Incidental Mutation 'IGL00944:Zfp668'
ID |
27850 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Zfp668
|
Ensembl Gene |
ENSMUSG00000049728 |
Gene Name |
zinc finger protein 668 |
Synonyms |
E130018B19Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.147)
|
Stock # |
IGL00944
|
Quality Score |
|
Status
|
|
Chromosome |
7 |
Chromosomal Location |
127462219-127476000 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 127467079 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Tryptophan
at position 166
(R166W)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000101870
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054415]
[ENSMUST00000106261]
[ENSMUST00000106262]
[ENSMUST00000106263]
[ENSMUST00000144721]
|
AlphaFold |
Q8K2R5 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000054415
AA Change: R166W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000056105 Gene: ENSMUSG00000049728 AA Change: R166W
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
ZnF_C2H2
|
112 |
134 |
3.63e-3 |
SMART |
ZnF_C2H2
|
140 |
162 |
2.36e-2 |
SMART |
ZnF_C2H2
|
168 |
190 |
1.98e-4 |
SMART |
ZnF_C2H2
|
196 |
218 |
2.91e-2 |
SMART |
ZnF_C2H2
|
224 |
246 |
1.26e-2 |
SMART |
ZnF_C2H2
|
252 |
274 |
5.21e-4 |
SMART |
ZnF_C2H2
|
280 |
302 |
2.57e-3 |
SMART |
ZnF_C2H2
|
308 |
330 |
5.59e-4 |
SMART |
ZnF_C2H2
|
336 |
358 |
1.79e-2 |
SMART |
ZnF_C2H2
|
364 |
386 |
7.9e-4 |
SMART |
ZnF_C2H2
|
392 |
414 |
5.5e-3 |
SMART |
low complexity region
|
428 |
470 |
N/A |
INTRINSIC |
ZnF_C2H2
|
516 |
538 |
3.63e-3 |
SMART |
ZnF_C2H2
|
544 |
566 |
1.3e-4 |
SMART |
ZnF_C2H2
|
572 |
594 |
5.59e-4 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000106261
AA Change: R166W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000101868 Gene: ENSMUSG00000049728 AA Change: R166W
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
ZnF_C2H2
|
112 |
134 |
3.63e-3 |
SMART |
ZnF_C2H2
|
140 |
162 |
2.36e-2 |
SMART |
ZnF_C2H2
|
168 |
190 |
1.98e-4 |
SMART |
ZnF_C2H2
|
196 |
218 |
2.91e-2 |
SMART |
ZnF_C2H2
|
224 |
246 |
1.26e-2 |
SMART |
ZnF_C2H2
|
252 |
274 |
5.21e-4 |
SMART |
ZnF_C2H2
|
280 |
302 |
2.57e-3 |
SMART |
ZnF_C2H2
|
308 |
330 |
5.59e-4 |
SMART |
ZnF_C2H2
|
336 |
358 |
1.79e-2 |
SMART |
ZnF_C2H2
|
364 |
386 |
7.9e-4 |
SMART |
ZnF_C2H2
|
392 |
414 |
5.5e-3 |
SMART |
low complexity region
|
428 |
470 |
N/A |
INTRINSIC |
ZnF_C2H2
|
516 |
538 |
3.63e-3 |
SMART |
ZnF_C2H2
|
544 |
566 |
1.3e-4 |
SMART |
ZnF_C2H2
|
572 |
594 |
5.59e-4 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000106262
AA Change: R166W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000101869 Gene: ENSMUSG00000049728 AA Change: R166W
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
ZnF_C2H2
|
112 |
134 |
3.63e-3 |
SMART |
ZnF_C2H2
|
140 |
162 |
2.36e-2 |
SMART |
ZnF_C2H2
|
168 |
190 |
1.98e-4 |
SMART |
ZnF_C2H2
|
196 |
218 |
2.91e-2 |
SMART |
ZnF_C2H2
|
224 |
246 |
1.26e-2 |
SMART |
ZnF_C2H2
|
252 |
274 |
5.21e-4 |
SMART |
ZnF_C2H2
|
280 |
302 |
2.57e-3 |
SMART |
