Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01410:Or2ag15'

278426

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2ag15

Ensembl Gene

ENSMUSG00000051591

Gene Name

olfactory receptor family 2 subfamily AG member 15

Synonyms

GA_x6K02T2PBJ9-9119301-9118348, Olfr697, MOR283-5

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

IGL01410

Quality Score

Status

Chromosome

Chromosomal Location

106340112-106341163 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 106340706 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 145 (V145A)

Ref Sequence

ENSEMBL: ENSMUSP00000152039 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050541] [ENSMUST00000217734]

AlphaFold

Q8VFM4

Predicted Effect

probably benign
Transcript: ENSMUST00000050541
AA Change: V145A

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000055207
Gene: ENSMUSG00000051591
AA Change: V145A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.2e-46	PFAM
Pfam:7TM_GPCR_Srsx	35	305	4.7e-7	PFAM
Pfam:7tm_1	41	290	8.7e-26	PFAM
Pfam:7TM_GPCR_Srx	69	306	4.3e-6	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000217734
AA Change: V145A

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox1	T	A	1: 58,145,184 (GRCm39)		probably null	Het
Aspm	C	T	1: 139,410,182 (GRCm39)	T1359I	probably benign	Het
Atp13a2	A	G	4: 140,719,509 (GRCm39)	D26G	probably benign	Het
Atrnl1	G	A	19: 58,119,536 (GRCm39)	A1343T	probably damaging	Het
Ccsap	A	C	8: 124,585,969 (GRCm39)	S61A	probably damaging	Het
Cdh1	A	T	8: 107,384,485 (GRCm39)	M318L	probably benign	Het
Cfap69	G	A	5: 5,696,979 (GRCm39)	P106S	probably damaging	Het
Cfp	G	A	X: 20,795,963 (GRCm39)	T88I	probably damaging	Het
Chst1	A	T	2: 92,444,475 (GRCm39)	I316F	probably damaging	Het
Col7a1	A	T	9: 108,793,686 (GRCm39)	D1382V	unknown	Het
Cr2	T	A	1: 194,845,542 (GRCm39)	M514L	possibly damaging	Het
Cubn	G	A	2: 13,470,719 (GRCm39)	H558Y	probably benign	Het
Cul9	A	T	17: 46,839,572 (GRCm39)	M802K	probably damaging	Het
Dennd2d	A	T	3: 106,398,542 (GRCm39)	I169L	probably damaging	Het
Dnah11	T	A	12: 118,010,991 (GRCm39)	K162*	probably null	Het
Dnah3	T	A	7: 119,566,943 (GRCm39)	T2428S	possibly damaging	Het
Dock11	T	A	X: 35,301,296 (GRCm39)	H1284Q	probably damaging	Het
Flrt2	T	A	12: 95,745,966 (GRCm39)	D101E	probably damaging	Het
Gabrr2	G	A	4: 33,085,626 (GRCm39)	V349M	probably damaging	Het
Gli2	C	A	1: 118,764,621 (GRCm39)	V1177L	probably benign	Het
Gm16506	A	G	14: 43,961,630 (GRCm39)	Y206H	probably benign	Het
Gm5612	C	T	9: 18,338,869 (GRCm39)		probably benign	Het
Gvin3	C	T	7: 106,202,258 (GRCm39)		noncoding transcript	Het
Heg1	C	T	16: 33,545,936 (GRCm39)	T460I	possibly damaging	Het
Lgals9	T	G	11: 78,863,977 (GRCm39)	D56A	probably damaging	Het
Lpgat1	A	T	1: 191,508,544 (GRCm39)		probably null	Het
Megf6	T	A	4: 154,337,020 (GRCm39)		probably null	Het
Megf8	G	A	7: 25,059,296 (GRCm39)	M2265I	probably benign	Het
Memo1	G	A	17: 74,548,976 (GRCm39)	R121*	probably null	Het
Morc1	T	C	16: 48,432,677 (GRCm39)	V715A	probably benign	Het
Mycbp2	A	T	14: 103,466,928 (GRCm39)		probably null	Het
Ncapg2	T	A	12: 116,388,270 (GRCm39)	V318D	possibly damaging	Het
Ndst1	T	C	18: 60,833,517 (GRCm39)	Y498C	probably damaging	Het
Nod1	C	T	6: 54,921,341 (GRCm39)	A326T	probably damaging	Het
Or4c11	T	A	2: 88,695,864 (GRCm39)	M305K	probably benign	Het
Peg3	T	C	7: 6,710,624 (GRCm39)	S1533G	probably benign	Het
Pgc	G	T	17: 48,045,165 (GRCm39)	G361V	probably damaging	Het
Phka1	C	T	X: 101,629,712 (GRCm39)	R477H	probably damaging	Het
Plagl2	C	T	2: 153,074,574 (GRCm39)	R109Q	probably damaging	Het
Prr36	T	A	8: 4,266,230 (GRCm39)	I107F	probably benign	Het
Ptpdc1	T	A	13: 48,740,080 (GRCm39)	R450S	probably damaging	Het
Ptprb	A	T	10: 116,138,179 (GRCm39)	D361V	possibly damaging	Het
Rbm44	A	G	1: 91,096,551 (GRCm39)	D970G	probably benign	Het
Scrn2	T	G	11: 96,921,396 (GRCm39)	V52G	probably benign	Het
Sdk1	C	T	5: 142,197,875 (GRCm39)	T2176I	probably benign	Het
Serpina1d	T	A	12: 103,729,993 (GRCm39)	E396D	probably benign	Het
Slc38a5	A	C	X: 8,146,070 (GRCm39)	Q465P	probably benign	Het
Slc38a5	G	T	X: 8,146,071 (GRCm39)	Q465H	probably benign	Het
Smarca1	T	C	X: 46,981,255 (GRCm39)	T48A	possibly damaging	Het
Trak2	A	T	1: 58,962,766 (GRCm39)	I132N	probably damaging	Het
Trank1	A	G	9: 111,194,117 (GRCm39)	T714A	probably benign	Het
Trank1	T	C	9: 111,194,327 (GRCm39)	S784P	probably benign	Het
Trp53i13	G	A	11: 77,399,083 (GRCm39)		probably benign	Het
Trrap	A	C	5: 144,767,831 (GRCm39)	D2596A	probably benign	Het
Ttyh1	A	T	7: 4,127,656 (GRCm39)	T19S	probably damaging	Het
Tyk2	C	T	9: 21,020,660 (GRCm39)	V947M	probably damaging	Het
Ugt2b34	G	A	5: 87,040,689 (GRCm39)	A411V	possibly damaging	Het
Virma	T	A	4: 11,518,929 (GRCm39)	Y725*	probably null	Het
Vmn1r192	A	G	13: 22,372,079 (GRCm39)	L47P	probably damaging	Het
Vmn2r74	T	C	7: 85,610,500 (GRCm39)	D64G	possibly damaging	Het

