Incidental Mutation 'IGL01373:Lmcd1'
ID278484
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lmcd1
Ensembl Gene ENSMUSG00000057604
Gene NameLIM and cysteine-rich domains 1
Synonymsdyxin
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01373
Quality Score
Status
Chromosome6
Chromosomal Location112273758-112330425 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 112310625 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 91 (I91V)
Ref Sequence ENSEMBL: ENSMUSP00000032376 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032376]
Predicted Effect probably benign
Transcript: ENSMUST00000032376
AA Change: I91V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000032376
Gene: ENSMUSG00000057604
AA Change: I91V

DomainStartEndE-ValueType
Pfam:PET 107 201 4.9e-39 PFAM
LIM 242 299 7.29e-8 SMART
LIM 307 359 1.97e-13 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm4 C T 7: 119,711,419 R510* probably null Het
Adamts12 A T 15: 11,310,730 E1024D probably benign Het
Aff2 T A X: 69,867,729 D1239E possibly damaging Het
Agps T C 2: 75,852,784 V151A probably benign Het
Cables1 A T 18: 11,888,764 R276S probably damaging Het
Cep72 A G 13: 74,059,459 S64P probably damaging Het
Cmah A T 13: 24,430,549 D159V probably damaging Het
Cox6a1 C A 5: 115,345,839 probably benign Het
Cpxm1 T C 2: 130,394,135 E369G probably damaging Het
Dnah6 A G 6: 73,074,748 L3021P probably benign Het
Esyt1 T C 10: 128,518,941 E530G possibly damaging Het
Fancd2 A G 6: 113,553,752 I449V probably benign Het
Fbxw24 C T 9: 109,623,633 G98D probably damaging Het
Folh1 T C 7: 86,746,142 I361V probably benign Het
Gm12666 A G 4: 92,191,625 V42A probably damaging Het
Gpr19 T A 6: 134,870,321 H41L possibly damaging Het
Kcnq4 A G 4: 120,717,032 V143A probably damaging Het
Lpin3 G T 2: 160,903,729 D651Y probably damaging Het
Ms4a6b A T 19: 11,529,507 H220L possibly damaging Het
Mxd4 G A 5: 34,184,346 probably benign Het
Nxnl2 T C 13: 51,171,452 F44L probably damaging Het
Olfr698 T C 7: 106,752,446 probably benign Het
Olfr744 T A 14: 50,618,612 I130N probably damaging Het
Pcdhb20 A T 18: 37,506,568 R716W probably benign Het
Pcx T A 19: 4,620,235 probably null Het
Plekhf1 T C 7: 38,221,797 T116A probably benign Het
Psmb2 G T 4: 126,687,092 R93L probably damaging Het
Pstpip2 T A 18: 77,835,216 L42* probably null Het
Ptpn22 A T 3: 103,886,204 D557V probably damaging Het
Rbbp5 G A 1: 132,492,601 V191I probably benign Het
Rgs1 T A 1: 144,245,378 D185V probably damaging Het
Selenoh A G 2: 84,670,594 probably benign Het
Slc6a5 C T 7: 49,917,733 P312S probably benign Het
Snapc1 T A 12: 73,964,680 M40K probably benign Het
Sptbn2 T G 19: 4,745,972 Y1726* probably null Het
Syne2 T C 12: 75,987,107 I3710T probably damaging Het
Tdrd9 G A 12: 112,040,434 V911M probably damaging Het
Tex9 A T 9: 72,480,754 D134E possibly damaging Het
Ttc41 G T 10: 86,775,957 C1063F possibly damaging Het
Usp38 C A 8: 80,990,018 A496S possibly damaging Het
Vmn2r13 T A 5: 109,156,702 Y621F probably damaging Het
Vmn2r67 T A 7: 85,136,626 M724L probably benign Het
Other mutations in Lmcd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Lmcd1 APN 6 112329808 missense probably benign 0.29
IGL00963:Lmcd1 APN 6 112329934 missense probably damaging 1.00
IGL01339:Lmcd1 APN 6 112310625 missense probably benign
IGL03088:Lmcd1 APN 6 112310688 missense probably damaging 1.00
IGL03090:Lmcd1 APN 6 112310499 missense probably benign 0.32
R0940:Lmcd1 UTSW 6 112328697 missense probably benign 0.01
R1144:Lmcd1 UTSW 6 112310751 splice site probably benign
R1245:Lmcd1 UTSW 6 112315712 missense probably benign 0.01
R1338:Lmcd1 UTSW 6 112305128 missense probably damaging 1.00
R1567:Lmcd1 UTSW 6 112310565 missense probably damaging 1.00
R1615:Lmcd1 UTSW 6 112273950 missense probably benign 0.40
R1748:Lmcd1 UTSW 6 112329914 missense probably benign 0.01
R1793:Lmcd1 UTSW 6 112328751 missense probably benign 0.00
R2014:Lmcd1 UTSW 6 112328741 missense probably damaging 1.00
R2042:Lmcd1 UTSW 6 112315890 missense probably benign 0.00
R4322:Lmcd1 UTSW 6 112315763 missense possibly damaging 0.54
R4344:Lmcd1 UTSW 6 112288007 intron probably benign
R4771:Lmcd1 UTSW 6 112315873 missense probably damaging 1.00
R4863:Lmcd1 UTSW 6 112287871 intron probably benign
R5256:Lmcd1 UTSW 6 112288126 intron probably benign
R5296:Lmcd1 UTSW 6 112315588 missense probably damaging 1.00
R6453:Lmcd1 UTSW 6 112315828 missense probably benign
R6972:Lmcd1 UTSW 6 112310698 missense probably damaging 1.00
R7239:Lmcd1 UTSW 6 112315784 missense possibly damaging 0.94
R7278:Lmcd1 UTSW 6 112310539 missense possibly damaging 0.73
Z1177:Lmcd1 UTSW 6 112310674 missense possibly damaging 0.68
Z1177:Lmcd1 UTSW 6 112310676 missense probably benign 0.03
Posted On2015-04-16