ZnF_C2H2
|
308 |
330 |
5.59e-4 |
SMART |
ZnF_C2H2
|
336 |
358 |
1.79e-2 |
SMART |
ZnF_C2H2
|
364 |
386 |
7.9e-4 |
SMART |
ZnF_C2H2
|
392 |
414 |
5.5e-3 |
SMART |
low complexity region
|
428 |
470 |
N/A |
INTRINSIC |
ZnF_C2H2
|
516 |
538 |
3.63e-3 |
SMART |
ZnF_C2H2
|
544 |
566 |
1.3e-4 |
SMART |
ZnF_C2H2
|
572 |
594 |
5.59e-4 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000106263
AA Change: R166W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000101870 Gene: ENSMUSG00000049728 AA Change: R166W
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
ZnF_C2H2
|
112 |
134 |
3.63e-3 |
SMART |
ZnF_C2H2
|
140 |
162 |
2.36e-2 |
SMART |
ZnF_C2H2
|
168 |
190 |
1.98e-4 |
SMART |
ZnF_C2H2
|
196 |
218 |
2.91e-2 |
SMART |
ZnF_C2H2
|
224 |
246 |
1.26e-2 |
SMART |
ZnF_C2H2
|
252 |
274 |
5.21e-4 |
SMART |
ZnF_C2H2
|
280 |
302 |
2.57e-3 |
SMART |
ZnF_C2H2
|
308 |
330 |
5.59e-4 |
SMART |
ZnF_C2H2
|
336 |
358 |
1.79e-2 |
SMART |
ZnF_C2H2
|
364 |
386 |
7.9e-4 |
SMART |
ZnF_C2H2
|
392 |
414 |
5.5e-3 |
SMART |
low complexity region
|
428 |
470 |
N/A |
INTRINSIC |
ZnF_C2H2
|
516 |
538 |
3.63e-3 |
SMART |
ZnF_C2H2
|
544 |
566 |
1.3e-4 |
SMART |
ZnF_C2H2
|
572 |
594 |
5.59e-4 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000144721
|
SMART Domains |
Protein: ENSMUSP00000116730 Gene: ENSMUSG00000049728
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 34 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Atp10b |
A |
G |
11: 43,092,988 (GRCm39) |
N441S |
probably damaging |
Het |
Bod1l |
A |
G |
5: 41,974,166 (GRCm39) |
C2383R |
probably benign |
Het |
Dapk3 |
G |
T |
10: 81,019,910 (GRCm39) |
|
probably null |
Het |
Dock6 |
T |
C |
9: 21,757,930 (GRCm39) |
D58G |
possibly damaging |
Het |
Etl4 |
G |
A |
2: 20,534,865 (GRCm39) |
V107I |
possibly damaging |
Het |
Fam163b |
A |
G |
2: 27,003,597 (GRCm39) |
L19P |
probably damaging |
Het |
Fbxl20 |
A |
C |
11: 98,004,068 (GRCm39) |
F73L |
probably damaging |
Het |
Foxj2 |
T |
C |
6: 122,816,594 (GRCm39) |
L492P |
probably damaging |
Het |
Hfm1 |
A |
T |
5: 107,049,996 (GRCm39) |
V391E |
possibly damaging |
Het |
Ift74 |
T |
C |
4: 94,581,259 (GRCm39) |
Y586H |
probably damaging |
Het |
Klhl12 |
A |
G |
1: 134,411,491 (GRCm39) |
N280S |
probably benign |
Het |
Lctl |
T |
A |
9: 64,040,411 (GRCm39) |
Y292* |
probably null |
Het |
Ltb |
C |
A |
17: 35,413,642 (GRCm39) |
Q49K |
possibly damaging |
Het |
Mapk1 |
T |
A |
16: 16,853,322 (GRCm39) |
D289E |
probably benign |
Het |
Mideas |
A |
G |
12: 84,207,322 (GRCm39) |
|
probably benign |
Het |
Mroh2b |
C |
T |
15: 4,980,609 (GRCm39) |
|
probably benign |
Het |
Myot |
T |
C |
18: 44,470,181 (GRCm39) |
S53P |
possibly damaging |
Het |
Opn5 |
G |
A |
17: 42,922,119 (GRCm39) |
L28F |
probably damaging |
Het |
Or5b97 |
A |
T |
19: 12,878,719 (GRCm39) |
Y142N |
probably benign |
Het |
Or8k39 |
A |
G |
2: 86,563,905 (GRCm39) |
I17T |
possibly damaging |
Het |
Pals2 |
T |
C |
6: 50,140,436 (GRCm39) |
V152A |
possibly damaging |
Het |
Pld1 |
T |
A |
