Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01405:Malrd1'

278416

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Malrd1

Ensembl Gene

ENSMUSG00000075520

Gene Name

MAM and LDL receptor class A domain containing 1

Synonyms

Diet1, Gm13364, Gm13318

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.076) question?

Stock #

IGL01405

Quality Score

Status

Chromosome

Chromosomal Location

15526479-16255555 bp(+) (GRCm38)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

G to A at 16101957 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000116869 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000146205]

AlphaFold

A2AJX4

Predicted Effect

probably null
Transcript: ENSMUST00000146205

SMART Domains

Protein: ENSMUSP00000116869
Gene: ENSMUSG00000075520

Domain	Start	End	E-Value	Type
Pfam:MAM	8	171	1.6e-36	PFAM
LDLa	181	219	6.89e-8	SMART
LDLa	225	262	4.37e-10	SMART
LDLa	264	303	9.55e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcf1	G	A	17: 35,964,010 (GRCm38)	R82W	probably damaging	Het
Atxn7	T	C	14: 14,100,105 (GRCm38)	V597A	probably benign	Het
Bsg	T	A	10: 79,711,514 (GRCm38)	M205K	probably benign	Het
Ccdc18	T	C	5: 108,202,186 (GRCm38)		probably benign	Het
Cdh1	T	C	8: 106,649,001 (GRCm38)	V57A	probably damaging	Het
Ddost	A	G	4: 138,311,703 (GRCm38)	D378G	probably damaging	Het
Depdc5	A	G	5: 32,937,689 (GRCm38)	E779G	possibly damaging	Het
Elp5	T	C	11: 69,969,136 (GRCm38)	R250G	probably damaging	Het
Gnb1	A	G	4: 155,543,188 (GRCm38)	H142R	probably damaging	Het
Ift172	G	T	5: 31,261,852 (GRCm38)	Y1148*	probably null	Het
Kif5a	T	C	10: 127,245,990 (GRCm38)	N153S	probably damaging	Het
Man2a2	T	A	7: 80,360,934 (GRCm38)	M770L	probably benign	Het
Msh2	T	C	17: 87,678,235 (GRCm38)	L80P	probably damaging	Het
Naip5	A	T	13: 100,221,945 (GRCm38)	S928T	probably benign	Het
Olfr855	T	A	9: 19,585,205 (GRCm38)	S223T	probably benign	Het
Pla2g4d	T	C	2: 120,266,823 (GRCm38)	N765S	probably benign	Het
Plcb4	C	T	2: 135,950,347 (GRCm38)	T330I	probably damaging	Het
Ppp3ca	A	G	3: 136,868,721 (GRCm38)	I127V	probably benign	Het
Rapgef5	C	A	12: 117,721,380 (GRCm38)	T320K	probably benign	Het
Rbfa	A	G	18: 80,192,865 (GRCm38)	V223A	probably benign	Het
Rfx7	A	G	9: 72,610,344 (GRCm38)	M187V	probably benign	Het
Ric1	T	C	19: 29,567,370 (GRCm38)		probably benign	Het
Slc22a16	C	T	10: 40,585,195 (GRCm38)	T331M	probably benign	Het
Slc34a1	T	C	13: 55,412,128 (GRCm38)	S303P	probably damaging	Het
Slfn3	T	C	11: 83,214,716 (GRCm38)	V513A	possibly damaging	Het
Tbce	A	T	13: 14,003,695 (GRCm38)	I370N	probably damaging	Het
Zfp358	G	A	8: 3,495,663 (GRCm38)	D109N	probably benign	Het
Zfp523	T	C	17: 28,204,506 (GRCm38)	S152P	probably damaging	Het
Zfp961	A	G	8: 71,967,934 (GRCm38)	N78S	possibly damaging	Het

