Incidental Mutation 'IGL01410:Olfr1206'
ID278427
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1206
Ensembl Gene ENSMUSG00000062757
Gene Nameolfactory receptor 1206
SynonymsOlfr1207, GA_x6K02T2Q125-50338497-50339264, MOR230-3, GA_x6K02T2Q125-50339974-50340609
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL01410
Quality Score
Status
Chromosome2
Chromosomal Location88863231-88867753 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 88865520 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 305 (M305K)
Ref Sequence ENSEMBL: ENSMUSP00000149929 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077302] [ENSMUST00000216950]
Predicted Effect probably benign
Transcript: ENSMUST00000077302
AA Change: M305K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000076532
Gene: ENSMUSG00000062757
AA Change: M305K

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 3.2e-48 PFAM
Pfam:7tm_1 39 285 1.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216950
AA Change: M305K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox1 T A 1: 58,106,025 probably null Het
Aspm C T 1: 139,482,444 T1359I probably benign Het
Atp13a2 A G 4: 140,992,198 D26G probably benign Het
Atrnl1 G A 19: 58,131,104 A1343T probably damaging Het
Ccsap A C 8: 123,859,230 S61A probably damaging Het
Cdh1 A T 8: 106,657,853 M318L probably benign Het
Cfap69 G A 5: 5,646,979 P106S probably damaging Het
Cfp G A X: 20,929,724 T88I probably damaging Het
Chst1 A T 2: 92,614,130 I316F probably damaging Het
Col7a1 A T 9: 108,964,618 D1382V unknown Het
Cr2 T A 1: 195,163,234 M514L possibly damaging Het
Cubn G A 2: 13,465,908 H558Y probably benign Het
Cul9 A T 17: 46,528,646 M802K probably damaging Het
Dennd2d A T 3: 106,491,226 I169L probably damaging Het
Dnah11 T A 12: 118,047,256 K162* probably null Het
Dnah3 T A 7: 119,967,720 T2428S possibly damaging Het
Dock11 T A X: 36,037,643 H1284Q probably damaging Het
Flrt2 T A 12: 95,779,192 D101E probably damaging Het
Gabrr2 G A 4: 33,085,626 V349M probably damaging Het
Gli2 C A 1: 118,836,891 V1177L probably benign Het
Gm16506 A G 14: 43,724,173 Y206H probably benign Het
Gm1966 C T 7: 106,603,051 noncoding transcript Het
Gm5612 C T 9: 18,427,573 probably benign Het
Heg1 C T 16: 33,725,566 T460I possibly damaging Het
Lgals9 T G 11: 78,973,151 D56A probably damaging Het
Lpgat1 A T 1: 191,776,432 probably null Het
Megf6 T A 4: 154,252,563 probably null Het
Megf8 G A 7: 25,359,871 M2265I probably benign Het
Memo1 G A 17: 74,241,981 R121* probably null Het
Morc1 T C 16: 48,612,314 V715A probably benign Het
Mycbp2 A T 14: 103,229,492 probably null Het
Ncapg2 T A 12: 116,424,650 V318D possibly damaging Het
Ndst1 T C 18: 60,700,445 Y498C probably damaging Het
Nod1 C T 6: 54,944,356 A326T probably damaging Het
Olfr697 A G 7: 106,741,499 V145A probably benign Het
Peg3 T C 7: 6,707,625 S1533G probably benign Het
Pgc G T 17: 47,734,240 G361V probably damaging Het
Phka1 C T X: 102,586,106 R477H probably damaging Het
Plagl2 C T 2: 153,232,654 R109Q probably damaging Het
Prr36 T A 8: 4,216,230 I107F probably benign Het
Ptpdc1 T A 13: 48,586,604 R450S probably damaging Het
Ptprb A T 10: 116,302,274 D361V possibly damaging Het
Rbm44 A G 1: 91,168,829 D970G probably benign Het
Scrn2 T G 11: 97,030,570 V52G probably benign Het
Sdk1 C T 5: 142,212,120 T2176I probably benign Het
Serpina1d T A 12: 103,763,734 E396D probably benign Het
Slc38a5 A C X: 8,279,831 Q465P probably benign Het
Slc38a5 G T X: 8,279,832 Q465H probably benign Het
Smarca1 T C X: 47,892,378 T48A possibly damaging Het
Trak2 A T 1: 58,923,607 I132N probably damaging Het
Trank1 T C 9: 111,365,259 S784P probably benign Het
Trank1 A G 9: 111,365,049 T714A probably benign Het
Trp53i13 G A 11: 77,508,257 probably benign Het
Trrap A C 5: 144,831,021 D2596A probably benign Het
Ttyh1 A T 7: 4,124,657 T19S probably damaging Het
Tyk2 C T 9: 21,109,364 V947M probably damaging Het
Ugt2b34 G A 5: 86,892,830 A411V possibly damaging Het
Virma T A 4: 11,518,929 Y725* probably null Het
Vmn1r192 A G 13: 22,187,909 L47P probably damaging Het
Vmn2r74 T C 7: 85,961,292 D64G possibly damaging Het
Other mutations in Olfr1206
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01415:Olfr1206 APN 2 88865520 missense probably benign 0.00
IGL01783:Olfr1206 APN 2 88864842 missense probably damaging 0.98
PIT4812001:Olfr1206 UTSW 2 88864970 missense probably benign 0.27
R0437:Olfr1206 UTSW 2 88864885 missense probably benign 0.01
R0561:Olfr1206 UTSW 2 88864680 missense possibly damaging 0.68
R0669:Olfr1206 UTSW 2 88864928 missense probably benign
R0835:Olfr1206 UTSW 2 88865001 missense probably benign
R0987:Olfr1206 UTSW 2 88865183 missense probably benign 0.00
R1271:Olfr1206 UTSW 2 88865131 nonsense probably null
R1386:Olfr1206 UTSW 2 88865353 missense probably benign 0.14
R1618:Olfr1206 UTSW 2 88865527 synonymous probably null
R1935:Olfr1206 UTSW 2 88865180 missense probably benign
R2098:Olfr1206 UTSW 2 88864871 missense probably benign 0.43
R2112:Olfr1206 UTSW 2 88865201 missense possibly damaging 0.67
R2157:Olfr1206 UTSW 2 88864869 missense probably benign
R2912:Olfr1206 UTSW 2 88865114 missense probably benign 0.17
R2913:Olfr1206 UTSW 2 88865114 missense probably benign 0.17
R4583:Olfr1206 UTSW 2 88865494 missense probably benign 0.07
R4631:Olfr1206 UTSW 2 88864830 missense probably benign 0.00
R7707:Olfr1206 UTSW 2 88864809 missense possibly damaging 0.78
Posted On2015-04-16