Incidental Mutation 'IGL00944:Zfp668'
ID 27850
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp668
Ensembl Gene ENSMUSG00000049728
Gene Name zinc finger protein 668
Synonyms E130018B19Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # IGL00944
Quality Score
Status
Chromosome 7
Chromosomal Location 127462219-127476000 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 127467079 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Tryptophan at position 166 (R166W)
Ref Sequence ENSEMBL: ENSMUSP00000101870 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054415] [ENSMUST00000106261] [ENSMUST00000106262] [ENSMUST00000106263] [ENSMUST00000144721]
AlphaFold Q8K2R5
Predicted Effect probably damaging
Transcript: ENSMUST00000054415
AA Change: R166W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000056105
Gene: ENSMUSG00000049728
AA Change: R166W

DomainStartEndE-ValueType
ZnF_C2H2 22 44 7.67e-2 SMART
ZnF_C2H2 84 106 9.44e-2 SMART
ZnF_C2H2 112 134 3.63e-3 SMART
ZnF_C2H2 140 162 2.36e-2 SMART
ZnF_C2H2 168 190 1.98e-4 SMART
ZnF_C2H2 196 218 2.91e-2 SMART
ZnF_C2H2 224 246 1.26e-2 SMART
ZnF_C2H2 252 274 5.21e-4 SMART
ZnF_C2H2 280 302 2.57e-3 SMART
ZnF_C2H2 308 330 5.59e-4 SMART
ZnF_C2H2 336 358 1.79e-2 SMART
ZnF_C2H2 364 386 7.9e-4 SMART
ZnF_C2H2 392 414 5.5e-3 SMART
low complexity region 428 470 N/A INTRINSIC
ZnF_C2H2 516 538 3.63e-3 SMART
ZnF_C2H2 544 566 1.3e-4 SMART
ZnF_C2H2 572 594 5.59e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000106261
AA Change: R166W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101868
Gene: ENSMUSG00000049728
AA Change: R166W

DomainStartEndE-ValueType
ZnF_C2H2 22 44 7.67e-2 SMART
ZnF_C2H2 84 106 9.44e-2 SMART
ZnF_C2H2 112 134 3.63e-3 SMART
ZnF_C2H2 140 162 2.36e-2 SMART
ZnF_C2H2 168 190 1.98e-4 SMART
ZnF_C2H2 196 218 2.91e-2 SMART
ZnF_C2H2 224 246 1.26e-2 SMART
ZnF_C2H2 252 274 5.21e-4 SMART
ZnF_C2H2 280 302 2.57e-3 SMART
ZnF_C2H2 308 330 5.59e-4 SMART
ZnF_C2H2 336 358 1.79e-2 SMART
ZnF_C2H2 364 386 7.9e-4 SMART
ZnF_C2H2 392 414 5.5e-3 SMART
low complexity region 428 470 N/A INTRINSIC
ZnF_C2H2 516 538 3.63e-3 SMART
ZnF_C2H2 544 566 1.3e-4 SMART
ZnF_C2H2 572 594 5.59e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000106262
AA Change: R166W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101869
Gene: ENSMUSG00000049728
AA Change: R166W

DomainStartEndE-ValueType
ZnF_C2H2 22 44 7.67e-2 SMART
ZnF_C2H2 84 106 9.44e-2 SMART
ZnF_C2H2 112 134 3.63e-3 SMART
ZnF_C2H2 140 162 2.36e-2 SMART
ZnF_C2H2 168 190 1.98e-4 SMART
ZnF_C2H2 196 218 2.91e-2 SMART
ZnF_C2H2 224 246 1.26e-2 SMART
ZnF_C2H2 252 274 5.21e-4 SMART
ZnF_C2H2 280 302 2.57e-3 SMART
ZnF_C2H2 308 330 5.59e-4 SMART
ZnF_C2H2 336 358 1.79e-2 SMART
ZnF_C2H2 364 386 7.9e-4 SMART
ZnF_C2H2 392 414 5.5e-3 SMART
low complexity region 428 470 N/A INTRINSIC
ZnF_C2H2 516 538 3.63e-3 SMART
ZnF_C2H2 544 566 1.3e-4 SMART
ZnF_C2H2 572 594 5.59e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000106263
AA Change: R166W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101870
Gene: ENSMUSG00000049728
AA Change: R166W

DomainStartEndE-ValueType
ZnF_C2H2 22 44 7.67e-2 SMART
ZnF_C2H2 84 106 9.44e-2 SMART
ZnF_C2H2 112 134 3.63e-3 SMART
ZnF_C2H2 140 162 2.36e-2 SMART
ZnF_C2H2 168 190 1.98e-4 SMART
ZnF_C2H2 196 218 2.91e-2 SMART
ZnF_C2H2 224 246 1.26e-2 SMART
ZnF_C2H2 252 274 5.21e-4 SMART
ZnF_C2H2 280 302 2.57e-3 SMART
ZnF_C2H2 308 330 5.59e-4 SMART
ZnF_C2H2 336 358 1.79e-2 SMART
ZnF_C2H2 364 386 7.9e-4 SMART
ZnF_C2H2 392 414 5.5e-3 SMART
low complexity region 428 470 N/A INTRINSIC
ZnF_C2H2 516 538 3.63e-3 SMART
ZnF_C2H2 544 566 1.3e-4 SMART
ZnF_C2H2 572 594 5.59e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000144721
SMART Domains Protein: ENSMUSP00000116730
Gene: ENSMUSG00000049728

