Incidental Mutation 'IGL01415:Olfr697'
ID278461
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr697
Ensembl Gene ENSMUSG00000051591
Gene Nameolfactory receptor 697
SynonymsGA_x6K02T2PBJ9-9119301-9118348, MOR283-5
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.100) question?
Stock #IGL01415
Quality Score
Status
Chromosome7
Chromosomal Location106740834-106742443 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 106741499 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 145 (V145A)
Ref Sequence ENSEMBL: ENSMUSP00000152039 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050541] [ENSMUST00000217734]
Predicted Effect probably benign
Transcript: ENSMUST00000050541
AA Change: V145A

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000055207
Gene: ENSMUSG00000051591
AA Change: V145A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 305 4.7e-7 PFAM
Pfam:7tm_1 41 290 8.7e-26 PFAM
Pfam:7TM_GPCR_Srx 69 306 4.3e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217734
AA Change: V145A

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700023F06Rik T C 11: 103,200,928 Q42R probably damaging Het
Ankrd44 T C 1: 54,752,928 H316R probably damaging Het
Arfgef2 G A 2: 166,867,355 M1117I probably damaging Het
Cdc42bpg A G 19: 6,310,851 D213G probably damaging Het
Cfap69 G A 5: 5,646,979 P106S probably damaging Het
Chkb A T 15: 89,428,784 L30H probably damaging Het
Cit A G 5: 115,941,903 K758E possibly damaging Het
Clstn3 G A 6: 124,438,822 Q634* probably null Het
Esrra C A 19: 6,912,732 W98C probably damaging Het
Ganab A G 19: 8,914,694 probably benign Het
Gcnt3 G T 9: 70,034,457 H276Q probably benign Het
Gm16506 A G 14: 43,724,173 Y206H probably benign Het
Gm1966 C T 7: 106,603,051 noncoding transcript Het
Hkdc1 T A 10: 62,393,859 N680Y probably damaging Het
Ighe A C 12: 113,271,391 L383R unknown Het
Lgals9 T G 11: 78,973,151 D56A probably damaging Het
Marveld3 G A 8: 109,962,073 T12I possibly damaging Het
Nab2 A T 10: 127,665,103 L40Q probably damaging Het
Naip6 T C 13: 100,303,290 E323G probably benign Het
Nubpl T A 12: 52,271,070 V182E possibly damaging Het
Olfr1206 T A 2: 88,865,520 M305K probably benign Het
Olfr1414 A G 1: 92,511,252 Y259H probably damaging Het
Peg3 A G 7: 6,711,653 I190T probably damaging Het
Plcl1 G A 1: 55,696,396 V299M possibly damaging Het
Ppp4r1 G A 17: 65,813,527 E219K probably damaging Het
Sh3d19 G A 3: 86,098,185 A280T probably benign Het
Srebf2 A G 15: 82,177,462 I370V probably benign Het
Tfb2m A G 1: 179,532,130 probably benign Het
Ttll7 T G 3: 146,909,599 S273A possibly damaging Het
Unc79 A G 12: 103,108,685 N1401D probably damaging Het
Vmn2r115 T A 17: 23,359,781 S743T probably damaging Het
Zfand4 G A 6: 116,314,869 R588Q probably benign Het
Other mutations in Olfr697
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Olfr697 APN 7 106741701 missense probably benign 0.20
IGL00937:Olfr697 APN 7 106741157 missense probably damaging 1.00
IGL01368:Olfr697 APN 7 106741622 missense probably benign 0.19
IGL01410:Olfr697 APN 7 106741499 missense probably benign 0.19
IGL01962:Olfr697 APN 7 106741784 missense probably benign 0.12
IGL02654:Olfr697 APN 7 106741348 nonsense probably null
IGL02903:Olfr697 APN 7 106741710 missense probably damaging 1.00
IGL03347:Olfr697 APN 7 106740970 utr 3 prime probably benign
IGL03391:Olfr697 APN 7 106741755 missense probably damaging 1.00
R0139:Olfr697 UTSW 7 106741625 missense probably benign 0.05
R0142:Olfr697 UTSW 7 106741765 missense probably benign 0.36
R1293:Olfr697 UTSW 7 106741851 missense probably damaging 0.98
R1522:Olfr697 UTSW 7 106741005 missense probably benign 0.03
R1715:Olfr697 UTSW 7 106741548 missense probably damaging 1.00
R1959:Olfr697 UTSW 7 106741394 missense probably damaging 1.00
R1960:Olfr697 UTSW 7 106741394 missense probably damaging 1.00
R2031:Olfr697 UTSW 7 106741898 missense probably damaging 1.00
R4790:Olfr697 UTSW 7 106741791 missense probably benign 0.05
R5550:Olfr697 UTSW 7 106741133 missense probably benign 0.01
R6232:Olfr697 UTSW 7 106741554 missense probably damaging 0.96
R6293:Olfr697 UTSW 7 106741406 missense probably damaging 1.00
R6643:Olfr697 UTSW 7 106741704 missense probably benign 0.06
R7831:Olfr697 UTSW 7 106741413 missense probably damaging 0.99
R7914:Olfr697 UTSW 7 106741413 missense probably damaging 0.99
R8013:Olfr697 UTSW 7 106741617 missense probably benign 0.00
R8014:Olfr697 UTSW 7 106741617 missense probably benign 0.00
RF018:Olfr697 UTSW 7 106741485 missense probably benign 0.02
X0020:Olfr697 UTSW 7 106741136 missense probably damaging 0.97
Z1088:Olfr697 UTSW 7 106741143 missense probably benign 0.21
Posted On2015-04-16