3: 28,099,247 (GRCm39) |
|
probably null |
Het |
Rc3h2 |
A |
G |
2: 37,288,250 (GRCm39) |
|
probably benign |
Het |
Robo2 |
T |
A |
16: 73,730,585 (GRCm39) |
H1009L |
possibly damaging |
Het |
Setd7 |
T |
A |
3: 51,440,459 (GRCm39) |
D194V |
probably damaging |
Het |
Sh3bp1 |
A |
T |
15: 78,789,314 (GRCm39) |
D288V |
possibly damaging |
Het |
Smpd4 |
T |
C |
16: 17,460,621 (GRCm39) |
I809T |
probably benign |
Het |
Spata6 |
C |
T |
4: 111,663,125 (GRCm39) |
|
probably benign |
Het |
Trnau1ap |
C |
A |
4: 132,055,817 (GRCm39) |
V30L |
possibly damaging |
Het |
Trpm4 |
T |
C |
7: 44,967,773 (GRCm39) |
H386R |
probably benign |
Het |
Ttc3 |
T |
G |
16: 94,227,620 (GRCm39) |
|
probably null |
Het |
Ufd1 |
T |
C |
16: 18,643,781 (GRCm39) |
V180A |
possibly damaging |
Het |
Vmn2r102 |
A |
G |
17: 19,899,154 (GRCm39) |
I499V |
probably damaging |
Het |
Zfp112 |
C |
A |
7: 23,825,021 (GRCm39) |
Q330K |
probably benign |
Het |
|
Other mutations in Zfp668 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01063:Zfp668
|
APN |
7 |
127,465,454 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01909:Zfp668
|
APN |
7 |
127,465,994 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02404:Zfp668
|
APN |
7 |
127,465,532 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02543:Zfp668
|
APN |
7 |
127,467,494 (GRCm39) |
nonsense |
probably null |
|
IGL02946:Zfp668
|
APN |
7 |
127,465,690 (GRCm39) |
missense |
possibly damaging |
0.70 |
R0078:Zfp668
|
UTSW |
7 |
127,467,210 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1521:Zfp668
|
UTSW |
7 |
127,466,252 (GRCm39) |
missense |
probably benign |
0.09 |
R1775:Zfp668
|
UTSW |
7 |
127,465,778 (GRCm39) |
missense |
possibly damaging |
0.75 |
R1873:Zfp668
|
UTSW |
7 |
127,465,654 (GRCm39) |
splice site |
probably null |
|
R1875:Zfp668
|
UTSW |
7 |
127,465,654 (GRCm39) |
splice site |
probably null |
|
R2066:Zfp668
|
UTSW |
7 |
127,466,203 (GRCm39) |
missense |
probably damaging |
0.98 |
R2068:Zfp668
|
UTSW |
7 |
127,465,837 (GRCm39) |
missense |
probably benign |
0.06 |
R2278:Zfp668
|
UTSW |
7 |
127,465,998 (GRCm39) |
missense |
probably benign |
0.05 |
R5516:Zfp668
|
UTSW |
7 |
127,466,318 (GRCm39) |
missense |
probably damaging |
1.00 |
R5569:Zfp668
|
UTSW |
7 |
127,466,995 (GRCm39) |
nonsense |
probably null |
|
R5875:Zfp668
|
UTSW |
7 |
127,465,474 (GRCm39) |
missense |
possibly damaging |
0.61 |
R6663:Zfp668
|
UTSW |
7 |
127,466,941 (GRCm39) |
missense |
probably damaging |
1.00 |
R8543:Zfp668
|
UTSW |
7 |
127,466,392 (GRCm39) |
missense |
probably damaging |
1.00 |
R8822:Zfp668
|
UTSW |
7 |
127,466,315 (GRCm39) |
missense |
probably damaging |
1.00 |
R8905:Zfp668
|
UTSW |
7 |
127,465,598 (GRCm39) |
missense |
probably benign |
0.04 |
R9191:Zfp668
|
UTSW |
7 |
127,465,658 (GRCm39) |
missense |
probably benign |
|
R9217:Zfp668
|
UTSW |
7 |
127,465,804 (GRCm39) |
nonsense |
probably null |
|
R9655:Zfp668
|
UTSW |
7 |
127,466,113 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Posted On |
2013-04-17 |