Other mutations in Malrd1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Malrd1	APN	2	16,142,186 (GRCm38)	splice site	probably benign
IGL01295:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01296:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01399:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01400:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01401:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01402:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL01406:Malrd1	APN	2	16,101,957 (GRCm38)	critical splice donor site	probably null
IGL02105:Malrd1	APN	2	16,127,863 (GRCm38)	missense	unknown
IGL02581:Malrd1	APN	2	16,142,312 (GRCm38)	nonsense	probably null
IGL03015:Malrd1	APN	2	16,042,271 (GRCm38)	missense	unknown
IGL03038:Malrd1	APN	2	16,127,967 (GRCm38)	missense	unknown
R1353:Malrd1	UTSW	2	16,127,968 (GRCm38)	missense	unknown
R1385:Malrd1	UTSW	2	16,042,228 (GRCm38)	missense	unknown
R2242:Malrd1	UTSW	2	16,101,944 (GRCm38)	missense	unknown
R2888:Malrd1	UTSW	2	16,074,757 (GRCm38)	missense	unknown
R4398:Malrd1	UTSW	2	16,150,783 (GRCm38)	missense	unknown
R4982:Malrd1	UTSW	2	16,042,129 (GRCm38)	missense	probably benign	0.29
R5148:Malrd1	UTSW	2	16,142,226 (GRCm38)	missense	unknown
R5195:Malrd1	UTSW	2	16,150,810 (GRCm38)	missense	unknown
R5828:Malrd1	UTSW	2	15,526,653 (GRCm38)	missense	probably benign	0.00
R5892:Malrd1	UTSW	2	15,614,267 (GRCm38)	missense	probably benign	0.03
R6034:Malrd1	UTSW	2	15,845,326 (GRCm38)	missense	possibly damaging	0.78
R6034:Malrd1	UTSW	2	15,845,326 (GRCm38)	missense	possibly damaging	0.78
R6195:Malrd1	UTSW	2	15,695,326 (GRCm38)	missense	probably damaging	1.00
R6318:Malrd1	UTSW	2	16,042,267 (GRCm38)	missense	unknown
R6438:Malrd1	UTSW	2	15,614,206 (GRCm38)	missense
R6457:Malrd1	UTSW	2	15,667,929 (GRCm38)	missense	probably benign	0.41
R6457:Malrd1	UTSW	2	15,526,597 (GRCm38)	start gained	probably benign
R6499:Malrd1	UTSW	2	15,931,689 (GRCm38)	missense	probably benign	0.03
R6575:Malrd1	UTSW	2	15,842,628 (GRCm38)	missense	probably benign	0.00
R6792:Malrd1	UTSW	2	16,150,756 (GRCm38)	missense	unknown
R6796:Malrd1	UTSW	2	15,869,784 (GRCm38)	missense	unknown
R6930:Malrd1	UTSW	2	15,797,667 (GRCm38)	missense	unknown
R6959:Malrd1	UTSW	2	16,218,009 (GRCm38)	missense	probably damaging	0.97
R6993:Malrd1	UTSW	2	16,150,791 (GRCm38)	missense	unknown
R7102:Malrd1	UTSW	2	16,142,303 (GRCm38)	missense	unknown
R7112:Malrd1	UTSW	2	15,925,176 (GRCm38)	missense	unknown
R7248:Malrd1	UTSW	2	16,101,911 (GRCm38)	missense	unknown
R7249:Malrd1	UTSW	2	15,623,340 (GRCm38)	missense	probably damaging	0.97
R7334:Malrd1	UTSW	2	16,006,718 (GRCm38)	missense	probably damaging	0.99