DomainStartEndE-ValueType
ZnF_C2H2 22 44 7.67e-2 SMART
ZnF_C2H2 84 106 9.44e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp10b A G 11: 43,092,988 (GRCm39) N441S probably damaging Het
Bod1l A G 5: 41,974,166 (GRCm39) C2383R probably benign Het
Dapk3 G T 10: 81,019,910 (GRCm39) probably null Het
Dock6 T C 9: 21,757,930 (GRCm39) D58G possibly damaging Het
Etl4 G A 2: 20,534,865 (GRCm39) V107I possibly damaging Het
Fam163b A G 2: 27,003,597 (GRCm39) L19P probably damaging Het
Fbxl20 A C 11: 98,004,068 (GRCm39) F73L probably damaging Het
Foxj2 T C 6: 122,816,594 (GRCm39) L492P probably damaging Het
Hfm1 A T 5: 107,049,996 (GRCm39) V391E possibly damaging Het
Ift74 T C 4: 94,581,259 (GRCm39) Y586H probably damaging Het
Klhl12 A G 1: 134,411,491 (GRCm39) N280S probably benign Het
Lctl T A 9: 64,040,411 (GRCm39) Y292* probably null Het
Ltb C A 17: 35,413,642 (GRCm39) Q49K possibly damaging Het
Mapk1 T A 16: 16,853,322 (GRCm39) D289E probably benign Het
Mideas A G 12: 84,207,322 (GRCm39) probably benign Het
Mroh2b C T 15: 4,980,609 (GRCm39) probably benign Het
Myot T C 18: 44,470,181 (GRCm39) S53P possibly damaging Het
Opn5 G A 17: 42,922,119 (GRCm39) L28F probably damaging Het
Or5b97 A T 19: 12,878,719 (GRCm39) Y142N probably benign Het
Or8k39 A G 2: 86,563,905 (GRCm39) I17T possibly damaging Het
Pals2 T C 6: 50,140,436 (GRCm39) V152A possibly damaging Het
Pld1 T A 3: 28,099,247 (GRCm39) probably null Het
Rc3h2 A G 2: 37,288,250 (GRCm39) probably benign Het
Robo2 T A 16: 73,730,585 (GRCm39) H1009L possibly damaging Het
Setd7 T A 3: 51,440,459 (GRCm39) D194V probably damaging Het
Sh3bp1 A T 15: 78,789,314 (GRCm39) D288V possibly damaging Het
Smpd4 T C 16: 17,460,621 (GRCm39) I809T probably benign Het
Spata6 C T 4: 111,663,125 (GRCm39) probably benign Het
Trnau1ap C A 4: 132,055,817 (GRCm39) V30L possibly damaging Het
Trpm4 T C 7: 44,967,773 (GRCm39) H386R probably benign Het
Ttc3 T G 16: 94,227,620 (GRCm39) probably null Het
Ufd1 T C 16: 18,643,781 (GRCm39) V180A possibly damaging Het
Vmn2r102 A G 17: 19,899,154 (GRCm39) I499V probably damaging Het
Zfp112 C A 7: 23,825,021 (GRCm39) Q330K probably benign Het
Other mutations in Zfp668
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01063:Zfp668 APN 7 127,465,454 (GRCm39) missense probably damaging 1.00
IGL01909:Zfp668 APN 7 127,465,994 (GRCm39) missense probably damaging 1.00
IGL02404:Zfp668 APN 7 127,465,532 (GRCm39) missense probably damaging 1.00
IGL02543:Zfp668 APN 7 127,467,494 (GRCm39) nonsense probably null
IGL02946:Zfp668 APN 7 127,465,690 (GRCm39) missense possibly damaging 0.70
R0078:Zfp668 UTSW 7 127,467,210 (GRCm39) missense possibly damaging 0.94
R1521:Zfp668 UTSW 7 127,466,252 (GRCm39) missense probably benign 0.09
R1775:Zfp668 UTSW 7 127,465,778 (GRCm39) missense possibly damaging 0.75
R1873:Zfp668 UTSW 7 127,465,654 (GRCm39) splice site probably null
R1875:Zfp668 UTSW 7 127,465,654 (GRCm39) splice site probably null
R2066:Zfp668 UTSW 7 127,466,203 (GRCm39) missense probably damaging 0.98
R2068:Zfp668 UTSW 7 127,465,837 (GRCm39) missense probably benign 0.06
R2278:Zfp668 UTSW 7 127,465,998 (GRCm39) missense probably benign 0.05
R5516:Zfp668 UTSW 7 127,466,318 (GRCm39) missense probably damaging 1.00
R5569:Zfp668 UTSW 7 127,466,995 (GRCm39) nonsense probably null
R5875:Zfp668 UTSW 7 127,465,474 (GRCm39) missense possibly damaging 0.61
R6663:Zfp668 UTSW 7 127,466,941 (GRCm39) missense probably damaging 1.00
R8543:Zfp668 UTSW 7 127,466,392 (GRCm39) missense probably damaging 1.00
R8822:Zfp668 UTSW 7 127,466,315 (GRCm39) missense probably damaging 1.00
R8905:Zfp668 UTSW 7 127,465,598 (GRCm39) missense probably benign 0.04
R9191:Zfp668 UTSW 7 127,465,658 (GRCm39) missense probably benign
R9217:Zfp668 UTSW 7 127,465,804 (GRCm39) nonsense probably null
R9655:Zfp668 UTSW 7 127,466,113 (GRCm39) missense possibly damaging 0.70
Posted On 2013-04-17