	7	106,340,972 (GRCm39)	missense	probably benign	0.36
R1293:Or2ag15	UTSW	7	106,341,058 (GRCm39)	missense	probably damaging	0.98
R1522:Or2ag15	UTSW	7	106,340,212 (GRCm39)	missense	probably benign	0.03
R1715:Or2ag15	UTSW	7	106,340,755 (GRCm39)	missense	probably damaging	1.00
R1959:Or2ag15	UTSW	7	106,340,601 (GRCm39)	missense	probably damaging	1.00
R1960:Or2ag15	UTSW	7	106,340,601 (GRCm39)	missense	probably damaging	1.00
R2031:Or2ag15	UTSW	7	106,341,105 (GRCm39)	missense	probably damaging	1.00
R4790:Or2ag15	UTSW	7	106,340,998 (GRCm39)	missense	probably benign	0.05
R5550:Or2ag15	UTSW	7	106,340,340 (GRCm39)	missense	probably benign	0.01
R6232:Or2ag15	UTSW	7	106,340,761 (GRCm39)	missense	probably damaging	0.96
R6293:Or2ag15	UTSW	7	106,340,613 (GRCm39)	missense	probably damaging	1.00
R6643:Or2ag15	UTSW	7	106,340,911 (GRCm39)	missense	probably benign	0.06
R7831:Or2ag15	UTSW	7	106,340,620 (GRCm39)	missense	probably damaging	0.99
R8013:Or2ag15	UTSW	7	106,340,824 (GRCm39)	missense	probably benign	0.00
R8014:Or2ag15	UTSW	7	106,340,824 (GRCm39)	missense	probably benign	0.00
R8883:Or2ag15	UTSW	7	106,340,274 (GRCm39)	missense	possibly damaging	0.74
R9072:Or2ag15	UTSW	7	106,340,759 (GRCm39)	nonsense	probably null
RF018:Or2ag15	UTSW	7	106,340,692 (GRCm39)	missense	probably benign	0.02
X0020:Or2ag15	UTSW	7	106,340,343 (GRCm39)	missense	probably damaging	0.97
Z1088:Or2ag15	UTSW	7	106,340,350 (GRCm39)	missense	probably benign	0.21

Posted On

2013-04-17