R7394:Malrd1	UTSW	2	15,695,199 (GRCm38)	missense	unknown
R7399:Malrd1	UTSW	2	15,610,090 (GRCm38)	missense
R7476:Malrd1	UTSW	2	16,142,304 (GRCm38)	missense	unknown
R7582:Malrd1	UTSW	2	15,695,270 (GRCm38)	missense	unknown
R7604:Malrd1	UTSW	2	15,925,192 (GRCm38)	missense	unknown
R7662:Malrd1	UTSW	2	15,871,454 (GRCm38)	missense	unknown
R7681:Malrd1	UTSW	2	16,218,102 (GRCm38)	missense	unknown
R7740:Malrd1	UTSW	2	15,614,215 (GRCm38)	missense	not run
R7747:Malrd1	UTSW	2	16,074,835 (GRCm38)	missense	unknown
R7754:Malrd1	UTSW	2	15,797,799 (GRCm38)	splice site	probably null
R7950:Malrd1	UTSW	2	16,128,068 (GRCm38)	missense	unknown
R8194:Malrd1	UTSW	2	15,925,120 (GRCm38)	missense	unknown
R8260:Malrd1	UTSW	2	15,614,206 (GRCm38)	missense
R8314:Malrd1	UTSW	2	15,752,832 (GRCm38)	missense	unknown
R8342:Malrd1	UTSW	2	15,633,224 (GRCm38)	missense	unknown
R8386:Malrd1	UTSW	2	15,696,844 (GRCm38)	missense	unknown
R8492:Malrd1	UTSW	2	15,610,123 (GRCm38)	missense
R8728:Malrd1	UTSW	2	15,696,942 (GRCm38)	nonsense	probably null
R8756:Malrd1	UTSW	2	15,752,895 (GRCm38)	critical splice donor site	probably null
R8869:Malrd1	UTSW	2	15,565,557 (GRCm38)	critical splice donor site	probably null
R8888:Malrd1	UTSW	2	15,845,227 (GRCm38)	missense	unknown
R8895:Malrd1	UTSW	2	15,845,227 (GRCm38)	missense	unknown
R8902:Malrd1	UTSW	2	16,255,334 (GRCm38)	nonsense	probably null
R8954:Malrd1	UTSW	2	15,551,367 (GRCm38)	missense
R8960:Malrd1	UTSW	2	15,565,430 (GRCm38)	nonsense	probably null
R9005:Malrd1	UTSW	2	15,845,329 (GRCm38)	missense	unknown
R9135:Malrd1	UTSW	2	15,797,705 (GRCm38)	missense	unknown
R9267:Malrd1	UTSW	2	16,255,266 (GRCm38)	missense	unknown
R9330:Malrd1	UTSW	2	16,255,278 (GRCm38)	missense	unknown
R9359:Malrd1	UTSW	2	15,614,177 (GRCm38)	missense
R9383:Malrd1	UTSW	2	15,695,201 (GRCm38)	missense	unknown
R9389:Malrd1	UTSW	2	15,703,156 (GRCm38)	missense	unknown
R9403:Malrd1	UTSW	2	15,614,177 (GRCm38)	missense
R9454:Malrd1	UTSW	2	15,797,726 (GRCm38)	nonsense	probably null
R9454:Malrd1	UTSW	2	15,752,849 (GRCm38)	missense	unknown
R9520:Malrd1	UTSW	2	16,074,820 (GRCm38)	missense	unknown
R9544:Malrd1	UTSW	2	15,635,998 (GRCm38)	missense	unknown
R9609:Malrd1	UTSW	2	15,695,270 (GRCm38)	missense	unknown
R9667:Malrd1	UTSW	2	15,565,215 (GRCm38)	critical splice acceptor site	probably null
R9721:Malrd1	UTSW	2	15,696,827 (GRCm38)	missense	unknown
R9787:Malrd1	UTSW	2	15,620,590 (GRCm38)	missense	unknown
R9800:Malrd1	UTSW	2	15,842,594 (GRCm38)	missense	unknown
Z1176:Malrd1	UTSW	2	16,217,845 (GRCm38)	missense	unknown
Z1191:Malrd1	UTSW	2	16,042,226 (GRCm38)	missense	unknown

Posted On

2015-04-16