Other mutations in Or2ag15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Or2ag15	APN	7	106,340,908 (GRCm39)	missense	probably benign	0.20
IGL00937:Or2ag15	APN	7	106,340,364 (GRCm39)	missense	probably damaging	1.00
IGL01368:Or2ag15	APN	7	106,340,829 (GRCm39)	missense	probably benign	0.19
IGL01415:Or2ag15	APN	7	106,340,706 (GRCm39)	missense	probably benign	0.19
IGL01962:Or2ag15	APN	7	106,340,991 (GRCm39)	missense	probably benign	0.12
IGL02654:Or2ag15	APN	7	106,340,555 (GRCm39)	nonsense	probably null
IGL02903:Or2ag15	APN	7	106,340,917 (GRCm39)	missense	probably damaging	1.00
IGL03347:Or2ag15	APN	7	106,340,177 (GRCm39)	utr 3 prime	probably benign
IGL03391:Or2ag15	APN	7	106,340,962 (GRCm39)	missense	probably damaging	1.00
R0139:Or2ag15	UTSW	7	106,340,832 (GRCm39)	missense	probably benign	0.05
R0142:Or2ag15	UTSW	7	106,340,972 (GRCm39)	missense	probably benign	0.36
R1293:Or2ag15	UTSW	7	106,341,058 (GRCm39)	missense	probably damaging	0.98
R1522:Or2ag15	UTSW	7	106,340,212 (GRCm39)	missense	probably benign	0.03
R1715:Or2ag15	UTSW	7	106,340,755 (GRCm39)	missense	probably damaging	1.00
R1959:Or2ag15	UTSW	7	106,340,601 (GRCm39)	missense	probably damaging	1.00
R1960:Or2ag15	UTSW	7	106,340,601 (GRCm39)	missense	probably damaging	1.00
R2031:Or2ag15	UTSW	7	106,341,105 (GRCm39)	missense	probably damaging	1.00
R4790:Or2ag15	UTSW	7	106,340,998 (GRCm39)	missense	probably benign	0.05
R5550:Or2ag15	UTSW	7	106,340,340 (GRCm39)	missense	probably benign	0.01
R6232:Or2ag15	UTSW	7	106,340,761 (GRCm39)	missense	probably damaging	0.96
R6293:Or2ag15	UTSW	7	106,340,613 (GRCm39)	missense	probably damaging	1.00
R6643:Or2ag15	UTSW	7	106,340,911 (GRCm39)	missense	probably benign	0.06
R7831:Or2ag15	UTSW	7	106,340,620 (GRCm39)	missense	probably damaging	0.99
R8013:Or2ag15	UTSW	7	106,340,824 (GRCm39)	missense	probably benign	0.00
R8014:Or2ag15	UTSW	7	106,340,824 (GRCm39)	missense	probably benign	0.00
R8883:Or2ag15	UTSW	7	106,340,274 (GRCm39)	missense	possibly damaging	0.74
R9072:Or2ag15	UTSW	7	106,340,759 (GRCm39)	nonsense	probably null
RF018:Or2ag15	UTSW	7	106,340,692 (GRCm39)	missense	probably benign	0.02
X0020:Or2ag15	UTSW	7	106,340,343 (GRCm39)	missense	probably damaging	0.97
Z1088:Or2ag15	UTSW	7	106,340,350 (GRCm39)	missense	probably benign	0.21

Posted On

2015-04-16